Article
Multidisciplinary Sciences
Asit Kumar, Namita Sinha, Sanjana Haque, Sunitha Kodidela, Tengfei Wang, Angel G. Martinez, Hao Chen, Santosh Kumar
Summary: This study investigated the effects of self-administered nicotine with menthol and audiovisual cues on nicotine-metabolizing CYP2A6, oxidative stress modulators, and cytokines/chemokines in plasma extracellular vesicles (EVs) in rats. The results showed altered levels of CD9, CYP2A6, and cytokines/chemokines in plasma EVs after self-administered nicotine with menthol and AV cue, suggesting a potential impact on cell-cell communication, nicotine metabolism, and inflammation.
SCIENTIFIC REPORTS
(2021)
Article
Food Science & Technology
Andrey Savio de Almeida Assuncao, Renata Aparecida Martins, Jose Cavalcante Souza Vieira, Leone Campos Rocha, Fernanda Kaiser de Lima Krenchinski, Marilia Afonso Rabelo Buzalaf, Jose Roberto Sartori, Pedro de Magalhaes Padilha
Summary: The aim of this study was to investigate the differential expression of proteins in the pectoralis major muscle of broilers supplemented with passion fruit seed oil (PFSO) under cyclic heat stress conditions. The results showed that 57 proteins exhibited changes in expression, with four proteins upregulated and 46 proteins downregulated in the pectoralis major muscle of broilers supplemented with 0.9% PFSO. Additionally, seven proteins were exclusively expressed in the control group.
FOOD RESEARCH INTERNATIONAL
(2023)
Article
Chemistry, Medicinal
Amandyne Linares-Maurizi, Guillaume Reversat, Rana Awad, Valerie Bultel-Ponce, Camille Oger, Jean-Marie Galano, Laurence Balas, Anaelle Durbec, Justine Bertrand-Michel, Thierry Durand, Remi Pradelles, Claire Vigor
Summary: This study aims to analyze the profile of oxylipins in five microalgae species grown under optimal conditions, and found a high diversity of non-enzymatic and enzymatic oxylipins in these microalgae. These bioactive lipids may have important functions in preventive health measures and amelioration of inflammation.
Article
Multidisciplinary Sciences
Asit Kumar, Namita Sinha, Sunitha Kodidela, Lina Zhou, Udai P. Singh, Santosh Kumar
Summary: The study found that Benzo(a)pyrene (BaP) contributes partly to macrophage and astrocyte-mediated neuroinflammation by inducing the production of IL-1 beta and MCP-1, likely involving the CYP and/or oxidative stress pathways.
Article
Environmental Sciences
Sridhar Chinthakindi, Kurunthachalam Kannan
Summary: Primary aromatic amines (AAs) and tobacco smoke markers were found to be prevalent in indoor house dust samples from 10 countries, with concentrations varying significantly between countries. Aniline was identified as the most abundant contaminant among AAs, while nicotine was consistently detected in all indoor samples. Concentrations of AAs in house dust were strongly correlated with nicotine levels.
ENVIRONMENT INTERNATIONAL
(2021)
Article
Biochemistry & Molecular Biology
Islam El-Garawani, Sobhy Hassab El-Nabi, Ahmed El Kattan, Azza Sallam, Sabha Elballat, Shaimaa Abou-Ghanima, Islam H. El Azab, Hesham R. El-Seedi, Shaden A. M. Khalifa, Sawsan El-Shamy
Summary: The study demonstrated that Arabic gum has a protective effect against oxidative stress and genotoxicity induced by a radiographic contrast medium. The active metabolites in Arabic gum were identified as key contributors to this protective role.
Article
Environmental Sciences
Sridhar Chinthakindi, Kurunthachalam Kannan
Summary: In this study, the concentrations of 30 primary aromatic amines (AAs), nicotine, and cotinine were measured in urine samples collected over a five-week period from 15 participants. The study found that eight AAs were detected in urine with varying frequencies, and their concentrations showed temporal variability within and between individuals. Gender and ethnicity were found to have significant effects on the concentrations of AAs.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Chemistry, Analytical
Kazushi Noro, Ayana Komatsu, Miyu Moriya, Yoko Kai, Qi Wang, Yuichi Miyake, Takashi Amagai
Summary: Passive smoking is a concern due to its harmful health risks. We developed a passive sampler coupled with perforated covers to improve sampling accuracy. Furthermore, a highly sensitive nicotine analysis method was developed. The results showed that the developed passive sampler and analytical method are promising tools for monitoring nicotine.
MICROCHEMICAL JOURNAL
(2023)
Article
Environmental Sciences
Sridhar Chinthakindi, Qingqing Zhu, Chunyang Liao, Kurunthachalam Kannan
Summary: This study investigated the occurrence of 35 primary aromatic amines and two tobacco chemical markers in 119 samples of house dust collected from five provinces in China, finding that most samples contained these chemicals, with higher concentrations in Henan and Shanxi provinces. Significant positive correlations were observed between concentrations of nicotine and aromatic amines in the dust samples.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Review
Biochemical Research Methods
Asmin Andries, Jef Rozenski, Pieter Vermeersch, Djalila Mekahli, Ann Van Schepdael
Summary: A healthy body maintains a balance between the production of reactive oxygen and nitrogen species and antioxidant defense mechanisms. Oxidative stress disrupts this balance, causing damage to biological molecules. LC-MS/MS methods are increasingly used to analyze oxidative stress biomarkers in biofluids.
Article
Biochemical Research Methods
Arezoo Habibagahi, Shabana Siddique, Shelley A. Harris, Nicholas Alderman, Rocio Aranda-Rodriguez, Imen Farhat, Jonathan Chevrier, Cariton Kubwabo
Summary: This study aimed to investigate quality control measures in the determination of urinary nicotine and related compounds, with results showing that a one-step extraction procedure using cold acetone achieved very low detection limits, good recoveries, and precisions. Target analyte levels were higher in urine samples from smokers compared to non-smokers, with no significant differences observed between former smokers, never smokers, and individuals exposed to environmental tobacco smoke.
JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
(2021)
Article
Chemistry, Medicinal
Nashwah G. M. Attallah, Fatma Alzahraa Mokhtar, Engy Elekhnawy, Selim Z. Heneidy, Eman Ahmed, Sameh Magdeldin, Walaa A. Negm, Aya H. El-Kadem
Summary: This study assessed the hepatoprotective effects of Salvinia auriculata methanol extract (SAME) against methotrexate (MTX)-induced hepatotoxicity and identified the possible mechanisms involved. The results showed that SAME effectively improved MTX-induced liver damage, suppressed inflammation, and decreased cellular apoptosis. Furthermore, SAME exhibited antibacterial activity.
Article
Pharmacology & Pharmacy
Yassin Ismail, Dina M. Fahmy, Maivel H. Ghattas, Mai M. Ahmed, Walaa Zehry, Samy M. Saleh, Dina M. Abo-elmatty
Summary: This study revealed for the first time that Matricaria aurea has antidiabetic activity by simultaneously modulating multiple targets and pathways, including inflammatory pathways, energy-sensing/endocrine/metabolic pathways, and oxidative stress pathways.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Alan Goncalves Amaral, Isabela Aparecida Moretto, Flavia da Silva Zandonadi, Hans Rolando Zamora-Obando, Isabela Rocha, Alessandra Sussulini, Andre Alexandre de Thomaz, Regina Vincenzi Oliveira, Aline Mara dos Santos, Ana Valeria Colnaghi Simionato
Summary: Cardiovascular diseases (CVDs) are complex noncommunicable diseases with a high mortality rate. Oxidative stress (OS) plays a pivotal role in CVC, and studying cellular metabolomics can help evaluate cardiac dysfunction. The results of this study suggest that LC-MS method is effective for studying cardiomyocyte metabolism and has good fitness and predictability.
FRONTIERS IN CHEMISTRY
(2022)
Article
Chemistry, Analytical
Ryu Mochizuki, Akane Kobayashi, Hiromitsu Takayama, Toshihiko Toida, Yasumitsu Ogra
Summary: The Konig reaction is a useful method for detecting cyanide and its derivatives. In this study, we found that it can also be used to quantify glutathione and applied it to determine the levels of reduced and oxidized glutathiones. The method showed good sensitivity and was successfully applied to measure GSH and GSSG levels in cells exposed to oxidative stress.
ANALYTICAL METHODS
(2023)