Article
Genetics & Heredity
Veronique Caron, Nicolas Chassaing, Nicola Ragge, Felix Boschann, Angelina My-Hoa Ngu, Elisabeth Meloche, Sarah Chor, Saquib A. Lakhani, Weizhen Ji, Laurie Steiner, Julien Marcadier, Philip R. Jansen, Laura A. van de Pol, Johanna M. van Hagen, Alvaro Serrano Russi, Gwenael Le Guyader, Magnus Nordenskjold, Ann Nordgren, Britt-Marie Anderlid, Julie Plaisancie, Corinna Stoltenburg, Denise Horn, Anne Drenckhahn, Fadi F. Hamdan, Mathilde Lefebvre, Tania Attie-Bitach, Peggy Forey, Vasily Smirnov, Francoise Ernould, Marie-Line Jacquemont, Sarah Grotto, Alberto Alcantud, Alicia Coret, Rosario Ferrer-Avargues, Siddharth Srivastava, Catherine Vincent-Delorme, Shelby Romoser, Nicole Safina, Dimah Saade, James R. Lupski, Daniel G. Calame, David Genevieve, Nicolas Chatron, Caroline Schluth-Bolard, Kenneth A. Myers, William B. Dobyns, Patrick Calvas, Caroline Salmon, Richard Holt, Frances Elmslie, Marc Allaire, Daniil M. Prigozhin, Andre Tremblay, Jacques L. Michaud
Summary: This study reports 25 individuals with pathogenic or likely pathogenic variants in the RARB gene, aiming to characterize their functional impact and the clinical spectrum of MCOPS12. The findings show that all tested RARB variants exhibit either gain-of-function or loss-of-function activity, leading to disrupted RARB function and variable clinical manifestations associated with MCOPS12.
GENETICS IN MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Marta Melis, Xiao-Han Tang, Nabeel Attarwala, Qiuying Chen, Carlos Prishker, Lihui Qin, Steven S. Gross, Lorraine J. Gudas, Steven E. Trasino
Summary: The study showed that the use of the retinoic acid receptor agonist AC261 could reduce the severity of alcohol liver disease (ALD) and decrease liver damage. Although AC261 did not prevent alcohol-induced hepatic retinoid depletion, it was able to reduce the increase in serum retinol caused by alcohol. These findings suggest the potential of AC261 in preventing ALD.
Article
Immunology
Zixin Pi, Jiani Liu, Yangfan Xiao, Xinglan He, Ruixuan Zhu, Rui Tang, Xiangning Qiu, Yi Zhan, Zhuotong Zeng, Yaqian Shi, Rong Xiao
Summary: Systemic sclerosis (SSc) is an autoimmune disease that causes irreversible fibrosis of the skin and internal organs. This study confirms the pro-fibrotic effect of the transcription factor Fra2 in SSc and demonstrates that all-trans retinoic acid (ATRA) can reduce fibrosis by decreasing Fra2 expression. The findings suggest that ATRA could be a potential treatment for SSc.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Chemistry, Medicinal
Na Hyun Lee, Mi Jin Choi, Hana Yu, Jea Il Kim, Hyae Gyeong Cheon
Summary: Adapalene, an anti-acne agent, has been found to promote adipose browning by activating RAR beta and increasing phosphorylation of p38 MAPK and ATF2. This study provides a new therapeutic strategy for obesity treatment.
ARCHIVES OF PHARMACAL RESEARCH
(2022)
Article
Endocrinology & Metabolism
Nana Zheng, Wenbo Zhang, Xiaodan Zhang, Biao Li, Zhanying Wu, Yashuang Weng, Weiyong Wang, Jingjing Miao, Jing Yang, Meijia Zhang, Wei Xia
Summary: RA-RAR signaling promotes vaginal opening by increasing ss- catenin expression and vaginal epithelial cell apoptosis.
REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Reza Zolfaghari, Jessica A. Bonzo, Frank J. Gonzalez, A. Catharine Ross
Summary: HNF4 alpha regulates lipid and glucose metabolism genes. RA can act as an antagonist for HNF4 alpha in genes lacking RARE and as an agonist for RARE-containing genes. Overall, RA may interfere with HNF4 alpha function and deregulate genes important for lipid and glucose metabolism.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Physiology
Kaidi Jin, Qianqian Jin, Zhongqiang Cai, Baoyu Huang, Lei Wei, Meiwei Zhang, Wen Guo, Yaqiong Liu, Xiaotong Wang
Summary: Recent studies reveal that retinoic acid receptors have a higher expression level in mollusks, potentially playing a role in development and metabolism. After injection with retinoic acid, both receptors showed elevated expression levels, indicating a potential regulatory mechanism in mollusks. Additionally, the receptors can interact to form a heterodimer complex, suggesting a conserved function in signaling pathways.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Gastroenterology & Hepatology
Vu L. Ngo, Zhenda Shi, Baoming Jiang, Andrew T. Gewirtz
Summary: Prevention of RV infection by gut-resident SFB is mediated by the generation of RA, which activates RAR signaling and enhances enterocyte migration to impede RV infection.
Review
Physiology
Anqun Chen, Yu Liu, Yu Lu, Kyung Lee, John Cijiang He
Summary: Retinoic acid (RA) has dual effects in kidney disease, providing renal protection while also potentially inducing podocyte injury and apoptosis, highlighting the need to target specific RA-mediated pathways for effective therapeutic treatments.
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Geoffrey Brown
Summary: All-trans retinoic acid plays a role in embryogenesis and also acts as a teratogen. The deregulation of cytosolic aldehyde dehydrogenases in various human cancers affects the synthesis of all-trans retinoic acid. Inhibiting these enzymes reduces cancer cell proliferation, induces apoptosis, and enhances chemotherapeutic sensitivity. RAR gamma is an oncogene in several types of cancer, and inhibiting its action leads to cancer cell death. Targeting the retinoic acid pathway shows promise in eliminating cancer stem cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Nutrition & Dietetics
Earl H. Harrison
Summary: Naturally occurring retinoids have different metabolic pathways, with β-apocarotenoids being regarded as an important subclass. β-apocarotenoids are found in plant-based foods, and while their levels are relatively low, they may be generated in vivo under oxidative stress conditions. These compounds are structurally similar to retinol and may modulate retinol metabolism and signaling.
Article
Cell Biology
Trey Polvadore, Malcolm Maden
Summary: This study reveals the impact of retinoic acid treatment on the control of positional information during axolotl limb regeneration. Through RNA sequencing, the genes interacting with RAR alpha were identified, shedding light on the mechanism of action for future research.
Article
Cell Biology
Fathima N. Cassim Bawa, Raja Gopoju, Yanyong Xu, Shuwei Hu, Yingdong Zhu, Shaoru Chen, Kavita Jadhav, Yanqiao Zhang
Summary: The study reveals the important role of macrophage retinoic acid receptor alpha (RARα) in regulating atherosclerosis. It protects against atherosclerosis by inducing cholesterol efflux and inhibiting inflammation.
Article
Biochemistry & Molecular Biology
Cynthia Sung, Wan Jiao, Sun Young Park, Michael Cooper, Antoun Bouz, Dahae Choi, Eunson Jung, Gene Kim, Young Kwon Hong, Alex K. K. Wong
Summary: Secondary lymphedema is a debilitating disease caused by dysfunction of the lymphatic system, characterized by abnormal soft tissue swelling. Despite its high prevalence, there are no approved therapeutic agents that can prevent disease progression. Previous studies have shown that 9-cis-retinoic acid (9-cisRA) has the potential to be repurposed for lymphedema by promoting lymphangiogenesis. This study demonstrates that the nuclear receptor RXR alpha plays a critical role in the therapeutic efficacy of 9-cisRA in treating postsurgical lymphedema.
Article
Chemistry, Physical
Narayan Ture, Sharayu Govardhane, Pravin Shende
Summary: The use of retinoic acid in cancer treatment is limited by rapid decrease in plasma concentration, low aqueous solubility, and topical irritation. This study focused on formulating lipid-complexed with DNA to enhance the delivery of retinoic acid in colorectal cancer cells. Lipoplexes showed promising results for site-specific action in cancer treatment.
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2021)