Article
Pharmacology & Pharmacy
Alexander Gomez-A, Carol A. Dannenhoffer, Amanda Elton, Sung-Ho Lee, Woomi Ban, Yen-Yu Ian Shih, Charlotte A. Boettiger, Donita L. Robinson
Summary: Adolescent alcohol exposure can have significant impacts on behavioral flexibility and brain functional connectivity in adult animals, leading to impairments in attentional set reversals and decreased connectivity among key brain regions supporting flexible behavior. The study demonstrates a crucial link between reduced brain functional connectivity resulting from alcohol exposure during adolescence and deficits in behavioral flexibility.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Gastroenterology & Hepatology
Christophe Corpechot, Fabrice Carrat, Farid Gaouar, Frederic Chau, Gideon Hirschfield, Aliya Gulamhusein, Aldo J. Montano-Loza, Ellina Lytvyak, Christoph Schramm, Albert Pares, Ignasi Olivas, John E. Eaton, Karim T. Osman, George Dalekos, Nikolaos Gatselis, Frederik Nevens, Nora Cazzagon, Alessandra Zago, Francesco Paolo Russo, Nadir Abbas, Palak Trivedi, Douglas Thorburn, Francesca Saffioti, Laszlo Barkai, Davide Roccarina, Vicenza Calvaruso, Anna Fichera, Adele Delamarre, Esli Medina-Morales, Alan Bonder, Vilas Patwardhan, Cristina Rigamonti, Marco Carbone, Pietro Invernizzi, Laura Cristoferi, Adriaan van der Meer, Rozanne de Veer, Ehud Zigmond, Eyal Yehezkel, Andreas E. Kremer, Ansgar Deibel, Jerome Dumortier, Tony Bruns, Karsten Grosse, Georges-Philippe Pageaux, Aaron Wetten, Jessica Dyson, David Jones, Olivier Chazouilleres, Bettina Hansen, Victor de Ledinghen
Summary: In the largest ever study of LSM in patients with PBC, LSM assessed by VCTE improves prediction of survival beyond biochemical response, established prognostic scores, and age categories, independent of time. LSM can reasonably be regarded as a useful prognostic marker and a potential surrogate endpoint in PBC clinical trials.
JOURNAL OF HEPATOLOGY
(2022)
Article
Endocrinology & Metabolism
Kanchana Ngaosuwan, Desmond G. Johnston, Ian F. Godsland, Jeremy Cox, Azeem Majeed, Jennifer K. Quint, Nick Oliver, Stephen Robinson
Summary: The study found that mortality was higher with prednisolone in patients with primary adrenal insufficiency compared to hydrocortisone. Despite the large scale of the study, the number of prednisolone-treated patients was small, and they had greater risk factors.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Immunology
Sahar Etemadi, Seyyed Meysam Abtahi Froushani, Seyyed Mohammad Hashemi Asl, Alireza Mahmoudian
Summary: The combination therapy with atorvastatin and pentoxifylline at half doses showed synergistic benefits in treating arthritis induced by CFA, leading to regression of clinical and radiological appearance of arthritis in non-injected paws and significant reduction in inflammatory biochemical parameters.
INFLAMMOPHARMACOLOGY
(2022)
Article
Medicine, General & Internal
Shaan Dudani, Guillermo de Velasco, J. Connor Wells, Chun Loo Gan, Frede Donskov, Camillo Porta, Anna Fraccon, Felice Pasini, Jae Lyun Lee, Aaron Hansen, Georg A. Bjarnason, Benoit Beuselinck, Sumanta K. Pal, Takeshi Yuasa, Nils Kroeger, Ravindran Kanesvaran, M. Neil Reaume, Christina Canil, Toni K. Choueiri, Daniel Y. C. Heng
Summary: This study found that patterns of metastasis vary between histologic subtypes of metastatic RCC and are associated with overall survival. The data highlight the clinical and biological variability between histologic subtypes and suggest that patterns of metastasis may reflect differences in underlying disease biology. Further research is encouraged to investigate differences in immune, molecular, and genetic profiles between metastatic sites and histologic subtypes.
Article
Immunology
Jing Yuan, Ze-Yin Liang, Yu-Jun Dong, Han-Yun Ren
Summary: This study retrospectively analyzed patients who underwent cord blood transplantation and described the incidence, risk factors, and treatment options of autoimmune hemolytic anemia (AIHA) occurring after the transplantation. The study found that AIHA is a clinically significant common complication, with an incidence of 8% in post-transplant patients. Risk factors for developing AIHA include concomitant infections, CMV reactivation, GvHD, and HLA mismatch.
JOURNAL OF INFLAMMATION RESEARCH
(2022)
Article
Immunology
Xiangliang Liu, Wenxin Zhang, Wei Ji, Kaiwen Zheng, Yixin Zhao, Yuwei He, Jiuwei Cui, Wei Li
Summary: The study aimed to investigate the impact of alcohol on the inflammatory status and prognosis of patients with malignancy. Clinical data was collected and analyzed, revealing a significant correlation between alcohol consumption and patient outcomes. A scoring system was developed to predict survival benefits.
JOURNAL OF INFLAMMATION RESEARCH
(2022)
Article
Multidisciplinary Sciences
Min Kyu Lee, Eun-Tae Jeon, Namyoung Baek, Jeong Hwan Kim, Yoon Chan Rah, June Choi
Summary: This study used artificial intelligence to develop prognosis models to predict recovery from idiopathic sudden sensorineural hearing loss (ISSNHL). The light gradient boosting machine model had the best performance in terms of prediction accuracy and balanced accuracy, with initial audiogram shape being identified as the most important prognostic factor.
SCIENTIFIC REPORTS
(2022)
Article
Gastroenterology & Hepatology
Ruben Hernaez, Constantine J. Karvellas, Yan Liu, Sophie-Caroline Sacleux, Saro Khemichian, Lance L. Stein, Kirti Shetty, Christina C. Lindenmeyer, Justin R. Boike, Douglas A. Simonetto, Robert S. Rahimi, Prasun K. Jalal, Manhal Izzy, Michael S. Kriss, Gene Y. Im, Ming V. Lin, Janice H. Jou, Brett E. Fortune, George Cholankeril, Alexander Kuo, Nadim Mahmud, Fasiha Kanwal, Faouzi Saliba, Vinay Sundaram, Thierry Artzner, Rajiv Jalan, Atef Al Attar, Kambiz Kosari, Richard Garcia, Gevork Salmastyan, William Cranford, Preet Patel, Pei Xue, Soumya Mishra, Madison Parks, Gianina Flocco, Mariana Hurtado, Islam Mohamed, Ross Vyhmeister, Christine R. Lopez, Braidie Campbell, Adam C. Winters, Mary Ann Simpson
Summary: The SALT-M score can predict one-year post-LT mortality in patients with severe ACLF. The ACLF-LT-LoS score can predict the median length of stay after LT. The use of these scores could assist in determining the benefits of transplantation.
JOURNAL OF HEPATOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Anna Maria Meyer, Lena Pickert, Annika Heess, Ingrid Becker, Christine Kurschat, Malte P. Bartram, Thomas Benzing, Maria Cristina Polidori
Summary: The negative impact of chronic kidney disease (CKD) on older patients' health and quality of life has been well documented. This study found that most older CKD inpatients were prefrail or frail, and a comprehensive geriatric assessment can accurately assess the frailty and long-term prognosis of these patients. Kidney transplant recipients and patients with hypoalbuminemia had a higher frailty and risk of mortality. Further research is needed to explore the prognostic and frailty-related signature of laboratory biomarkers in CKD.
Review
Medicine, General & Internal
Alexandros Loukas Grammatis, Ektoras X. Georgiou, Christian M. Becker
Summary: The review evaluated the effectiveness and safety of pentoxifylline in managing endometriosis. However, due to limited studies with low-quality evidence, there is currently insufficient support for the use of pentoxifylline in managing endometriosis in terms of subfertility and pain relief outcomes.
COCHRANE DATABASE OF SYSTEMATIC REVIEWS
(2021)
Review
Clinical Neurology
Clarissa Ern Hui Fang, Desta Bokre, Sui Hsien Wong
Summary: This systematic review aimed to determine the clinical characteristics of patients with ocular myasthenia gravis (OMG) and the proportion of conversion to secondary generalized myasthenia gravis (SGMG). The findings suggest that female sex and anti-acetylcholine receptor (AChR) positivity may be associated with the development of SGMG, although more high-quality observational studies are needed.
Article
Gastroenterology & Hepatology
Juan Pablo Arab, Luis Antonio Diaz, Natalia Baeza, Francisco Idalsoaga, Eduardo Fuentes-Lopez, Jorge Arnold, Carolina A. Ramirez, Dalia Morales-Arraez, Meritxell Ventura-Cots, Edilmar Alvarado-Tapias, Wei Zhang, Virginia Clark, Douglas Simonetto, Joseph C. Ahn, Seth Buryska, Tej I. Mehta, Horia Stefanescu, Adelina Horhat, Andreea Bumbu, Winston Dunn, Bashar Attar, Rohit Agrawal, Zohaib Syed Haque, Muhammad Majeed, Joaquin Cabezas, Ines Garcia-Carrera, Richard Parker, Berta Cuyas, Maria Poca, German Soriano, Shiv K. Sarin, Rakhi Maiwall, Prasun K. Jalal, Saba Abdulsada, Maria Fatima Higuera-de la Tijera, Anand V. Kulkarni, P. Nagaraja Rao, Patricia Guerra Salazar, Lubomir Skladany, Natalia Bystrianska, Veronica Prado, Ana Clemente-Sanchez, Diego Rincon, Tehseen Haider, Kristina R. Chacko, Fernando Cairo, Marcela de Sousa Coelho, Gustavo A. Romero, Florencia D. Pollarsky, Juan Carlos Restrepo, Susana Castro-Sanchez, Luis G. Toro, Pamela Yaquich, Manuel Mendizabal, Maria Laura Garrido, Adrian Narvaez, Fernando Bessone, Julio Santiago Marcelo, Diego Piombino, Melisa Dirchwolf, Juan Pablo Arancibia, Jose Altamirano, Won Kim, Roberta C. Araujo, Andres Duarte Rojo, Victor Vargas, Pierre-Emmanuel Rautou, Tazime Issoufaly, Felipe Zamarripa, Aldo Torre, Michael R. Lucey, Philippe Mathurin, Alexandre Louvet, Guadalupe Garcia-Tsao, Jose Alberto Gonzalez, Elizabeth Verna, Robert S. Brown, Juan Pablo Roblero, Juan G. Abraldes, Marco Arrese, Vijay H. Shah, Patrick S. Kamath, Ashwani K. Singal, Ramon Bataller
Summary: This international multi-center cohort study found that corticosteroid treatment only improved 30-day survival in patients with severe alcohol-associated hepatitis (AH), particularly those with MELD scores between 25 and 39. There was no survival benefit observed in patients with MELD scores over 51.
JOURNAL OF HEPATOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Jong -Chan Youn, Darae Kim, Mi-Hyang Jung, Jin-Jin Kim, In-Cheol Kim, Hye Sun Lee, Jin-Oh Choi, Eun-Seok Jeon, Keith Nishihara, Osamu Seguchi, Evan P. Kransdorf, David H. Chang, Michelle M. Kittleson, Jignesh K. Patel, Robert M. Cole, Jaime D. Moriguchi, Danny Ramzy, Fardad Esmailian, Jon A. Kobashigawa
Summary: This study investigated the 3-year post-transplant outcomes of desensitized mechanical circulatory support (MCS) patients. The results showed that desensitization therapy significantly reduced panel reactive antibody (PRA) levels and the clinical outcomes of desensitized MCS patients were comparable to non-desensitized control patients, demonstrating the safety and efficacy of desensitization therapy.
JOURNAL OF HEART AND LUNG TRANSPLANTATION
(2023)
Article
Gastroenterology & Hepatology
Carolin Lackner, Rudolf E. Stauber, Susan Davies, Helmut Denk, Hans Peter Dienes, Viviane Gnemmi, Maria Guido, Rosa Miquel, Valerie Paradis, Peter Schirmacher, Luigi Terracciano, Andrea Berghold, Gudrun Pregartner, Lukas Binder, Philipp Douschan, Florian Rainer, Stephan Sygulla, Marion Jager, Pierre-Emmanuel Rautou, Andreea Bumbu, Adelina Horhat, Ioana Rusu, Horia Stefanescu, Sonke Detlefsen, Aleksander Krag, Maja Thiele, Helena Cortez-Pinto, Christophe Moreno, Annette S. H. Gouw, Dina G. Tiniakos
Summary: The SALVE Histopathology Group developed and validated a grading and staging system for alcohol-related liver disease (ALD) and evaluated its prognostic utility in a multinational cohort of 445 patients. The system showed significant associations with disease activity and fibrosis stage, impacting both long-term and short-term outcomes in ALD patients.
JOURNAL OF HEPATOLOGY
(2021)