Inflammation and Cancer: Extra- and Intracellular Determinants of Tumor-Associated Macrophages as Tumor Promoters

Forced Activation of Notch in Macrophages Represses Tumor Growth by Upregulating miR-125a and Disabling Tumor-Associated Macrophages

(2016) Jun-Long Zhao et al.   CANCER RESEARCH

Epigenetic regulation of gene expression and M2 macrophage polarization as new potential omega-3 polyunsaturated fatty acid targets in colon inflammation and cancer

(2016) Simona Serini et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Emerging role of microRNAs in regulating macrophage activation and polarization in immune response and inflammation

(2016) Xiao-qin Wu et al.   IMMUNOLOGY

Myeloid-derived suppressor cells as effectors of immune suppression in cancer

(2016) Athalia Rachel Pyzer et al.   INTERNATIONAL JOURNAL OF CANCER

Bacterial Sepsis Increases Survival in Metastatic Melanoma: Chlamydophila Pneumoniae Induces Macrophage Polarization and Tumor Regression

(2016) Krisztina Buzás et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Tumor-Associated Macrophages and Neutrophils in Tumor Microenvironment

(2016) Jaehong Kim et al.   MEDIATORS OF INFLAMMATION

MiRNA-Mediated Macrophage Polarization and its Potential Role in the Regulation of Inflammatory Response

(2016) Kobina Essandoh et al.   SHOCK

The Nature of Myeloid-Derived Suppressor Cells in the Tumor Microenvironment

(2016) Vinit Kumar et al.   TRENDS IN IMMUNOLOGY

Recommendations for myeloid-derived suppressor cell nomenclature and characterization standards

(2016) Vincenzo Bronte et al.   Nature Communications

Pancreatic Cancer Cell Exosome-Mediated Macrophage Reprogramming and the Role of MicroRNAs 155 and 125b2 Transfection using Nanoparticle Delivery Systems

(2016) Mei-Ju Su et al.   Scientific Reports

Cancer-Associated Myeloid Regulatory Cells

(2016) Yannick De Vlaeminck et al.   Frontiers in Immunology

miRNA let-7b modulates macrophage polarization and enhances tumor-associated macrophages to promote angiogenesis and mobility in prostate cancer

(2016) Zhigang Wang et al.   Scientific Reports

Molecular Targets of Omega-3 Fatty Acids for Cancer Therapy

(2015) K. Devi et al.   Anti-Cancer Agents in Medicinal Chemistry

RORC1 Regulates Tumor-Promoting “Emergency” Granulo-Monocytopoiesis

(2015) Laura Strauss et al.   CANCER CELL

Macrophage polarization in pathology

(2015) Antonio Sica et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

C-Myb+ Erythro-Myeloid Progenitor-Derived Fetal Monocytes Give Rise to Adult Tissue-Resident Macrophages

(2015) Guillaume Hoeffel et al.   IMMUNITY

Myeloid cells in cancer-related inflammation

(2015) Nicoletta Caronni et al.   IMMUNOBIOLOGY

MicroRNA-33–dependent regulation of macrophage metabolism directs immune cell polarization in atherosclerosis

(2015) Mireille Ouimet et al.   JOURNAL OF CLINICAL INVESTIGATION

Tumor-induced myeloid deviation: when myeloid-derived suppressor cells meet tumor-associated macrophages

(2015) Stefano Ugel et al.   JOURNAL OF CLINICAL INVESTIGATION

Optical In Vivo Imaging of the Alarmin S100A9 in Tumor Lesions Allows for Estimation of the Individual Malignant Potential by Evaluation of Tumor-Host Cell Interaction

(2015) A. Becker et al.   JOURNAL OF NUCLEAR MEDICINE

The Glia-Derived Alarmin IL-33 Orchestrates the Immune Response and Promotes Recovery following CNS Injury

(2015) Sachin P. Gadani et al.   NEURON

Molecular and epigenetic basis of macrophage polarized activation

(2015) Chiara Porta et al.   SEMINARS IN IMMUNOLOGY

Proinflammatory TLR signalling is regulated by a TRAF2-dependent proteolysis mechanism in macrophages

(2015) Jin Jin et al.   Nature Communications

Delineating CSF-1-dependent regulation of myeloid cell diversity in tumors

(2015) Amy-Jo Casbon et al.   OncoImmunology

Exosome and Exosomal MicroRNA: Trafficking, Sorting, and Function

(2015) Jian Zhang et al.   GENOMICS PROTEOMICS & BIOINFORMATICS

MicroRNA 21 Is a Homeostatic Regulator of Macrophage Polarization and Prevents Prostaglandin E2-Mediated M2 Generation

(2015) Zhuo Wang et al.   PLoS One

A lovastatin-elicited genetic program inhibits M2 macrophage polarization and enhances T cell infiltration into spontaneous mouse mammary tumors

(2015) Emilia Mira et al.   Oncotarget

Myeloid WNT7b Mediates the Angiogenic Switch and Metastasis in Breast Cancer

(2014) E.-J. Yeo et al.   CANCER RESEARCH

Myeloid Cell COX-2 deletion reduces mammary tumor growth through enhanced cytotoxic T-lymphocyte function

(2014) Edward P. Chen et al.   CARCINOGENESIS

CD8+T-cell immunosurveillance constrains lymphoid premetastatic myeloid cell accumulation

(2014) Wang Zhang et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

In situ proliferation contributes to accumulation of tumor-associated macrophages in spontaneous mammary tumors

(2014) Piotr Tymoszuk et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Macrophage Activation and Polarization: Nomenclature and Experimental Guidelines

(2014) Peter J. Murray et al.   IMMUNITY

Molecular Profiling Reveals a Tumor-Promoting Phenotype of Monocytes and Macrophages in Human Cancer Progression

(2014) Manesh Chittezhath et al.   IMMUNITY

Interleukin-34 promotes tumor progression and metastatic process in osteosarcoma through induction of angiogenesis and macrophage recruitment

(2014) Aude I. Ségaliny et al.   INTERNATIONAL JOURNAL OF CANCER

Triggering Receptor Expressed on Myeloid Cells 1 (TREM-1)-mediated Bcl-2 Induction Prolongs Macrophage Survival

(2014) Zhihong Yuan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PD-L1 is a novel direct target of HIF-1α, and its blockade under hypoxia enhanced MDSC-mediated T cell activation

(2014) Muhammad Zaeem Noman et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Combination of unsaturated fatty acids and ionizing radiation on human glioma cells: cellular, biochemical and gene expression analysis

(2014) Otilia Antal et al.   Lipids in Health and Disease

The Role of Interleukin 17 in Tumour Proliferation, Angiogenesis, and Metastasis

(2014) Bob Yang et al.   MEDIATORS OF INFLAMMATION

CSF1-ETS2-induced microRNA in myeloid cells promote metastatic tumor growth

(2014) H Mathsyaraja et al.   ONCOGENE

Functional significance of macrophage-derived exosomes in inflammation and pain

(2014) Marguerite K. McDonald et al.   PAIN

TREM-1 Is Induced in Tumor Associated Macrophages by Cyclo-Oxygenase Pathway in Human Non-Small Cell Lung Cancer

(2014) Zhihong Yuan et al.   PLoS One

Hypoxia-inducible factor-dependent signaling between triple-negative breast cancer cells and mesenchymal stem cells promotes macrophage recruitment

(2014) P. Chaturvedi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Transforming Growth Factor-Beta and Matrix Metalloproteinases: Functional Interactions in Tumor Stroma-Infiltrating Myeloid Cells

(2014) Jelena Krstic et al.   TheScientificWorldJOURNAL

Functional Relationship between Tumor-Associated Macrophages and Macrophage Colony-Stimulating Factor as Contributors to Cancer Progression

(2014) Damya Laoui et al.   Frontiers in Immunology

Mechanisms Driving Macrophage Diversity and Specialization in Distinct Tumor Microenvironments and Parallelisms with Other Tissues

(2014) Eva Van Overmeire et al.   Frontiers in Immunology

MicroRNAs in Immune Response and Macrophage Polarization

(2013) Gang Liu et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Recent insights into NF-κB signalling pathways and the link between inflammation and prostate cancer

(2013) Daniel P. Nguyen et al.   BJU INTERNATIONAL

A role for miR-155 in enabling tumor-infiltrating innate immune cells to mount effective antitumor responses in mice

(2013) E. Zonari et al.   BLOOD

Impeding Macrophage Entry into Hypoxic Tumor Areas by Sema3A/Nrp1 Signaling Blockade Inhibits Angiogenesis and Restores Antitumor Immunity

(2013) Andrea Casazza et al.   CANCER CELL

BMP-6 in Renal Cell Carcinoma Promotes Tumor Proliferation through IL-10-Dependent M2 Polarization of Tumor-Associated Macrophages

(2013) J.-H. Lee et al.   CANCER RESEARCH

Myeloid-Specific Expression of Ron Receptor Kinase Promotes Prostate Tumor Growth

(2013) D. Gurusamy et al.   CANCER RESEARCH

Tumor Hypoxia Does Not Drive Differentiation of Tumor-Associated Macrophages but Rather Fine-Tunes the M2-like Macrophage Population

(2013) D. Laoui et al.   CANCER RESEARCH

Myeloid TGF-β signaling contributes to colitis-associated tumorigenesis in mice

(2013) Jingyi Li et al.   CARCINOGENESIS

S100B Promotes Glioma Growth through Chemoattraction of Myeloid-Derived Macrophages

(2013) H. Wang et al.   CLINICAL CANCER RESEARCH

Expansion of CCR8+ Inflammatory Myeloid Cells in Cancer Patients with Urothelial and Renal Carcinomas

(2013) E. Eruslanov et al.   CLINICAL CANCER RESEARCH

Angiotensin II Drives the Production of Tumor-Promoting Macrophages

(2013) Virna Cortez-Retamozo et al.   IMMUNITY

Expression profiles of miRNAs in polarized macrophages

(2013) YINGYING ZHANG et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

miR-125a-5p Regulates Differential Activation of Macrophages and Inflammation

(2013) Sami Banerjee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Negative regulation of Toll-like receptor 4 signaling by IL-10-dependent microRNA-146b

(2013) G. Curtale et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tumor-associated macrophages: functional diversity, clinical significance, and open questions

(2013) Subhra K. Biswas et al.   Seminars in Immunopathology

MicroRNA-mediated control of macrophages and its implications for cancer

(2013) Mario Leonardo Squadrito et al.   TRENDS IN IMMUNOLOGY

Macrophage-Induced Tumor Angiogenesis Is Regulated by the TSC2-mTOR Pathway

(2012) W. Chen et al.   CANCER RESEARCH

A Novel Regulator of Macrophage Activation

(2012) Guoqing Zhuang et al.   CIRCULATION

Hypoxia-mediated regulation of macrophage functions in pathophysiology

(2012) Elena Riboldi et al.   INTERNATIONAL IMMUNOLOGY

MicroRNA-155 promotes atherosclerosis by repressing Bcl6 in macrophages

(2012) Maliheh Nazari-Jahantigh et al.   JOURNAL OF CLINICAL INVESTIGATION

Macrophage plasticity and polarization: in vivo veritas

(2012) Antonio Sica et al.   JOURNAL OF CLINICAL INVESTIGATION

Wnt5a Induces a Tolerogenic Phenotype of Macrophages in Sepsis and Breast Cancer Patients

(2012) C. Bergenfelz et al.   JOURNAL OF IMMUNOLOGY

Interleukin-17 and Prostaglandin E2 Are Involved in Formation of an M2 Macrophage-Dominant Microenvironment in Lung Cancer

(2012) Lunxu Liu et al.   Journal of Thoracic Oncology

Fibroblast Growth Factor Receptor 1 Activation in Mammary Tumor Cells Promotes Macrophage Recruitment in a CX3CL1-Dependent Manner

(2012) Johanna R. Reed et al.   PLoS One

Origins of tumor-associated macrophages and neutrophils

(2012) V. Cortez-Retamozo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Re-polarization of tumor-associated macrophages to pro-inflammatory M1 macrophages by microRNA-155

(2012) Xing Cai et al.   Journal of Molecular Cell Biology

Regulation of Monocyte Functional Heterogeneity by miR-146a and Relb

(2012) Martin Etzrodt et al.   Cell Reports

miR-511-3p Modulates Genetic Programs of Tumor-Associated Macrophages

(2012) Mario Leonardo Squadrito et al.   Cell Reports

Epistasis between MicroRNAs 155 and 146a during T Cell-Mediated Antitumor Immunity

(2012) Thomas B. Huffaker et al.   Cell Reports

Role of c-MYC in alternative activation of human macrophages and tumor-associated macrophage biology

(2011) O. M. Pello et al.   BLOOD

Transition of tumor-associated macrophages from MHC class IIhi to MHC class IIlow mediates tumor progression in mice

(2011) Benfan Wang et al.   BMC IMMUNOLOGY

TLR signaling-mediated differential histone modification at IL-10 and IL-12 promoter region leads to functional impairments in tumor-associated macrophages

(2011) Sayantan Banerjee et al.   CARCINOGENESIS

MicroRNA-125b Potentiates Macrophage Activation

(2011) Aadel A. Chaudhuri et al.   JOURNAL OF IMMUNOLOGY

MicroRNA-146a regulates both transcription silencing and translation disruption of TNF-α during TLR4-induced gene reprogramming

(2011) Mohamed El Gazzar et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Tumor-secreted SDF-1 promotes glioma invasiveness and TAM tropism toward hypoxia in a murine astrocytoma model

(2011) Shu-Chi Wang et al.   LABORATORY INVESTIGATION

MicroRNA profile of polyunsaturated fatty acid treated glioma cells reveal apoptosis-specific expression changes

(2011) Nóra Faragó et al.   Lipids in Health and Disease

TGF-β-induced IRAK-M expression in tumor-associated macrophages regulates lung tumor growth

(2011) T J Standiford et al.   ONCOGENE

Mutator activity induced by microRNA-155 (miR-155) links inflammation and cancer

(2011) E. Tili et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Local Macrophage Proliferation, Rather than Recruitment from the Blood, Is a Signature of TH2 Inflammation

(2011) S. J. Jenkins et al.   SCIENCE

The chemokine CXCL12 regulates monocyte-macrophage differentiation and RUNX3 expression

(2010) L. Sanchez-Martin et al.   BLOOD

Notch Signaling Determines the M1 versus M2 Polarization of Macrophages in Antitumor Immune Responses

(2010) Yao-Chun Wang et al.   CANCER RESEARCH

Macrophage Expression of Hypoxia-Inducible Factor-1  Suppresses T-Cell Function and Promotes Tumor Progression

(2010) A. L. Doedens et al.   CANCER RESEARCH

Corosolic acid inhibits glioblastoma cell proliferation by suppressing the activation of signal transducer and activator of transcription-3 and nuclear factor-kappa B in tumor cells and tumor-associated macrophages

(2010) Yukio Fujiwara et al.   CANCER SCIENCE

MicroRNA-155 Regulates Inflammatory Cytokine Production in Tumor-associated Macrophages via Targeting C/EBPβ

(2010) Min He et al.   Cellular & Molecular Immunology

The Interleukin 13 (IL-13) Pathway in Human Macrophages Is Modulated by MicroRNA-155 via Direct Targeting of Interleukin 13 Receptor α1 (IL13Rα1)

(2010) Rocio T. Martinez-Nunez et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Up-regulation of MicroRNA-155 in Macrophages Contributes to Increased Tumor Necrosis Factor α (TNFα) Production via Increased mRNA Half-life in Alcoholic Liver Disease

(2010) Shashi Bala et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hypoxia-inducible factor 2α regulates macrophage function in mouse models of acute and tumor inflammation

(2010) Hongxia Z. Imtiyaz et al.   JOURNAL OF CLINICAL INVESTIGATION

HIF-1α regulates function and differentiation of myeloid-derived suppressor cells in the tumor microenvironment

(2010) Cesar A. Corzo et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Inducible microRNA-155 Feedback Promotes Type I IFN Signaling in Antiviral Innate Immunity by Targeting Suppressor of Cytokine Signaling 1

(2010) P. Wang et al.   JOURNAL OF IMMUNOLOGY

An Antimicrobial Peptide Regulates Tumor-Associated Macrophage Trafficking via the Chemokine Receptor CCR2, a Model for Tumorigenesis

(2010) Ge Jin et al.   PLoS One

Modulation of mismatch repair and genomic stability by miR-155

(2010) N. Valeri et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Malignant cells fuel tumor growth by educating infiltrating leukocytes to produce the mitogen Gas6

(2009) S. Loges et al.   BLOOD

Toll-like Receptor 9 Activation of Signal Transducer and Activator of Transcription 3 Constrains Its Agonist-Based Immunotherapy

(2009) M. Kortylewski et al.   CANCER RESEARCH

Stromal cell-derived CSF-1 blockade prolongs xenograft survival of CSF-1-negative neuroblastoma

(2009) Dietmar Abraham et al.   INTERNATIONAL JOURNAL OF CANCER

miR-146a Is Critical for Endotoxin-induced Tolerance

(2009) Md A. Nahid et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

CCL2 and Interleukin-6 Promote Survival of Human CD11b+Peripheral Blood Mononuclear Cells and Induce M2-type Macrophage Polarization

(2009) Hernan Roca et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Spontaneous regression of metastases from melanoma: review of the literature

(2009) Louise Vennegaard Kalialis et al.   MELANOMA RESEARCH

Tolerance and M2 (alternative) macrophage polarization are related processes orchestrated by p50 nuclear factor  B

(2009) C. Porta et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A CREB-C/EBP  cascade induces M2 macrophage-specific gene expression and promotes muscle injury repair

(2009) D. Ruffell et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inositol phosphatase SHIP1 is a primary target of miR-155

(2009) R. M. O'Connell et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Stat3 mediates myeloid cell–dependent tumor angiogenesis in mice

(2008) Maciej Kujawski et al.   JOURNAL OF CLINICAL INVESTIGATION

The tumor suppressor semaphorin 3B triggers a prometastatic program mediated by interleukin 8 and the tumor microenvironment

(2008) Charlotte Rolny et al.   JOURNAL OF EXPERIMENTAL MEDICINE

“Re-educating” tumor-associated macrophages by targeting NF-κB

(2008) Thorsten Hagemann et al.   JOURNAL OF EXPERIMENTAL MEDICINE

An antiinflammatory role for IKKβ through the inhibition of “classical” macrophage activation

(2008) Carol Ho Yan Fong et al.   JOURNAL OF EXPERIMENTAL MEDICINE

NF-κB links innate immunity to the hypoxic response through transcriptional regulation of HIF-1α

(2008) Jordi Rius et al.   NATURE