IgG cooperativity – Is there allostery? Implications for antibody functions and therapeutic antibody development

Fc-Galactosylation of Human Immunoglobulin Gamma Isotypes Improves C1q Binding and Enhances Complement-Dependent Cytotoxicity

(2017) Benjamin Peschke et al.   Frontiers in Immunology

Influence of immunoglobulin isotype on therapeutic antibody function

(2016) Stephen A. Beers et al.   BLOOD

Antibodies to watch in 2017

(2016) Janice M. Reichert   mAbs

Comparing domain interactions within antibody Fabs with kappa and lambda light chains

(2016) Raheleh Toughiri et al.   mAbs

Molecular Basis of Assembly and Activation of Complement Component C1 in Complex with Immunoglobulin G1 and Antigen

(2016) Guanbo Wang et al.   MOLECULAR CELL

Anti-DNA antibody mediated catalysis is isotype dependent

(2016) Yumin Xia et al.   MOLECULAR IMMUNOLOGY

Revisiting the Immunoglobulin Intramolecular Signaling Hypothesis

(2016) Anthony Bowen et al.   TRENDS IN IMMUNOLOGY

Inhibition of allergen-dependent IgE activity by antibodies of the same specificity but different class

(2015) T. S. Dodev et al.   ALLERGY

Variable Region Identical IgA and IgE toCryptococcus neoformansCapsular Polysaccharide Manifest Specificity Differences

(2015) Alena Janda et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Antibody Glycosylation and Its Impact on the Pharmacokinetics and Pharmacodynamics of Monoclonal Antibodies and Fc-Fusion Proteins

(2015) Liming Liu   JOURNAL OF PHARMACEUTICAL SCIENCES

Molecular properties of human IgG subclasses and their implications for designing therapeutic monoclonal antibodies against infectious diseases

(2015) Vashti Irani et al.   MOLECULAR IMMUNOLOGY

Complement in therapy and disease

(2015) Joost P.M. Melis et al.   MOLECULAR IMMUNOLOGY

The future of immune checkpoint therapy

(2015) P. Sharma et al.   SCIENCE

Structural basis for binding of human IgG1 to its high-affinity human receptor FcγRI

(2015) Masato Kiyoshi et al.   Nature Communications

Diversity in structure and functions of antibody sialylation in the Fc

(2014) T Shantha Raju et al.   CURRENT OPINION IN BIOTECHNOLOGY

The therapeutic monoclonal antibody market

(2014) Dawn M Ecker et al.   mAbs

Complement Is Activated by IgG Hexamers Assembled at the Cell Surface

(2014) C. A. Diebolder et al.   SCIENCE

Role of κ→λ light-chain constant-domain switch in the structure and functionality of A17 reactibody

(2014) Natalia Ponomarenko et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

IgG Subclasses and Allotypes: From Structure to Effector Functions

(2014) Gestur Vidarsson et al.   Frontiers in Immunology

Thermodynamic Analysis of the Binding of 2F5 (Fab and Immunoglobulin G Forms) to Its gp41 Epitope Reveals a Strong Influence of the Immunoglobulin Fc Region on Affinity

(2013) Sara Crespillo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Global structures of IgG isotypes expressing identical variable regions

(2013) Ertan Eryilmaz et al.   MOLECULAR IMMUNOLOGY

The constant region affects antigen binding of antibodies to DNA by altering secondary structure

(2013) Yumin Xia et al.   MOLECULAR IMMUNOLOGY

General mechanism for modulating immunoglobulin effector function

(2013) P. Sondermann et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Vaccine-induced plasma IgA specific for the C1 region of the HIV-1 envelope blocks binding and effector function of IgG

(2013) G. D. Tomaras et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Antibody Therapeutics in Cancer

(2013) M. X. Sliwkowski et al.   SCIENCE

Constant domains influence binding of mouse–human chimeric antibodies to the capsular polypeptide ofBacillus anthracis

(2013) Mark A Hubbard et al.   Virulence

IgG Subclass and Heavy Chain Domains Contribute to Binding and Protection by mAbs to the Poly γ-D-glutamic Acid Capsular Antigen of Bacillus anthracis

(2013) Maria Hovenden et al.   PLoS Pathogens

Isotype and glycoform selection for antibody therapeutics

(2012) Roy Jefferis   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

The constant region contributes to the antigenic specificity and renal pathogenicity of murine anti-DNA antibodies

(2012) Yumin Xia et al.   JOURNAL OF AUTOIMMUNITY

Variable Region Identical Immunoglobulins Differing in Isotype Express Different Paratopes

(2012) Alena Janda et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Avidity confers FcγR binding and immune effector function to aglycosylated immunoglobulin G1

(2012) Thomas C. Nesspor et al.   JOURNAL OF MOLECULAR RECOGNITION

The impact of glycosylation on monoclonal antibody conformation and stability

(2012) Kai Zheng et al.   mAbs

Galactosylation variations in marketed therapeutic antibodies

(2012) T. Shantha Raju et al.   mAbs

Disulfide bond structures of IgG molecules

(2012) Hongcheng Liu et al.   mAbs

Isotype modulates epitope specificity, affinity, and antiviral activities of anti-HIV-1 human broadly neutralizing 2F5 antibody

(2012) D. Tudor et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Immunoglobulin isotype influences affinity and specificity

(2012) A. Casadevall et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The antibody paradigm: present and future development as a scaffold for biopharmaceutical drugs

(2011) Roy Jefferis   Biotechnology & Genetic Engineering Reviews

Structural basis for improved efficacy of therapeutic antibodies on defucosylation of their Fc glycans

(2011) Tsunehiro Mizushima et al.   GENES TO CELLS

Unique carbohydrate-carbohydrate interactions are required for high affinity binding between Fc RIII and antibodies lacking core fucose

(2011) C. Ferrara et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Natural Catalytic Antibodies in Norm, Autoimmune, Viral, and Bacterial Diseases

(2011) Georgy A. Nevinsky et al.   TheScientificWorldJOURNAL

A requirement for FcγR in antibody-mediated bacterial toxin neutralization

(2010) Nareen Abboud et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Stability of IgG isotypes in serum

(2010) Ivan Correia   mAbs

Circular Dichroism reveals evidence of coupling between immunoglobulin constant and variable region secondary structure☆

(2010) Alena Janda et al.   MOLECULAR IMMUNOLOGY

Characterization of IgG1 Conformation and Conformational Dynamics by Hydrogen/Deuterium Exchange Mass Spectrometry

(2009) Damian Houde et al.   ANALYTICAL CHEMISTRY

Anti-CD20 monoclonal antibodies: historical and future perspectives

(2009) S. H. Lim et al.   HAEMATOLOGICA

Glycosylation as a strategy to improve antibody-based therapeutics

(2009) Roy Jefferis   NATURE REVIEWS DRUG DISCOVERY

Specificity and affinity of human Fc  receptors and their polymorphic variants for human IgG subclasses

(2008) P. Bruhns et al.   BLOOD

Terminal sugars of Fc glycans influence antibody effector functions of IgGs

(2008) T Shantha Raju   CURRENT OPINION IN IMMUNOLOGY

Isothermal Titration Calorimetry Reveals Differential Binding Thermodynamics of Variable Region-identical Antibodies Differing in Constant Region for a Univalent Ligand

(2008) Tarun K. Dam et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Human IgG2 Antibodies Display Disulfide-mediated Structural Isoforms

(2008) Jette Wypych et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural and Functional Characterization of Disulfide Isoforms of the Human IgG2 Subclass

(2008) Thomas M. Dillon et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Human IgG2 Antibody Disulfide Rearrangementin Vivo

(2008) Y. Diana Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The immunoglobulin constant region contributes to affinity and specificity

(2008) Marcela Torres et al.   TRENDS IN IMMUNOLOGY