The impact of glycosylation on monoclonal antibody conformation and stability

Construction, MD Simulation, and Hydrodynamic Validation of an All-Atom Model of a Monoclonal IgG Antibody

(2010) J. Paul Brandt et al.   BIOPHYSICAL JOURNAL

Glycosylation influences on the aggregation propensity of therapeutic monoclonal antibodies

(2010) Veysel Kayser et al.   Biotechnology Journal

Ultraviolet Spectroscopy as a Tool in Therapeutic Protein Development

(2010) Henryk Mach et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Global antibody development trends

(2010) Janice M. Reichert   mAbs

Effect of the conserved oligosaccharides of recombinant monoclonal antibodies on the separation by protein A and protein G chromatography

(2009) Georgeen Gaza-Bulseco et al.   JOURNAL OF CHROMATOGRAPHY A

Aggregation-Prone Motifs in Human Immunoglobulin G

(2009) Naresh Chennamsetty et al.   JOURNAL OF MOLECULAR BIOLOGY

Use of a folding model and in situ spectroscopic techniques for rational formulation development and stability testing of monoclonal antibody therapeutics**Gauri Rao and Vandana Iyer contributed equally to this work.

(2009) Gauri Rao et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

High throughput thermostability screening of monoclonal antibody formulations

(2009) Feng He et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Detection of IgG Aggregation by a High Throughput Method Based on Extrinsic Fluorescence

(2009) Feng He et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Dynamic Fluctuations of Protein-Carbohydrate Interactions Promote Protein Aggregation

(2009) Vladimir Voynov et al.   PLoS One

Design of therapeutic proteins with enhanced stability

(2009) N. Chennamsetty et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Recombinant antibody therapeutics: the impact of glycosylation on mechanisms of action

(2009) Royston Jefferis   TRENDS IN PHARMACOLOGICAL SCIENCES

Reversible Self-Association of a Concentrated Monoclonal Antibody Solution Mediated by Fab–Fab Interaction That Impacts Solution Viscosity

(2008) Sonoko Kanai et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Structural stability of hepatitis C virus envelope glycoprotein E1: Effect of pH and dissociative detergents

(2008) Feng He et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Using empirical phase diagrams to understand the role of intramolecular dynamics in immunoglobulin G stability

(2008) Joshua D. Ramsey et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Evaluation of the physical stability of the EC5 domain of E-cadherin: Effects of pH, temperature, ionic strength, and disulfide bonds

(2008) Kai Zheng et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Effects of glycosylation on the stability of protein pharmaceuticals

(2008) Ricardo J. Solá et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Fragmentation of a Recombinant Monoclonal Antibody at Various pH

(2008) Georgeen Gaza-Bulseco et al.   PHARMACEUTICAL RESEARCH

pH dependent effect of glycosylation on protein stability

(2007) Wei Wang et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Contribution of Variable Domains to the Stability of Humanized IgG1 Monoclonal Antibodies

(2007) Roxana M. Ionescu et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Structural effect of deglycosylation and methionine oxidation on a recombinant monoclonal antibody

(2007) Hongcheng Liu et al.   MOLECULAR IMMUNOLOGY