Journal
TRENDS IN IMMUNOLOGY
Volume 37, Issue 11, Pages 721-723Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.it.2016.08.014
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Funding
- NIAID NIH HHS [R01 AI033142, R01 AI033774] Funding Source: Medline
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A generation ago, the immunoglobulin intramolecular signaling, or allosteric, hypothesis was abandoned in favor of the associative hypothesis, which posited that Fc receptor crosslinking produced the increased affinity of antigen antibody complexes. This essay argues that there is sufficient evidence to resuscitate the allosteric hypothesis, at least for some antibodies.
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