Assessment of Physical Stability of an Antibody Drug Conjugate by Higher Order Structure Analysis: Impact of Thiol- Maleimide Chemistry

Molecular origins of surfactant-mediated stabilization of protein drugs

(2011) Hyo Jin Lee et al.   ADVANCED DRUG DELIVERY REVIEWS

Investigation of Protein Conformational Stability Employing a Multimodal Spectrometer

(2011) Lei Hu et al.   ANALYTICAL CHEMISTRY

Tunable Degradation of Maleimide–Thiol Adducts in Reducing Environments

(2011) Aaron D. Baldwin et al.   BIOCONJUGATE CHEMISTRY

Identification of Amino Acid Residues Responsible for the Release of Free Drug from an Antibody–Drug Conjugate Utilizing Lysine–Succinimidyl Ester Chemistry

(2011) Hung-Wei Chih et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Opalescence of an IgG2 monoclonal antibody solution as it relates to liquid–liquid phase separation

(2011) Bruce D. Mason et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Aggregation in Protein-Based Biotherapeutics: Computational Studies and Tools to Identify Aggregation-Prone Regions

(2011) Neeraj J. Agrawal et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Nonnative Aggregation of an IgG1 Antibody in Acidic Conditions, Part 2: Nucleation and Growth Kinetics with Competing Growth Mechanisms

(2011) Rebecca K. Brummitt et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Conformational stability and aggregation of therapeutic monoclonal antibodies studied with ANS and Thioflavin T binding

(2011) Veysel Kayser et al.   mAbs

Analytical methods for physicochemical characterization of antibody drug conjugates

(2011) Aditya Wakankar et al.   mAbs

Physicochemical Stability of the Antibody−Drug Conjugate Trastuzumab-DM1: Changes due to Modification and Conjugation Processes

(2010) Aditya A. Wakankar et al.   BIOCONJUGATE CHEMISTRY

Comparative Effects of pH and Ionic Strength on Protein–Protein Interactions, Unfolding, and Aggregation for IgG1 Antibodies

(2010) Erinc Sahin et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Increased aggregation propensity of IgG2 subclass over IgG1: Role of conformational changes and covalent character in isolated aggregates

(2010) Heather Franey et al.   PROTEIN SCIENCE

Environment-sensitive behavior of fluorescent molecular rotors

(2010) Mark A Haidekker et al.   Journal of Biological Engineering

High throughput thermostability screening of monoclonal antibody formulations

(2009) Feng He et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Fluorescent Molecular Rotors as Dyes to Characterize Polysorbate-Containing IgG Formulations

(2009) Andrea Hawe et al.   PHARMACEUTICAL RESEARCH

Contribution of Linker Stability to the Activities of Anticancer Immunoconjugates

(2008) Stephen C. Alley et al.   BIOCONJUGATE CHEMISTRY

Using empirical phase diagrams to understand the role of intramolecular dynamics in immunoglobulin G stability

(2008) Joshua D. Ramsey et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Targeted Cancer Therapy: Conferring Specificity to Cytotoxic Drugs

(2007) Ravi V. J. Chari   ACCOUNTS OF CHEMICAL RESEARCH

A Biophysical Characterization of the Peptide Drug Pramlintide (AC137) Using Empirical Phase Diagrams

(2007) Akihisa Nonoyama et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Contribution of Variable Domains to the Stability of Humanized IgG1 Monoclonal Antibodies

(2007) Roxana M. Ionescu et al.   JOURNAL OF PHARMACEUTICAL SCIENCES