Article
Biochemistry & Molecular Biology
Zsolt Szekeres, Barbara Sandor, Zita Bognar, Fadi H. J. Ramadan, Anita Palfi, Beata Bodis, Kalman Toth, Eszter Szabados
Summary: Obesity is a global public health issue associated with various diseases, particularly type 2 diabetes. Leptin plays a crucial role in regulating food intake and metabolism. Sodium glucose co-transport 2 inhibitors have beneficial effects and can be potent antihyperglycemic drugs. This study aimed to investigate the metabolic state and leptin level among obese and type 2 diabetic patients, as well as the impact of empagliflozin treatment. The results showed that empagliflozin treatment led to lower body mass index, body fat, visceral fat, and leptin levels compared to conventional antidiabetic treatments. Leptin levels were increased in both obese and type 2 diabetic patients. Empagliflozin treatment also resulted in lower body mass index, body fat, and visceral fat percentages, while preserving renal function.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Clinical Neurology
Eduardo Rivera-Mancilla, Linda Al-Hassany, Carlos M. Villalon, Antoinette MaassenVanDenBrink
Summary: Migraine is a disabling neurovascular disorder that can drastically affect patients' quality of life, with a higher prevalence in women. Metabolic disorders such as obesity and diabetes mellitus may be related to migraine, but the mechanisms involved are not yet well established. Further research is needed to understand the possible connections between migraine and metabolic disorders.
FRONTIERS IN NEUROLOGY
(2021)
Article
Multidisciplinary Sciences
Shaza B. Zaghlool, Anna Halama, Nisha Stephan, Valborg Gudmundsdottir, Vilmundur Gudnason, Lori L. Jennings, Manonanthini Thangam, Emma Ahlqvist, Rayaz A. Malik, Omar M. E. Albagha, Karsten Suhre, Abdul Badi Abou-Samra
Summary: This study translates T2D subtypes previously identified in European individuals to an Arab population and identifies specific metabolic and proteomic signatures for each subtype, providing further understanding of the pathogenesis of these subtypes.
NATURE COMMUNICATIONS
(2022)
Article
Medicine, General & Internal
Hsiu-Fen Jao, Chih-Hsuan Wung, Hui-Chen Yu, Mei-Yueh Lee, Po-Chih Chen, Szu-Chia Chen, Jer-Ming Chang
Summary: The study revealed significant relationships between obesity-related indices and MetS among patients with type 2 DM, with LAP and VAI being powerful predictors in both sexes. Additionally, the associations of BMI, WHR, and CI on MetS were more significant in men than in women.
INTERNATIONAL JOURNAL OF MEDICAL SCIENCES
(2021)
Review
Environmental Sciences
Tapan Behl, Aayush Sehgal, Madhuri Grover, Sukhbir Singh, Neelam Sharma, Saurabh Bhatia, Ahmed Al-Harrasi, Lotfi Aleya, Simona Bungau
Summary: Metabolic disorders such as diabetes, obesity, and cardiovascular complications are increasing worldwide. The dysregulation of lipid and glucose transporters plays a critical role in the onset of diabetes mellitus which requires the search for new therapeutic targets. Studies suggest the involvement of ATP-binding cassette transporters in different diseases, highlighting their potential as treatment targets for insulin resistance and dysregulated glucose metabolism in diabetes.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Alexandra Katsimardou, Dimitrios Patoulias, Ioanna Zografou, Fotios Siskos, Konstantinos Stavropoulos, Konstantinos Imprialos, Zoi Tegou, Aristi Boulmpou, Vivian Georgopoulou, Nikoleta Hatzipapa, Christodoulos Papadopoulos, Michael Doumas
Summary: This study aimed to examine the impact of metabolic syndrome and its components on the erectile function of patients with type 2 diabetes mellitus. The results showed that metabolic syndrome was not associated with erectile dysfunction (ED) or its severity. However, high-density lipoprotein cholesterol (HDL) was found to be associated with ED and erectile function scores.
Review
Endocrinology & Metabolism
Ming Yang, Chongbin Liu, Na Jiang, Yan Liu, Shilu Luo, Chenrui Li, Hao Zhao, Yachun Han, Wei Chen, Li Li, Li Xiao, Lin Sun
Summary: Metabolic syndrome is a complex metabolic disorder characterized by obesity, hyperglycemia, hypertension, and hyperlipidemia. Insulin resistance, adipose tissue dysfunction, and chronic inflammation are believed to play a role in the development of metabolic syndrome, but effective clinical prevention and treatment measures are still lacking. Studies have shown that myostatin (MSTN) may be a potential therapeutic target for metabolic syndrome as it is involved in the development of obesity, hyperlipidemia, diabetes, and hypertension. This article discusses the transcriptional regulation and receptor binding pathway of MSTN, its role in regulating mitochondrial function and autophagy, and reviews the progress of MSTN research in metabolic syndrome. Additionally, MSTN inhibitors under clinical trial are summarized and proposed as potential targets for the treatment of metabolic syndrome.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Cell Biology
Veronica Murcia-Belmonte, Maria Tercero-Diaz, Diego Barrasa-Martin, Sandra Lopez de la Vieja, Marina Munoz-Lopez, Pedro F. Esteban
Summary: The X-linked form of Kallmann syndrome is caused by mutations in the ANOS1 gene, resulting in hypogonadotropic hypogonadism and anosmia. This study reveals that anosmin 1 can enhance the activation of the PK2/PKR2 pathway and modulate its biological effects. The N-terminal region of anosmin 1 interacts with PKR2, and the whey acidic protein domain is necessary for this modulatory activity, while the cysteine-rich and FnIII.1 domains may assist in binding to PKR2 and regulating receptor activation by PK2.
CELLULAR SIGNALLING
(2022)
Review
Nutrition & Dietetics
Gabriele Piuri, Monica Zocchi, Matteo Della Porta, Valentina Ficara, Michele Manoni, Gian Vincenzo Zuccotti, Luciano Pinotti, Jeanette A. Maier, Roberta Cazzola
Summary: Magnesium (Mg2+) deficiency is often underestimated in Western countries, especially in obese individuals with type 2 diabetes and metabolic syndrome. Proper intake of Mg2+ can help improve metabolic syndrome by regulating gene expression, proteomic profile, and impacting intestinal microbiota and vitamin metabolism.
Review
Endocrinology & Metabolism
Niansi Pan, Shimei Yang, Xiaohong Niu
Summary: This review discusses the prevalence of MetS in LADA and the risk and role of insulin resistance in the development of LADA from the perspectives of inflammatory factors, environmental factors, and the gut microbiota, aiming to improve our understanding of this condition.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Holger Steinbrenner, Leonidas H. H. Duntas, Margaret P. P. Rayman
Summary: This review discusses the role of selenium in T2DM and its metabolic co-morbidities, emphasizing the relevance of inflammation and oxidative stress. It describes the epidemiology of selenium studies in diabetes and explains the interaction between selenium status and glucose control. According to current research, dietary selenium supplementation does not appear to be a major causal factor for the development of T2DM.
Article
Chemistry, Multidisciplinary
Arianna Bonizzi, Marta Sevieri, Leopoldo Sitia, Andrea Rizzi, Lorenzo Conti, Fabio Corsi, Carlo Morasso, Serena Mazzucchelli
Summary: The study revealed that despite the improvements in weight, glycemic control, and lipid profile of type 2 diabetes mellitus patients after bariatric surgery, Raman spectroscopy indicated that their metabolic profiles were not fully restored post-surgery.
APPLIED SCIENCES-BASEL
(2021)
Article
Biochemistry & Molecular Biology
Lupe Furtado-Alle, Luciane Tureck, Carolina S. de Oliveira, Joao V. M. Hortega, Ricardo L. R. Souza
Summary: Butyrylcholinesterase (BChE) is an enzyme found primarily in the liver, plasma, and brain, and it has been recognized for its role in the hydrolysis of choline esters. Recent studies have shown its involvement in lipid metabolism, suggesting it plays a crucial role in maintaining lipid homeostasis. However, the relationship between external factors and BChE activity in lipid metabolic pathways is still complex and requires further investigation.
CHEMICO-BIOLOGICAL INTERACTIONS
(2023)
Article
Endocrinology & Metabolism
Zi-yi Chen, Lei Liu, Xu-xiu Zhuang, Yi-cong Zhang, Ya-nan Ma, Yang Liu, De-liang Wen
Summary: This study aimed to confirm and compare the associations of non-traditional lipid profiles with metabolic syndrome (MetS) in Chinese adolescents, determine the lipid parameter with better predictive potential, and investigate its discriminatory power on MetS. Medical measurements and blood tests were conducted on 1112 adolescents aged 13-18. Univariate and multivariate logistic regression analyses were used to assess the relationships between lipid profiles and MetS. The lipid accumulation product (LAP) index was found to have the closest association with MetS and showed sufficient capabilities to identify adolescents with MetS and its components.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Nutrition & Dietetics
Rodolfo Deusdara, Amanda de Moura Souza, Moyses Szklo
Summary: This study evaluated the additive and multiplicative interactions between components of Metabolic syndrome (MetS) regarding type 2 diabetes mellitus. The results showed that the joint presence of certain components had a stronger association with the prevalence of type 2 diabetes mellitus in adolescents.