Mitochondrial Ca 2+ transport in the endothelium: regulation by ions, redox signalling and mechanical forces

Autophagy as a regulator of cardiovascular redox homeostasis

(2017) Ye Yan et al.   FREE RADICAL BIOLOGY AND MEDICINE

Changes in vascular reactivity and endothelial Ca2+ dynamics with chronic low flow

(2017) Mark S. Taylor et al.   MICROCIRCULATION

Redox Control of Mitochondrial Calcium Uptake

(2017) Nicolas Demaurex et al.   MOLECULAR CELL

Mitochondrial Ca 2+ Uniporter Is a Mitochondrial Luminal Redox Sensor that Augments MCU Channel Activity

(2017) Zhiwei Dong et al.   MOLECULAR CELL

The mitochondrial Na+/Ca2+ exchanger is essential for Ca2+ homeostasis and viability

(2017) Timothy S. Luongo et al.   NATURE

Pharmacological modulation of autophagy: therapeutic potential and persisting obstacles

(2017) Lorenzo Galluzzi et al.   NATURE REVIEWS DRUG DISCOVERY

Ion and inhibitor binding of the double-ring ion selectivity filter of the mitochondrial calcium uniporter

(2017) Chan Cao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TFEB inhibits endothelial cell inflammation and reduces atherosclerosis

(2017) Haocheng Lu et al.   Science Signaling

TFEB inhibits endothelial cell inflammation and reduces atherosclerosis

(2017) Haocheng Lu et al.   Science Signaling

Mitochondria in endothelial cells: Sensors and integrators of environmental cues

(2017) Sergio Caja et al.   Redox Biology

Endothelial mitochondria regulate the intracellular Ca2+ response to fluid shear stress

(2016) Christopher G. Scheitlin et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Mitochondrial Reactive Oxygen Species Mediate Lysophosphatidylcholine-Induced Endothelial Cell ActivationHighlights

(2016) Xinyuan Li et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Analysis of the structure and function of EMRE in a yeast expression system

(2016) Takenori Yamamoto et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Endothelial Cell Dysfunction and the Pathobiology of Atherosclerosis

(2016) Michael A. Gimbrone et al.   CIRCULATION RESEARCH

Functional role of mitochondrial reactive oxygen species in physiology

(2016) Plamena R. Angelova et al.   FREE RADICAL BIOLOGY AND MEDICINE

Differential Roles of Protein Complexes NOX1-NOXO1 and NOX2-p47phox in Mediating Endothelial Redox Responses to Oscillatory and Unidirectional Laminar Shear Stress

(2016) Kin Lung Siu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Architecture of the mitochondrial calcium uniporter

(2016) Kirill Oxenoid et al.   NATURE

Role of biomechanical forces in the natural history of coronary atherosclerosis

(2016) Adam J. Brown et al.   Nature Reviews Cardiology

Association of Hemodynamic Factors With Intracranial Aneurysm Formation and Rupture

(2016) Anil Can et al.   NEUROSURGERY

Calcium at the Center of Cell Signaling: Interplay between Endoplasmic Reticulum, Mitochondria, and Lysosomes

(2016) Anna Raffaello et al.   TRENDS IN BIOCHEMICAL SCIENCES

MICU1 regulation of mitochondrial Ca2+ uptake dictates survival and tissue regeneration

(2016) Anil Noronha Antony et al.   Nature Communications

MICU1 Serves as a Molecular Gatekeeper to Prevent In Vivo Mitochondrial Calcium Overload

(2016) Julia C. Liu et al.   Cell Reports

MCUR1 Is a Scaffold Factor for the MCU Complex Function and Promotes Mitochondrial Bioenergetics

(2016) Dhanendra Tomar et al.   Cell Reports

EMRE Is a Matrix Ca 2+ Sensor that Governs Gatekeeping of the Mitochondrial Ca 2+ Uniporter

(2016) Horia Vais et al.   Cell Reports

Mia40 is a trans-site receptor that drives protein import into the mitochondrial intermembrane space by hydrophobic substrate binding

(2016) Valentina Peleh et al.   eLife

Dual functions of a small regulatory subunit in the mitochondrial calcium uniporter complex

(2016) Ming-Feng Tsai et al.   eLife

Thiol dependent intramolecular locking of Orai1 channels

(2016) Dalia Alansary et al.   Scientific Reports

Disturbed Flow Induces Autophagy, but Impairs Autophagic Flux to Perturb Mitochondrial Homeostasis

(2015) Rongsong Li et al.   ANTIOXIDANTS & REDOX SIGNALING

Heart Disease and Stroke Statistics—2016 Update

(2015) Dariush Mozaffarian et al.   CIRCULATION

The Role of Autophagy in Vascular Biology

(2015) S. C. Nussenzweig et al.   CIRCULATION RESEARCH

Structure and function of the N-terminal domain of the human mitochondrial calcium uniporter

(2015) Y. Lee et al.   EMBO REPORTS

P2Y2 and Gq/G11 control blood pressure by mediating endothelial mechanotransduction

(2015) ShengPeng Wang et al.   JOURNAL OF CLINICAL INVESTIGATION

Ca2+signals regulate mitochondrial metabolism by stimulating CREB-mediated expression of the mitochondrial Ca2+uniporter geneMCU

(2015) Santhanam Shanmughapriya et al.   Science Signaling

Ca2+signals regulate mitochondrial metabolism by stimulating CREB-mediated expression of the mitochondrial Ca2+uniporter geneMCU

(2015) Santhanam Shanmughapriya et al.   Science Signaling

Calcium and ROS: A mutual interplay

(2015) Agnes Görlach et al.   Redox Biology

The Role of Shear Stress in Arteriovenous Fistula Maturation and Failure: A Systematic Review

(2015) Leonard D. Browne et al.   PLoS One

Glutaredoxin-1 AttenuatesS-Glutathionylation of the Death Receptor Fas and Decreases Resolution ofPseudomonas aeruginosaPneumonia

(2014) Vikas Anathy et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Autophagy Regulates Vascular Endothelial Cell eNOS and ET-1 Expression Induced by Laminar Shear Stress in an Ex Vivo Perfused System

(2014) Fengxia Guo et al.   ANNALS OF BIOMEDICAL ENGINEERING

Disturbed Flow Promotes Endothelial Senescence via a p53-Dependent Pathway

(2014) Christina M. Warboys et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Mechanoresponsive Networks Controlling Vascular Inflammation

(2014) Matthew T. Bryan et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Regulation of the mitochondrial Ca2+ uniporter by MICU1 and MICU2

(2014) J. Kevin Foskett et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Impairment of autophagy in endothelial cells prevents shear-stress-induced increases in nitric oxide bioavailability

(2014) Leena P. Bharath et al.   CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY

Fluid Mechanical Forces and Endothelial Mitochondria: A Bioengineering Perspective

(2014) Christopher G. Scheitlin et al.   Cellular and Molecular Bioengineering

Structural and mechanistic insights into MICU1 regulation of mitochondrial calcium uptake

(2014) L. Wang et al.   EMBO JOURNAL

The gatekeepers of mitochondrial calcium influx: MICU1 and MICU2

(2014) M. Ahuja et al.   EMBO REPORTS

MICU1 and MICU2 play nonredundant roles in the regulation of the mitochondrial calcium uniporter

(2014) K. J. Kamer et al.   EMBO REPORTS

Isoform- and Species-specific Control of Inositol 1,4,5-Trisphosphate (IP3) Receptors by Reactive Oxygen Species

(2014) Száva Bánsághi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SLC25A23 augments mitochondrial Ca2+ uptake, interacts with MCU, and induces oxidative stress–mediated cell death

(2014) Nicholas E. Hoffman et al.   MOLECULAR BIOLOGY OF THE CELL

MICU1 and MICU2 Finely Tune the Mitochondrial Ca2+ Uniporter by Exerting Opposite Effects on MCU Activity

(2014) Maria Patron et al.   MOLECULAR CELL

Directed evolution of APEX2 for electron microscopy and proximity labeling

(2014) Stephanie S Lam et al.   NATURE METHODS

Mitochondrial Calcium Uniporter MCU Supports Cytoplasmic Ca2+ Oscillations, Store-Operated Ca2+ Entry and Ca2+-Dependent Gene Expression in Response to Receptor Stimulation

(2014) Krishna Samanta et al.   PLoS One

Structural differences among subfamilies of EF-hand proteins-A view from the pseudo two-fold symmetry axis

(2014) Hiroshi Kawasaki et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Imaging intraorganellar Ca2+ at subcellular resolution using CEPIA

(2014) Junji Suzuki et al.   Nature Communications

Mechanobiology and Developmental Control

(2013) Tadanori Mammoto et al.   Annual Review of Cell and Developmental Biology

Endothelial Cell Sensing of Flow Direction

(2013) Chong Wang et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

The atherosusceptible endothelium: endothelial phenotypes in complex haemodynamic shear stress regions in vivo

(2013) Peter F. Davies et al.   CARDIOVASCULAR RESEARCH

Flow detection and calcium signalling in vascular endothelial cells

(2013) Joji Ando et al.   CARDIOVASCULAR RESEARCH

MICU1 Controls Both the Threshold and Cooperative Activation of the Mitochondrial Ca2+ Uniporter

(2013) György Csordás et al.   Cell Metabolism

Mitochondria and Endothelial Function

(2013) Matthew A. Kluge et al.   CIRCULATION RESEARCH

The mitochondrial calcium uniporter is a multimer that can include a dominant-negative pore-forming subunit

(2013) Anna Raffaello et al.   EMBO JOURNAL

Molecular Biology of Atherosclerosis

(2013) Paul N. Hopkins   PHYSIOLOGICAL REVIEWS

MICU2, a Paralog of MICU1, Resides within the Mitochondrial Uniporter Complex to Regulate Calcium Handling

(2013) Molly Plovanich et al.   PLoS One

Ca2+ channel nanodomains boost local Ca2+ amplitude

(2013) M. R. Tadross et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

EMRE Is an Essential Component of the Mitochondrial Calcium Uniporter Complex

(2013) Y. Sancak et al.   SCIENCE

Human haemodynamic frequency harmonics regulate the inflammatory phenotype of vascular endothelial cells

(2013) Ryan E. Feaver et al.   Nature Communications

MICU1 Motifs Define Mitochondrial Calcium Uniporter Binding and Activity

(2013) Nicholas E. Hoffman et al.   Cell Reports

Site-Specific MicroRNA-92a Regulation of Krüppel-Like Factors 4 and 2 in Atherosusceptible Endothelium

(2012) Yun Fang et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

MICU1 Is an Essential Gatekeeper for MCU-Mediated Mitochondrial Ca2+ Uptake that Regulates Cell Survival

(2012) Karthik Mallilankaraman et al.   CELL

PERK is required at the ER-mitochondrial contact sites to convey apoptosis after ROS-based ER stress

(2012) T Verfaillie et al.   CELL DEATH AND DIFFERENTIATION

CaMKII determines mitochondrial stress responses in heart

(2012) Mei-ling A. Joiner et al.   NATURE

Engineered ascorbate peroxidase as a genetically encoded reporter for electron microscopy

(2012) Jeffrey D Martell et al.   NATURE BIOTECHNOLOGY

MCUR1 is an essential component of mitochondrial Ca2+ uptake that regulates cellular metabolism

(2012) Karthik Mallilankaraman et al.   NATURE CELL BIOLOGY

Spatiotemporal Correlations between Cytosolic and Mitochondrial Ca2+ Signals Using a Novel Red-Shifted Mitochondrial Targeted Cameleon

(2012) Markus Waldeck-Weiermair et al.   PLoS One

Mitochondrial Ca2+ uptake contributes to buffering cytoplasmic Ca2+ peaks in cardiomyocytes

(2012) I. Drago et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Relating Form and Function of EF-Hand Calcium Binding Proteins

(2011) Walter J. Chazin   ACCOUNTS OF CHEMICAL RESEARCH

Basic Principles and Emerging Concepts in the Redox Control of Transcription Factors

(2011) Regina Brigelius-Flohé et al.   ANTIOXIDANTS & REDOX SIGNALING

Regulation of Endothelial Function by Mitochondrial Reactive Oxygen Species

(2011) Michael E. Widlansky et al.   ANTIOXIDANTS & REDOX SIGNALING

Redox-Based Regulation of Apoptosis: S-Glutathionylation As a Regulatory Mechanism to Control Cell Death

(2011) Vikas Anathy et al.   ANTIOXIDANTS & REDOX SIGNALING

Two distinct phases of calcium signalling under flow

(2011) Bo Liu et al.   CARDIOVASCULAR RESEARCH

Purinergic P2Y2 receptors mediate rapid Ca2+ mobilization, membrane hyperpolarization and nitric oxide production in human vascular endothelial cells

(2011) Abdul Raqeeb et al.   CELL CALCIUM

Flow-Dependent Regulation of Krüppel-Like Factor 2 Is Mediated by MicroRNA-92a

(2011) Wei Wu et al.   CIRCULATION

Coronary Artery Endothelial Transcriptome In Vivo

(2011) Mete Civelek et al.   Circulation-Cardiovascular Genetics

Visualization of flow-induced ATP release and triggering of Ca2+ waves at caveolae in vascular endothelial cells

(2011) K. Yamamoto et al.   JOURNAL OF CELL SCIENCE

Mitochondrial reactive oxygen species promote production of proinflammatory cytokines and are elevated in TNFR1-associated periodic syndrome (TRAPS)

(2011) Ariel C. Bulua et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Integrative genomics identifies MCU as an essential component of the mitochondrial calcium uniporter

(2011) Joshua M. Baughman et al.   NATURE

A forty-kilodalton protein of the inner membrane is the mitochondrial calcium uniporter

(2011) Diego De Stefani et al.   NATURE

Progress and challenges in translating the biology of atherosclerosis

(2011) Peter Libby et al.   NATURE

Sensing cellular stress through STIM proteins

(2011) Jonathan Soboloff et al.   Nature Chemical Biology

Flow Shear Stress and Atherosclerosis: A Matter of Site Specificity

(2010) Patrizia Nigro et al.   ANTIOXIDANTS & REDOX SIGNALING

p53 Impairs Endothelial Function by Transcriptionally Repressing Kruppel-Like Factor 2

(2010) Ajay Kumar et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Endothelial mitochondria and heart disease

(2010) S. M. Davidson   CARDIOVASCULAR RESEARCH

Redox-mediated reciprocal regulation of SERCA and Na+–Ca2+ exchanger contributes to sarcoplasmic reticulum Ca2+ depletion in cardiac myocytes

(2010) Gabriela M. Kuster et al.   FREE RADICAL BIOLOGY AND MEDICINE

Reactive oxygen species, cellular redox systems, and apoptosis

(2010) Magdalena L. Circu et al.   FREE RADICAL BIOLOGY AND MEDICINE

S-glutathionylation activates STIM1 and alters mitochondrial homeostasis

(2010) Brian J. Hawkins et al.   JOURNAL OF CELL BIOLOGY

MICU1 encodes a mitochondrial EF hand protein required for Ca2+ uptake

(2010) Fabiana Perocchi et al.   NATURE

Dali server: conservation mapping in 3D

(2010) Liisa Holm et al.   NUCLEIC ACIDS RESEARCH

Nitric oxide and oxidative stress in vascular disease

(2010) Ulrich Förstermann   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Pore architecture of the ORAI1 store-operated calcium channel

(2010) Y. Zhou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Decoding cytosolic Ca2+ oscillations

(2010) Anant B. Parekh   TRENDS IN BIOCHEMICAL SCIENCES

Partial carotid ligation is a model of acutely induced disturbed flow, leading to rapid endothelial dysfunction and atherosclerosis

(2009) Douglas Nam et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Modulation of calcium signalling by mitochondria

(2009) Ciara Walsh et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Fluid shear stress stimulates phosphorylation-dependent nuclear export of HDAC5 and mediates expression of KLF2 and eNOS

(2009) W. Wang et al.   BLOOD

Chronic Endoplasmic Reticulum Stress Activates Unfolded Protein Response in Arterial Endothelium in Regions of Susceptibility to Atherosclerosis

(2009) Mete Civelek et al.   CIRCULATION RESEARCH

Redox amplification of apoptosis by caspase-dependent cleavage of glutaredoxin 1 and S-glutathionylation of Fas

(2009) Vikas Anathy et al.   JOURNAL OF CELL BIOLOGY

Mitochondria-Derived Reactive Oxygen Species Mediate Heme Oxygenase-1 Expression in Sheared Endothelial Cells

(2009) Z. Han et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Execution of Superoxide-Induced Cell Death by the Proapoptotic Bcl-2-Related Proteins Bid and Bak

(2009) M. Madesh et al.   MOLECULAR AND CELLULAR BIOLOGY

NAADP mobilizes calcium from acidic organelles through two-pore channels

(2009) Peter J. Calcraft et al.   NATURE

NCLX is an essential component of mitochondrial Na+/Ca2+ exchange

(2009) R. Palty et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Endothelial cell respiration is affected by the oxygen tension during shear exposure: role of mitochondrial peroxynitrite

(2008) Charles I. Jones et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

How mitochondria produce reactive oxygen species

(2008) Michael P. Murphy   BIOCHEMICAL JOURNAL

Inositol trisphosphate and calcium signalling mechanisms

(2008) Michael J. Berridge   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Searching protein structure databases with DaliLite v.3

(2008) L. Holm et al.   BIOINFORMATICS

Ca2+-Dependent Inactivation of the Mitochondrial Ca2+ Uniporter Involves Proton Flux through the ATP Synthase

(2008) Ben Moreau et al.   CURRENT BIOLOGY