Impact of physiological, pathological and environmental factors on the expression and activity of human cytochrome P450 2D6 and implications in precision medicine
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Title
Impact of physiological, pathological and environmental factors on the expression and activity of human cytochrome P450 2D6 and implications in precision medicine
Authors
Keywords
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Journal
DRUG METABOLISM REVIEWS
Volume 47, Issue 4, Pages 470-519
Publisher
Informa UK Limited
Online
2015-11-17
DOI
10.3109/03602532.2015.1101131
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Note: Only part of the references are listed.- Modulation of the pentose phosphate pathway alters phase I metabolism of testosterone and dextromethorphan in HepG2 cells
- (2015) Wen-jing Xiao et al. ACTA PHARMACOLOGICA SINICA
- Hepatocyte nuclear factor (HNF) 4α transactivation of cytochrome P450 (Cyp) 2d40 promoter is enhanced during pregnancy in mice
- (2015) Miaoran Ning et al. BIOCHEMICAL PHARMACOLOGY
- Intake of St John's wort improves the glucose tolerance in healthy subjects who ingest metformin compared with metformin alone
- (2015) Tore Bjerregaard Stage et al. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
- Influence of gestational diabetes on the stereoselective pharmacokinetics and placental distribution of metoprolol and its metabolites in parturients
- (2015) Natalícia de Jesus Antunes et al. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
- The genetics of Parkinson's disease
- (2015) Stephen Mullin et al. BRITISH MEDICAL BULLETIN
- Pharmacokinetic Interactions Between Herbal Medicines and Prescribed Drugs: Focus on Drug Metabolic Enzymes and Transporters
- (2015) Qiang Meng et al. CURRENT DRUG METABOLISM
- Alcohol Addiction: A Molecular Biology Perspective
- (2015) Giampiero Ferraguti et al. CURRENT MEDICINAL CHEMISTRY
- Efficacy of Obeticholic Acid in Patients With Primary Biliary Cirrhosis and Inadequate Response to Ursodeoxycholic Acid
- (2015) Gideon M. Hirschfield et al. GASTROENTEROLOGY
- Molecular Evolution of the CYP2D Subfamily in Primates: Purifying Selection on Substrate Recognition Sites without the Frequent or Long-Tract Gene Conversion
- (2015) Yoshiki Yasukochi et al. Genome Biology and Evolution
- The Kruppel-like factors in female reproductive system pathologies
- (2015) R. C. M. Simmen et al. JOURNAL OF MOLECULAR ENDOCRINOLOGY
- Farnesoid X nuclear receptor ligand obeticholic acid for non-cirrhotic, non-alcoholic steatohepatitis (FLINT): a multicentre, randomised, placebo-controlled trial
- (2015) Brent A Neuschwander-Tetri et al. LANCET
- Parkinson's disease
- (2015) Lorraine V Kalia et al. LANCET
- Alzheimer's disease and other dementias: advances in 2014
- (2015) Randall Bateman LANCET NEUROLOGY
- Neuroinflammation in Alzheimer's disease
- (2015) Michael T Heneka et al. LANCET NEUROLOGY
- Alzheimer disease (AD) specific transcription, DNA methylation and splicing in twenty AD associated loci
- (2015) Crystal Humphries et al. MOLECULAR AND CELLULAR NEUROSCIENCE
- Conserved epigenomic signals in mice and humans reveal immune basis of Alzheimer’s disease
- (2015) Elizabeta Gjoneska et al. NATURE
- Innate immunity in Alzheimer's disease
- (2015) Michael T Heneka et al. NATURE IMMUNOLOGY
- Parkinson disease GWAS: The question of lumping or splitting is back again
- (2015) J. Simon-Sanchez et al. NEUROLOGY
- The resolution of inflammation: Principles and challenges
- (2015) Sarah E. Headland et al. SEMINARS IN IMMUNOLOGY
- Amyloid biomarkers in Alzheimer's disease
- (2015) Kaj Blennow et al. TRENDS IN PHARMACOLOGICAL SCIENCES
- The Chemokine System in Innate Immunity
- (2015) Caroline L. Sokol et al. Cold Spring Harbor Perspectives in Biology
- Differences in the Epigenetic Regulation of Cytochrome P450 Genes between Human Embryonic Stem Cell-Derived Hepatocytes and Primary Hepatocytes
- (2015) Han-Jin Park et al. PLoS One
- 2014 Report on the Milestones for the US National Plan to Address Alzheimer's Disease
- (2014) Keith N. Fargo et al. Alzheimers & Dementia
- Deaths in the United States among persons with Alzheimer's disease (2010–2050)
- (2014) Jennifer Weuve et al. Alzheimers & Dementia
- Apolipoprotein E in Alzheimer's Disease: An Update
- (2014) Jin-Tai Yu et al. Annual Review of Neuroscience
- Alzheimer disease: Epidemiology, diagnostic criteria, risk factors and biomarkers
- (2014) Christiane Reitz et al. BIOCHEMICAL PHARMACOLOGY
- TAM receptors, Gas6, and protein S: roles in inflammation and hemostasis
- (2014) J. H. M. van der Meer et al. BLOOD
- Identification of a novel Parkinson’s disease locus via stratified genome-wide association study
- (2014) Erin M Hill-Burns et al. BMC GENOMICS
- Genetic and epigenetic regulation of gene expression in fetal and adult human livers
- (2014) Marc Bonder et al. BMC GENOMICS
- Genetic associations of Nrf2-encoding NFE2L2 variants with Parkinson’s disease – a multicenter study
- (2014) Malin von Otter et al. BMC Medical Genetics
- Interleukin-6 mediated upregulation of CYP1B1 and CYP2E1 in colorectal cancer involves DNA methylation, miR27b and STAT3
- (2014) S A A Patel et al. BRITISH JOURNAL OF CANCER
- Citalopram and escitalopram plasma drug and metabolite concentrations: genome-wide associations
- (2014) Yuan Ji et al. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
- Cancer, Inflammation, and Therapy: Effects on Cytochrome P450–Mediated Drug Metabolism and Implications for Novel Immunotherapeutic Agents
- (2014) R Donald Harvey et al. CLINICAL PHARMACOLOGY & THERAPEUTICS
- ABC Transporters in Multidrug Resistance and Pharmacokinetics, and Strategies for Drug Development
- (2014) Young Choi et al. CURRENT PHARMACEUTICAL DESIGN
- Cytochrome P450 enzyme regulation by glucocorticoids and consequences in terms of drug interaction
- (2014) Petra Matoulková et al. Expert Opinion on Drug Metabolism & Toxicology
- Genetic markers for diagnosis and pathogenesis of Alzheimer's disease
- (2014) Dong Hee Kim et al. GENE
- Alzheimer’s Disease—A Panorama Glimpse
- (2014) Li Zhao et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Hepatic cytochrome P450 ubiquitination: Conformational phosphodegrons for E2/E3 recognition?
- (2014) Maria Almira Correia et al. IUBMB LIFE
- Pregnane X Receptor as the “Sensor and Effector” in Regulating Epigenome
- (2014) Xi Ma et al. JOURNAL OF CELLULAR PHYSIOLOGY
- A pharmacokinetic drug interaction study between nebivolol and paroxetine in healthy volunteers
- (2014) C. Briciu et al. JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS
- Structural diversity of ABC transporters
- (2014) Josy ter Beek et al. JOURNAL OF GENERAL PHYSIOLOGY
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- (2014) Neeraj Kumar Singh et al. JOURNAL OF GERIATRIC PSYCHIATRY AND NEUROLOGY
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- (2014) Guiyou Liu et al. MOLECULAR NEUROBIOLOGY
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- (2014) Mike A Nalls et al. NATURE GENETICS
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- (2014) Celeste M. Karch et al. NEURON
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- (2014) Robin P. Smith et al. PLoS Genetics
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- (2013) William T. Wissemann et al. AMERICAN JOURNAL OF HUMAN GENETICS
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- (2013) Priya Duggal et al. ANNALS OF INTERNAL MEDICINE
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- (2013) Beth Williamson et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
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- (2013) Muhammad Imran et al. ARCHIVES OF VIROLOGY
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- (2013) Alun W. Newsome et al. BIOTECHNOLOGY AND APPLIED BIOCHEMISTRY
- SnapShot: Pathobiology of Alzheimer's Disease
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- Molecular Pathways: MERTK Signaling in Cancer
- (2013) C. T. Cummings et al. CLINICAL CANCER RESEARCH
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- (2013) N Inui et al. CLINICAL PHARMACOLOGY & THERAPEUTICS
- Genetics, Epigenetics, and Regulation of Drug-Metabolizing Cytochrome P450 Enzymes
- (2013) U M Zanger et al. CLINICAL PHARMACOLOGY & THERAPEUTICS
- Post-translational and Post-transcriptional Modifications of Pregnane X Receptor (PXR) in Regulation of the Cytochrome P450 Superfamily
- (2013) Tomas Smutny et al. CURRENT DRUG METABOLISM
- The Evolution of Cytochrome P450 Enzymes as Biocatalysts in Drug Discovery and Development
- (2013) Elizabeth Gillam et al. CURRENT TOPICS IN MEDICINAL CHEMISTRY
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- The endogenous substrates of brain CYP2D
- (2013) Xiaoshuang Wang et al. EUROPEAN JOURNAL OF PHARMACOLOGY
- Efficacy and Safety of the Farnesoid X Receptor Agonist Obeticholic Acid in Patients With Type 2 Diabetes and Nonalcoholic Fatty Liver Disease
- (2013) Sunder Mudaliar et al. GASTROENTEROLOGY
- Mutations in the Genes Encoding the Transcription Factors Hepatocyte Nuclear Factor 1 Alpha and 4 Alpha in Maturity-Onset Diabetes of the Young and Hyperinsulinemic Hypoglycemia
- (2013) Kevin Colclough et al. HUMAN MUTATION
- Cytochrome P450 isoforms are differently up-regulated in aflatoxin B1-exposed human lymphocytes and monocytes
- (2013) Abbas Bahari et al. IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY
- Altered Expression of Small Heterodimer Partner Governs Cytochrome P450 (CYP) 2D6 Induction during Pregnancy in CYP2D6-humanized Mice
- (2013) Kwi Hye Koh et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Drug-Induced Liver Injury: The Role of Drug Metabolism and Transport
- (2013) Alberto Corsini et al. JOURNAL OF CLINICAL PHARMACOLOGY
- A genome-wide association study of HCV-induced liver cirrhosis in the Japanese population identifies novel susceptibility loci at the MHC region
- (2013) Yuji Urabe et al. JOURNAL OF HEPATOLOGY
- Recent advances in Parkinson’s disease genetics
- (2013) Steven Lubbe et al. JOURNAL OF NEUROLOGY
- CYP2D6 phenotypes and Parkinson's disease risk: A meta-analysis
- (2013) Yu Lu et al. JOURNAL OF THE NEUROLOGICAL SCIENCES
- Effects of chronic kidney disease and uremia on hepatic drug metabolism and transport
- (2013) Catherine K. Yeung et al. KIDNEY INTERNATIONAL
- Global burden of disease attributable to mental and substance use disorders: findings from the Global Burden of Disease Study 2010
- (2013) Harvey A Whiteford et al. LANCET
- Treating HCV in HIV 2013: on the cusp of change
- (2013) Valérie Martel-Laferrière et al. LIVER INTERNATIONAL
- Rare coding variants in the phospholipase D3 gene confer risk for Alzheimer’s disease
- (2013) Carlos Cruchaga et al. NATURE
- Integrative genomics identifies APOE ε4 effectors in Alzheimer's disease
- (2013) Herve Rhinn et al. NATURE
- HCV causes systemic disorders that can be cured
- (2013) Francesco Negro Nature Reviews Gastroenterology & Hepatology
- Advances in the genetics of Parkinson disease
- (2013) Joanne Trinh et al. Nature Reviews Neurology
- CYP2D6 -1584C>G promoter polymorphism and debrisoquine ultrarapid hydroxylation in healthy volunteers
- (2013) Adrian LLerena et al. PHARMACOGENOMICS
- NADPH P450 oxidoreductase: Structure, function, and pathology of diseases
- (2013) Amit V. Pandey et al. PHARMACOLOGY & THERAPEUTICS
- Cytochrome P450 enzymes in drug metabolism: Regulation of gene expression, enzyme activities, and impact of genetic variation
- (2013) Ulrich M. Zanger et al. PHARMACOLOGY & THERAPEUTICS
- Epigenetic Changes in Gene Expression for Drug-Metabolizing Enzymes and Transporters
- (2013) In-Wha Kim et al. PHARMACOTHERAPY
- Unusual properties of the cytochrome P450 superfamily
- (2013) D. C. Lamb et al. PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
- Human cytochromes P450 in health and disease
- (2013) D. W. Nebert et al. PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
- Microbial cytochromes P450: biodiversity and biotechnology. Where do cytochromes P450 come from, what do they do and what can they do for us?
- (2013) S. L. Kelly et al. PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
- Systematic Functional Study of Cytochrome P450 2D6 Promoter Polymorphisms in the Chinese Han Population
- (2013) Xueli Gong et al. PLoS One
- CYP2D6*4 Allele Polymorphism Increases the Risk of Parkinson’s Disease: Evidence from Meta-Analysis
- (2013) Yu Lu et al. PLoS One
- Novel Single Nucleotide Polymorphism Markers for Low Dose Aspirin-Associated Small Bowel Bleeding
- (2013) Akiko Shiotani et al. PLoS One
- Possibility of Decrease in CYP1A2 Function in Patients With End-Stage Renal Disease
- (2013) Masayuki Tsujimoto et al. THERAPEUTIC APHERESIS AND DIALYSIS
- Transcriptional Suppression of CYP2A13 Expression by Lipopolysaccharide in Cultured Human Lung Cells and the Lungs of a CYP2A13-Humanized Mouse Model
- (2013) Hong Wu et al. TOXICOLOGICAL SCIENCES
- β-Secretase: its biology as a therapeutic target in diseases
- (2013) Haibo Wang et al. TRENDS IN PHARMACOLOGICAL SCIENCES
- CYP2D6 T188C variant is associated with lung cancer risk in the Chinese population
- (2013) Yan Huang et al. TUMOR BIOLOGY
- Potential role of CYP2D6 in the central nervous system
- (2013) Jie Cheng et al. XENOBIOTICA
- Biology of the TAM Receptors
- (2013) G. Lemke Cold Spring Harbor Perspectives in Biology
- Genetics of Parkinson's Disease
- (2013) C. Klein et al. Cold Spring Harbor Perspectives in Medicine
- Maturity onset diabetes of the young: identification and diagnosis
- (2013) T. J. McDonald et al. ANNALS OF CLINICAL BIOCHEMISTRY
- NADPH–cytochrome P450 oxidoreductase: Prototypic member of the diflavin reductase family
- (2012) Takashi Iyanagi et al. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
- Alzheimer Mechanisms and Therapeutic Strategies
- (2012) Yadong Huang et al. CELL
- Systematic Functional Prioritization of Protein Posttranslational Modifications
- (2012) Pedro Beltrao et al. CELL
- Effect of Diabetes Mellitus on Pharmacokinetic and Pharmacodynamic Properties of Drugs
- (2012) Miroslav Dostalek et al. CLINICAL PHARMACOKINETICS
- Update on rifampin, rifabutin, and rifapentine drug interactions
- (2012) Anne M. Baciewicz et al. CURRENT MEDICAL RESEARCH AND OPINION
- Farnesoid X receptor: from medicinal chemistry to clinical applications
- (2012) Stefano Fiorucci et al. Future Medicinal Chemistry
- Genome-Wide Association Study Identifies Variants Associated With Progression of Liver Fibrosis From HCV Infection
- (2012) Etienne Patin et al. GASTROENTEROLOGY
- Krüppel-Like Factor 9 and Progesterone Receptor Coregulation of Decidualizing Endometrial Stromal Cells: Implications for the Pathogenesis of Endometriosis
- (2012) John Mark P. Pabona et al. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
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- (2012) Tung-Ming Leung et al. JOURNAL OF HEPATOLOGY
- Profiling the kinome: Current capabilities and future challenges
- (2012) James D.R. Knight et al. Journal of Proteomics
- Liver kidney microsomal type 1 antibodies reduce the CYP2D6 activity in patients with chronic hepatitis C virus infection
- (2012) F. Girardin et al. JOURNAL OF VIRAL HEPATITIS
- Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the Global Burden of Disease Study 2010
- (2012) Rafael Lozano et al. LANCET
- Epigenetic-dependent regulation of drug transport and metabolism: an update
- (2012) Marina Kacevska et al. PHARMACOGENOMICS
- Hepatocellular carcinoma in chronic hepatitis C: from bench to bedside
- (2012) Alessio Aghemo et al. Seminars in Immunopathology
- US Mortality from Liver Cirrhosis and Alcoholic Liver Disease in 1999–2004: Regional and State Variation in Relation to Per Capita Alcohol Consumption
- (2012) Anthony P. Polednak SUBSTANCE USE & MISUSE
- Functional characterization of SAG/RBX2/ROC2/RNF7, an antioxidant protein and an E3 ubiquitin ligase
- (2012) Yi Sun et al. Protein & Cell
- Role of Rifampin-Based Combination Therapy for Severe Community-Acquired Legionella pneumophila Pneumonia
- (2011) Terra R Varner et al. ANNALS OF PHARMACOTHERAPY
- Molecular Mechanisms Regulating the Mitochondrial Targeting of Microsomal Cytochrome P450 EnzymesMolecular Mechanisms Regulating the Mitochondrial Targeting of Microsomal Cytochrome P450 Enzymes
- (2011) Taeho Ahn et al. CURRENT DRUG METABOLISM
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- (2011) Katalin Monostory et al. CURRENT DRUG METABOLISM
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- (2011) B. J. Kirby et al. DRUG METABOLISM AND DISPOSITION
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- (2011) G. Zadoyan et al. EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY
- Bimodal targeting of cytochrome P450s to endoplasmic reticulum and mitochondria: the concept of chimeric signals
- (2011) Narayan G. Avadhani et al. FEBS Journal
- Evolution of the CYP2D gene cluster in humans and four non-human primates
- (2011) Yoshiki Yasukochi et al. GENES & GENETIC SYSTEMS
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- (2011) Edith Hintermann et al. JOURNAL OF AUTOIMMUNITY
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- (2011) Patty C. Kandalepas et al. JOURNAL OF NEUROCHEMISTRY
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- (2011) Miki Nakajima et al. PHARMACOLOGY & THERAPEUTICS
- Phenobarbital Mediates an Epigenetic Switch at the Constitutive Androstane Receptor (CAR) Target Gene Cyp2b10 in the Liver of B6C3F1 Mice
- (2011) Harri Lempiäinen et al. PLoS One
- Functional Evaluation of Genetic and Environmental Regulators of P450 mRNA Levels
- (2011) Dazhi Wang et al. PLoS One
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- (2011) Curtis D. Klaassen et al. TOXICOLOGY MECHANISMS AND METHODS
- Hepatic FXR: key regulator of whole-body energy metabolism
- (2011) João Soeiro Teodoro et al. TRENDS IN ENDOCRINOLOGY AND METABOLISM
- The tubby family proteins
- (2011) Saikat Mukhopadhyay et al. GENOME BIOLOGY
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- (2010) Wei-Dong Chen et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
- Fyn-Tau-Amyloid: A Toxic Triad
- (2010) Christian Haass et al. CELL
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- (2010) Mark A. Lemmon et al. CELL
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- (2010) Jang-Ik Lee et al. CLINICAL PHARMACOKINETICS
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- (2010) An-Kui Yang et al. CURRENT MEDICINAL CHEMISTRY
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- (2010) Wendy W Hwang-Verslues et al. CURRENT OPINION IN PHARMACOLOGY
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- (2009) Hindupur K. Anandatheerthavarada et al. JOURNAL OF BIOLOGICAL CHEMISTRY
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- (2009) Pedro Dorado et al. PHARMACOGENOMICS
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- (2009) Alan R. Brash PHYTOCHEMISTRY
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- (2008) Etienne P. A. Neve et al. ANALYTICAL AND BIOANALYTICAL CHEMISTRY
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- (2008) Jiansong Yang et al. CURRENT DRUG METABOLISM
- Xenobiotic-Induced Transcriptional Regulation of Xenobiotic Metabolizing Enzymes of the Cytochrome P450 Superfamily in Human Extrahepatic Tissues
- (2008) Petr Pavek et al. CURRENT DRUG METABOLISM
- Developmental Changes in Human Liver CYP2D6 Expression
- (2008) J. C. Stevens et al. DRUG METABOLISM AND DISPOSITION
- Expression and Functional Analysis of CYP2D6.24, CYP2D6.26, CYP2D6.27, and CYP2D7 Isozymes
- (2008) W.-Y. Zhang et al. DRUG METABOLISM AND DISPOSITION
- Functional Characterization of 17 CYP2D6 Allelic Variants (CYP2D6.2, 10, 14A-B, 18, 27, 36, 39, 47-51, 53-55, and 57)
- (2008) K. Sakuyama et al. DRUG METABOLISM AND DISPOSITION
- Regulation of Drug-Metabolizing Enzymes and Transporters in Infection, Inflammation, and Cancer
- (2008) E. T. Morgan et al. DRUG METABOLISM AND DISPOSITION
- Decreased Expression of Cytochromes P450 1A2, 2E1, and 3A4 and Drug Transporters Na+-Taurocholate-Cotransporting Polypeptide, Organic Cation Transporter 1, and Organic Anion-Transporting Peptide-C Correlates with the Progression of Liver Fibrosis in Chronic Hepatitis C Patients
- (2008) K. Nakai et al. DRUG METABOLISM AND DISPOSITION
- Coordinated induction of drug transporters and phase I and II metabolism in human liver slices
- (2008) P. Olinga et al. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
- The effect of chronic renal failure on drug metabolism and transport
- (2008) Albert W Dreisbach et al. Expert Opinion on Drug Metabolism & Toxicology
- Sex-specific differences in CYP450 isoforms in humans
- (2008) Marissa J Scandlyn et al. Expert Opinion on Drug Metabolism & Toxicology
- Paroxetine
- (2008) Siu Wa Tang et al. EXPERT OPINION ON PHARMACOTHERAPY
- Genetic polymorphism of hepatocyte nuclear factor-4α influences human cytochrome P450 2D6 activity
- (2008) Sang Seop Lee et al. HEPATOLOGY
- Pharmacokinetics and pharmacodynamics of drug interactions involving rifampicin, rifabutin and antimalarial drugs
- (2008) M. Sousa et al. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
- A Role for Protein Phosphorylation in Cytochrome P450 3A4 Ubiquitin-dependent Proteasomal Degradation
- (2008) YongQiang Wang et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Characterization of Cullin-box Sequences That Direct Recruitment of Cul2-Rbx1 and Cul5-Rbx2 Modules to Elongin BC-based Ubiquitin Ligases
- (2008) Nawel Mahrour et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Structural Analysis of CYP2R1 in Complex with Vitamin D3
- (2008) Natallia Strushkevich et al. JOURNAL OF MOLECULAR BIOLOGY
- The Endocannabinoid Anandamide Is a Substrate for the Human Polymorphic Cytochrome P450 2D6
- (2008) N. T. Snider et al. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
- Distinction between Human Cytochrome P450 (CYP) Isoforms and Identification of New Phosphorylation Sites by Mass Spectrometry
- (2008) Gorden Redlich et al. JOURNAL OF PROTEOME RESEARCH
- Aromatase is phosphorylated in situ at serine-118
- (2008) Todd W. Miller et al. JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
- Linking the kinome and phosphorylome—a comprehensive review of approaches to find kinase targets
- (2008) Richelle Sopko et al. Molecular BioSystems
- Clinical assessment of CYP2D6‐mediated herb–drug interactions in humans: Effects of milk thistle, black cohosh, goldenseal, kava kava, St. John's wort, andEchinacea
- (2008) Bill J. Gurley et al. MOLECULAR NUTRITION & FOOD RESEARCH
- Development of CYP2D6 and CYP3A4 in the First Year of Life
- (2007) TN Johnson et al. CLINICAL PHARMACOLOGY & THERAPEUTICS
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