Application of mechanism-based CYP inhibition for predicting drug–drug interactions

Application of CYP3A4 in vitro data to predict clinical drug–drug interactions; predictions of compounds as objects of interaction

(2008) Kuresh A. Youdim et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

The Effect of Gemfibrozil on Repaglinide Pharmacokinetics Persists for at Least 12 h After the Dose: Evidence for Mechanism-based Inhibition of CYP2C8 In Vivo

(2008) A Tornio et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Irreversible CYP3A Inhibition Accompanied by Plasma Protein–Binding Displacement: A Comparative Analysis in Subjects With Normal and Impaired Liver Function

(2008) R Orlando et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Clinical Pharmacogenetics and Potential Application in Personalized Medicine

(2008) Shu-Feng Zhou et al.   CURRENT DRUG METABOLISM

Drugs Behave as Substrates, Inhibitors and Inducers of Human Cytochrome P450 3A4

(2008) Shu-Feng Zhou   CURRENT DRUG METABOLISM

Cytochrome P450 Turnover: Regulation of Synthesis and Degradation, Methods for Determining Rates, and Implications for the Prediction of Drug Interactions

(2008) Jiansong Yang et al.   CURRENT DRUG METABOLISM

Methods for Predicting In Vivo Pharmacokinetics Using Data from In Vitro Assays

(2008) J. Houston et al.   CURRENT DRUG METABOLISM

Potential Strategies for Minimizing Mechanism-Based Inhibition of Cytochrome P450 3A4

(2008) Shu-Feng Zhou   CURRENT PHARMACEUTICAL DESIGN

An Inhibitory Metabolite Leads to Dose- and Time-Dependent Pharmacokinetics of (R)-N- -N-pyridin-3-yl-methyl-2-(4-trifluoromethoxy-phenyl)-acetamide (AMG 487) in Human Subjects After Multiple Dosing

(2008) G. R. Tonn et al.   DRUG METABOLISM AND DISPOSITION

A Combined Model for Predicting CYP3A4 Clinical Net Drug-Drug Interaction Based on CYP3A4 Inhibition, Inactivation, and Induction Determined in Vitro

(2008) O. A. Fahmi et al.   DRUG METABOLISM AND DISPOSITION

Mechanism-based inhibition of cytochrome P450 enzymes: An evaluation of early decision making in vitro approaches and drug–drug interaction prediction methods

(2008) Kenneth H. Grime et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

The Consequences of 3,4-Methylenedioxymethamphetamine Induced CYP2D6 Inhibition in Humans

(2008) Brian O'Mathúna et al.   JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY

Assessing and minimizing time-dependent inhibition of cytochrome P450 3A in drug discovery: A case study with melanocortin-4 receptor agonists

(2008) W. Tang et al.   XENOBIOTICA