Review
Immunology
Chao Yang, Dan Li, Dehong Teng, Yueru Zhou, Lei Zhang, Zhangfeng Zhong, Guan-Jun Yang
Summary: This review discusses the research on the pathogenesis of rheumatoid arthritis (RA) in the past five years based on epigenetic modifications, providing new methods and strategies for the diagnosis and treatment of this disease.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Cell Biology
Hao Song, Juanli Chen, Jin Huang, Peng Sun, Yanming Liu, Li Xu, Chuanfei Wei, Xin Mu, Xianjie Lu, Wei Wang, Nan Zhang, Miwei Shang, Mei Mo, Wei Zhang, Hui Zhao, Fabin Han
Summary: Parkinson's disease (PD) is a common neurodegenerative disorder caused by genetic, epigenetic, and environmental factors. Recent advance in genomics and epigenetics have revealed epigenetic mechanisms in PD. These epigenetic modifications include DNA methylation, post-translational histone modifications, chromatin remodeling, and RNA-based mechanisms, which regulate cellular functions in almost all cells. Epigenetic alterations are involved in multiple aspects of neuronal development and neurodegeneration in PD.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Immunology
Chloe D. Goldsmith, Thomasina Donovan, Nicole Vlahovich, David B. Pyne
Summary: This perspective article discusses how exercise can delay T cell ageing by analyzing the relationship between metabolism and epigenetics, proposing a potential impact of exercise on CD4+ T cell plasticity.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Marcello Bergonzini, Francesco Loreni, Antonio Lio, Marco Russo, Guglielmo Saitto, Antonio Cammardella, Francesco Irace, Corrado Tramontin, Massimo Chello, Mario Lusini, Antonio Nenna, Chiara Ferrisi, Federico Ranocchi, Francesco Musumeci
Summary: Epigenetic modifications play a crucial role in the progression of coronary artery disease (CAD), including DNA and histone methylation, acetylation, and phosphorylation. miRNAs, lncRNAs, and circRNAs are also involved, regulating gene expression patterns. The concept of personalized medicine has gained attention in CAD research, and understanding the interplay between genetic variants and epigenetic modifications holds promise for more precise diagnostic tools and targeted therapies.
Review
Biochemistry & Molecular Biology
Futaba Inoue, Kenbun Sone, Yusuke Toyohara, Yu Takahashi, Asako Kukita, Aki Hara, Ayumi Taguchi, Michihiro Tanikawa, Tetsushi Tsuruga, Yutaka Osuga
Summary: Epigenetic changes play a crucial role in endometrial cancer, including DNA methylation and histone modification. There are currently inhibitors targeting epigenetic regulators in preclinical studies and clinical trials.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Pharmacology & Pharmacy
Manoj Kumar Gupta, He Peng, Yang Li, Cheng-Jian Xu
Summary: Epigenetics serves as a connection between genetic and environmental factors, and DNA methylation, in particular, has been associated with many immune-related diseases. It has great potential for personalized medicine in disease prevention, diagnosis, and treatment.
PHARMACOLOGY & THERAPEUTICS
(2023)
Review
Cell Biology
Kenya Bonitto, Kirthana Sarathy, Kaiser Atai, Mithun Mitra, Hilary A. Coller
Summary: This article discusses the epigenetic changes during cell entry into and exit from quiescence, examines the role of different histone marks during quiescence, and explores the possibility of a quiescence histone code.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Biology
Wenlong Du, Guojun Shi, Chun-Min Shan, Zhiming Li, Bing Zhu, Songtao Jia, Qing Li, Zhiguo Zhang
Summary: This review summarizes the recent advances in the molecular mechanisms of epigenetic inheritance, discusses the potential impacts on normal development and diseases, and outlines future research directions in this field.
SCIENCE CHINA-LIFE SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Sreepoorna Pramodh, Ritu Raina, Arif Hussain, Sali Abubaker Bagabir, Shafiul Haque, Syed Tasleem Raza, Mohammad Rehan Ajmal, Shalini Behl, Deepika Bhagavatula
Summary: This study analyzed the epigenetic modulatory behavior of luteolin on HeLa cells and found that luteolin can inhibit migration and colony formation in HeLa cells. It can also reactivate silenced tumor suppressor genes by modulating DNA methylation, enzyme activity, and global DNA methylation. Therefore, luteolin-targeted epigenetic alterations provide a potential approach for cancer prevention and intervention.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Chemistry, Medicinal
Amir Ajoolabady, Hamid Aslkhodapasandhokmabad, Yuan Zhou, Jun Ren
Summary: This article discusses the pathogenesis of alcohol-related liver disease (ARLD) and alcoholic liver disease (ALD), with a focus on the role of epigenetic factors in the development of liver disorders. Through cellular and animal model studies, the alcohol-induced epigenetic modifications (AIEM) and their relationship with liver diseases are explored, and epigenetics-based therapeutic options for managing ARLD and ALD are proposed.
MEDICINAL RESEARCH REVIEWS
(2022)
Review
Plant Sciences
Kajal Samantara, Aalok Shiv, Lorenna Lopes de Sousa, Karansher Singh Sandhu, Parichita Priyadarshini, Sourav Ranjan Mohapatra
Summary: Epigenetics is an important mechanism that can help plants cope with various stressors by altering gene expression without involving changes in DNA sequences. It provides diversity to aid plants in responding to the impacts of climate change.
ENVIRONMENTAL AND EXPERIMENTAL BOTANY
(2021)
Article
Environmental Sciences
Yawen Xu, Li Wang, Jun Zhu, Ping Jiang, Zhan Zhang, Lei Li, Qian Wu
Summary: The study found that both Cr (III) and Cr (VI) can interfere with one carbon metabolism, affecting DNA methylation and histone methylation to regulate the expression of neuro-related genes, leading to neurotoxicity.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Review
Biochemistry & Molecular Biology
Yuexuan Wang, Yu Han, Yuzhen Jin, Qiang He, Zhicheng Wang
Summary: This study discusses the pathogenesis of cancer and the impact of radiotherapy on cancer. It has been found that epigenetic modification plays an important role in the occurrence and development of cancer. Radiation therapy affects the epigenetic modifications of DNA, chromatin, etc., which in turn affects the treatment outcomes. Therefore, studying the interaction between radiotherapy and epigenetic modifications can help us better understand cancer treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Oncology
Judy S. Crabtree
Summary: Gastroenteropancreatic neuroendocrine neoplasms are rare and diverse tumors associated with genetic disorders and epigenetic regulation. Epigenetic signatures can be used as biomarkers for diagnosis and as targets for the development of new treatment approaches.
FRONTIERS IN ONCOLOGY
(2022)
Review
Plant Sciences
Justin Su, Zhujun Yao, Yixuan Wu, Joohyun Lee, Jeeyon Jeong
Summary: This article mainly introduces the latest understanding of chromatin-based regulation of iron homeostasis in plants, highlighting recent studies in Arabidopsis and rice. Understanding iron homeostasis in plants is crucial as it is relevant to fundamental biological questions, agriculture, biofortification, and human health.
FRONTIERS IN PLANT SCIENCE
(2022)