Microparticulate and nanoparticulate drug delivery systems for metformin hydrochloride

Proton pump inhibitors do not impair the effectiveness of metformin in patients with diabetes

(2015) James Flory et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Comparative Pharmacokinetic Study Among 3 Metformin Formulations in Healthy Mexican Volunteers: A Single-Dose, Randomized, Open-Label, 3-Period Crossover Study

(2015) Sandra Lucía Montoya-Eguía et al.   CURRENT THERAPEUTIC RESEARCH-CLINICAL AND EXPERIMENTAL

Few Drugs Display Flip-Flop Pharmacokinetics and These Are Primarily Associated with Classes 3 and 4 of the BDDCS

(2015) Kimberly L. Garrison et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Metformin inhibits epithelial–mesenchymal transition in prostate cancer cells: Involvement of the tumor suppressor miR30a and its target gene SOX4

(2014) Jing Zhang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Dichloroacetate enhances apoptotic cell death via oxidative damage and attenuates lactate production in metformin-treated breast cancer cells

(2014) Allison B. Haugrud et al.   BREAST CANCER RESEARCH AND TREATMENT

Verapamil decreases the glucose-lowering effect of metformin in healthy volunteers

(2014) Sung Kweon Cho et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Metformin-Loaded BSA Nanoparticles in Cancer Therapy: A New Perspective for an Old Antidiabetic Drug

(2014) Pinkybel Jose et al.   CELL BIOCHEMISTRY AND BIOPHYSICS

Pharmacokinetic Evaluations of the Co-Administrations of Vandetanib and Metformin, Digoxin, Midazolam, Omeprazole or Ranitidine

(2014) Susanne Johansson et al.   CLINICAL PHARMACOKINETICS

The biguanides metformin and phenformin inhibit angiogenesis, local and metastatic growth of breast cancer by targeting both neoplastic and microenvironment cells

(2014) Stefania Orecchioni et al.   INTERNATIONAL JOURNAL OF CANCER

Surfactant-Mediated Dissolution of Metformin Hydrochloride Tablets: Wetting Effects Versus Ion Pairs Diffusivity

(2014) Divyakant Desai et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Metformin—mode of action and clinical implications for diabetes and cancer

(2014) Ida Pernicova et al.   Nature Reviews Endocrinology

In Vitro and In Vivo Biological Evaluation of O-Carboxymethyl Chitosan Encapsulated Metformin Nanoparticles for Pancreatic Cancer Therapy

(2014) K. S. Snima et al.   PHARMACEUTICAL RESEARCH

Metformin: A Potential Therapeutic Agent for Recurrent Colon Cancer

(2014) Pratima Nangia-Makker et al.   PLoS One

Association between Phosphorylated AMP-Activated Protein Kinase and Acetyl-CoA Carboxylase Expression and Outcome in Patients with Squamous Cell Carcinoma of the Head and Neck

(2014) Ying-Wen Su et al.   PLoS One

Can formulation and drug delivery reduce attrition during drug discovery and development—review of feasibility, benefits and challenges

(2014) S Basavaraj et al.   Acta Pharmaceutica Sinica B

Pharmacologic Management of Type 2 Diabetes

(2013) William Harper et al.   Canadian Journal of Diabetes

Glucose promotes breast cancer aggression and reduces metformin efficacy

(2013) Reema Wahdan-Alaswad et al.   CELL CYCLE

Formulation and evaluation of novel solid lipid microparticles as a sustained release system for the delivery of metformin hydrochloride

(2013) M. A. Momoh et al.   DRUG DELIVERY

Formulation and evaluation of metformin hydrochloride-loaded niosomes as controlled release drug delivery system

(2013) Azza A. Hasan et al.   DRUG DELIVERY

Development of an ex vivo retention model simulating bioadhesion in the oral cavity using human saliva and physiologically relevant irrigation media

(2013) Katrine D. Madsen et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Interplay of biopharmaceutics, biopharmaceutics drug disposition and salivary excretion classification systems

(2013) Nasir M. Idkaidek   SAUDI PHARMACEUTICAL JOURNAL

Metformin loaded non-ionic surfactant vesicles: optimization of formulation, effect of process variables and characterization

(2013) Anchal Sankhyan et al.   DARU-Journal of Pharmaceutical Sciences

Mechanisms of current therapies for diabetes mellitus type 2

(2012) Peter M. Thulé   ADVANCES IN PHYSIOLOGY EDUCATION

O-Carboxymethyl chitosan nanoparticles for metformin delivery to pancreatic cancer cells

(2012) K.S. Snima et al.   CARBOHYDRATE POLYMERS

Characterizations and microsphere formulation of polysaccharide from the marine clam (Mactra veneriformis)

(2012) Ling Chong Wang et al.   CARBOHYDRATE POLYMERS

The UCSF-FDA TransPortal: A Public Drug Transporter Database

(2012) K M Morrissey et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Pharmacokinetic and pharmacodynamic evaluation of floating microspheres of metformin hydrochloride

(2012) Vinay Pandit et al.   DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY

Metformin pathways

(2012) Li Gong et al.   Pharmacogenetics and Genomics

Optimization of a Dual Mechanism Gastrofloatable and Gastroadhesive Delivery System for Narrow Absorption Window Drugs

(2011) Caragh Murphy et al.   AAPS PHARMSCITECH

Understanding the benefit of metformin use in cancer treatment

(2011) Ryan JO Dowling et al.   BMC Medicine

Clinical Pharmacokinetics of Metformin

(2011) Garry G. Graham et al.   CLINICAL PHARMACOKINETICS

Cellular and molecular mechanisms of metformin: an overview

(2011) Benoit Viollet et al.   CLINICAL SCIENCE

Metformin and Colorectal Cancer Risk in Diabetic Patients

(2011) G. N. Ioannou et al.   DIABETES CARE

Use of Metformin in the Setting of Mild-to-Moderate Renal Insufficiency

(2011) K. J. Lipska et al.   DIABETES CARE

Metformin and cancer: new applications for an old drug

(2011) Taxiarchis V. Kourelis et al.   MEDICAL ONCOLOGY

Preparation and characterization of metformin hydrochloride loaded-Eudragit®RSPO and Eudragit®RSPO/PLGA nanoparticles

(2011) Meltem Cetin et al.   PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY

Metformin inhibits P-glycoprotein expression via the NF-κB pathway and CRE transcriptional activity through AMPK activation

(2010) Hyung Gyun Kim et al.   BRITISH JOURNAL OF PHARMACOLOGY

Pathogenesis of Fasting and Postprandial Hyperglycemia in Type 2 Diabetes: Implications for Therapy

(2010) R. A. Rizza   DIABETES

Metformin regulates the incretin receptor axis via a pathway dependent on peroxisome proliferator-activated receptor-α in mice

(2010) A. Maida et al.   DIABETOLOGIA

Pharmacokinetics of Metformin during Pregnancy

(2010) S. Eyal et al.   DRUG METABOLISM AND DISPOSITION

The Role of Transporters in the Pharmacokinetics of Orally Administered Drugs

(2009) Sarah Shugarts et al.   PHARMACEUTICAL RESEARCH

Gastroretentive Drug Delivery of Metformin Hydrochloride: Formulation and In Vitro Evaluation Using 32 Full Factorial Design

(2009) Sanjay Boldhane et al.   Current Drug Delivery

Cellulose Acetate Microspheres as Floating Depot Systems to Increase Gastric Retention of Antidiabetic Drug: Formulation, Characterization and In Vitro–In Vivo Evaluation

(2008) Pratim K. Choudhury et al.   DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY

Controlled release metformin hydrochloride microspheres of ethyl cellulose prepared by different methods and study on the polymer affected parameters

(2008) Pratim K. Choudhury et al.   JOURNAL OF MICROENCAPSULATION

Sustained-release matrix tablets of metformin hydrochloride in combination with triacetyl-β-cyclodextrin

(2007) Giovanna Corti et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS