Melatonin, the circadian multioscillator system and health: the need for detailed analyses of peripheral melatonin signaling

Circadian disruption induced by light-at-night accelerates aging and promotes tumorigenesis in rats

(2016) Irina A. Vinogradova et al.   Aging-US

Antioxidant N-acetyl-L-cysteine ameliorates symptoms of premature aging associated with the deficiency of the circadian protein BMAL1

(2016) Roman V. Kondratov et al.   Aging-US

The aging clock: to ‘BMAL'icious toward learning and memory

(2016) Jason R. Gerstner   Aging-US

Deficiency of circadian protein CLOCK reduces lifespan and increases age-related cataract development in mice

(2016) Yuliya V. Dubrovsky et al.   Aging-US

Melatonin-mitochondria Interplay in Health and Disease

(2012) Dario Acuna Castroviejo et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Aberrant Cytoplasm Localization and Protein Stability of SIRT1 is Regulated by PI3K/IGF-1R Signaling in Human Cancer Cells

(2012) Vanessa Byles et al.   International Journal of Biological Sciences

Adrenal peripheral oscillator in generating the circadian glucocorticoid rhythm

(2011) Sooyoung Chung et al.   Annals of the New York Academy of Sciences

Circadian rhythm of adrenal glucocorticoid: Its regulation and clinical implications

(2011) Sooyoung Chung et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

A common polymorphism rs3781637 in MTNR1B is associated with type 2 diabetes and lipids levels in Han Chinese individuals

(2011) Yan Ling et al.   Cardiovascular Diabetology

JNK2-dependent regulation of SIRT1 protein stability

(2011) Jack Ford et al.   CELL CYCLE

Crosstalk between Components of Circadian and Metabolic Cycles in Mammals

(2011) Gad Asher et al.   Cell Metabolism

Circadian Rhythms, Melatonin and Depression

(2011) M. A. Quera Salva et al.   CURRENT PHARMACEUTICAL DESIGN

No effect by the common gene variant rs10830963 of the melatonin receptor 1B on the association between sleep disturbances and type 2 diabetes: results from the Nord-Trøndelag Health Study

(2011) L. Olsson et al.   DIABETOLOGIA

A Circadian Clock Entrained by Melatonin Is Ticking in the Rat Fetal Adrenal

(2011) C. Torres-Farfan et al.   ENDOCRINOLOGY

Circadian clock gene Per3 variants influence the postpartum onset of bipolar disorder

(2011) S. Dallaspezia et al.   EUROPEAN PSYCHIATRY

Melatonin Receptor 1A Gene Polymorphism Associated with Polycystic Ovary Syndrome

(2011) Chao Li et al.   GYNECOLOGIC AND OBSTETRIC INVESTIGATION

Melatonin Exerts Direct Inhibitory Actions on ACTH Responses in the Human Adrenal Gland

(2011) C. Campino et al.   HORMONE AND METABOLIC RESEARCH

A Promoter in the Novel Exon of hPPARγ Directs the Circadian Expression of PPARγ

(2011) Seiichiro Takahashi et al.   Journal of Atherosclerosis and Thrombosis

Association of Polymorphism in the Promoter of the Melatonin Receptor 1A Gene with Schizophrenia and with Insomnia Symptoms in Schizophrenia Patients

(2011) Hae Jeong Park et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Regulation of the expression of death receptors and their ligands by melatonin in haematological cancer cell lines and in leukaemia cells from patients

(2011) Sara Casado-Zapico et al.   JOURNAL OF PINEAL RESEARCH

Perspectives on the use of melatonin to reduce cytotoxic and genotoxic effects of methacrylate-based dental materials

(2011) Janusz Blasiak et al.   JOURNAL OF PINEAL RESEARCH

Circadian regulation of molecular, dietary, and metabolic signaling mechanisms of human breast cancer growth by the nocturnal melatonin signal and the consequences of its disruption by light at night

(2011) David E. Blask et al.   JOURNAL OF PINEAL RESEARCH

Melatonin inhibits insulin secretion in rat insulinoma β-cells (INS-1) heterologously expressing the human melatonin receptor isoform MT2

(2011) Eckhard Mühlbauer et al.   JOURNAL OF PINEAL RESEARCH

Phosphoinositide 3-kinase as a novel functional target for the regulation of the insulin signaling pathway by SIRT1

(2011) Sara Fröjdö et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Retinoic acid-related orphan receptor γ directly regulates neuronal PAS domain protein 2 transcription in vivo

(2011) Yukimasa Takeda et al.   NUCLEIC ACIDS RESEARCH

Relationship between MTNR1B (melatonin receptor 1B gene) polymorphism rs10830963 and glucose levels in overweight children and adolescents†

(2011) Thomas Reinehr et al.   PEDIATRIC DIABETES

Shift work, chronodisruption and cancer?—the IARC 2007 challenge for research and prevention and 10 theses from the Cologne Colloquium 2008

(2011) Thomas C Erren et al.   SCANDINAVIAN JOURNAL OF WORK ENVIRONMENT & HEALTH

Gastrointestinal disorders among shift workers

(2011) Anders Knutsson et al.   SCANDINAVIAN JOURNAL OF WORK ENVIRONMENT & HEALTH

Shift work and cardiovascular disease – pathways from circadian stress to morbidity

(2011) Sampsa Puttonen et al.   SCANDINAVIAN JOURNAL OF WORK ENVIRONMENT & HEALTH

Association Study of BMP4, IL6, Leptin, MMP3, and MTNR1B Gene Promoter Polymorphisms and Adolescent Idiopathic Scoliosis

(2011) Mónika Mórocz et al.   SPINE

Cadmium-Induced Disruption in 24-h Expression of Clock and Redox Enzyme Genes in Rat Medial Basal Hypothalamus: Prevention by Melatonin

(2011) Vanesa Jiménez-Ortega et al.   Frontiers in Neurology

Antidepressant- and anxiolytic effects of the novel melatonin agonist Neu-P11 in rodent models

(2010) Shao-wen Tian et al.   ACTA PHARMACOLOGICA SINICA

A cross-sectional study on the shift work and metabolic syndrome in Japanese male workers

(2010) Tomoyuki Kawada et al.   Aging Male

Combination of starvation interval and food volume determines the phase of liver circadian rhythm in Per2::Luc knock-in mice under two meals per day feeding

(2010) Akiko Hirao et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Beneficial effects of melatonin in cardiovascular disease

(2010) Russel J. Reiter et al.   ANNALS OF MEDICINE

Genetic variants inMTNR1Baffecting insulin secretion

(2010) Karsten Müssig et al.   ANNALS OF MEDICINE

Prospective Study of Common Variants in the Retinoic Acid Receptor–Related Orphan Receptor α Gene and Risk of Neovascular Age-Related Macular Degeneration

(2010) Debra A. Schaumberg   ARCHIVES OF OPHTHALMOLOGY

Increased levels of resistin in rotating shift workers: A potential mediator of cardiovascular risk associated with circadian misalignment

(2010) Adriana Burgueño et al.   ATHEROSCLEROSIS

Association study between a polymorphism at the 3'-untranslated region of CLOCK gene and attention deficit hyperactivity disorder

(2010) Xiaohui Xu et al.   Behavioral and Brain Functions

New evidence for a role of melatonin in glucose regulation

(2010) Elmar Peschke et al.   BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM

Genome-Wide Association Scan of Trait Depression

(2010) Antonio Terracciano et al.   BIOLOGICAL PSYCHIATRY

Phenotypic effects of the circadian gene Cryptochrome 2 on cancer-related pathways

(2010) Aaron E Hoffman et al.   BMC CANCER

MTNR1B rs10830963 is associated with fasting plasma glucose, HbA1Cand impaired beta-cell function in Chinese Hans from Shanghai

(2010) Chen Liu et al.   BMC Medical Genetics

Sleep health and asynchronization

(2010) Jun Kohyama   BRAIN & DEVELOPMENT

Impact of aging on diurnal expression patterns of CLOCK and BMAL1 in the mouse brain

(2010) Cathy A. Wyse et al.   BRAIN RESEARCH

The role of polymorphisms in circadian pathway genes in breast tumorigenesis

(2010) Hongji Dai et al.   BREAST CANCER RESEARCH AND TREATMENT

The Core Circadian Gene Cryptochrome 2 Influences Breast Cancer Risk, Possibly by Mediating Hormone Signaling

(2010) A. E. Hoffman et al.   Cancer Prevention Research

CLOCK in Breast Tumorigenesis: Genetic, Epigenetic, and Transcriptional Profiling Analyses

(2010) A. E. Hoffman et al.   CANCER RESEARCH

Multiscale complexity in the mammalian circadian clock

(2010) YR Yamada et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Detailed Physiologic Characterization Reveals Diverse Mechanisms for Novel Genetic Loci Regulating Glucose and Insulin Metabolism in Humans

(2010) E. Ingelsson et al.   DIABETES

Genetic Predisposition to Long-Term Nondiabetic Deteriorations in Glucose Homeostasis: Ten-Year Follow-Up of the GLACIER Study

(2010) F. Renstrom et al.   DIABETES

Common Variants at 10 Genomic Loci Influence Hemoglobin A1C Levels via Glycemic and Nonglycemic Pathways

(2010) N. Soranzo et al.   DIABETES

Two susceptible diabetogenic variants near/inMTNR1Bare associated with fasting plasma glucose in a Han Chinese cohort

(2010) M. Y. Kan et al.   DIABETIC MEDICINE

Association of a MTNR1B gene variant with fasting glucose and HOMA-B in children and adolescents with high BMI-SDS

(2010) Christina Holzapfel et al.   EUROPEAN JOURNAL OF ENDOCRINOLOGY

Involvement of dopamine receptors in the antidepressant-like effect of melatonin in the tail suspension test

(2010) Ricardo W. Binfaré et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Investigational melatonin receptor agonists

(2010) Rüdiger Hardeland   EXPERT OPINION ON INVESTIGATIONAL DRUGS

The chronobiology, etiology and pathophysiology of obesity

(2010) M Garaulet et al.   INTERNATIONAL JOURNAL OF OBESITY

CLOCK gene is implicated in weight reduction in obese patients participating in a dietary programme based on the Mediterranean diet

(2010) M Garaulet et al.   INTERNATIONAL JOURNAL OF OBESITY

Shift work and metabolic syndrome, diabetes mellitus and ischaemic heart disease

(2010) Dorota Szosland   International Journal of Occupational Medicine and Environmental Health

Deficiency in core circadian protein Bmal1 is associated with a prothrombotic and vascular phenotype

(2010) Payaningal R. Somanath et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Melatonin Potentiates the Neuroprotective Properties of Resveratrol Against Beta-Amyloid-Induced Neurodegeneration by Modulating AMP-Activated Protein Kinase Pathways

(2010) Kyoung Ja Kwon et al.   Journal of Clinical Neurology

Disruption of Peripheral Circadian Timekeeping in a Mouse Model of Huntington's Disease and Its Restoration by Temporally Scheduled Feeding

(2010) E. S. Maywood et al.   JOURNAL OF NEUROSCIENCE

The role of melatonin in post-partum psychosis and depression associated with bipolar disorder

(2010) George Anderson   JOURNAL OF PERINATAL MEDICINE

REVIEW ARTICLE: Melatonin plus exercise-based neurorehabilitative therapy for spinal cord injury

(2010) Yonggeun Hong et al.   JOURNAL OF PINEAL RESEARCH

The role of melatonin in glaucoma: implications concerning pathophysiological relevance and therapeutic potential

(2010) Agorastos Agorastos et al.   JOURNAL OF PINEAL RESEARCH

Single-nucleotide polymorphisms and mRNA expression for melatonin synthesis rate-limiting enzyme in recurrent depressive disorder

(2010) Piotr Gałecki et al.   JOURNAL OF PINEAL RESEARCH

Signal transduction of receptor-mediated antiproliferative action of melatonin on human prostate epithelial cells involves dual activation of Gαs and Gαq proteins

(2010) Stephen Y. W. Shiu et al.   JOURNAL OF PINEAL RESEARCH

Melatonin receptor 1-dependent gene expression in the mouse pars tuberalis as revealed by cDNA microarray analysis andin situhybridization

(2010) Claudia Unfried et al.   JOURNAL OF PINEAL RESEARCH

Update on the use of melatonin in pediatrics

(2010) Eloisa Gitto et al.   JOURNAL OF PINEAL RESEARCH

Melatonin, cardiolipin and mitochondrial bioenergetics in health and disease

(2010) Giuseppe Paradies et al.   JOURNAL OF PINEAL RESEARCH

Matrix metalloproteinases in health and disease: regulation by melatonin

(2010) Snehasikta Swarnakar et al.   JOURNAL OF PINEAL RESEARCH

Long-term enteral administration of melatonin reduces plasma insulin and increases expression of pineal insulin receptors in both Wistar and type 2-diabetic Goto-Kakizaki rats

(2010) Elmar Peschke et al.   JOURNAL OF PINEAL RESEARCH

Melatonin reduces pancreatic tumor cell viability by altering mitochondrial physiology

(2010) Antonio Gonzalez et al.   JOURNAL OF PINEAL RESEARCH

Melatonin induces pro-apoptotic signaling pathway in human pancreatic carcinoma cells (PANC-1)

(2010) Anna Leja-Szpak et al.   JOURNAL OF PINEAL RESEARCH

PERIOD2 Variants Are Associated with Abdominal Obesity, Psycho-Behavioral Factors, and Attrition in the Dietary Treatment of Obesity

(2010) Marta Garaulet et al.   JOURNAL OF THE AMERICAN DIETETIC ASSOCIATION

Disruption of the clock components CLOCK and BMAL1 leads to hypoinsulinaemia and diabetes

(2010) Biliana Marcheva et al.   NATURE

New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk

(2010) Josée Dupuis et al.   NATURE GENETICS

Clocks not winding down: unravelling circadian networks

(2010) Eric E. Zhang et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Differential Association of Circadian Genes with Mood Disorders: CRY1 and NPAS2 are Associated with Unipolar Major Depression and CLOCK and VIP with Bipolar Disorder

(2010) Virginia Soria et al.   NEUROPSYCHOPHARMACOLOGY

Obesity and shift work: chronobiological aspects

(2010) L. C. Antunes et al.   NUTRITION RESEARCH REVIEWS

Removal of Melatonin Receptor Type 1 Induces Insulin Resistance in the Mouse

(2010) Susana Contreras-Alcantara et al.   Obesity

Considerations of circadian impact for defining 'shift work' in cancer studies: IARC Working Group Report

(2010) R. G. Stevens et al.   OCCUPATIONAL AND ENVIRONMENTAL MEDICINE

Shift work: coping with the biological clock

(2010) J. Arendt   OCCUPATIONAL MEDICINE-OXFORD

Physiology of Circadian Entrainment

(2010) Diego A. Golombek et al.   PHYSIOLOGICAL REVIEWS

CRY2 Is Associated with Depression

(2010) Catharina Lavebratt et al.   PLoS One

Disrupting Circadian Homeostasis of Sympathetic Signaling Promotes Tumor Development in Mice

(2010) Susie Lee et al.   PLoS One

Effects of GCK, GCKR, G6PC2 and MTNR1B Variants on Glucose Metabolism and Insulin Secretion

(2010) Cheng Hu et al.   PLoS One

CRY2 Is Associated with Rapid Cycling in Bipolar Disorder Patients

(2010) Louise K. Sjöholm et al.   PLoS One

Common Polymorphisms in MTNR1B, G6PC2 and GCK Are Associated with Increased Fasting Plasma Glucose and Impaired Beta-Cell Function in Chinese Subjects

(2010) Claudia Ha Ting Tam et al.   PLoS One

The Comparison between Circadian Oscillators in Mouse Liver and Pituitary Gland Reveals Different Integration of Feeding and Light Schedules

(2010) Isabelle M. Bur et al.   PLoS One

Variants from GIPR, TCF7L2, DGKB, MADD, CRY2, GLIS3, PROX1, SLC30A8 and IGF1 Are Associated with Glucose Metabolism in the Chinese

(2010) Cheng Hu et al.   PLoS One

Melatonin—A pleiotropic, orchestrating regulator molecule

(2010) Rüdiger Hardeland et al.   PROGRESS IN NEUROBIOLOGY

Temperature as a Universal Resetting Cue for Mammalian Circadian Oscillators

(2010) E. D. Buhr et al.   SCIENCE

Circadian Integration of Metabolism and Energetics

(2010) J. Bass et al.   SCIENCE

Spectral Responses of the Human Circadian System Depend on the Irradiance and Duration of Exposure to Light

(2010) J. J. Gooley et al.   Science Translational Medicine

Genetic Variants in Melatonin Synthesis and Signaling Pathway are not Associated with Adolescent Idiopathic Scoliosis

(2010) Lesa M. Nelson et al.   SPINE

Melatonin inhibits mitogenic cross-talk between retinoic acid-related orphan receptor alpha (RORα) and ERα in MCF-7 human breast cancer cells

(2010) Chunmin Dong et al.   STEROIDS

Melatonin: Action as antioxidant and potential applications in human disease and aging

(2010) Dominique Bonnefont-Rousselot et al.   TOXICOLOGY

Shift Work, Light at Night, and the Risk of Breast Cancer

(2010) Virginia A. Reed   AAOHN Journal

The Effects of Red and Blue Lights on Circadian Variations in Cortisol, Alpha Amylase, and Melatonin

(2010) Mariana G. Figueiro et al.   International Journal of Endocrinology

PPARs: Nuclear Receptors Controlled by, and Controlling, Nutrient Handling through Nuclear and Cytosolic Signaling

(2010) Maria Moreno et al.   PPAR Research

New approaches in the management of insomnia: weighing the advantages of prolonged-release melatonin and synthetic melatoninergic agonists

(2010) Ruediger Hardeland   Neuropsychiatric Disease and Treatment

CLOCK genetic variation and metabolic syndrome risk: modulation by monounsaturated fatty acids

(2009) Marta Garaulet et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Melatonin: Signaling mechanisms of a pleiotropic agent

(2009) Rüdiger Hardeland   BIOFACTORS

A Genomewide Association Study of Citalopram Response in Major Depressive Disorder

(2009) Holly A. Garriock et al.   BIOLOGICAL PSYCHIATRY

Melatonin and Reproduction Revisited

(2009) Russel J. Reiter et al.   BIOLOGY OF REPRODUCTION

Association study of 21 circadian genes with bipolar I disorder, schizoaffective disorder, and schizophrenia

(2009) Hader A Mansour et al.   BIPOLAR DISORDERS

Evidence for genetic association of RORB with bipolar disorder

(2009) Casey L McGrath et al.   BMC Psychiatry

Obesity alters circadian expressions of molecular clock genes in the brainstem

(2009) Keizo Kaneko et al.   BRAIN RESEARCH

High expression of the circadian gene mPer2 diminishes the radiosensitivity of NIH 3T3 cells

(2009) L. Chang et al.   BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH

Melatonin sensitizes human malignant glioma cells against TRAIL-induced cell death

(2009) Vanesa Martín et al.   CANCER LETTERS

Clock-Cancer Connection in Non-Hodgkin's Lymphoma: A Genetic Association Study and Pathway Analysis of the Circadian Gene Cryptochrome 2

(2009) A. E. Hoffman et al.   CANCER RESEARCH

Testing the Circadian Gene Hypothesis in Prostate Cancer: A Population-Based Case-Control Study

(2009) Y. Zhu et al.   CANCER RESEARCH

Epigenetic Inactivation of the Circadian Clock Gene BMAL1 in Hematologic Malignancies

(2009) H. Taniguchi et al.   CANCER RESEARCH

Human Core Temperature Responses during Exercise and Subsequent Recovery: An Important Interaction between Diurnal Variation and Measurement Site

(2009) Chris Morris et al.   CHRONOBIOLOGY INTERNATIONAL

THE CIRCADIAN CLOCK GENEPER1SUPPRESSES CANCER CELL PROLIFERATION AND TUMOR GROWTH AT SPECIFIC TIMES OF DAY

(2009) Xiaoming Yang et al.   CHRONOBIOLOGY INTERNATIONAL

Shift Work and Metabolic Syndrome: Respective Impacts of Job Strain, Physical Activity, and Dietary Rhythms

(2009) Yolande Esquirol et al.   CHRONOBIOLOGY INTERNATIONAL

Chronobiology, genetics and metabolic syndrome

(2009) Marta Garaulet et al.   CURRENT OPINION IN LIPIDOLOGY

Common Genetic Variation Near Melatonin Receptor MTNR1B Contributes to Raised Plasma Glucose and Increased Risk of Type 2 Diabetes Among Indian Asians and European Caucasians

(2009) J. C. Chambers et al.   DIABETES

Examination of All Type 2 Diabetes GWAS Loci Reveals HHEX-IDE as a Locus Influencing Pediatric BMI

(2009) J. Zhao et al.   DIABETES

Common Genetic Determinants of Glucose Homeostasis in Healthy Children

(2009) Clara Kelliny et al.   DIABETES

Combined Risk Allele Score of Eight Type 2 Diabetes Genes Is Associated With Reduced First-Phase Glucose-Stimulated Insulin Secretion During Hyperglycemic Clamps

(2009) L. M. 't Hart et al.   DIABETES

Association of 18 Confirmed Susceptibility Loci for Type 2 Diabetes With Indices of Insulin Release, Proinsulin Conversion, and Insulin Sensitivity in 5,327 Nondiabetic Finnish Men

(2009) A. Stancakova et al.   DIABETES

G-allele of Intronic rs10830963 in MTNR1B Confers Increased Risk of Impaired Fasting Glycemia and Type 2 Diabetes Through an Impaired Glucose-Stimulated Insulin Release: Studies Involving 19,605 Europeans

(2009) T. Sparso et al.   DIABETES

Combined effects of single-nucleotide polymorphisms in GCK, GCKR, G6PC2 and MTNR1B on fasting plasma glucose and type 2 diabetes risk

(2009) E. Reiling et al.   DIABETOLOGIA

Common variants at the GCK, GCKR, G6PC2–ABCB11 and MTNR1B loci are associated with fasting glucose in two Asian populations

(2009) F. Takeuchi et al.   DIABETOLOGIA

A common variant in MTNR1B, encoding melatonin receptor 1B, is associated with type 2 diabetes and fasting plasma glucose in Han Chinese individuals

(2009) T. Rönn et al.   DIABETOLOGIA

Genetic variants in human CLOCK associate with total energy intake and cytokine sleep factors in overweight subjects (GOLDN population)

(2009) Marta Garaulet et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Peripheral oscillators: the driving force for food-anticipatory activity

(2009) Carolina Escobar et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

The SCN-independent clocks, methamphetamine and food restriction

(2009) Ken-ichi Honma et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Antidepressant-like effects of melatonin in the mouse chronic mild stress model

(2009) Bernardo C. Detanico et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Loss of melatonin signalling and its impact on circadian rhythms in mouse organs regulating blood glucose

(2009) Eckhard Mühlbauer et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Melatonin and breast cancer: cellular mechanisms, clinical studies and future perspectives

(2009) Stephen G. Grant et al.   EXPERT REVIEWS IN MOLECULAR MEDICINE

SIRT1 controls circadian clock circuitry and promotes cell survival: a connection with age-related neoplasms

(2009) Brittney Jung-Hynes et al.   FASEB JOURNAL

Transcripts of Calcium/Calmodulin-dependent Kinases are Changed After Forskolin- or IBMX-induced Insulin Secretion due to Melatonin Treatment of Rat Insulinoma β-Cells (INS-1)

(2009) I. Bazwinsky-Wutschke et al.   HORMONE AND METABOLIC RESEARCH

Melatonin as a potential therapeutic agent in psychiatric illness

(2009) Maria D. Maldonado et al.   HUMAN PSYCHOPHARMACOLOGY-CLINICAL AND EXPERIMENTAL

Light-Mediated Perturbations of Circadian Timing and Cancer Risk: A Mechanistic Analysis

(2009) Russel J. Reiter et al.   INTEGRATIVE CANCER THERAPIES

Circadian Clock Manipulation for Cancer Prevention and Control and the Relief of Cancer Symptoms

(2009) William J. M. Hrushesky et al.   INTEGRATIVE CANCER THERAPIES

Circadian Time-Dependent Tumor Suppressor Function of Period Genes

(2009) Xiaoming Yang et al.   INTEGRATIVE CANCER THERAPIES

Circadian Stage-Dependent Inhibition of Human Breast Cancer Metabolism and Growth by the Nocturnal Melatonin Signal: Consequences of Its Disruption by Light at Night in Rats and Women

(2009) David E. Blask et al.   INTEGRATIVE CANCER THERAPIES

Clock Genes and Cancer

(2009) Patricia A. Wood et al.   INTEGRATIVE CANCER THERAPIES

Molecular Mechanisms of Melatonin Anticancer Effects

(2009) Steven M. Hill et al.   INTEGRATIVE CANCER THERAPIES

Abnormal expressions of circadian-clock and circadian clock-controlled genes in the livers and kidneys of long-term, high-fat-diet-treated mice

(2009) M-C Hsieh et al.   INTERNATIONAL JOURNAL OF OBESITY

Effect of rhythmic melatonin administration on clock gene expression in the suprachiasmatic nucleus and the heart of hypertensive TGR(mRen2)27 rats

(2009) Michal Zeman et al.   JOURNAL OF HYPERTENSION

Mammalian Clock Gene Cryptochrome Regulates Arthritis via Proinflammatory Cytokine TNF- 

(2009) A. Hashiramoto et al.   JOURNAL OF IMMUNOLOGY

Melatonin ameliorates high fat diet-induced diabetes and stimulates glycogen synthesis via a PKCζ-Akt-GSK3β pathway in hepatic cells

(2009) Jiunn-Min Shieh et al.   JOURNAL OF PINEAL RESEARCH

Melatonin preserves longevity protein (sirtuin 1) expression in the hippocampus of total sleep-deprived rats

(2009) Hung-Ming Chang et al.   JOURNAL OF PINEAL RESEARCH

Anti-aging properties of melatonin in an in vitro murine senescence model: involvement of the sirtuin 1 pathway

(2009) M. Tajes et al.   JOURNAL OF PINEAL RESEARCH

Defining chronodisruption

(2009) Thomas C. Erren et al.   JOURNAL OF PINEAL RESEARCH

Malaria: therapeutic implications of melatonin

(2009) Venkataramanujan Srinivasan et al.   JOURNAL OF PINEAL RESEARCH

Sirtuins, melatonin and circadian rhythms: building a bridge between aging and cancer

(2009) Brittney Jung-Hynes et al.   JOURNAL OF PINEAL RESEARCH

Sleep and Health Consequences of Shift Work in Women

(2009) Sharon A. Chung et al.   JOURNAL OF WOMENS HEALTH

The melatonin-producing system is fully functional in retinal pigment epithelium (ARPE-19)

(2009) Michał A. Żmijewski et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Correlated downregulation of estrogen receptor beta and the circadian clock gene Per1 in human colorectal cancer

(2009) Nazanin Mostafaie et al.   MOLECULAR CARCINOGENESIS

Neuroprotection by Radical Avoidance: Search for Suitable Agents

(2009) Rüdiger Hardeland   MOLECULES

Working against our endogenous circadian clock: Breast cancer and electric lighting in the modern world

(2009) Richard G. Stevens   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

Circadian disruption accelerates liver carcinogenesis in mice

(2009) Elisabeth Filipski et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

Circadian Rhythm of Clock Genes in Human Adipose Explants

(2009) Cecilia Gómez-Santos et al.   Obesity

Incidence of metabolic syndrome among night-shift healthcare workers

(2009) A Pietroiusti et al.   OCCUPATIONAL AND ENVIRONMENTAL MEDICINE

Effects of Nocturnal Light on (Clock) Gene Expression in Peripheral Organs: A Role for the Autonomic Innervation of the Liver

(2009) Cathy Cailotto et al.   PLoS One

JNK1 Phosphorylates SIRT1 and Promotes Its Enzymatic Activity

(2009) Nargis Nasrin et al.   PLoS One

Pathophysiology of depression: Role of sleep and the melatonergic system

(2009) Venkataramanujan Srinivasan et al.   PSYCHIATRY RESEARCH

Role of melatonin in metabolic regulation

(2009) Ahmet Korkmaz et al.   REVIEWS IN ENDOCRINE & METABOLIC DISORDERS

Daily Electrical Silencing in the Mammalian Circadian Clock

(2009) M. D. C. Belle et al.   SCIENCE

Circadian Control of the NAD+ Salvage Pathway by CLOCK-SIRT1

(2009) Y. Nakahata et al.   SCIENCE

A Circadian Loop asSIRTs Itself

(2009) H. Wijnen   SCIENCE

Circadian Clock Feedback Cycle Through NAMPT-Mediated NAD+ Biosynthesis

(2009) K. M. Ramsey et al.   SCIENCE

Disturbance of circadian gene expression in breast cancer

(2009) Shou-Jen Kuo et al.   VIRCHOWS ARCHIV

Convergence of linkage, gene expression and association data demonstrates the influence of the RAR-related orphan receptor alpha (RORA) gene on neovascular AMD: A systems biology based approach

(2009) Alexandra C. Silveira et al.   VISION RESEARCH

Clock genes may influence bipolar disorder susceptibility and dysfunctional circadian rhythm

(2008) Jiajun Shi et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS

Genome-wide association scan of quantitative traits for attention deficit hyperactivity disorder identifies novel associations and confirms candidate gene associations

(2008) Jessica Lasky-Su et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS

Convergent functional genomics of genome-wide association data for bipolar disorder: Comprehensive identification of candidate genes, pathways and mechanisms

(2008) H. Le-Niculescu et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS

Transcriptional Activation of HIF-1 by RORα and its Role in Hypoxia Signaling

(2008) Eun-Jin Kim et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

The relation of exposure to shift work with atherosclerosis and myocardial infarction in a general population

(2008) Christiane M. Haupt et al.   ATHEROSCLEROSIS

Circadian regulation of response to oxidative stress in Drosophila melanogaster

(2008) Natraj Krishnan et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The circadian clock system in the mammalian retina

(2008) Gianluca Tosini et al.   BIOESSAYS

A newly proposed disease condition produced by light exposure during night: Asynchronization

(2008) Jun Kohyama   BRAIN & DEVELOPMENT

Role of melatonin in the epigenetic regulation of breast cancer

(2008) Ahmet Korkmaz et al.   BREAST CANCER RESEARCH AND TREATMENT

Down regulation of circadian clock gene Period 2 accelerates breast cancer growth by altering its daily growth rhythm

(2008) Xiaoming Yang et al.   BREAST CANCER RESEARCH AND TREATMENT

Circadian photoreception: ageing and the eye's important role in systemic health

(2008) P L Turner et al.   BRITISH JOURNAL OF OPHTHALMOLOGY

High Expression of Circadian Gene mPer2 Diminishes Radiosensitivity of Tumor Cells

(2008) Jing Zhang et al.   CANCER BIOTHERAPY AND RADIOPHARMACEUTICALS

Circulating melatonin and the risk of breast and endometrial cancer in women

(2008) Akila N. Viswanathan et al.   CANCER LETTERS

SIRT1 Is a Circadian Deacetylase for Core Clock Components

(2008) William J. Belden et al.   CELL

The NAD+-Dependent Deacetylase SIRT1 Modulates CLOCK-Mediated Chromatin Remodeling and Circadian Control

(2008) Yasukazu Nakahata et al.   CELL

SIRT1 Regulates Circadian Clock Gene Expression through PER2 Deacetylation

(2008) Gad Asher et al.   CELL

Mitochondria—A Nexus for Aging, Calorie Restriction, and Sirtuins?

(2008) Leonard Guarente   CELL

SirT1 Inhibition Reduces IGF-I/IRS-2/Ras/ERK1/2 Signaling and Protects Neurons

(2008) Ying Li et al.   Cell Metabolism

Melatonin, hormone of darkness and more – occurrence, control mechanisms, actions and bioactive metabolites

(2008) R. Hardeland   CELLULAR AND MOLECULAR LIFE SCIENCES

A novel interplay between membrane and nuclear melatonin receptors in human lymphocytes: significance in IL-2 production

(2008) P. J. Lardone et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Clock Gene Expression in Adult Primate Suprachiasmatic Nuclei and Adrenal: Is the Adrenal a Peripheral Clock Responsive to Melatonin?

(2008) F. J. Valenzuela et al.   ENDOCRINOLOGY

Assessment of cardiovascular risk in shift healthcare workers

(2008) Alfredo Copertaro et al.   EUROPEAN JOURNAL OF CARDIOVASCULAR PREVENTION & REHABILITATION

Linking sirtuins, IGF-I signaling, and starvation

(2008) Valter D. Longo   EXPERIMENTAL GERONTOLOGY

Effects of light cues on re-entrainment of the food-dominated peripheral clocks in mammals

(2008) Tao Wu et al.   GENE

Chromatin remodeling, metabolism and circadian clocks: The interplay of CLOCK and SIRT1

(2008) Benedetto Grimaldi et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Night-time work predisposes to non-Hodgkin lymphoma

(2008) Tuuli A. Lahti et al.   INTERNATIONAL JOURNAL OF CANCER

 -Catenin Induces  -TrCP-Mediated PER2 Degradation Altering Circadian Clock Gene Expression in Intestinal Mucosa of ApcMin/+ Mice

(2008) X. Yang et al.   JOURNAL OF BIOCHEMISTRY

The PDZ Protein Mupp1 Promotes GiCoupling and Signaling of the Mt1Melatonin Receptor

(2008) Jean-Luc Guillaume et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Glucocorticoids and the circadian clock

(2008) Thomas Dickmeis   JOURNAL OF ENDOCRINOLOGY

Melatonin and the circadian entrainment of metabolic and hormonal activities in primary isolated adipocytes

(2008) Maria Isabel Cardoso Alonso-Vale et al.   JOURNAL OF PINEAL RESEARCH

The antiproliferative activity of melatonin in B65 rat dopaminergic neuroblastoma cells is related to the downregulation of cell cycle-related genes

(2008) Javier G. Pizarro et al.   JOURNAL OF PINEAL RESEARCH

Melatonin as a negative mitogenic hormonal regulator of human prostate epithelial cell growth: potential mechanisms and clinical significance

(2008) Chun W. Tam et al.   JOURNAL OF PINEAL RESEARCH

Evaluation of potential pro-survival pathways regulated by melatonin in a murine senescence model

(2008) Javier Gutierrez-Cuesta et al.   JOURNAL OF PINEAL RESEARCH

Function and expression of melatonin receptors on human pancreatic islets

(2008) Reshma D. Ramracheya et al.   JOURNAL OF PINEAL RESEARCH

Involvement of the cGMP pathway in mediating the insulin-inhibitory effect of melatonin in pancreatic β-cells

(2008) Ina Stumpf et al.   JOURNAL OF PINEAL RESEARCH

The melatonin receptor MT1 is required for the differential regulatory actions of melatonin on neuronal ‘clock’ gene expression in striatal neurons in vitro

(2008) Marta Imbesi et al.   JOURNAL OF PINEAL RESEARCH

Endogenous melatonin provides an effective circadian message to both the suprachiasmatic nuclei and the pars tuberalis of the rat

(2008) Laurence Agez et al.   JOURNAL OF PINEAL RESEARCH

Modulation of the cGMP signaling pathway by melatonin in pancreaticβ-cells

(2008) Ina Stumpf et al.   JOURNAL OF PINEAL RESEARCH

Combination of melatonin and a peroxisome proliferator-activated receptor-γ agonist induces apoptosis in a breast cancer cell line

(2008) Ahmet Korkmaz et al.   JOURNAL OF PINEAL RESEARCH

The Circadian Gene NPAS2, a Putative Tumor Suppressor, Is Involved in DNA Damage Response

(2008) A. E. Hoffman et al.   MOLECULAR CANCER RESEARCH

Period 2 Mutation Accelerates ApcMin/+ Tumorigenesis

(2008) P. A. Wood et al.   MOLECULAR CANCER RESEARCH

Common variant in MTNR1B associated with increased risk of type 2 diabetes and impaired early insulin secretion

(2008) Valeriya Lyssenko et al.   NATURE GENETICS

A variant near MTNR1B is associated with increased fasting plasma glucose levels and type 2 diabetes risk

(2008) Nabila Bouatia-Naji et al.   NATURE GENETICS

A length polymorphism in the circadian clock gene Per3 influences age at onset of bipolar disorder

(2008) Francesco Benedetti et al.   NEUROSCIENCE LETTERS

Investigation of 3111T/C polymorphism of the CLOCK gene in obese individuals with or without binge eating disorder: Association with higher body mass index

(2008) Palmiero Monteleone et al.   NEUROSCIENCE LETTERS

SIRT1 Overexpression Antagonizes Cellular Senescence with Activated ERK/S6k1 Signaling in Human Diploid Fibroblasts

(2008) Jing Huang et al.   PLoS One

Polymorphisms within the Novel Type 2 Diabetes Risk Locus MTNR1B Determine β-Cell Function

(2008) Harald Staiger et al.   PLoS One

Physiological significance of a peripheral tissue circadian clock

(2008) K. A. Lamia et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The effect of melatonergic and non-melatonergic antidepressants on sleep: weighing the alternatives

(2008) Seithikurippu R. Pandi-Perumal et al.   WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY

An Autonomous Circadian Clock in the Inner Mouse Retina Regulated by Dopamine and GABA

(2008) Guo-Xiang Ruan et al.   PLOS BIOLOGY

Disruption of the circadian clock within the cardiomyocyte influences myocardial contractile function, metabolism, and gene expression

(2007) Molly S. Bray et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Rhythmic Expression of Functional MT1 Melatonin Receptors in the Rat Adrenal Gland

(2007) Hans G. Richter et al.   ENDOCRINOLOGY

Effects of exogenous melatonin and circadian synchronization on tumor progression in melanoma-bearing C57BL6 mice

(2007) B. B. Otálora et al.   JOURNAL OF PINEAL RESEARCH