A computational systems analysis of factors regulating α cell glucagon secretion

γ-Aminobutyric acid (GABA) signalling in human pancreatic islets is altered in type 2 diabetes

(2012) J. Taneera et al.   DIABETOLOGIA

Glucagonocentric restructuring of diabetes: a pathophysiologic and therapeutic makeover

(2012) Roger H. Unger et al.   JOURNAL OF CLINICAL INVESTIGATION

Model for Glucagon Secretion by Pancreatic α-Cells

(2012) Virginia González-Vélez et al.   PLoS One

Diminished glucagon suppression after β-cell reduction is due to impaired α-cell function rather than an expansion of α-cell mass

(2011) Juris J. Meier et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Regulation of calcium in pancreatic α- and β-cells in health and disease

(2011) Patrik Rorsman et al.   CELL CALCIUM

Glucose- and Hormone-Induced cAMP Oscillations in  - and  -Cells Within Intact Pancreatic Islets

(2011) G. Tian et al.   DIABETES

A role for zinc in pancreatic islet β-cell cross-talk with the α-cell during hypoglycaemia

(2011) R. P. Robertson et al.   DIABETES OBESITY & METABOLISM

Regulation of glucagon secretion by incretins

(2011) J. J. Holst et al.   DIABETES OBESITY & METABOLISM

Regulation of glucagon secretion by glucose: paracrine, intrinsic or both?

(2011) J. N. Walker et al.   DIABETES OBESITY & METABOLISM

Pancreatic alpha cell mass in European subjects with type 2 diabetes

(2011) J. C. Henquin et al.   DIABETOLOGIA

Minireview: Glucagon in the Pathogenesis of Hypoglycemia and Hyperglycemia in Diabetes

(2011) Philip E. Cryer   ENDOCRINOLOGY

Liraglutide as additional treatment for type 1 diabetes

(2011) Ajay Varanasi et al.   EUROPEAN JOURNAL OF ENDOCRINOLOGY

Glucose-dependent docking and SNARE protein-mediated exocytosis in mouse pancreatic alpha-cell

(2011) Sofia A. Andersson et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Coupling of metabolic, second messenger pathways and insulin granule dynamics in pancreatic beta-cells: A computational analysis

(2011) Leonid E. Fridlyand et al.   PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY

Mathematical modeling and statistical analysis of calcium-regulated insulin granule exocytosis in β-cells from mice and humans

(2011) Morten Gram Pedersen et al.   PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY

Molecular physiology of glucagon-like peptide-1 insulin secretagogue action in pancreatic β cells

(2011) Colin A. Leech et al.   PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY

Electrophysiology of pancreatic β-cells in intact mouse islets of Langerhans

(2011) Patrik Rorsman et al.   PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY

Mechanisms of glucose sensing in the pancreatic β-cell

(2011) Leonid E. Fridlyand et al.   Islets

Bursting and calcium oscillations in pancreatic β-cells: specific pacemakers for specific mechanisms

(2010) L. E. Fridlyand et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

GLP-1 Inhibits and Adrenaline Stimulates Glucagon Release by Differential Modulation of N- and L-Type Ca2+ Channel-Dependent Exocytosis

(2010) Yang Z. De Marinis et al.   Cell Metabolism

 -Aminobutyric Acid (GABA) Is an Autocrine Excitatory Transmitter in Human Pancreatic  -Cells

(2010) M. Braun et al.   DIABETES

Insulin Reciprocally Regulates Glucagon Secretion in Humans

(2010) B. A. Cooperberg et al.   DIABETES

Membrane Potential-Dependent Inactivation of Voltage-Gated Ion Channels in  -Cells Inhibits Glucagon Secretion From Human Islets

(2010) R. Ramracheya et al.   DIABETES

Unique Arrangement of  - and  -Cells in Human Islets of Langerhans

(2010) D. Bosco et al.   DIABETES

Voltage-dependent K+ channels are positive regulators of alpha cell action potential generation and glucagon secretion in mice and humans

(2010) A. F. Spigelman et al.   DIABETOLOGIA

Glucose Suppression of Glucagon Secretion

(2010) Sylvain J. Le Marchand et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Unperturbed islet α-cell function examined in mouse pancreas tissue slices

(2010) Ya-Chi Huang et al.   JOURNAL OF PHYSIOLOGY-LONDON

Paracrinology of islets and the paracrinopathy of diabetes

(2010) R. H. Unger et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Loss of high-frequency glucose-induced Ca2+ oscillations in pancreatic islets correlates with impaired glucose tolerance in Trpm5-/- mice

(2010) B. Colsoul et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Glucose sensing in the pancreatic beta cell: a computational systems analysis

(2010) Leonid E Fridlyand et al.   Theoretical Biology and Medical Modelling

A Model of Action Potentials and Fast Ca2+ Dynamics in Pancreatic β-Cells

(2009) L.E. Fridlyand et al.   BIOPHYSICAL JOURNAL

ATP-Sensitive K+ Channel Mediates the Zinc Switch-Off Signal for Glucagon Response During Glucose Deprivation

(2009) M. Slucca et al.   DIABETES

Inhibitory Effects of Leptin on Pancreatic  -Cell Function

(2009) E. Tuduri et al.   DIABETES

 -Cell-Mediated Signaling Predominates Over Direct  -Cell Signaling in the Regulation of Glucagon Secretion in Humans

(2009) B. A. Cooperberg et al.   DIABETES CARE

Roles of cAMP signalling in insulin granule exocytosis

(2009) S. Seino et al.   DIABETES OBESITY & METABOLISM

Enhancement of glucagon secretion in mouse and human pancreatic alpha cells by protein kinase C (PKC) involves intracellular trafficking of PKCα and PKCδ

(2009) Y. Z. De Marinis et al.   DIABETOLOGIA

Leptin-dependent Phosphorylation of PTEN Mediates Actin Restructuring and Activation of ATP-sensitive K+Channels

(2009) Ke Ning et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Synaptotagmin-7 is a principal Ca2+sensor for Ca2+-induced glucagon exocytosis in pancreas

(2009) Natalia Gustavsson et al.   JOURNAL OF PHYSIOLOGY-LONDON

Insulin as a physiological modulator of glucagon secretion

(2008) Pritpal Bansal et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Mechanism of action of exenatide to reduce postprandial hyperglycemia in type 2 diabetes

(2008) Antonio Cervera et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Glucose and Pharmacological Modulators of ATP-Sensitive K+ Channels Control [Ca2+]c by Different Mechanisms in Isolated Mouse  -Cells

(2008) N. Quoix et al.   DIABETES

Somatostatin Secreted by Islet  -Cells Fulfills Multiple Roles as a Paracrine Regulator of Islet Function

(2008) A. C. Hauge-Evans et al.   DIABETES

Voltage-Gated Ion Channels in Human Pancreatic  -Cells: Electrophysiological Characterization and Role in Insulin Secretion

(2008) M. Braun et al.   DIABETES

Glucagon-like peptide-1, but not glucose-dependent insulinotropic peptide, inhibits glucagon secretion via somatostatin (receptor subtype 2) in the perfused rat pancreas

(2008) J. de Heer et al.   DIABETOLOGIA

Differential contribution of the Na+-K+-2Cl− cotransporter NKCC1 to chloride handling in rat embryonic dorsal root ganglion neurons and motor neurons

(2008) J. N. Chabwine et al.   FASEB JOURNAL

Physiology of the pancreatic α-cell and glucagon secretion: role in glucose homeostasis and diabetes

(2008) Ivan Quesada et al.   JOURNAL OF ENDOCRINOLOGY

Novel aspects of the molecular mechanisms controlling insulin secretion

(2008) Lena Eliasson et al.   JOURNAL OF PHYSIOLOGY-LONDON

UCP2 is highly expressed in pancreatic  -cells and influences secretion and survival

(2008) J. Diao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Making insulin-deficient type 1 diabetic rodents thrive without insulin

(2008) X. Yu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

KATP-channels and glucose-regulated glucagon secretion

(2008) Patrik Rorsman et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM