Holocranohistochemistry enables the visualization of α-synuclein expression in the murine olfactory system and discovery of its systemic anti-microbial effects

The olfactory bulb as the entry site for prion-like propagation in neurodegenerative diseases

(2018) Nolwen L. Rey et al.   NEUROBIOLOGY OF DISEASE

Phosphorylated α-synuclein immunoreactivity in nerve fibers from minor salivary glands in Parkinson's disease

(2017) Raffaella Carletti et al.   PARKINSONISM & RELATED DISORDERS

Functional characterization of alpha-synuclein protein with antimicrobial activity

(2016) Seong-Cheol Park et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Gut Microbiota Regulate Motor Deficits and Neuroinflammation in a Model of Parkinson’s Disease

(2016) Timothy R. Sampson et al.   CELL

K45A mutation of RIPK1 results in poor necroptosis and cytokine signaling in macrophages, which impacts inflammatory responses in vivo

(2016) B Shutinoski et al.   CELL DEATH AND DIFFERENTIATION

Modelling idiopathic Parkinson disease as a complex illness can inform incidence rate in healthy adults: the PREDIGT score

(2016) Michael G. Schlossmacher et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

A critical role for alpha-synuclein in development and function of T lymphocytes

(2016) Afshin Shameli et al.   IMMUNOBIOLOGY

A TgCRND8 Mouse Model of Alzheimer’s Disease Exhibits Sexual Dimorphisms in Behavioral Indices of Cognitive Reserve

(2016) Matthew W. Granger et al.   JOURNAL OF ALZHEIMERS DISEASE

Microbes and Alzheimer’s Disease

(2016) Ruth F. Itzhaki et al.   JOURNAL OF ALZHEIMERS DISEASE

α-Synuclein Fibrils Exhibit Gain of Toxic Function, Promoting Tau Aggregation and Inhibiting Microtubule Assembly

(2016) Takayuki Oikawa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Biological confounders for the values of cerebrospinal fluid proteins in Parkinson's disease and related disorders

(2016) Brit Mollenhauer et al.   JOURNAL OF NEUROCHEMISTRY

Increased peripheral inflammation in asymptomatic leucine-rich repeat kinase 2 mutation carriers

(2016) Nicolas Dzamko et al.   MOVEMENT DISORDERS

First-in-human assessment of PRX002, an anti-α-synuclein monoclonal antibody, in healthy volunteers

(2016) Dale B. Schenk et al.   MOVEMENT DISORDERS

A critical appraisal of the pathogenic protein spread hypothesis of neurodegeneration

(2016) Dominic M. Walsh et al.   NATURE REVIEWS NEUROSCIENCE

Dose-dependent progression of parkinsonism in manganese-exposed welders

(2016) Brad A. Racette et al.   NEUROLOGY

Monitoring of 30 marker candidates in early Parkinson disease as progression markers

(2016) Brit Mollenhauer et al.   NEUROLOGY

Review: Sporadic Parkinson's disease: development and distribution ofα-synuclein pathology

(2016) K. Del Tredici et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Genetic Factors Are Not the Major Causes of Chronic Diseases

(2016) Stephen M. Rappaport   PLoS One

Amyloid-β peptide protects against microbial infection in mouse and worm models of Alzheimer’s disease

(2016) Deepak Kumar Vijaya Kumar et al.   Science Translational Medicine

Prevalence of Submandibular Gland Synucleinopathy in Parkinson’s Disease, Dementia with Lewy Bodies and other Lewy Body Disorders

(2016) Thomas G. Beach et al.   Journal of Parkinsons Disease

A Missense LRRK2 Variant Is a Risk Factor for Excessive Inflammatory Responses in Leprosy

(2016) Vinicius M. Fava et al.   PLoS Neglected Tropical Diseases

Alpha-Synuclein Oligomers—Neurotoxic Molecules in Parkinson's Disease and Other Lewy Body Disorders

(2016) Martin Ingelsson   Frontiers in Neuroscience

Exposure to the Functional Bacterial Amyloid Protein Curli Enhances Alpha-Synuclein Aggregation in Aged Fischer 344 Rats and Caenorhabditis elegans

(2016) Shu G. Chen et al.   Scientific Reports

Association between α-synuclein blood transcripts and early, neuroimaging-supported Parkinson’s disease

(2015) Joseph J. Locascio et al.   BRAIN

Alpha-Synuclein Expression Restricts RNA Viral Infections in the Brain

(2015) Erica L. Beatman et al.   JOURNAL OF VIROLOGY

MDS research criteria for prodromal Parkinson's disease

(2015) Daniela Berg et al.   MOVEMENT DISORDERS

Tau in physiology and pathology

(2015) Yipeng Wang et al.   NATURE REVIEWS NEUROSCIENCE

Generation and characterization of novel conformation-specific monoclonal antibodies for α-synuclein pathology

(2015) Nishant N. Vaikath et al.   NEUROBIOLOGY OF DISEASE

An Interglomerular Circuit Gates Glomerular Output and Implements Gain Control in the Mouse Olfactory Bulb

(2015) Arkarup Banerjee et al.   NEURON

Augmentation of phenotype in a transgenic Parkinson mouse heterozygous for a Gaucher mutation

(2014) Ianai Fishbein et al.   BRAIN

Late stages of hematopoiesis and B cell lymphopoiesis are regulated by α-synuclein, a key player in Parkinson's disease

(2014) Wenbin Xiao et al.   IMMUNOBIOLOGY

Gut microbiota are related to Parkinson's disease and clinical phenotype

(2014) Filip Scheperjans et al.   MOVEMENT DISORDERS

A Test for Creutzfeldt–Jakob Disease Using Nasal Brushings

(2014) Christina D. Orrú et al.   NEW ENGLAND JOURNAL OF MEDICINE

Alpha-synuclein in the appendiceal mucosa of neurologically intact subjects

(2013) Madison T. Gray et al.   MOVEMENT DISORDERS

CLARITY for mapping the nervous system

(2013) Kwanghun Chung et al.   NATURE METHODS

Advances in the genetics of Parkinson disease

(2013) Joanne Trinh et al.   Nature Reviews Neurology

Rasagiline Ameliorates Olfactory Deficits in an Alpha-Synuclein Mouse Model of Parkinson's Disease

(2013) Géraldine H. Petit et al.   PLoS One

Leucine-Rich Repeat Kinase 2 (LRRK2)-Deficient Rats Exhibit Renal Tubule Injury and Perturbations in Metabolic and Immunological Homeostasis

(2013) Daniel Ness et al.   PLoS One

Elevated Alpha-Synuclein Impairs Innate Immune Cell Function and Provides a Potential Peripheral Biomarker for Parkinson's Disease

(2013) Shyra J. Gardai et al.   PLoS One

Respiratory infection of mice with mammalian reoviruses causes systemic infection with age and strain dependent pneumonia and encephalitis

(2013) Lianne Gauvin et al.   Virology Journal

Association of Cerebrospinal Fluid β-Amyloid 1-42, T-tau, P-tau181, and α-Synuclein Levels With Clinical Features of Drug-Naive Patients With Early Parkinson Disease

(2013) Ju-Hee Kang   JAMA Neurology

Considerations Regarding the Etiology and Future Treatment of Autosomal Recessive Versus Idiopathic Parkinson Disease

(2012) Tohru Kitada et al.   Current Treatment Options in Neurology

MutantGBA1Expression and Synucleinopathy Risk: First Insights from Cellular and Mouse Models

(2012) S. Pablo Sardi et al.   Neurodegenerative Diseases

Total CSF α-synuclein is lower in de novo Parkinson patients than in healthy subjects

(2012) Brit Mollenhauer et al.   NEUROSCIENCE LETTERS

Acid β-glucosidase mutants linked to gaucher disease, parkinson disease, and lewy body dementia alter α-synuclein processing

(2011) Valerie Cullen et al.   ANNALS OF NEUROLOGY

Parkinson’s disease-linked LRRK2 is expressed in circulating and tissue immune cells and upregulated following recognition of microbial structures

(2011) Mansoureh Hakimi et al.   JOURNAL OF NEURAL TRANSMISSION

The kinase LRRK2 is a regulator of the transcription factor NFAT that modulates the severity of inflammatory bowel disease

(2011) Zhihua Liu et al.   NATURE IMMUNOLOGY

Genome-Wide Association Study Confirms SNPs inSNCAand theMAPTRegion as Common Risk Factors for Parkinson Disease

(2010) Todd L. Edwards et al.   ANNALS OF HUMAN GENETICS

Independent and joint effects of the MAPT and SNCA genes in Parkinson disease

(2010) Alexis Elbaz et al.   ANNALS OF NEUROLOGY

Extensive enteric nervous system abnormalities in mice transgenic for artificial chromosomes containing Parkinson disease-associated α-synuclein gene mutations precede central nervous system changes

(2010) Yien-Ming Kuo et al.   HUMAN MOLECULAR GENETICS

LRRK2 Is Involved in the IFN-  Response and Host Response to Pathogens

(2010) A. Gardet et al.   JOURNAL OF IMMUNOLOGY

The Alzheimer's Disease-Associated Amyloid β-Protein Is an Antimicrobial Peptide

(2010) Stephanie J. Soscia et al.   PLoS One

Olfactory epithelium amyloid-β and paired helical filament-tau pathology in Alzheimer disease

(2009) Steven E. Arnold et al.   ANNALS OF NEUROLOGY

Lewy body pathology in fetal grafts

(2009) Yaping Chu et al.   Annals of the New York Academy of Sciences

Highly pathogenic H5N1 influenza virus can enter the central nervous system and induce neuroinflammation and neurodegeneration

(2009) H. Jang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Olfactory deficits in mice overexpressing human wildtype -synuclein

(2008) Sheila M. Fleming et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Direct quantification of CSF α-synuclein by ELISA and first cross-sectional study in patients with neurodegeneration

(2008) Brit Mollenhauer et al.   EXPERIMENTAL NEUROLOGY

GATA transcription factors directly regulate the Parkinson's disease-linked gene  -synuclein

(2008) C. R. Scherzer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA