Role of CD44 in Regulating TLR2 Activation of Human Macrophages and Downstream Expression of Proinflammatory Cytokines

Osteoarthritis: toward a comprehensive understanding of pathological mechanism

(2017) Di Chen et al.   Bone Research

CD44 Antibody Inhibition of Macrophage Phagocytosis Targets Fcγ Receptor– and Complement Receptor 3–Dependent Mechanisms

(2016) Alaa Amash et al.   JOURNAL OF IMMUNOLOGY

Low-grade inflammation as a key mediator of the pathogenesis of osteoarthritis

(2016) William H. Robinson et al.   Nature Reviews Rheumatology

Direct in vivo evidence of activated macrophages in human osteoarthritis

(2016) V.B. Kraus et al.   OSTEOARTHRITIS AND CARTILAGE

The Role of Innate Immunity in Osteoarthritis: When Our First Line of Defense Goes On the Offensive

(2015) E. W. Orlowsky et al.   JOURNAL OF RHEUMATOLOGY

The interaction of lubricin/proteoglycan 4 (PRG4) with toll-like receptors 2 and 4: an anti-inflammatory role of PRG4 in synovial fluid

(2015) Ali Alquraini et al.   ARTHRITIS RESEARCH & THERAPY

Lubricin/Proteoglycan 4 Binding to CD44 Receptor: A Mechanism of the Suppression of Proinflammatory Cytokine-Induced Synoviocyte Proliferation by Lubricin

(2015) Afnan Al-Sharif et al.   Arthritis & Rheumatology

Articular Joint Lubricants during Osteoarthritis and Rheumatoid Arthritis Display Altered Levels and Molecular Species

(2015) Marta Krystyna Kosinska et al.   PLoS One

CD44 Suppresses TLR-Mediated Inflammation

(2014) H. Kawana et al.   JOURNAL OF IMMUNOLOGY

TLR4 signalling in osteoarthritis—finding targets for candidate DMOADs

(2014) Rodolfo Gómez et al.   Nature Reviews Rheumatology

Obesity and osteoarthritis, more than just wear and tear: pivotal roles for inflamed adipose tissue and dyslipidaemia in obesity-induced osteoarthritis

(2014) E. Thijssen et al.   RHEUMATOLOGY

Mechanisms involved in suppression of ADAMTS4 expression in synoviocytes by high molecular weight hyaluronic acid

(2013) Yoshihiro Kataoka et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Role of inflammation in the pathogenesis of osteoarthritis: latest findings and interpretations

(2013) Jeremy Sokolove et al.   Therapeutic Advances in Musculoskeletal Disease

Osteoarthritis: A disease of the joint as an organ

(2012) Richard F. Loeser et al.   ARTHRITIS AND RHEUMATISM

Synovial fluid from patients with early osteoarthritis modulates fibroblast-like synoviocyte responses to Toll-like receptor 4 and Toll-like receptor 2 ligands via soluble CD14

(2012) Anjali Nair et al.   ARTHRITIS AND RHEUMATISM

The role of synovitis in osteoarthritis pathogenesis

(2012) Carla R. Scanzello et al.   BONE

Synovial inflammation, immune cells and their cytokines in osteoarthritis: a review

(2012) B.J.E. de Lange-Brokaar et al.   OSTEOARTHRITIS AND CARTILAGE

Plasma proteins present in osteoarthritic synovial fluid can stimulate cytokine production via Toll-like receptor 4

(2012) Dong Sohn et al.   ARTHRITIS RESEARCH & THERAPY

Presence of MRI-detected joint effusion and synovitis increases the risk of cartilage loss in knees without osteoarthritis at 30-month follow-up: the MOST study

(2011) F. W. Roemer et al.   ANNALS OF THE RHEUMATIC DISEASES

Hyaluronan reduces inflammation in experimental arthritis by modulating TLR-2 and TLR-4 cartilage expression

(2011) Giuseppe M. Campo et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Basic Calcium Phosphate Crystals Induce Monocyte/Macrophage IL-1  Secretion through the NLRP3 Inflammasome In Vitro

(2011) B. Pazar et al.   JOURNAL OF IMMUNOLOGY

Relationships between biomarkers of cartilage, bone, synovial metabolism and knee pain provide insights into the origins of pain in early knee osteoarthritis

(2011) Muneaki Ishijima et al.   ARTHRITIS RESEARCH & THERAPY

The role of synovial macrophages and macrophage-produced mediators in driving inflammatory and destructive responses in osteoarthritis

(2010) Jan Bondeson et al.   ARTHRITIS AND RHEUMATISM

Innate immune system activation in osteoarthritis: is osteoarthritis a chronic wound?

(2008) Carla R Scanzello et al.   CURRENT OPINION IN RHEUMATOLOGY