The interaction of lubricin/proteoglycan 4 (PRG4) with toll-like receptors 2 and 4: an anti-inflammatory role of PRG4 in synovial fluid

Treatment with recombinant lubricin attenuates osteoarthritis by positive feedback loop between articular cartilage and subchondral bone in ovariectomized rats

(2015) Zhuang Cui et al.   BONE

The impact of early intra-articular administration of interleukin-1 receptor antagonist on lubricin metabolism and cartilage degeneration in an anterior cruciate ligament transection model

(2015) K.A. Elsaid et al.   OSTEOARTHRITIS AND CARTILAGE

Bioactivity in an Aggrecan 32-mer Fragment Is Mediated via Toll-like Receptor 2

(2015) Sophie Lees et al.   Arthritis & Rheumatology

Lubricin/Proteoglycan 4 Binding to CD44 Receptor: A Mechanism of the Suppression of Proinflammatory Cytokine-Induced Synoviocyte Proliferation by Lubricin

(2015) Afnan Al-Sharif et al.   Arthritis & Rheumatology

Articular Joint Lubricants during Osteoarthritis and Rheumatoid Arthritis Display Altered Levels and Molecular Species

(2015) Marta Krystyna Kosinska et al.   PLoS One

Characterization of full-length recombinant human Proteoglycan 4 as an ocular surface boundary lubricant

(2014) Michael L. Samsom et al.   EXPERIMENTAL EYE RESEARCH

TheO-glycomap of Lubricin, a Novel Mucin Responsible for Joint Lubrication, Identified by Site-specific Glycopeptide Analysis

(2014) Liaqat Ali et al.   MOLECULAR & CELLULAR PROTEOMICS

TLR4 signalling in osteoarthritis—finding targets for candidate DMOADs

(2014) Rodolfo Gómez et al.   Nature Reviews Rheumatology

The role of glycoprotein 96 in the persistent inflammation of rheumatoid arthritis

(2012) Qi-Quan Huang et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Glycoprotein 96 perpetuates the persistent inflammation of rheumatoid arthritis

(2012) Qi-Quan Huang et al.   ARTHRITIS AND RHEUMATISM

Synovial fluid from patients with early osteoarthritis modulates fibroblast-like synoviocyte responses to Toll-like receptor 4 and Toll-like receptor 2 ligands via soluble CD14

(2012) Anjali Nair et al.   ARTHRITIS AND RHEUMATISM

Human Synovial Lubricin Expresses Sialyl Lewis x Determinant and Has L-selectin Ligand Activity

(2012) Chunsheng Jin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The stimulation of adenosine 2A receptor reduces inflammatory response in mouse articular chondrocytes treated with hyaluronan oligosaccharides

(2012) Giuseppe M. Campo et al.   MATRIX BIOLOGY

The impact of forced joint exercise on lubricin biosynthesis from articular cartilage following ACL transection and intra-articular lubricin's effect in exercised joints following ACL transection

(2012) K.A. Elsaid et al.   OSTEOARTHRITIS AND CARTILAGE

Plasma proteins present in osteoarthritic synovial fluid can stimulate cytokine production via Toll-like receptor 4

(2012) Dong Sohn et al.   ARTHRITIS RESEARCH & THERAPY

Prevention of cartilage degeneration and gait asymmetry by lubricin tribosupplementation in the rat following anterior cruciate ligament transection

(2011) Gregory D. Jay et al.   ARTHRITIS AND RHEUMATISM

Intrinsic danger: activation of Toll-like receptors in rheumatoid arthritis

(2011) F. G. Goh et al.   RHEUMATOLOGY

Trapped in a vicious loop: Toll-like receptors sustain the spontaneous cytokine production by rheumatoid synovium

(2011) Shahla Abdollahi-Roodsaz et al.   ARTHRITIS RESEARCH & THERAPY

Effects of Supplemental Intra-articular Lubricin and Hyaluronic Acid on the Progression of Posttraumatic Arthritis in the Anterior Cruciate Ligament–Deficient Rat Knee

(2010) Erin Teeple et al.   AMERICAN JOURNAL OF SPORTS MEDICINE

Prevention of cartilage degeneration and restoration of chondroprotection by lubricin tribosupplementation in the rat following anterior cruciate ligament transection

(2010) Gregory D. Jay et al.   ARTHRITIS AND RHEUMATISM

The glycosylation of human synovial lubricin: implications for its role in inflammation

(2010) Ruby P. Estrella et al.   BIOCHEMICAL JOURNAL

Deciphering the complexity of Toll-like receptor signaling

(2010) Renato Ostuni et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Prevention of cartilage degeneration in a rat model of osteoarthritis by intraarticular treatment with recombinant lubricin

(2009) Carl R. Flannery et al.   ARTHRITIS AND RHEUMATISM

The interleukin-1 receptor/Toll-like receptor superfamily: 10 years of progress

(2009) Luke A. J. O'Neill   IMMUNOLOGICAL REVIEWS

Synergism of toll-like receptor 2 (TLR2), TLR4, and TLR6 ligation on the production of tumor necrosis factor (TNF)-α in a spontaneous arthritis animal model of interleukin (IL)-1 receptor antagonist-deficient mice

(2009) Young Ok Jung et al.   IMMUNOLOGY LETTERS

Decreased lubricin concentrations and markers of joint inflammation in the synovial fluid of patients with anterior cruciate ligament injury

(2008) K. A. Elsaid et al.   ARTHRITIS AND RHEUMATISM

Innate immune system activation in osteoarthritis: is osteoarthritis a chronic wound?

(2008) Carla R Scanzello et al.   CURRENT OPINION IN RHEUMATOLOGY

Boundary mode lubrication of articular cartilage by recombinant human lubricin

(2008) Jason P. Gleghorn et al.   JOURNAL OF ORTHOPAEDIC RESEARCH