Lysosomal targeting strategies for design and delivery of bioactive for therapeutic interventions

Overcoming cellular barriers for RNA therapeutics

(2017) Steven F Dowdy   NATURE BIOTECHNOLOGY

Highly Versatile Polyelectrolyte Complexes for Improving the Enzyme Replacement Therapy of Lysosomal Storage Disorders

(2016) Marina I. Giannotti et al.   ACS Applied Materials & Interfaces

Intra- and trans-cellular delivery of enzymes by direct conjugation with non-multivalent anti-ICAM molecules

(2016) Rasa Ghaffarian et al.   JOURNAL OF CONTROLLED RELEASE

A Comparative Study on the Alterations of Endocytic Pathways in Multiple Lysosomal Storage Disorders

(2016) Jeff Rappaport et al.   MOLECULAR PHARMACEUTICS

α-Galactosidase-A Loaded-Nanoliposomes with Enhanced Enzymatic Activity and Intracellular Penetration

(2016) Ingrid Cabrera et al.   Advanced Healthcare Materials

Targeting the lysosome in cancer

(2015) Shengfu Piao et al.   Annals of the New York Academy of Sciences

Lysosomal Storage Diseases: From Pathophysiology to Therapy

(2015) Giancarlo Parenti et al.   Annual Review of Medicine

Lysosomal Physiology

(2015) Haoxing Xu et al.   Annual Review of Physiology

Mechanisms of apoptosis

(2015) M. A. Savitskaya et al.   BIOCHEMISTRY-MOSCOW

Novel lysosome targeted molecular transporter built on a guanidinium-poly-(propylene imine) hybrid dendron for efficient delivery of doxorubicin into cancer cells

(2015) Jyothi B. Nair et al.   CHEMICAL COMMUNICATIONS

Recycling endosomes

(2015) James R Goldenring   CURRENT OPINION IN CELL BIOLOGY

The Role of Autophagy in Lupus Nephritis

(2015) Linlin Wang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The Function of Autophagy in Neurodegenerative Diseases

(2015) Yoshimitsu Kiriyama et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Autophagy in autoimmune disease

(2015) Zhen Yang et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Use of Polylactide-Co-Glycolide-Nanoparticles for Lysosomal Delivery of a Therapeutic Enzyme in Glycogenosis Type II Fibroblasts

(2015) Tancini Brunella et al.   JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY

Tuning the Buffering Capacity of Polyethylenimine with Glycerol Molecules for Efficient Gene Delivery: Staying In or Out of the Endosomes

(2015) Bijay Singh et al.   MACROMOLECULAR BIOSCIENCE

Taming Cell Penetrating Peptides: Never Too Old To Teach Old Dogs New Tricks

(2015) Qianyu Zhang et al.   MOLECULAR PHARMACEUTICS

Potentiating the cellular targeting and anti-tumor activity of Dp44mT via binding to human serum albumin: two saturable mechanisms of Dp44mT uptake by cells

(2015) Angelica M. Merlot et al.   Oncotarget

Manipulating Autophagic Processes in Autoimmune Diseases: A Special Focus on Modulating Chaperone-Mediated Autophagy, an Emerging Therapeutic Target

(2015) Fengjuan Wang et al.   Frontiers in Immunology

Actin Controls the Vesicular Fraction of Dopamine Released During Extended Kiss and Run Exocytosis

(2014) Raphaël Trouillon et al.   ACS Chemical Biology

Lipoprotein-Based Nanoparticles Rescue the Memory Loss of Mice with Alzheimer’s Disease by Accelerating the Clearance of Amyloid-Beta

(2014) Qingxiang Song et al.   ACS Nano

Anti-cancer agent siramesine is a lysosomotropic detergent that induces cytoprotective autophagosome accumulation

(2014) Marie Stampe Ostenfeld et al.   Autophagy

Copper chelation selectively kills colon cancer cells through redox cycling and generation of reactive oxygen species

(2014) Maamoun Fatfat et al.   BMC CANCER

Targeting lysosomal membrane permeabilization to induce and image apoptosis in cancer cells by multifunctional Au–ZnO hybrid nanoparticles

(2014) Wen Gao et al.   CHEMICAL COMMUNICATIONS

Autophagy Inhibition Augments the Anticancer Effects of Epirubicin Treatment in Anthracycline-Sensitive and -Resistant Triple-Negative Breast Cancer

(2014) S. Chittaranjan et al.   CLINICAL CANCER RESEARCH

Lysosomal membrane permeabilization in cell death: Concepts and challenges

(2014) Urška Repnik et al.   MITOCHONDRION

Clathrin-Mediated Endocytosis Is Impaired in Type A–B Niemann–Pick Disease Model Cells and Can Be Restored by ICAM-1-Mediated Enzyme Replacement

(2014) Jeff Rappaport et al.   MOLECULAR PHARMACEUTICS

Single-Walled Carbon Nanotubes Alleviate Autophagic/Lysosomal Defects in Primary Glia from a Mouse Model of Alzheimer’s Disease

(2014) Xue Xue et al.   NANO LETTERS

A lysosome-targeted drug delivery system based on sorbitol backbone towards efficient cancer therapy

(2014) Santhi Maniganda et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Targeting, Endocytosis, and Lysosomal Delivery of Active Enzymes to Model Human Neurons by ICAM-1-Targeted Nanocarriers

(2014) Janet Hsu et al.   PHARMACEUTICAL RESEARCH

A display of pH-sensitive fusogenic GALA peptide facilitates endosomal escape from a Bio-nanocapsule via an endocytic uptake pathway

(2014) Yuya Nishimura et al.   JOURNAL OF NANOBIOTECHNOLOGY

Engineered nanoparticles interacting with cells: size matters

(2014) Li Shang et al.   JOURNAL OF NANOBIOTECHNOLOGY

Autophagy as a Possible Underlying Mechanism of Nanomaterial Toxicity

(2014) Vanessa Cohignac et al.   Nanomaterials

Lysosomal Membrane Permeabilization by Targeted Magnetic Nanoparticles in Alternating Magnetic Fields

(2013) Maribella Domenech et al.   ACS Nano

Autophagy and human diseases

(2013) Peidu Jiang et al.   CELL RESEARCH

Targeting HER2+ breast cancer cells: Lysosomal accumulation of anti-HER2 antibodies is influenced by antibody binding site and conjugation to polymeric nanoparticles

(2013) Shawn C. Owen et al.   JOURNAL OF CONTROLLED RELEASE

Autophagy in Human Health and Disease

(2013) Augustine M.K. Choi et al.   NEW ENGLAND JOURNAL OF MEDICINE

Emerging role of autophagy in pediatric neurodegenerative and neurometabolic diseases

(2013) Darius Ebrahimi-Fakhari et al.   PEDIATRIC RESEARCH

Dysregulation of Multiple Facets of Glycogen Metabolism in a Murine Model of Pompe Disease

(2013) Kristin M. Taylor et al.   PLoS One

Nanomaterials and Autophagy: New Insights in Cancer Treatment

(2013) Elisa Panzarini et al.   Cancers

Endocytosis at the nanoscale

(2012) Irene Canton et al.   CHEMICAL SOCIETY REVIEWS

Lysosomal pathways to cell death and their therapeutic applications

(2012) Maruša Hafner Česen et al.   EXPERIMENTAL CELL RESEARCH

Peptide-mediated cell penetration and targeted delivery of gold nanoparticles into lysosomes

(2012) Chaitali D. Dekiwadia et al.   JOURNAL OF PEPTIDE SCIENCE

Lysosome-targeted octadecyl-rhodamine B-liposomes enhance lysosomal accumulation of glucocerebrosidase in Gaucher’s cellsin vitro

(2012) Ritesh Thekkedath et al.   Nanomedicine

Autophagy and lysosomal dysfunction as emerging mechanisms of nanomaterial toxicity

(2012) Stephan T Stern et al.   Particle and Fibre Toxicology

Lysosomotropic Properties of Weakly Basic Anticancer Agents Promote Cancer Cell Selectivity In Vitro

(2012) Rosemary A. Ndolo et al.   PLoS One

Acidic Nanoparticles Are Trafficked to Lysosomes and Restore an Acidic Lysosomal pH and Degradative Function to Compromised ARPE-19 Cells

(2012) Gabriel C. Baltazar et al.   PLoS One

Multicomponent nanoparticles as nonviral vectors for the treatment of Fabry disease by gene therapy

(2012) Aritz Perez Ruiz de Garibay et al.   Drug Design Development and Therapy

Lysosomal Function and Dysfunction: Mechanism and Disease

(2011) Patricia Boya   ANTIOXIDANTS & REDOX SIGNALING

Lysosomes and lysosomal cathepsins in cell death

(2011) Urška Repnik et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

pH-Responsive Polysaccharide-Based Polyelectrolyte Complexes As Nanocarriers for Lysosomal Delivery of Therapeutic Proteins

(2011) Marina I. Giannotti et al.   BIOMACROMOLECULES

Endosomal escape and the knockdown efficiency of liposomal-siRNA by the fusogenic peptide shGALA

(2011) Yu Sakurai et al.   BIOMATERIALS

Autophagy in immunity and inflammation

(2011) Beth Levine et al.   NATURE

Combating apoptosis and multidrug resistant cancers by targeting lysosomes

(2010) Line Groth-Pedersen et al.   CANCER LETTERS

Endosomal escape pathways for delivery of biologicals

(2010) Amir K. Varkouhi et al.   JOURNAL OF CONTROLLED RELEASE

Macrophage delivery of therapeutic nanozymes in a murine model of Parkinson’s disease

(2010) Anna M Brynskikh et al.   Nanomedicine

Pharmacological and toxicological target organelles and safe use of single-walled carbon nanotubes as drug carriers in treating Alzheimer disease

(2010) Zhong Yang et al.   Nanomedicine-Nanotechnology Biology and Medicine

New biotechnological and nanomedicine strategies for treatment of lysosomal storage disorders

(2010) Silvia Muro   Wiley Interdisciplinary Reviews-Nanomedicine and Nanobiotechnology

Delivery of Macromolecules Using Arginine-Rich Cell-Penetrating Peptides: Ways to Overcome Endosomal Entrapment

(2009) Ayman El-Sayed et al.   AAPS Journal

The lysosome and neurodegenerative diseases

(2009) L. Zhang et al.   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

Mechanisms of Endocytosis

(2009) Gary J. Doherty et al.   Annual Review of Biochemistry

The delivery of endocytosed cargo to lysosomes: Figure 1

(2009) J. Paul Luzio et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

In vivolabelling of hippocampal β-amyloid in triple-transgenic mice with a fluorescent acetylcholinesterase inhibitor released from nanoparticles

(2009) Wolfgang Härtig et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Synthetic and natural iron chelators: therapeutic potential and clinical use

(2009) Heather C Hatcher et al.   Future Medicinal Chemistry

Functional Protein Delivery into Neurons Using Polymeric Nanoparticles

(2009) Linda Hasadsri et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pathways and mechanisms of endocytic recycling

(2009) Barth D. Grant et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

PAMAM Nanoparticles Promote Acute Lung Injury by Inducing Autophagic Cell Death through the Akt-TSC2-mTOR Signaling Pathway

(2009) C. Li et al.   Journal of Molecular Cell Biology

The Receptor-Mediated Endocytosis of Nonspherical Particles

(2008) P. Decuzzi et al.   BIOPHYSICAL JOURNAL

Delivery of Acid Sphingomyelinase in Normal and Niemann-Pick Disease Mice Using Intercellular Adhesion Molecule-1-Targeted Polymer Nanocarriers

(2008) C. Garnacho et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Role of Particle Size in Phagocytosis of Polymeric Microspheres

(2008) Julie A. Champion et al.   PHARMACEUTICAL RESEARCH