Nanomaterials and Autophagy: New Insights in Cancer Treatment

Targeting Cancer Gene Therapy with Magnetic Nanoparticles

(2015) Charles Li et al.   Oncotarget

Role for nanomaterial-autophagy interaction in neurodegenerative disease

(2014) Stephan T. Stern et al.   Autophagy

Regulation of autophagy by a beclin 1-targeted microRNA, miR-30a, in cancer cells

(2014) Hua Zhu et al.   Autophagy

Biodegradable core-shell nanoassemblies for the delivery of docetaxel and Zn(II)-phthalocyanine inspired by combination therapy for cancer

(2013) C. Conte et al.   JOURNAL OF CONTROLLED RELEASE

miR-376b controls starvation and mTOR inhibition-related autophagy by targeting ATG4C and BECN1

(2012) Gozde Korkmaz et al.   Autophagy

Guidelines for the use and interpretation of assays for monitoring autophagy

(2012) Daniel J. Klionsky et al.   Autophagy

Graphene quantum dots as autophagy-inducing photodynamic agents

(2012) Zoran M. Markovic et al.   BIOMATERIALS

Autophagy in tumorigenesis and cancer therapy: Dr. Jekyll or Mr. Hyde?

(2012) Shengtao Zhou et al.   CANCER LETTERS

MicroRNA regulation of autophagy

(2012) L. B. Frankel et al.   CARCINOGENESIS

The anticancer activity of chloroquine-gold nanoparticles against MCF-7 breast cancer cells

(2012) Prachi Joshi et al.   COLLOIDS AND SURFACES B-BIOINTERFACES

Autophagy Attenuates the Adaptive Immune Response by Destabilizing the Immunologic Synapse

(2012) Manon E. Wildenberg et al.   GASTROENTEROLOGY

Autophagy inhibition in cancer therapy: metabolic considerations for antitumor immunity

(2012) Katelin N. Townsend et al.   IMMUNOLOGICAL REVIEWS

Cellular Delivery of Doxorubicin via pH-Controlled Hydrazone Linkage Using Multifunctional Nano Vehicle Based on Poly(β-L-Malic Acid)

(2012) Rameshwar Patil et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Toxicity of Engineered Nanomaterials: A Physicochemical Perspective

(2012) Ramakrishna Podila et al.   JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY

Preparation and physicochemical characterization of a novel paclitaxel-loaded amphiphilic aminocalixarene nanoparticle platform for anticancer chemotherapy

(2012) Clare Weeden et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

Autophagy and lysosomal dysfunction as emerging mechanisms of nanomaterial toxicity

(2012) Stephan T Stern et al.   Particle and Fibre Toxicology

MicroRNAs in cancer diagnosis and therapy: from bench to bedside

(2012) Isamu Hoshino et al.   SURGERY TODAY

Metabolic pathways in T cell fate and function

(2012) Valerie A. Gerriets et al.   TRENDS IN IMMUNOLOGY

Genotoxicity and carcinogenicity of cobalt-, nickel- and copper-based nanoparticles

(2012) RUTH MAGAYE et al.   Experimental and Therapeutic Medicine

Autophagy-assisted antigen cross-presentation

(2012) Yongxiang Yi et al.   OncoImmunology

Autophagy Contributes to the Death/Survival Balance in Cancer PhotoDynamic Therapy

(2012) Valentina Inguscio et al.   Cells

Targeting dendritic cells with nano-particulate PLGA cancer vaccine formulations

(2011) Samar Hamdy et al.   ADVANCED DRUG DELIVERY REVIEWS

Autophagy in Pulmonary Diseases

(2011) Stefan W. Ryter et al.   Annual Review of Physiology

Microautophagy in mammalian cells: Revisiting a 40-year-old conundrum

(2011) Dalibor Mijaljica et al.   Autophagy

Seeing is believing: The impact of electron microscopy on autophagy research

(2011) Eeva-Liisa Eskelinen et al.   Autophagy

Tumor eradication in rat glioma and bypass of immunosuppressive barriers using internal radiation with 188Re-lipid nanocapsules

(2011) Claire Vanpouille-Box et al.   BIOMATERIALS

The selective growth inhibition of oral cancer by iron core-gold shell nanoparticles through mitochondria-mediated autophagy

(2011) Ya-Na Wu et al.   BIOMATERIALS

The induction of innate and adaptive immunity by biodegradable poly(γ-glutamic acid) nanoparticles via a TLR4 and MyD88 signaling pathway

(2011) Tomofumi Uto et al.   BIOMATERIALS

Induction of ROS, mitochondrial damage and autophagy in lung epithelial cancer cells by iron oxide nanoparticles

(2011) Mohd Imran Khan et al.   BIOMATERIALS

Photodynamic therapy of cancer: An update

(2011) Patrizia Agostinis et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Molecular determinants of immunogenic cell death elicited by anticancer chemotherapy

(2011) Oliver Kepp et al.   CANCER AND METASTASIS REVIEWS

Rose Bengal Acetate photodynamic therapy-induced autophagy

(2011) Luciana Dini et al.   CANCER BIOLOGY & THERAPY

Autophagy modulation for cancer therapy

(2011) Zhineng J. Yang et al.   CANCER BIOLOGY & THERAPY

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Autophagy promotes T-cell survival through degradation of proteins of the cell death machinery

(2011) J R Kovacs et al.   CELL DEATH AND DIFFERENTIATION

Alternative pathways for MHC class I presentation: a new function for autophagy

(2011) Magali Chemali et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

MicroRNA Profiling of Sporadic and Hereditary Medullary Thyroid Cancer Identifies Predictors of Nodal Metastasis, Prognosis, and Potential Therapeutic Targets

(2011) D. Abraham et al.   CLINICAL CANCER RESEARCH

Tumor-Derived Autophagosome Vaccine: Mechanism of Cross-Presentation and Therapeutic Efficacy

(2011) Y. Li et al.   CLINICAL CANCER RESEARCH

Tumor-Derived Autophagosome Vaccine: Induction of Cross-Protective Immune Responses against Short-lived Proteins through a p62-Dependent Mechanism

(2011) C. G. Twitty et al.   CLINICAL CANCER RESEARCH

Principles and Current Strategies for Targeting Autophagy for Cancer Treatment

(2011) R. K. Amaravadi et al.   CLINICAL CANCER RESEARCH

Autophagy in tumorigenesis and energy metabolism: friend by day, foe by night

(2011) Robin Mathew et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

microRNA-101 is a potent inhibitor of autophagy

(2011) Lisa B Frankel et al.   EMBO JOURNAL

Comparative activity of biodegradable nanoparticles with aluminum adjuvants: Antigen uptake by dendritic cells and induction of immune response in mice

(2011) Tomofumi Uto et al.   IMMUNOLOGY LETTERS

Silica nanoconstruct cellular toleration threshold in vitro

(2011) Heather L. Herd et al.   JOURNAL OF CONTROLLED RELEASE

Surface-modified silica nanoparticles for tumor-targeted delivery of camptothecin and its biological evaluation

(2011) Pablo Botella et al.   JOURNAL OF CONTROLLED RELEASE

Temporal Regulation of Intracellular Organelle Homeostasis in T Lymphocytes by Autophagy

(2011) W. Jia et al.   JOURNAL OF IMMUNOLOGY

In Vitro and In Vivo Anti-Tumor Effects of Gemcitabine Loaded with a New Drug Delivery System

(2011) Qiang Tong et al.   JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY

Epigenetic modulation of human breast cancer by metallofullerenol nanoparticles: in vivo treatment and in vitro analysis

(2011) Jie Meng et al.   Nanoscale

Alpha-alumina nanoparticles induce efficient autophagy-dependent cross-presentation and potent antitumour response

(2011) Haiyan Li et al.   Nature Nanotechnology

Lipid Nanocapsules Loaded with Rhenium-188 Reduce Tumor Progression in a Rat Hepatocellular Carcinoma Model

(2011) Claire Vanpouille-Box et al.   PLoS One

EGFR-Targeted Hybrid Plasmonic Magnetic Nanoparticles Synergistically Induce Autophagy and Apoptosis in Non-Small Cell Lung Cancer Cells

(2011) Tomohisa Yokoyama et al.   PLoS One

A functionalized single-walled carbon nanotube-induced autophagic cell death in human lung cells through Akt–TSC2-mTOR signaling

(2011) H-L Liu et al.   Cell Death & Disease

Timing the multiple cell death pathways initiated by Rose Bengal acetate photodynamic therapy

(2011) E Panzarini et al.   Cell Death & Disease

Characterization of autophagosome formation site by a hierarchical analysis of mammalian Atg proteins

(2010) Eisuke Itakura et al.   Autophagy

ROS-mediated mechanisms of autophagy stimulation and their relevance in cancer therapy

(2010) Michael Dewaele et al.   Autophagy

Assessing autophagy in the context of photodynamic therapy

(2010) John J. Reiners et al.   Autophagy

SiO2 nanoparticles induce global genomic hypomethylation in HaCaT cells

(2010) Chunmei Gong et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Magnetic-nanoparticle-modified paclitaxel for targeted therapy for prostate cancer

(2010) Mu-Yi Hua et al.   BIOMATERIALS

The effectiveness of a magnetic nanoparticle-based delivery system for BCNU in the treatment of gliomas

(2010) Mu-Yi Hua et al.   BIOMATERIALS

Understanding the "lethal" drivers of tumor-stroma co-evolution

(2010) Michael P. Lisanti et al.   CANCER BIOLOGY & THERAPY

A natural BH3 mimetic induces autophagy in apoptosis-resistant prostate cancer via modulating Bcl-2–Beclin1 interaction at endoplasmic reticulum

(2010) J Lian et al.   CELL DEATH AND DIFFERENTIATION

Chaperone-mediated autophagy: machinery, regulation and biological consequences

(2010) Wenming Li et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Iron/ethylcellulose (core/shell) nanoplatform loaded with 5-fluorouracil for cancer targeting

(2010) José L. Arias et al.   COLLOIDS AND SURFACES B-BIOINTERFACES

Chemical vectors for gene delivery: uptake and intracellular trafficking

(2010) Chantal Pichon et al.   CURRENT OPINION IN BIOTECHNOLOGY

Crosstalk between apoptosis and autophagy within the Beclin 1 interactome

(2010) Maria Chiara Maiuri et al.   EMBO JOURNAL

Inhibition of autophagy augments 5-fluorouracil chemotherapy in human colon cancer in vitro and in vivo model

(2010) Jie Li et al.   EUROPEAN JOURNAL OF CANCER

Cisplatin filled multiwalled carbon nanotubes – a novel molecular hybrid of anticancer drug container

(2010) C. Tripisciano et al.   EUROPEAN PHYSICAL JOURNAL B

The carcinogenic potential of nanomaterials, their release from products and options for regulating them

(2010) Heidi Becker et al.   INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH

Identification of an Autophagy Defect in Smokers' Alveolar Macrophages

(2010) M. M. Monick et al.   JOURNAL OF IMMUNOLOGY

Macroautophagy Regulates Energy Metabolism during Effector T Cell Activation

(2010) V. M. Hubbard et al.   JOURNAL OF IMMUNOLOGY

How do carbon nanotubes serve as carriers for gemcitabine transport in a drug delivery system?

(2010) Uthumporn Arsawang et al.   JOURNAL OF MOLECULAR GRAPHICS & MODELLING

A Novel Controlled Release Drug Delivery System for Multiple Drugs Based on Electrospun Nanofibers Containing Nanoparticles

(2010) Yazhou Wang et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

The Pan-Bcl-2 Inhibitor (-)-Gossypol Triggers Autophagic Cell Death in Malignant Glioma

(2010) V. Voss et al.   MOLECULAR CANCER RESEARCH

Dual Inhibition of Akt/Mammalian Target of Rapamycin Pathway byNanoparticle Albumin-Bound–Rapamycin and Perifosine Induces Antitumor Activity in Multiple Myeloma

(2010) Diana Cirstea et al.   MOLECULAR CANCER THERAPEUTICS

Autophagy and the Integrated Stress Response

(2010) Guido Kroemer et al.   MOLECULAR CELL

Nanoparticles Targeted With NGR Motif Deliver c-myc siRNA and Doxorubicin for Anticancer Therapy

(2010) Yunching Chen et al.   MOLECULAR THERAPY

Protein−Nanoparticle Interaction: Identification of the Ubiquitin−Gold Nanoparticle Interaction Site

(2010) Luigi Calzolai et al.   NANO LETTERS

Biocompatible dispersions of carbon nanotubes: a potential tool for intracellular transport of anticancer drugs

(2010) Antonello Di Crescenzo et al.   Nanoscale

C60(Nd) nanoparticles enhance chemotherapeutic susceptibility of cancer cells by modulation of autophagy

(2010) Pengfei Wei et al.   NANOTECHNOLOGY

MicroRNA control of signal transduction

(2010) Masafumi Inui et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

SiO2 nanoparticles induce cytotoxicity and protein expression alteration in HaCaT cells

(2010) Xifei Yang et al.   Particle and Fibre Toxicology

Autophagy inhibition and antimalarials promote cell death in gastrointestinal stromal tumor (GIST)

(2010) A. Gupta et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Autophagy and Metabolism

(2010) J. D. Rabinowitz et al.   SCIENCE

Targeted Killing of Cancer Cells in Vivo and in Vitro with EGF-Directed Carbon Nanotube-Based Drug Delivery

(2009) Ashwin A. Bhirde et al.   ACS Nano

Inhibition of Autophagy by 3-MA Enhances the Effect of 5-FU-Induced Apoptosis in Colon Cancer Cells

(2009) Jie Li et al.   ANNALS OF SURGICAL ONCOLOGY

Photodynamic Therapy-Induced Apoptosis of HeLa Cells

(2009) Elisa Panzarini et al.   Annals of the New York Academy of Sciences

Autophagy-mediated chemosensitization in cancer cells by fullerene C60 nanocrystal

(2009) Qiang Zhang et al.   Autophagy

Autophagy facilitates the progression of ERα-positive breast cancer cells to antiestrogen resistance

(2009) Patricia V. Schoenlein et al.   Autophagy

Anti- and pro-tumor functions of autophagy

(2009) Eugenia Morselli et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

The Role of ATF4 Stabilization and Autophagy in Resistance of Breast Cancer Cells Treated with Bortezomib

(2009) M. Milani et al.   CANCER RESEARCH

Multifunctional nanoparticles for prostate cancer therapy

(2009) Carolina Salvador-Morales et al.   Expert Review of Anticancer Therapy

Targeting autophagy potentiates tyrosine kinase inhibitor–induced cell death in Philadelphia chromosome–positive cells, including primary CML stem cells

(2009) Cristian Bellodi et al.   JOURNAL OF CLINICAL INVESTIGATION

Antitumor activity of EGFR targeted pH-sensitive immunoliposomes encapsulating gemcitabine in A549 xenograft nude mice

(2009) In-Young Kim et al.   JOURNAL OF CONTROLLED RELEASE

Autophagy Is Essential for Mitochondrial Clearance in Mature T Lymphocytes

(2009) H. H. Pua et al.   JOURNAL OF IMMUNOLOGY

Dynamics and diversity in autophagy mechanisms: lessons from yeast

(2009) Hitoshi Nakatogawa et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Autophagy Facilitates the Development of Breast Cancer Resistance to the Anti-HER2 Monoclonal Antibody Trastuzumab

(2009) Alejandro Vazquez-Martin et al.   PLoS One

PAMAM Nanoparticles Promote Acute Lung Injury by Inducing Autophagic Cell Death through the Akt-TSC2-mTOR Signaling Pathway

(2009) C. Li et al.   Journal of Molecular Cell Biology

Conjugation of Kahalalide F with Gold Nanoparticles to Enhance inVitro Antitumoral Activity

(2008) Leticia Hosta et al.   BIOCONJUGATE CHEMISTRY

Imprinted tumor suppressor genesARHI andPEG3 are the most frequently down-regulated in human ovarian cancers by loss of heterozygosity and promoter methylation

(2008) Weiwei Feng et al.   CANCER

Efficient Cross-presentation Depends on Autophagy in Tumor Cells

(2008) Y. Li et al.   CANCER RESEARCH

Autophagy in the Pathogenesis of Disease

(2008) Beth Levine et al.   CELL

Control of autophagy by oncogenes and tumor suppressor genes

(2008) M C Maiuri et al.   CELL DEATH AND DIFFERENTIATION

Paclitaxel Encapsulated in Cationic Liposomes Increases Tumor Microvessel Leakiness and Improves Therapeutic Efficacy in Combination with Cisplatin

(2008) S. Strieth et al.   CLINICAL CANCER RESEARCH

188Re-loaded lipid nanocapsules as a promising radiopharmaceutical carrier for internal radiotherapy of malignant gliomas

(2008) E. Allard et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Multifunctional Micellar Nanomedicine for Cancer Therapy

(2008) Elvin Blanco et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

The role of oxidative stress in ambient particulate matter-induced lung diseases and its implications in the toxicity of engineered nanoparticles

(2008) Ning Li et al.   FREE RADICAL BIOLOGY AND MEDICINE

Inhibition of autophagy at a late stage enhances imatinib-induced cytotoxicity in human malignant glioma cells

(2008) Takashi Shingu et al.   INTERNATIONAL JOURNAL OF CANCER

Gelatin-coated magnetic iron oxide nanoparticles as carrier system: Drug loading and in vitro drug release study

(2008) B GAIHRE et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Involvement of Protective Autophagy in TRAIL Resistance of Apoptosis-defective Tumor Cells

(2008) Jie Han et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

MicroRNA-221/222 Confers Tamoxifen Resistance in Breast Cancer by Targeting p27Kip1

(2008) Tyler E. Miller et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Photodynamic Therapy Targets the mTOR Signaling Networkin Vitroandin Vivo

(2008) Anette Weyergang et al.   MOLECULAR PHARMACEUTICS

p53: The Janus of autophagy?

(2008) Beth Levine et al.   NATURE CELL BIOLOGY

Multifunctional nanoparticles – properties and prospects for their use in human medicine

(2008) Nuria Sanvicens et al.   TRENDS IN BIOTECHNOLOGY

Nanotechnology and Cancer

(2007) James R. Heath et al.   Annual Review of Medicine