Lysosomotropic Properties of Weakly Basic Anticancer Agents Promote Cancer Cell Selectivity In Vitro

Quantifying the chemical beauty of drugs

(2012) G. Richard Bickerton et al.   Nature Chemistry

Finding the sweet spot: the role of nature and nurture in medicinal chemistry

(2012) Michael M. Hann et al.   NATURE REVIEWS DRUG DISCOVERY

Targeted inhibition of mitochondrial Hsp90 suppresses localised and metastatic prostate cancer growth in a genetic mouse model of disease

(2011) B H Kang et al.   BRITISH JOURNAL OF CANCER

Improving Drug Candidates by Design: A Focus on Physicochemical Properties As a Means of Improving Compound Disposition and Safety

(2011) Nicholas A. Meanwell   CHEMICAL RESEARCH IN TOXICOLOGY

NMR determination of pKavalues of indoloquinoline alkaloids

(2009) Lenka Grycová et al.   MAGNETIC RESONANCE IN CHEMISTRY

Compartmentalized cancer drug discovery targeting mitochondrial Hsp90 chaperones

(2009) B H Kang et al.   ONCOGENE

Tumor Cell Metabolism: Cancer's Achilles' Heel

(2008) Guido Kroemer et al.   CANCER CELL

The SV40 Large T Antigen-p53 Complexes Bind and Activate the Insulin-like Growth Factor-I Promoter Stimulating Cell Growth

(2008) M. Bocchetta et al.   CANCER RESEARCH

Quantitative modeling of selective lysosomal targeting for drug design

(2008) Stefan Trapp et al.   EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS

Niemann-Pick C1 Functions in Regulating Lysosomal Amine Content

(2008) Allyn M. Kaufmann et al.   JOURNAL OF BIOLOGICAL CHEMISTRY