The Role of Autophagy in Lupus Nephritis

mTOR activation is a biomarker and a central pathway to autoimmune disorders, cancer, obesity, and aging

(2015) Andras Perl   Annals of the New York Academy of Sciences

Endothelial cell and podocyte autophagy synergistically protect from diabetes-induced glomerulosclerosis

(2015) Olivia Lenoir et al.   Autophagy

UV Light Potentiates STING (Stimulator of Interferon Genes)-dependent Innate Immune Signaling through Deregulation of ULK1 (Unc51-like Kinase 1)

(2015) Michael G. Kemp et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Apolipoprotein L1-Associated Nephropathy and the Future of Renal Diagnostics

(2015) C. P. Larsen et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Clinical Features and Histology of Apolipoprotein L1-Associated Nephropathy in the FSGS Clinical Trial

(2015) J. B. Kopp et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Resetting the autoreactive immune system with a therapeutic peptide in lupus

(2015) N Schall et al.   LUPUS

Autophagy is activated in systemic lupus erythematosus and required for plasmablast development

(2014) Alexander J Clarke et al.   ANNALS OF THE RHEUMATIC DISEASES

Emerging View of Autophagy in Systemic Lupus Erythematosus

(2014) Xu-jie Zhou et al.   INTERNATIONAL REVIEWS OF IMMUNOLOGY

Autophagy in Antimicrobial Immunity

(2014) Ligia C. Gomes et al.   MOLECULAR CELL

Treatment of severe lupus nephritis: the new horizon

(2014) Tak Mao Chan   Nature Reviews Nephrology

Trehalose, an mTOR Independent Autophagy Inducer, Alleviates Human Podocyte Injury after Puromycin Aminonucleoside Treatment

(2014) Yu-Lin Kang et al.   PLoS One

The expression of renal Epstein-Barr virus markers in patients with lupus nephritis

(2014) XIAO-XIA YU et al.   Experimental and Therapeutic Medicine

Brief Report: Identification ofMTMR3as a Novel Susceptibility Gene for Lupus Nephritis in Northern Han Chinese by Shared-Gene Analysis With IgA Nephropathy

(2014) Xu-jie Zhou et al.   Arthritis & Rheumatology

Pivotal role for the mTOR pathway in the formation of neutrophil extracellular traps via regulation of autophagy

(2013) Asako Itakura et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Lupus Nephritis and End-stage Kidney Disease

(2013) Natallia Maroz et al.   AMERICAN JOURNAL OF THE MEDICAL SCIENCES

ATG5 regulates plasma cell differentiation

(2013) Kara L. Conway et al.   Autophagy

Apolipoprotein L1 Risk Variants Associate with Systemic Lupus Erythematosus-Associated Collapsing Glomerulopathy

(2013) C. P. Larsen et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

The Pathogenesis of Lupus Nephritis

(2013) M. Lech et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Plasma cells require autophagy for sustainable immunoglobulin production

(2013) Niccolò Pengo et al.   NATURE IMMUNOLOGY

The role of autophagy in neurodegenerative disease

(2013) Ralph A Nixon   NATURE MEDICINE

End-Stage Renal Disease in African Americans With Lupus Nephritis Is Associated WithAPOL1

(2013) Barry I. Freedman et al.   Arthritis & Rheumatology

Meta-analysis Followed by Replication Identifies Loci in or near CDKN1B, TET3, CD80, DRAM1, and ARID5B as Associated with Systemic Lupus Erythematosus in Asians

(2012) Wanling Yang et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Uptake of SLE autoantibodies by podocytes

(2012) Anja Hillmann et al.   ANNALS OF THE RHEUMATIC DISEASES

Autophagy and the Immune System

(2012) Petric Kuballa et al.   Annual Review of Immunology

Autophagy in immunity

(2012) Xu-Jie Zhou et al.   Autophagy

Macroautophagy is deregulated in murine and human lupus T lymphocytes

(2012) Frédéric Gros et al.   Autophagy

Epstein-Barr Virus and Systemic Lupus Erythematosus

(2012) Anette Holck Draborg et al.   Clinical & Developmental Immunology

Neutrophil Extracellular Traps That Are Not Degraded in Systemic Lupus Erythematosus Activate Complement Exacerbating the Disease

(2012) J. Leffler et al.   JOURNAL OF IMMUNOLOGY

Activation of autophagy by inflammatory signals limits IL-1β production by targeting ubiquitinated inflammasomes for destruction

(2012) Chong-Shan Shi et al.   NATURE IMMUNOLOGY

Proliferation signal inhibitors in the treatment of lupus nephritis: Preliminary experience

(2012) DESMOND YH YAP et al.   NEPHROLOGY

Low Dose Rapamycin Exacerbates Autoimmune Experimental Uveitis

(2012) Zili Zhang et al.   PLoS One

Genetic association of PRDM1-ATG5 intergenic region and autophagy with systemic lupus erythematosus in a Chinese population

(2011) X.-j. Zhou et al.   ANNALS OF THE RHEUMATIC DISEASES

Microautophagy in mammalian cells: Revisiting a 40-year-old conundrum

(2011) Dalibor Mijaljica et al.   Autophagy

Hydroxychloroquine: From Malaria to Autoimmunity

(2011) Ilan Ben-Zvi et al.   CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY

Autophagy and cytokines

(2011) James Harris   CYTOKINE

Systemic Lupus Erythematosus

(2011) George C. Tsokos   NEW ENGLAND JOURNAL OF MEDICINE

Systemic Lupus Erythematosus and the Neutrophil

(2011) Xavier Bosch   NEW ENGLAND JOURNAL OF MEDICINE

HSC70 blockade by the therapeutic peptide P140 affects autophagic processes and endogenous MHCII presentation in murine lupus

(2010) N. Page et al.   ANNALS OF THE RHEUMATIC DISEASES

Monocyte and Macrophage Abnormalities in Systemic Lupus Erythematosus

(2010) Yi Li et al.   ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS

Glucocorticoids downregulate Fyn and inhibit IP3-mediated calcium signaling to promote autophagy in T lymphocytes

(2010) Michael W. Harr et al.   Autophagy

The role of PI3P phosphatases in the regulation of autophagy

(2010) Isabelle Vergne et al.   FEBS LETTERS

Knockdown of autophagy enhances the innate immune response in hepatitis C virus-infected hepatocytes

(2010) Shubham Shrivastava et al.   HEPATOLOGY

Autophagy influences glomerular disease susceptibility and maintains podocyte homeostasis in aging mice

(2010) Björn Hartleben et al.   JOURNAL OF CLINICAL INVESTIGATION

The PI3K/Akt/mTOR pathway is activated in murine lupus nephritis and downregulated by rapamycin

(2010) Kostas Stylianou et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Nuclear location of an endogenously expressed antigen, EBNA1, restricts access to macroautophagy and the range of CD4 epitope display

(2010) C. S. Leung et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Impairment of neutrophil extracellular trap degradation is associated with lupus nephritis

(2010) A. Hakkim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Modulation of Local PtdIns3P Levels by the PI Phosphatase MTMR3 Regulates Constitutive Autophagy

(2010) Naoko Taguchi-Atarashi et al.   TRAFFIC

Regulation Mechanisms and Signaling Pathways of Autophagy

(2009) Congcong He et al.   Annual Review of Genetics

Aberrant Epstein–Barr viral infection in systemic lupus erythematosus

(2009) Brian D. Poole et al.   AUTOIMMUNITY REVIEWS

Exposure to maternal smoking and incident SLE in a prospective cohort study

(2009) JF Simard et al.   LUPUS

DNase 1 activity in patients with systemic lupus erythematosus: relationship with epidemiological, clinical, immunological and therapeutical features

(2009) F Martinez-Valle et al.   LUPUS

A large-scale replication study identifies TNIP1, PRDM1, JAZF1, UHRF1BP1 and IL10 as risk loci for systemic lupus erythematosus

(2009) Vesela Gateva et al.   NATURE GENETICS

Autophagy in the Pathogenesis of Disease

(2008) Beth Levine et al.   CELL

Apolipoprotein L1, a Novel Bcl-2 Homology Domain 3-only Lipid-binding Protein, Induces Autophagic Cell Death

(2008) Guanghua Wan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1β production

(2008) Tatsuya Saitoh et al.   NATURE

Autophagy fights disease through cellular self-digestion

(2008) Noboru Mizushima et al.   NATURE

Genome-wide association scan in women with systemic lupus erythematosus identifies susceptibility variants in ITGAM, PXK, KIAA1542 and other loci

(2008) John B Harley et al.   NATURE GENETICS

Rapamycin attenuates the severity of established nephritis in lupus-prone NZB/W F1 mice

(2008) S. L. Lui et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Mapping similarities in mTOR pathway perturbations in mouse lupus nephritis models and human lupus nephritis

(2008) Padmalatha S Reddy et al.   ARTHRITIS RESEARCH & THERAPY