The Cdk5-Mcl-1 axis promotes mitochondrial dysfunction and neurodegeneration in a model of Alzheimer's disease

TFP5, a Peptide Inhibitor of Aberrant and Hyperactive Cdk5/p25, Attenuates Pathological Phenotypes and Restores Synaptic Function in CK-p25Tg Mice

(2017) Varsha Shukla et al.   JOURNAL OF ALZHEIMERS DISEASE

Aurora A-Twist1 axis promotes highly aggressive phenotypes in pancreatic carcinoma

(2017) Jing Wang et al.   JOURNAL OF CELL SCIENCE

Tale of the Good and the Bad Cdk5: Remodeling of the Actin Cytoskeleton in the Brain

(2017) Kavita Shah et al.   MOLECULAR NEUROBIOLOGY

The role of myocardin-related transcription factor-A in Aβ 25–35 induced neuron apoptosis and synapse injury

(2016) Ying Zhang et al.   BRAIN RESEARCH

Cdk5–Foxo3 axis: initially neuroprotective, eventually neurodegenerative in Alzheimer's disease models

(2016) Chun Shi et al.   JOURNAL OF CELL SCIENCE

Targeted Epigenetic Remodeling of the Cdk5 Gene in Nucleus Accumbens Regulates Cocaine- and Stress-Evoked Behavior

(2016) E. A. Heller et al.   JOURNAL OF NEUROSCIENCE

A Tale of the Good and Bad: Remodeling of the Microtubule Network in the Brain by Cdk5

(2016) Kavita Shah et al.   MOLECULAR NEUROBIOLOGY

Cdk5 Modulates Long-Term Synaptic Plasticity and Motor Learning in Dorsolateral Striatum

(2016) Adan Hernandez et al.   Scientific Reports

Enhancement of BACE1 Activity by p25/Cdk5-Mediated Phosphorylation in Alzheimer’s Disease

(2015) Woo-Joo Song et al.   PLoS One

Phosphorylation of Cyclin-dependent Kinase 5 (Cdk5) at Tyr-15 Is Inhibited by Cdk5 Activators and Does Not Contribute to the Activation of Cdk5

(2014) Hiroyuki Kobayashi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cdk5 activity in the brain - multiple paths of regulation

(2014) K. Shah et al.   JOURNAL OF CELL SCIENCE

Ischemic Stroke Injury Is Mediated by Aberrant Cdk5

(2014) D. A. Meyer et al.   JOURNAL OF NEUROSCIENCE

Deregulated Cdk5 Activity Is Involved in Inducing Alzheimer’s Disease

(2012) Varsha Shukla et al.   ARCHIVES OF MEDICAL RESEARCH

Chronic Excitotoxin-Induced Axon Degeneration in a Compartmented Neuronal Culture Model

(2012) Katherine A Hosie et al.   ASN Neuro

Trim17-mediated ubiquitination and degradation of Mcl-1 initiate apoptosis in neurons

(2012) M M Magiera et al.   CELL DEATH AND DIFFERENTIATION

LIMK2 is a crucial regulator and effector of Aurora-A-kinase-mediated malignancy

(2012) E. O. Johnson et al.   JOURNAL OF CELL SCIENCE

Deregulated Cdk5 triggers aberrant activation of cell cycle kinases and phosphatases inducing neuronal death

(2012) K.-H. Chang et al.   JOURNAL OF CELL SCIENCE

AMP-activated protein kinase (AMPK)-induced preconditioning in primary cortical neurons involves activation of MCL-1

(2012) Ujval Anilkumar et al.   JOURNAL OF NEUROCHEMISTRY

Interplay between MEK-ERK signaling, cyclin D1, and cyclin-dependent kinase 5 regulates cell cycle reentry and apoptosis of neurons

(2012) Prashant Kumar Modi et al.   MOLECULAR BIOLOGY OF THE CELL

Mitochondrial membrane potential probes and the proton gradient: a practical usage guide

(2011) Seth W. Perry et al.   BIOTECHNIQUES

Schizophrenia is associated with dysregulation of a Cdk5 activator that regulates synaptic protein expression and cognition

(2011) Olivia Engmann et al.   BRAIN

Cyclin E Constrains Cdk5 Activity to Regulate Synaptic Plasticity and Memory Formation

(2011) Junko Odajima et al.   DEVELOPMENTAL CELL

PHLDA1 is a crucial negative regulator and effector of Aurora A kinase in breast cancer

(2011) E. O. Johnson et al.   JOURNAL OF CELL SCIENCE

Glutathione-S-transferase P1 is a critical regulator of Cdk5 kinase activity

(2011) Kai-Hui Sun et al.   JOURNAL OF NEUROCHEMISTRY

Nuclear envelope dispersion triggered by deregulated Cdk5 precedes neuronal death

(2011) Kuei-Hua Chang et al.   MOLECULAR BIOLOGY OF THE CELL

Attention-Deficit/Hyperactivity Phenotype in Mice Lacking the Cyclin-Dependent Kinase 5 Cofactor p35

(2010) Justin M. Drerup et al.   BIOLOGICAL PSYCHIATRY

Cyclin I-Cdk5 governs survival in post-mitotic cells

(2010) Paul T. Brinkkoetter et al.   CELL CYCLE

Mcl-1; the molecular regulation of protein function

(2010) Luke W. Thomas et al.   FEBS LETTERS

Cdk5 is a major regulator of p38 cascade: relevance to neurotoxicity in Alzheimer’s disease

(2010) Kuei-Hua Chang et al.   JOURNAL OF NEUROCHEMISTRY

Regulation and role of cyclin-dependent kinase activity in neuronal survival and death

(2010) Shin-ichi Hisanaga et al.   JOURNAL OF NEUROCHEMISTRY

MCL-1ES, a novel variant of MCL-1, associates with MCL-1L and induces mitochondrial cell death

(2009) Jae-Hong Kim et al.   FEBS LETTERS

Mcl-1 Integrates the Opposing Actions of Signaling Pathways That Mediate Survival and Apoptosis

(2009) C. Morel et al.   MOLECULAR AND CELLULAR BIOLOGY

Direct and Indirect Roles of Cyclin-dependent Kinase 5 as an Upstream Regulator in the c-Jun NH2-Terminal Kinase Cascade: Relevance to Neurotoxic Insults in Alzheimer's Disease

(2009) Kai-Hui Sun et al.   MOLECULAR BIOLOGY OF THE CELL

Deregulated Cdk5 promotes oxidative stress and mitochondrial dysfunction

(2008) Kai-Hui Sun et al.   JOURNAL OF NEUROCHEMISTRY

Mcl-1 Is a Key Regulator of Apoptosis during CNS Development and after DNA Damage

(2008) N. Arbour et al.   JOURNAL OF NEUROSCIENCE

Novel Genetic Tools Reveal Cdk5's Major Role in Golgi Fragmentation in Alzheimer's Disease

(2008) Kai-Hui Sun et al.   MOLECULAR BIOLOGY OF THE CELL

Transcriptional Regulation of β-Secretase by p25/cdk5 Leads to Enhanced Amyloidogenic Processing

(2008) Yi Wen et al.   NEURON