Schizophrenia is associated with dysregulation of a Cdk5 activator that regulates synaptic protein expression and cognition

Optineurin inclusions occur in a minority of TDP-43 positive ALS and FTLD-TDP cases and are rarely observed in other neurodegenerative disorders

(2011) Tibor Hortobágyi et al.   ACTA NEUROPATHOLOGICA

Cyclin-Dependent Kinase 5 Activator p25 Is Generated During Memory Formation and Is Reduced at an Early Stage in Alzheimer's Disease

(2011) Olivia Engmann et al.   BIOLOGICAL PSYCHIATRY

Epigenetic Status of Gdnf in the Ventral Striatum Determines Susceptibility and Adaptation to Daily Stressful Events

(2011) Shusaku Uchida et al.   NEURON

Altered Cortical CDC42 Signaling Pathways in Schizophrenia: Implications for Dendritic Spine Deficits

(2010) Masayuki Ide et al.   BIOLOGICAL PSYCHIATRY

Nuclear import impairment causes cytoplasmic trans-activation response DNA-binding protein accumulation and is associated with frontotemporal lobar degeneration

(2010) Agnes L. Nishimura et al.   BRAIN

Homer-1 polymorphisms are associated with psychopathology and response to treatment in schizophrenic patients

(2010) Ilja Spellmann et al.   JOURNAL OF PSYCHIATRIC RESEARCH

Dixdc1 Is a Critical Regulator of DISC1 and Embryonic Cortical Development

(2010) Karun K. Singh et al.   NEURON

No difference in kinetics of tau or histone phosphorylation by CDK5/p25 versus CDK5/p35 in vitro

(2010) D. W. Peterson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Towards a molecular understanding of sex differences in memory formation

(2010) Keiko Mizuno et al.   TRENDS IN NEUROSCIENCES

Mitochondria in the striatum of subjects with schizophrenia

(2010) Shahza M. Somerville et al.   WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY

Recent advances in understanding the roles of Cdk5 in synaptic plasticity

(2009) Kwok-On Lai et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Molecular mechanisms underlying glutamatergic dysfunction in schizophrenia: therapeutic implications

(2009) Pablo A. Gaspar et al.   JOURNAL OF NEUROCHEMISTRY

Schizophrenia

(2009) Jim van Os et al.   LANCET

HDAC2 negatively regulates memory formation and synaptic plasticity

(2009) Ji-Song Guan et al.   NATURE

TDP-43 is consistently co-localized with ubiquitinated inclusions in sporadic and Guam amyotrophic lateral sclerosis but not in familial amyotrophic lateral sclerosis with and without SOD1 mutations

(2009) Satomi Maekawa et al.   NEUROPATHOLOGY

Regulation of Hippocampal and Behavioral Excitability by Cyclin-Dependent Kinase 5

(2009) Ammar H. Hawasli et al.   PLoS One

Modeling cognitive endophenotypes of schizophrenia in mice

(2009) Christoph Kellendonk et al.   TRENDS IN NEUROSCIENCES

Type III Neuregulin-1 Is Required for Normal Sensorimotor Gating, Memory-Related Behaviors, and Corticostriatal Circuit Components

(2008) Y.-J. J. Chen et al.   JOURNAL OF NEUROSCIENCE

Interplay between Cyclin-Dependent Kinase 5 and Glycogen Synthase Kinase 3  Mediated by Neuregulin Signaling Leads to Differential Effects on Tau Phosphorylation and Amyloid Precursor Protein Processing

(2008) Y. Wen et al.   JOURNAL OF NEUROSCIENCE

A comparison of the synaptic proteome in human chronic schizophrenia and rat ketamine psychosis suggest that prohibitin is involved in the synaptic pathology of schizophrenia

(2008) K-H Smalla et al.   MOLECULAR PSYCHIATRY

Deregulation of HDAC1 by p25/Cdk5 in Neurotoxicity

(2008) Dohoon Kim et al.   NEURON

Striatal dysregulation of Cdk5 alters locomotor responses to cocaine, motor learning, and dendritic morphology

(2008) D. A. Meyer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

DNA methylation and histone acetylation work in concert to regulate memory formation and synaptic plasticity

(2007) Courtney A. Miller et al.   NEUROBIOLOGY OF LEARNING AND MEMORY