A Tale of the Good and Bad: Remodeling of the Microtubule Network in the Brain by Cdk5

The Pathophysiology of Axonal Transport in Alzheimer's Disease

(2018) Elena Vicario-Orri et al.   JOURNAL OF ALZHEIMERS DISEASE

Phosphorylation of TRPV1 by cyclin-dependent kinase 5 promotes TRPV1 surface localization, leading to inflammatory thermal hyperalgesia

(2015) Jiao Liu et al.   EXPERIMENTAL NEUROLOGY

Effects of kinesin-5 inhibition on dendritic architecture and microtubule organization

(2015) Olga I. Kahn et al.   MOLECULAR BIOLOGY OF THE CELL

Phosphorylation of Cyclin-dependent Kinase 5 (Cdk5) at Tyr-15 Is Inhibited by Cdk5 Activators and Does Not Contribute to the Activation of Cdk5

(2014) Hiroyuki Kobayashi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cdk5 activity in the brain - multiple paths of regulation

(2014) K. Shah et al.   JOURNAL OF CELL SCIENCE

Ischemic Stroke Injury Is Mediated by Aberrant Cdk5

(2014) D. A. Meyer et al.   JOURNAL OF NEUROSCIENCE

Alzheimer amyloid beta inhibition of Eg5/kinesin 5 reduces neurotrophin and/or transmitter receptor function

(2014) Csilla Ari et al.   NEUROBIOLOGY OF AGING

Infantile postnatal exposure to lead (Pb) enhances tau expression in the cerebral cortex of aged mice: Relevance to AD

(2014) Syed Waseem Bihaqi et al.   NEUROTOXICOLOGY

Phosphorylation of Drebrin by Cyclin-Dependent Kinase 5 and Its Role in Neuronal Migration

(2014) Kazuya Tanabe et al.   PLoS One

CDK5 activator protein p25 preferentially binds and activates GSK3β

(2014) Hei-Man Chow et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Learning-induced and stathmin-dependent changes in microtubule stability are critical for memory and disrupted in ageing

(2014) Shusaku Uchida et al.   Nature Communications

Cdk5 Phosphorylation of ErbB4 is Required for Tangential Migration of Cortical Interneurons

(2013) Sonja Rakić et al.   CEREBRAL CORTEX

Loss of c-Jun N-terminal kinase-interacting protein-1 does not affect axonal transport of the amyloid precursor protein or Aβ production

(2013) Alessio Vagnoni et al.   HUMAN MOLECULAR GENETICS

Drebrin contains a cryptic F-actin–bundling activity regulated by Cdk5 phosphorylation

(2013) Daniel C. Worth et al.   JOURNAL OF CELL BIOLOGY

Synaptic Regulation of Microtubule Dynamics in Dendritic Spines by Calcium, F-Actin, and Drebrin

(2013) E. B. Merriam et al.   JOURNAL OF NEUROSCIENCE

Enhanced Recruitment of Endosomal Na+/H+ Exchanger NHE6 into Dendritic Spines of Hippocampal Pyramidal Neurons during NMDA Receptor-Dependent Long-Term Potentiation

(2013) E. C. Deane et al.   JOURNAL OF NEUROSCIENCE

Mice lacking collapsin response mediator protein 1 manifest hyperactivity, impaired learning and memory, and impaired prepulse inhibition

(2013) Naoya Yamashita et al.   Frontiers in Behavioral Neuroscience

Deregulated Cdk5 Activity Is Involved in Inducing Alzheimer’s Disease

(2012) Varsha Shukla et al.   ARCHIVES OF MEDICAL RESEARCH

Phosphorylation of CRMP2 is involved in proper bifurcation of the apical dendrite of hippocampal CA1 pyramidal neurons

(2012) Emi Niisato et al.   Developmental Neurobiology

Deregulated Cdk5 triggers aberrant activation of cell cycle kinases and phosphatases inducing neuronal death

(2012) K.-H. Chang et al.   JOURNAL OF CELL SCIENCE

Neurofilaments at a glance

(2012) A. Yuan et al.   JOURNAL OF CELL SCIENCE

Regulation of Mitochondrial Transport and Inter-Microtubule Spacing by Tau Phosphorylation at the Sites Hyperphosphorylated in Alzheimer's Disease

(2012) K. Shahpasand et al.   JOURNAL OF NEUROSCIENCE

Phosphorylation of CRMP2 (Collapsin Response Mediator Protein 2) Is Involved in Proper Dendritic Field Organization

(2012) N. Yamashita et al.   JOURNAL OF NEUROSCIENCE

Cyclin-Dependent Kinase 5 Controls TRPV1 Membrane Trafficking and the Heat Sensitivity of Nociceptors through KIF13B

(2012) B.-M. Xing et al.   JOURNAL OF NEUROSCIENCE

Activation of Aurora-A Is Essential for Neuronal Migration via Modulation of Microtubule Organization

(2012) T. Takitoh et al.   JOURNAL OF NEUROSCIENCE

Drebrin controls neuronal migration through the formation and alignment of the leading process

(2012) Xin-peng Dun et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Interplay between MEK-ERK signaling, cyclin D1, and cyclin-dependent kinase 5 regulates cell cycle reentry and apoptosis of neurons

(2012) Prashant Kumar Modi et al.   MOLECULAR BIOLOGY OF THE CELL

Cyclin-Dependent Kinases in Brain Development and Disease

(2011) Susan C. Su et al.   Annual Review of Cell and Developmental Biology

Schizophrenia is associated with dysregulation of a Cdk5 activator that regulates synaptic protein expression and cognition

(2011) Olivia Engmann et al.   BRAIN

Cyclin E Constrains Cdk5 Activity to Regulate Synaptic Plasticity and Memory Formation

(2011) Junko Odajima et al.   DEVELOPMENTAL CELL

Glutathione-S-transferase P1 is a critical regulator of Cdk5 kinase activity

(2011) Kai-Hui Sun et al.   JOURNAL OF NEUROCHEMISTRY

BDNF-Induced Increase of PSD-95 in Dendritic Spines Requires Dynamic Microtubule Invasions

(2011) X. Hu et al.   JOURNAL OF NEUROSCIENCE

Cdk5-Mediated Phosphorylation of Axin Directs Axon Formation during Cerebral Cortex Development

(2011) W.-Q. Fang et al.   JOURNAL OF NEUROSCIENCE

A Cdk5-Dependent Switch Regulates Lis1/Ndel1/Dynein-Driven Organelle Transport in Adult Axons

(2011) J. P. Pandey et al.   JOURNAL OF NEUROSCIENCE

Regulation of the cytoskeleton by Disrupted-in-Schizophrenia 1 (DISC1)

(2011) Qi Wang et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Nuclear envelope dispersion triggered by deregulated Cdk5 precedes neuronal death

(2011) Kuei-Hua Chang et al.   MOLECULAR BIOLOGY OF THE CELL

Collapsin Response Mediator Protein-2: An Emerging Pathologic Feature and Therapeutic Target for Neurodisease Indications

(2011) Kenneth Hensley et al.   MOLECULAR NEUROBIOLOGY

DISC1-dependent switch from progenitor proliferation to migration in the developing cortex

(2011) Koko Ishizuka et al.   NATURE

α2-chimaerin controls neuronal migration and functioning of the cerebral cortex through CRMP-2

(2011) Jacque P K Ip et al.   NATURE NEUROSCIENCE

S-Nitrosylation activates Cdk5 and contributes to synaptic spine loss induced by  -amyloid peptide

(2011) J. Qu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Attention-Deficit/Hyperactivity Phenotype in Mice Lacking the Cyclin-Dependent Kinase 5 Cofactor p35

(2010) Justin M. Drerup et al.   BIOLOGICAL PSYCHIATRY

Cyclin I-Cdk5 governs survival in post-mitotic cells

(2010) Paul T. Brinkkoetter et al.   CELL CYCLE

The neuroprotective effects of cyclin-dependent kinase-5 inhibition in mice with Niemann-Pick disease type C

(2010) Youguo Hao et al.   Journal of Huazhong University of Science and Technology-Medical Sciences

Cdk5 is a major regulator of p38 cascade: relevance to neurotoxicity in Alzheimer’s disease

(2010) Kuei-Hua Chang et al.   JOURNAL OF NEUROCHEMISTRY

Regulation and role of cyclin-dependent kinase activity in neuronal survival and death

(2010) Shin-ichi Hisanaga et al.   JOURNAL OF NEUROCHEMISTRY

Dixdc1 Is a Critical Regulator of DISC1 and Embryonic Cortical Development

(2010) Karun K. Singh et al.   NEURON

Molecular Motors in Neurons: Transport Mechanisms and Roles in Brain Function, Development, and Disease

(2010) Nobutaka Hirokawa et al.   NEURON

Glycogen synthase kinase-3β and the p25 activator of cyclin dependent kinase 5 increase pausing of mitochondria in neurons

(2010) M. Morel et al.   NEUROSCIENCE

An Atypical Role for Collapsin Response Mediator Protein 2 (CRMP-2) in Neurotransmitter Release via Interaction with Presynaptic Voltage-gated Calcium Channels

(2009) Joel M. Brittain et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Activated Actin-Depolymerizing Factor/Cofilin Sequesters Phosphorylated Microtubule-Associated Protein during the Assembly of Alzheimer-Like Neuritic Cytoskeletal Striations

(2009) I. T. Whiteman et al.   JOURNAL OF NEUROSCIENCE

The microtubule network and neuronal morphogenesis: Dynamic and coordinated orchestration through multiple players

(2009) Fabienne E. Poulain et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Direct and Indirect Roles of Cyclin-dependent Kinase 5 as an Upstream Regulator in the c-Jun NH2-Terminal Kinase Cascade: Relevance to Neurotoxic Insults in Alzheimer's Disease

(2009) Kai-Hui Sun et al.   MOLECULAR BIOLOGY OF THE CELL

The LEARn model: an epigenetic explanation for idiopathic neurobiological diseases

(2009) D K Lahiri et al.   MOLECULAR PSYCHIATRY

Dynamic Microtubules Regulate Dendritic Spine Morphology and Synaptic Plasticity

(2009) Jacek Jaworski et al.   NEURON

Balancing Structure and Function at Hippocampal Dendritic Spines

(2008) Jennifer N Bourne et al.   Annual Review of Neuroscience

Calmodulin Binding and Cdk5 Phosphorylation of p35 Regulate Its Effect on Microtubules

(2008) Lisheng He et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Myristoylation of p39 and p35 is a determinant of cytoplasmic or nuclear localization of active cycline-dependent kinase 5 complexes

(2008) Akiko Asada et al.   JOURNAL OF NEUROCHEMISTRY

Deregulated Cdk5 promotes oxidative stress and mitochondrial dysfunction

(2008) Kai-Hui Sun et al.   JOURNAL OF NEUROCHEMISTRY

Suppression of Mutant Huntingtin Aggregate Formation by Cdk5/p35 through the Effect on Microtubule Stability

(2008) S. Kaminosono et al.   JOURNAL OF NEUROSCIENCE

Dopaminergic and Glutamatergic Signaling Crosstalk in Huntington's Disease Neurodegeneration: The Role of p25/Cyclin-Dependent Kinase 5

(2008) P. Paoletti et al.   JOURNAL OF NEUROSCIENCE

Novel Genetic Tools Reveal Cdk5's Major Role in Golgi Fragmentation in Alzheimer's Disease

(2008) Kai-Hui Sun et al.   MOLECULAR BIOLOGY OF THE CELL

Targeting of the F-actin-binding protein drebrin by the microtubule plus-tip protein EB3 is required for neuritogenesis

(2008) Sara Geraldo et al.   NATURE CELL BIOLOGY

Striatal dysregulation of Cdk5 alters locomotor responses to cocaine, motor learning, and dendritic morphology

(2008) D. A. Meyer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA