The Hsp70/90 cochaperone, Sti1, suppresses proteotoxicity by regulating spatial quality control of amyloid-like proteins

Ubiquitin conjugation triggers misfolded protein sequestration into quality control foci when Hsp70 chaperone levels are limiting

(2013) Ayala Shiber et al.   MOLECULAR BIOLOGY OF THE CELL

The Type II Hsp40 Sis1 Cooperates with Hsp70 and the E3 Ligase Ubr1 to Promote Degradation of Terminally Misfolded Cytosolic Protein

(2013) Daniel W. Summers et al.   PLoS One

Heat shock protein (Hsp) 70 is an activator of the Hsp104 motor

(2013) J. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An intrinsically disordered yeast prion arrests the cell cycle by sequestering a spindle pole body component

(2012) Sebastian Treusch et al.   JOURNAL OF CELL BIOLOGY

Proteomic Analysis Identifies Dysfunction in Cellular Transport, Energy, and Protein Metabolism in Different Brain Regions of Atypical Frontotemporal Lobar Degeneration

(2012) Daniel Martins-de-Souza et al.   JOURNAL OF PROTEOME RESEARCH

Molecular chaperones and stress-inducible protein-sorting factors coordinate the spatiotemporal distribution of protein aggregates

(2012) Liliana Malinovska et al.   MOLECULAR BIOLOGY OF THE CELL

An anatomically comprehensive atlas of the adult human brain transcriptome

(2012) Michael J. Hawrylycz et al.   NATURE

C-terminal phosphorylation of Hsp70 and Hsp90 regulates alternate binding to co-chaperones CHIP and HOP to determine cellular protein folding/degradation balances

(2012) P Muller et al.   ONCOGENE

Compartmentalization of superoxide dismutase 1 (SOD1G93A) aggregates determines their toxicity

(2012) S. J. Weisberg et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Amyloid-like Aggregates Sequester Numerous Metastable Proteins with Essential Cellular Functions

(2011) Heidi Olzscha et al.   CELL

Amyloid deposits: Protection against toxic protein species?

(2011) Sebastian Treusch et al.   CELL CYCLE

BAG3 mediates chaperone-based aggresome-targeting and selective autophagy of misfolded proteins

(2011) Martin Gamerdinger et al.   EMBO REPORTS

Hsp42 is required for sequestration of protein aggregates into deposition sites inSaccharomyces cerevisiae

(2011) Sebastian Specht et al.   JOURNAL OF CELL BIOLOGY

Islet amyloid polypeptide demonstrates a persistent capacity to disrupt membrane integrity

(2011) N. B. Last et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Amyloid in neurodegenerative diseases: Friend or foe?

(2011) Katie J. Wolfe et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Sti1 Regulation of Hsp70 and Hsp90 Is Critical for Curing of Saccharomyces cerevisiae [PSI+] Prions by Hsp104

(2010) M. Reidy et al.   MOLECULAR AND CELLULAR BIOLOGY

Cellular strategies for controlling protein aggregation

(2010) Jens Tyedmers et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Mixed Hsp90–cochaperone complexes are important for the progression of the reaction cycle

(2010) Jing Li et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Prion protein interaction with stress-inducible protein 1 enhances neuronal protein synthesis via mTOR

(2010) M. Roffe et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Prion induction involves an ancient system for the sequestration of aggregated proteins and heritable changes in prion fragmentation

(2010) J. Tyedmers et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Thioflavine T interaction with synthetic Alzheimer's disease β-amyloid peptides: Detection of amyloid aggregation in solution

(2010) Harry Levine   PROTEIN SCIENCE

Reciprocal Efficiency of RNQ1 and Polyglutamine Detoxification in the Cytosol and Nucleus

(2009) Peter M. Douglas et al.   MOLECULAR BIOLOGY OF THE CELL

Abnormal proteins can form aggresome in yeast: aggresome-targeting signals and components of the machinery

(2008) Yan Wang et al.   FASEB JOURNAL

The Type I Hsp40 Ydj1 Utilizes a Farnesyl Moiety and Zinc Finger-like Region to Suppress Prion Toxicity

(2008) Daniel W. Summers et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

In Vivo Monitoring of the Prion Replication Cycle Reveals a Critical Role for Sis1 in Delivering Substrates to Hsp104

(2008) Kimberly A. Tipton et al.   MOLECULAR CELL

Misfolded proteins partition between two distinct quality control compartments

(2008) Daniel Kaganovich et al.   NATURE

HSP90/70 chaperones are required for rapid nucleosome removal upon induction of the GAL genes of yeast

(2008) M. Floer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Chaperone-dependent amyloid assembly protects cells from prion toxicity

(2008) P. M. Douglas et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA