Review
Oncology
Tingyu Shi, Jun Zhu, Xiang Zhang, Xinggang Mao
Summary: Glioblastoma multiforme (GBM) is a highly malignant brain tumor characterized by a small population of glioblastoma stem-like cells (GSCs) that possess self-renewal, proliferative, invasive, and tumorigenic capabilities, leading to radio- and chemoresistance. Hypoxia inducible factors (HIFs) play a crucial role in the maintenance and progression of GSCs. This review summarizes the roles of hypoxia-associated GSCs in GBM development, including hypoxia-induced signatures, genes, pathways, and metabolic alterations. The concept of the hypoxic peri-arteriolar niche of GSCs is discussed. Autophagy and potential causes of therapeutic resistance in GBM are explored, along with chemotherapeutic agents to enhance the effectiveness of chemo-, radio-, or immunotherapy. Hyperbaric oxygen therapy (HBOT) is proposed as an adjuvant therapy to reverse the hypoxic microenvironment in GBM. Overall, understanding the intricate interactions between hypoxia and GSCs can lead to the development of novel therapeutic strategies to improve GBM patient survival.
Article
Oncology
Kun Cao, Yuanyuan Chen, Songyun Zhao, Yijuan Huang, Tingting Liu, Hu Liu, Bailong Li, Jianguo Cui, Jianming Cai, Chong Bai, Yanyong Yang, Fu Gao
Summary: This study revealed the significant role of Sirt3 in radioresistance of NSCLC, with knockdown of Sirt3 increasing cellular sensitivity to radiation while overexpression promoting resistance. Additionally, Sirt3 was found to play a critical role in the activation of the ATM-Chk2 pathway.
Article
Biochemistry & Molecular Biology
Jyh-Der Leu, Shih-Ting Lin, Chiung-Tong Chen, C-Allen Chang, Yi-Jang Lee
Summary: BPR0C261 demonstrates dose-dependent cytotoxicity on A549 and H1299 cells, inducing maximum G2/M phase arrest and apoptosis in both cell lines. The combination of low concentration of BPR0C261 and X-rays shows a synergistic radiosensitizing effect on NSCLC cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Oncology
Ting Jiang, Jinfeng Chen, Zhenzhen Wang, Xiaofei Wang, Jun Ma, Fei Zhao, Chen Huang, Yanke Chen
Summary: In this study, the functional roles and target genes of miR-4796 and miR-1287 in breast cancer cells in response to radiation were investigated. It was found that miR-4796 can enhance radiation-induced cell death by targeting multiple DNA damage response and repair components, and repress NHEJ and HR DNA repair pathways. miR-4796 can act as an effective radiation sensitising agent.
Article
Biochemistry & Molecular Biology
Giulia Miglietta, Marco Russo, Renee C. Duardo, Giovanni Capranico
Summary: The study found that two unrelated G4 ligands can significantly activate innate immune genes at non-cytotoxic concentrations, triggering the activation of cytoplasmic STING signaling pathway and leading to an increase in micronuclei. Ligand activity can also induce type I interferon production and activation of innate immune genes.
NUCLEIC ACIDS RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Magdalena Zdrowowicz, Paulina Spisz, Aleksandra Hac, Anna Herman-Antosiewicz, Janusz Rak
Summary: This study found that breast and prostate cancer cells are more sensitive to the radiosensitizer 5-bromo-2'-deoxyuridine (BrdU) in a hypoxic environment. BrdU can more effectively induce double-strand breaks in cancer cells under hypoxia, thereby increasing sensitivity to radiotherapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Yingming Sun, Xiaoge Sun, Chengcheng You, Shijing Ma, Yuan Luo, Shan Peng, Fang Tang, Xiaoli Tian, Feng Wang, Zhengrong Huang, Hongnv Yu, Yu Xiao, Xiaoyong Wang, Junhong Zhang, Yan Gong, Conghua Xie
Summary: MUC3A is highly expressed in non-small cell lung cancer (NSCLC) and associated with poor prognosis, advanced staging, and low differentiation. Knockdown of MUC3A suppresses tumor growth and DNA damage repair pathways, suggesting it may be a potential oncogene.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Plant Sciences
Jiamin Li, Junzhen Zhou, Na Zhao, Zhendong Li, Xinwen Xu, Jingjing Tang, Ziyu Li, Xiaoying Zhang, Yuerui Wu, Qiang Li, Qing Zhang, Jianwei Jiang
Summary: This study demonstrated that the combination of EM-2 and EPI enhances therapeutic efficacy against MDA-MB-231, SKBR3, and EPI-resistant cells by inhibiting autophagy, inducing endoplasmic reticulum stress, and triggering DNA damage-mediated apoptosis. The combination treatment also showed a smaller breast cancer xenograft volume in vivo. These findings provide an experimental basis for the treatment of human breast cancer.
Article
Anatomy & Morphology
Wen Wang, Xiao-gan Jiang, Ya-ping Bai, Heng Li, Ling-xi Gao, Teng Zhang, Fang-yi Dong, Wen-ping Ding, Yan Zhang
Summary: Vanadium, a transition metal, naturally occurs in the environment and has various biological and physiological impacts on humans. Sodium orthovanadate (SOV), a well-known vanadium compound, has shown significant anti-cancer activity in different types of human malignancies. However, the effect of SOV on stomach cancer and its association with radiosensitivity have not been determined. Our study investigated the ability of SOV to increase the sensitivity of gastric cancer cells to radiation. Both in vitro and in vivo experiments demonstrated that SOV reduced the growth of stomach cancer cells and improved their radiosensitivity, potentially making it a promising agent for radiosensitizing gastric cancer.
Article
Medicine, Research & Experimental
Debasish Mohapatra, Biswajit Das, Voddu Suresh, Deepti Parida, Aliva Prity Minz, Usharani Nayak, Amlan Priyadarshee Mohapatra, Rajeeb K. Swain, Shantibhusan Senapati
Summary: Fluvastatin has the potential to sensitize pancreatic cancer cells to radiation and suppress intra-tumor radiation-induced fibrosis, suggesting it may be an effective therapeutic approach against PC when combined with radiation therapy.
LABORATORY INVESTIGATION
(2022)
Review
Oncology
Plabon Kumar Das, Farhadul Islam, Robert A. Smith, Alfred K. Lam
Summary: Cancer stem cells play a key role in esophageal cancer initiation, progression, and therapy resistance. Targeting signaling pathways, miRNA expression profiles, and hypoxia factors could provide effective therapeutic options against esophageal CSCs. Further research is needed to validate these strategies and potential therapeutic targets.
FRONTIERS IN ONCOLOGY
(2021)
Article
Cell Biology
Antje Guettler, Claus Weinholdt, Elisabeth Ruff, Judith Reidt, Elisa Darnstaedt, Alicia Wildemann, Marina Petrenko, Jacqueline Kessler, Matthias Kappler, Ivo Grosse, Dirk Vordermark, Matthias Bache
Summary: Betulinic acid (BA) is a natural compound with various beneficial effects, including anti-inflammatory, anti-viral, anti-bacterial, anti-malarial, and anti-tumor properties. In human breast cancer cells, BA exhibits enhanced cytotoxicity and radiosensitization under hypoxic conditions, potentially through the regulation of the p53 pathway.
Review
Genetics & Heredity
Liem Minh Phan, Abdol-Hossein Rezaeian
Summary: ATM is a critical initiator and coordinator of the DNA-damage response, regulating important cellular processes. Despite being considered a major tumor suppressor, increased ATM signaling in some cancer cells provides significant advantages for cancer cell survival.
Article
Biochemistry & Molecular Biology
Kai-Xuan Wang, Chen Yan, Xu Yang, Pei-Yan Zhu, Wen-Wen Cui, Cong Ye, Kan Hu, Ting Lan, Lin-Yan Huang, Wan Wang, Ping Ma, Su-Hua Qi, Bing Gu, Lan Luo
Summary: In this study, we found that autophagy-mediated Sirt1 downregulation may be a promising therapeutic target for prostate cancer.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Biology
Xiangli Ma, Guangmin Mao, Rulve Chang, Fang Wang, Xiangyan Zhang, Zhaolu Kong
Summary: Long-term fractionated irradiation is an effective method to establish the ARR-phenotype bladder cancer cell model, by enriching bladder cancer stem cells (BCSCs) and enhancing cells migration and invasion. Inhibiting the expression of autophagy-related proteins and using autophagy inhibitor can increase the sensitivity of ARR cells to taxol, indicating the potential important role of autophagy in chemical tolerance of ARR cells.
INTERNATIONAL JOURNAL OF RADIATION BIOLOGY
(2021)
Review
Medicine, General & Internal
Minghai Shao, Chi Zhang, Qin Qin, Zhaoyue Zhang, Hongcheng Zhu, Xiaoke Di, Xinchen Sun
Article
Oncology
Hua Min, Xiangdong Sun, Xi Yang, Hongcheng Zhu, Jia Liu, Yuandong Wang, Guangzong Chen, Xinchen Sun
PATHOLOGY & ONCOLOGY RESEARCH
(2018)
Article
Oncology
Tianli He, Jiayou Guo, Hongmei Song, Hongcheng Zhu, Xiaoke Di, Hua Min, Yuandong Wang, Guangzong Chen, Wangshu Dai, Jianhua Ma, Xinchen Sun, Jianxin Ma
PATHOLOGY & ONCOLOGY RESEARCH
(2018)
Article
Oncology
Hongcheng Zhu, Hongmei Song, Guangzong Chen, Xi Yang, Jia Liu, Yangyang Ge, Jing Lu, Qin Qin, Chi Zhang, Liping Xu, Xiaoke Di, Jing Cai, Jianxin Ma, Shu Zhang, Xinchen Sun
RADIOTHERAPY AND ONCOLOGY
(2017)
Article
Oncology
Guang-Zong Chen, Wang-Shu Dai, Hong-Cheng Zhu, Hong-Mei Song, Xi Yang, Yuan-Dong Wang, Hua Min, Qian Lu, Shu Liu, Xin-Chen Sun, Xiao-Ning Zeng
Article
Oncology
Gang Wu, Guangzong Chen, Jialiang Zhou, Hongcheng Zhu, Jianjun Chu, Fuzheng Zhang
Article
Genetics & Heredity
Yixuan Zhang, Hui Chen, Hongcheng Zhu, Xinchen Sun
Article
Oncology
Hui Chen, Xijuan Yao, Xiaoke Di, Yixuan Zhang, Hongcheng Zhu, Shu Liu, Tingting Chen, Dingyue Yu, Xinchen Sun
Article
Oncology
Hongcheng Zhu, Eleonor Rivin del Campo, Jinjun Ye, Charles B. Simone, Zhengfei Zhu, Weixin Zhao, Arya Amini, Jialiang Zhou, Chaoyang Wu, Huarong Tang, Min Fan, Ling Li, Qin Lin, Yi Xia, Yunhai Li, Jiancheng Li, Miao Mo, Huixun Jia, Saiquan Lu, Juanqi Wang, Yongzhan Nie, Junqiang Chen, Shixiu Wu, Masatsugu Hamaji, Waqar Haque, Bae Kwon Jeong, Ravi Shridhar, Zhen Zhang, Yun Chen, Kuaile Zhao
Summary: Involved-field irradiation in definitive chemoradiation therapy for locoregional esophageal squamous cell carcinoma can achieve low rates of nodal failure and satisfactory survival outcomes. The use of elective nodal irradiation may be unnecessary for this patient population.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2021)
Review
Oncology
Hongcheng Zhu, Xiao Ma, Ting Ye, Honggang Wang, Zezhou Wang, Qi Liu, Kuaile Zhao
Summary: China, as one of the largest developing countries with a fifth of the global population, is facing an increasing burden of cancer, particularly esophageal cancer (EC). This review outlines the existing control measures for EC in China, including epidemiology, diagnosis, treatment, and research, and emphasizes the need for international cooperation to improve prevention and clinical outcomes.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Article
Oncology
Hongcheng Zhu, Zezhou Wang, Bingbin Deng, Miao Mo, Honggang Wang, Ke Chen, Haoxuan Wu, Ting Ye, Boyan Wang, Dashan Ai, Shennan Hao, Ihsuan Tseng, Kuaile Zhao
Summary: Asia has a significantly high burden of esophageal cancer, with 79.7% and 79.8% of global new cases and deaths occurring in the region in 2020. The predicted number of new cases in Asia is expected to reach 781,000 by 2040, with a significant increase in incidence and mortality rates. It is crucial to prioritize strategies targeting high-incidence areas, the elderly, and survival in order to reduce the global burden of esophageal cancer, particularly in low- and middle-income countries in Asia.
Article
Oncology
Yu Gu, Hongcheng Zhu, Jiaying Deng, Junhua Zhang, Tianxiang Chen, Songtao Lai
Summary: Primary pure mucinous adenocarcinoma (PMA) is a rare type of lung cancer with unique clinical and prognosis characteristics. In this study, we found that PMA is more common in the lower lobes, has a higher degree of differentiation, fewer early T stages, and more positive lymph nodes compared to other adenocarcinoma subtypes. Patients with PMA have significantly worse survival, and postoperative radiotherapy is beneficial for patients with <= 7 positive lymph nodes, while chemotherapy is beneficial for patients with >7 positive lymph nodes.
Review
Oncology
Zhuocheng Xin, Qi Liu, Dashan Ai, Ke Chen, Elene Mariamidze, Mostafa Aziz Sumon, Bharti Devnani, Rille Pihlak, Hongcheng Zhu, Kuaile Zhao
Summary: Esophageal cancer is a global health problem, and radiation therapy plays a vital role in the management of advanced disease. Immunotherapy has become the standard care, and the combination of radiation therapy and immunotherapy offers new hope for patients with advanced esophageal cancer.
CURRENT TREATMENT OPTIONS IN ONCOLOGY
(2023)
Article
Oncology
Hui Chen, Xiao-Lin Ge, Zhao-Yue Zhang, Ming Liu, Rui-Yan Wu, Xiao-Fei Zhang, Li-Ping Xu, Hong-Yan Cheng, Xin-Chen Sun, Hong-Cheng Zhu
Summary: This study identified two m(5)C methylation modification patterns in lung adenocarcinoma patients, which were associated with distinct tumor microenvironment immune cell infiltration and prognosis. The m(5)C score was constructed to quantify the m(5)C modification pattern of individual patients, showing a correlation with better prognosis in the high m(5)C score group and potential implications for tumor immunotherapy.
TRANSLATIONAL LUNG CANCER RESEARCH
(2021)
Article
Geriatrics & Gerontology
Yu Gu, Junhua Zhang, Zhirui Zhou, Di Liu, Hongcheng Zhu, Junmiao Wen, Xinyan Xu, Tianxiang Chen, Min Fan
