Article
Cell Biology
Hsin-Ling Yang, Hui-Wen Liu, Sirjana Shrestha, Varadharajan Thiyagarajan, Hui-Chi Huang, You-Cheng Hseu
Summary: The traditional Chinese medicinal fungus Antrodia salmonea (AS) exhibits significant anti-cancer activity in colon cancer cells by inducing apoptosis and autophagy mechanisms mediated through reactive oxygen species (ROS).
Article
Biochemistry & Molecular Biology
Junyan Qu, Cheng Zeng, Tingting Zou, Xu Chen, Xiaolong Yang, Zhenghong Lin
Summary: Trichodermic acid (TDA) demonstrates anticancer effects on colorectal cancer cells by inducing endoplasmic reticulum stress and autophagy-mediated apoptosis, suggesting a potential effective strategy for CRC treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Joanna Wawszczyk, Katarzyna Jesse, Slawomir Smolik, Malgorzata Kapral
Summary: Pterostilbene, a dietary phytochemical, has been found to possess antioxidant and anti-inflammatory properties and shows potential as an anticancer agent. This study aimed to investigate the anticancer activity of pterostilbene against HT-29 human colon cancer cells and revealed that it inhibits cell proliferation and induces cell death. The effects of pterostilbene on cell cycle progression and signaling pathways were also evaluated. The down-regulation of STAT3 and AKT kinase pathways was found to mediate the anticancer activity of pterostilbene. These findings suggest that pterostilbene could be a promising therapeutic option for colon cancer in the future.
Article
Biochemistry & Molecular Biology
Shanbin Chen, Dong Zhao, Chunguang Luan, Jia Zheng, Wei Liu, Zheng Feng, Ruiqi Luo, Xinglin Han, Deliang Wang
Summary: This study investigated the potential role of ferulic acid (FA) as a means of inducing apoptosis and inhibiting colon cancer induced by CT26 cells. The results showed that FA adjuvant treatment upregulated autophagy-related gene expression, suppressed inflammatory response elements expression, and improved bodyweight, ALT, and AST levels. Furthermore, FA inhibited CT26 cell proliferation and induced apoptosis by activating the phosphorylation of ERK and JNK to enhance BCL-2 and BAX proteins in the apoptosis pathway. These findings suggest that FA could be a promising auxiliary therapeutic agent for colon cancer.
Article
Biochemistry & Molecular Biology
Laura Mosca, Martina Pagano, Annalisa Pecoraro, Luigi Borzacchiello, Luigi Mele, Giovanna Cacciapuoti, Marina Porcelli, Giulia Russo, Annapina Russo
Summary: This study demonstrated that S-adenosyl-l-methionine can overcome drug resistance in colon cancer cells lacking p53 through multiple mechanisms, including cell cycle arrest, autophagy inhibition, reactive oxygen species augmentation, and apoptosis induction. The results suggest that S-adenosyl-l-methionine may hold promise as a potential agent for cancer therapy by examining p53 and uL3 profiles in tumors to improve clinical outcomes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Jue Wang, Ting Hu, Qiong Wang, Renwang Chen, Yuxiu Xie, Haiyan Chang, Jing Cheng
Summary: The study found that AURKA is upregulated in NSCLC and is associated with poor prognosis, and that silencing AURKA can increase radiosensitivity and reduce migration and invasion ability. CXCL5 is identified as a key downstream effector of AURKA, and the AURKA-CXCL5 axis and autophagy play important roles in regulating NSCLC cells' sensitivity to radiotherapy.
Article
Nanoscience & Nanotechnology
Kai Xiong, Ying Zhou, Johannes Karges, Kejie Du, Jinchao Shen, Mingwei Lin, Fangmian Wei, Junfeng Kou, Yu Chen, Liangnian Ji, Hui Chao
Summary: This study presents a therapeutic copper polypyridine complex encapsulated in a natural nanocarrier, apoferritin, which shows higher cytotoxicity towards drug-resistant cancer cells compared to noncancerous cells. The compound triggers cell autophagy-dependent apoptosis, leading to cell death. Injection of this nanodrug conjugate into a mouse model with multidrug-resistant colon tumor results in a strong inhibition of tumor growth.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Oncology
Da Eun Lee, Geun Yong Lee, Hae Min Lee, Soo Young Choi, Su Jin Lee, Oh-Shin Kwon
Summary: This study aimed to investigate the effect of combined treatment with metformin and OSMI-1 on autophagy and apoptosis in colon cancer cells. The results showed that metformin induced autophagy by activating AMPK through ER stress, while OSMI-1 increased autophagy through ER stress. The combination treatment of metformin and OSMI-1 induced apoptosis by regulating signaling pathways, suggesting a potential strategy for colon cancer treatment.
CANCER CELL INTERNATIONAL
(2023)
Article
Oncology
Ho Soo Yoo, Sae Bom Won, Young Hye Kwon
Summary: The study suggests that luteolin inhibits the growth of colon cancer cells through enhancing p53 activity to induce apoptosis and cell cycle arrest in a p53-dependent manner, regardless of the induction of autophagy.
NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL
(2022)
Article
Biochemistry & Molecular Biology
Antonietta Notaro, Marianna Lauricella, Diana Di Liberto, Sonia Emanuele, Michela Giuliano, Alessandro Attanzio, Luisa Tesoriere, Daniela Carlisi, Mario Allegra, Anna De Blasio, Giuseppe Calvaruso, Antonella D'Anneo
Summary: Methyl gallate (MG), a gallotannin found in plants, showed potential as an anti-tumor phytomolecule for colon cancer treatment. It reduced the viability of HCT116 colon cancer cells but had no effect on differentiated Caco-2 cells. MG induced early ROS generation and ER stress, leading to autophagy and apoptotic cell death. The increase in p53 played a crucial role in the mechanism, which was tightly linked to oxidative injury.
Article
Anatomy & Morphology
Xiong Ni, Fu-Sheng Shang, Ting-Feng Wang, De-Jun Wu, Da-Gui Chen, Biao Zhuang
Summary: Research has shown that ellagic acid (EA), found in fruits and foods, is effective in treating breast, colon, and bladder cancer. However, the therapeutic mechanism of EA for colon cancer is still unclear due to its complexity. In this study, cell counting, Western blotting, flow cytometry, and luciferase reporter assays were used to investigate the effects of EA on colon cancer cells (HCT116). The results revealed that EA promotes apoptosis, induces autophagy, and inhibits the growth of colon cancer through the AMPK/mTOR pathway.
Article
Cell Biology
Li-Bo Dai, Jiang-Tao Zhong, Li-Fang Shen, Shui-Hong Zhou, Zhong-Jie Lu, Yang-Yang Bao, Jun Fan
Summary: This study demonstrated that curcumin and GLUT1 siRNA, either alone or in combination, sensitized laryngeal carcinoma cells to radiation by inducing autophagy. Inhibition of autophagy promoted apoptosis after radiation or treatment with curcumin and GLUT1 siRNA. The combined treatment of curcumin, GLUT1 siRNA and an autophagy inhibitor 3-MA provided the strongest sensitization in vivo, indicating a potential therapeutic strategy for laryngeal carcinoma.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2021)
Article
Chemistry, Applied
Yu Zhang, Yan Liu, Yinxing Zhou, Ziming Zheng, Wenqi Tang, Mengzi Song, Jinglin Wang, Kaiping Wang
Summary: Lentinan (SLNT) demonstrates direct cytotoxicity to cancer cells and inhibits tumor growth by inducing autophagy and endoplasmic reticulum stress (ERS) in human colon cancer cells and mice. ERS is identified as the common regulator of SLNT-induced increases in Ca2+ concentrations, autophagy, and apoptosis. This study provides novel insights into the anti-colon cancer therapy potential of SLNT.
CARBOHYDRATE POLYMERS
(2021)
Article
Obstetrics & Gynecology
Ji Geun Yoo, Yoon Kyung Lee, Keun Ho Lee
Summary: The effect of autophagy modulation on radiation treatment of cervical cancer cells was investigated in this study. HeLa and CaSki cells were treated with an autophagy inducer (rapamycin) or inhibitor (3-MA) before being irradiated with gamma-rays. The expression of LC3 and cell death were examined in both cell preparations. The results showed that radiation induced an increase in LC3 expression in both cell lines. Inhibition of autophagy resulted in a decrease in cell viability, and apoptosis occurred later than autophagy in radiation treatment.
JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Lijin Zhu, Yuanyuan Zhao, Li Yu, Xinjia He, Yingju Wang, Peng Jiang, Rong Yu, Wei Li, Bin Dong, Xiang Wang, Yinying Dong
Summary: ADAM9 expression increased in HCC cells after X-ray irradiation. Knockdown of ADAM9 increased radiosensitivity in MHCC97H cells, while overexpression of ADAM9 decreased radiosensitivity in Huh7 cells. Additionally, ADAM9 induced HCC cell autophagy by downregulating Nrf2 expression, and autophagy modulation reversed the effects of altered ADAM9 expression on radiosensitivity. Moreover, ADAM9 expression showed a negative correlation with Bax and p62 expression in HCC tissues post-radiotherapy.
