Conformational Profiling of the AT1 Angiotensin II Receptor Reflects Biased Agonism, G Protein Coupling, and Cellular Context

Predicting G protein-coupled receptor downstream signaling by tissue expression

(2016) Yun Hao et al.   BIOINFORMATICS

Labeling and Single-Molecule Methods To Monitor G Protein-Coupled Receptor Dynamics

(2016) He Tian et al.   CHEMICAL REVIEWS

Targeted Elimination of G Proteins and Arrestins Defines Their Specific Contributions to Both Intensity and Duration of G Protein-coupled Receptor Signaling

(2016) Elisa Alvarez-Curto et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Different Epidermal Growth Factor Receptor (EGFR) Agonists Produce Unique Signatures for the Recruitment of Downstream Signaling Proteins

(2016) Tom Ronan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Functional Modulation of a G Protein-Coupled Receptor Conformational Landscape in a Lipid Bilayer

(2016) Marina Casiraghi et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Quantifying biased signaling in GPCRs using BRET-based biosensors

(2016) Yoon Namkung et al.   METHODS

Designing BRET-based conformational biosensors for G protein-coupled receptors

(2016) Rory Sleno et al.   METHODS

Design and construction of conformational biosensors to monitor ion channel activation: A prototype FlAsH/BRET-approach to Kir3 channels

(2016) Derek N. Robertson et al.   METHODS

Structure of the adenosine A2A receptor bound to an engineered G protein

(2016) Byron Carpenter et al.   NATURE

The conformational signature of β-arrestin2 predicts its trafficking and signalling functions

(2016) Mi-Hye Lee et al.   NATURE

Activation of the A2A adenosine G-protein-coupled receptor by conformational selection

(2016) Libin Ye et al.   NATURE

Allosteric coupling from G protein to the agonist-binding pocket in GPCRs

(2016) Brian T. DeVree et al.   NATURE

β-Arrestin biosensors reveal a rapid, receptor-dependent activation/deactivation cycle

(2016) Susanne Nuber et al.   NATURE

Allosteric nanobodies reveal the dynamic range and diverse mechanisms of G-protein-coupled receptor activation

(2016) Dean P. Staus et al.   NATURE

Conformationally selective RNA aptamers allosterically modulate the β2-adrenoceptor

(2016) Alem W Kahsai et al.   Nature Chemical Biology

The role of kinetic context in apparent biased agonism at GPCRs

(2016) Carmen Klein Herenbrink et al.   Nature Communications

Optical probes based on G protein-coupled receptors - added work or added value?

(2015) A D Stumpf et al.   BRITISH JOURNAL OF PHARMACOLOGY

Structural Insights into the Dynamic Process of β 2 -Adrenergic Receptor Signaling

(2015) Aashish Manglik et al.   CELL

Structure of the Angiotensin Receptor Revealed by Serial Femtosecond Crystallography

(2015) Haitao Zhang et al.   CELL

Biased Signaling at Chemokine Receptors

(2015) Jenny Corbisier et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The I-TASSER Suite: protein structure and function prediction

(2015) Jianyi Yang et al.   NATURE METHODS

Ghrelin receptor conformational dynamics regulate the transition from a preassembled to an active receptor:Gq complex

(2015) Marjorie Damian et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Single-molecule view of basal activity and activation mechanisms of the G protein-coupled receptor β2AR

(2015) Rajan Lamichhane et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Multimodular biosensors reveal a novel platform for activation of G proteins by growth factor receptors

(2015) Krishna K. Midde et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Distinct profiles of functional discrimination among G proteins determine the actions of G protein–coupled receptors

(2015) Ikuo Masuho et al.   Science Signaling

The experimental power of FR900359 to study Gq-regulated biological processes

(2015) Ramona Schrage et al.   Nature Communications

Distinct profiles of functional discrimination among G proteins determine the actions of G protein–coupled receptors

(2015) Ikuo Masuho et al.   Science Signaling

Angiotensin II Type I and Prostaglandin F2α Receptors Cooperatively Modulate Signaling in Vascular Smooth Muscle Cells

(2014) Eugénie Goupil et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural determinants for binding, activation, and functional selectivity of the angiotensin AT1 receptor

(2014) P. Balakumar et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

Endosomal GPCR signaling turned off by negative feedback actions of PKA and v-ATPase

(2014) Alexandre Gidon et al.   Nature Chemical Biology

Spatial encoding of cyclic AMP signaling specificity by GPCR endocytosis

(2014) Nikoleta G Tsvetanova et al.   Nature Chemical Biology

Conformational biosensors reveal GPCR signalling from endosomes

(2013) Roshanak Irannejad et al.   NATURE

Genome engineering using the CRISPR-Cas9 system

(2013) F Ann Ran et al.   Nature Protocols

Signalling bias in new drug discovery: detection, quantification and therapeutic impact

(2013) Terry Kenakin et al.   NATURE REVIEWS DRUG DISCOVERY

D2-like dopamine and β-adrenergic receptors form a signaling complex that integrates Gs- and Gi-mediated regulation of adenylyl cyclase

(2012) R. Victor Rebois et al.   CELLULAR SIGNALLING

Deciphering biased-agonism complexity reveals a new active AT1 receptor entity

(2012) Aude Saulière et al.   Nature Chemical Biology

TGFα shedding assay: an accurate and versatile method for detecting GPCR activation

(2012) Asuka Inoue et al.   NATURE METHODS

The Gαq/11 Proteins Contribute to T Lymphocyte Migration by Promoting Turnover of Integrin LFA-1 through Recycling

(2012) Lena Svensson et al.   PLoS One

Biased Signaling Pathways in  2-Adrenergic Receptor Characterized by 19F-NMR

(2012) J. J. Liu et al.   SCIENCE

Differential  -Arrestin-Dependent Conformational Signaling and Cellular Responses Revealed by Angiotensin Analogs

(2012) B. Zimmerman et al.   Science Signaling

Nuclear GPCRs in cardiomyocytes: an insider's view of β-adrenergic receptor signaling

(2011) George Vaniotis et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Rotational Diffusion of the α2a Adrenergic Receptor Revealed by FlAsH Labeling in Living Cells

(2011) Jan-Hendrik Spille et al.   BIOPHYSICAL JOURNAL

A Fluorescence Resonance Energy Transfer-based M2Muscarinic Receptor Sensor Reveals Rapid Kinetics of Allosteric Modulation

(2010) Monika Maier-Peuschel et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Fluorescence Resonance Energy Transfer Analysis of  2a-Adrenergic Receptor Activation Reveals Distinct Agonist-Specific Conformational Changes

(2008) A. Zurn et al.   MOLECULAR PHARMACOLOGY