Optical probes based on G protein-coupled receptors - added work or added value?

Structural Insights into the Dynamic Process of β 2 -Adrenergic Receptor Signaling

(2015) Aashish Manglik et al.   CELL

Multiply labeling proteins for studies of folding and stability

(2015) Conor M Haney et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Single-molecule FRET and crosslinking studies in structural biology enabled by noncanonical amino acids

(2015) Swati Tyagi et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Molecular Spies for Bioimaging—Fluorescent Protein-Based Probes

(2015) Atsushi Miyawaki et al.   MOLECULAR CELL

Ghrelin receptor conformational dynamics regulate the transition from a preassembled to an active receptor:Gq complex

(2015) Marjorie Damian et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Uncovering Caffeine’s Adenosine A2A Receptor Inverse Agonism in Experimental Parkinsonism

(2014) Víctor Fernández-Dueñas et al.   ACS Chemical Biology

Interhelical Interaction and Receptor Phosphorylation Regulate the Activation Kinetics of Different Human β1-Adrenoceptor Variants

(2014) Andrea Ahles et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Toward Fluorescent Probes for G-Protein-Coupled Receptors (GPCRs)

(2014) Zhao Ma et al.   JOURNAL OF MEDICINAL CHEMISTRY

Structural and biophysical characterisation of G protein-coupled receptor ligand binding using resonance energy transfer and fluorescent labelling techniques

(2013) Richard J. Ward et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

The Concise Guide to PHARMACOLOGY 2013/14: G Protein-Coupled Receptors

(2013) Stephen P.H. Alexander et al.   BRITISH JOURNAL OF PHARMACOLOGY

Detection of G Protein-selective G Protein-coupled Receptor (GPCR) Conformations in Live Cells

(2013) Rabia U. Malik et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Carboxypeptidase M Is a Positive Allosteric Modulator of the Kinin B1 Receptor

(2013) Xianming Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Activation and allosteric modulation of a muscarinic acetylcholine receptor

(2013) Andrew C. Kruse et al.   NATURE

Molecular signatures of G-protein-coupled receptors

(2013) A. J. Venkatakrishnan et al.   NATURE

Conformational biosensors reveal GPCR signalling from endosomes

(2013) Roshanak Irannejad et al.   NATURE

Dynamic ligand binding dictates partial agonism at a G protein–coupled receptor

(2013) Andreas Bock et al.   Nature Chemical Biology

Emerging paradigms in GPCR allostery: implications for drug discovery

(2013) Denise Wootten et al.   NATURE REVIEWS DRUG DISCOVERY

The IUPHAR/BPS Guide to PHARMACOLOGY: an expert-driven knowledgebase of drug targets and their ligands

(2013) Adam J. Pawson et al.   NUCLEIC ACIDS RESEARCH

Voltage regulates adrenergic receptor function

(2013) Andreas Rinne et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Allosteric interactions within the AT1 angiotensin receptor homodimer: Role of the conserved DRY motif

(2012) Bence Szalai et al.   BIOCHEMICAL PHARMACOLOGY

Impact of human autoantibodies on β1-adrenergic receptor conformation, activity, and internalization

(2012) Beatrice Bornholz et al.   CARDIOVASCULAR RESEARCH

Intramolecular Fluorescence Resonance Energy Transfer (FRET) Sensors of the Orexin OX1and OX2Receptors Identify Slow Kinetics of Agonist Activation

(2012) Tian-Rui Xu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Fluorescent Sensor for GABA and Synthetic GABAB Receptor Ligands

(2012) Anastasiya Masharina et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Binding of Gq protein stabilizes the activated state of the muscarinic receptor type 1

(2012) Michihiro Tateyama et al.   NEUROPHARMACOLOGY

FRET-Based Detection of M1 Muscarinic Acetylcholine Receptor Activation by Orthosteric and Allosteric Agonists

(2012) Danijela Markovic et al.   PLoS One

Activation Biosensor for G Protein-Coupled Receptors: A FRET-Based m1 Muscarinic Activation Sensor That Regulates Gq

(2012) Seungwoo Chang et al.   PLoS One

Structural insights into biased G protein-coupled receptor signaling revealed by fluorescence spectroscopy

(2012) R. Rahmeh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sequential Inter- and Intrasubunit Rearrangements During Activation of Dimeric Metabotropic Glutamate Receptor 1

(2012) V. Hlavackova et al.   Science Signaling

The allosteric vestibule of a seven transmembrane helical receptor controls G-protein coupling

(2012) Andreas Bock et al.   Nature Communications

Development of Probes for Cellular Functions Using Fluorescent Proteins and Fluorescence Resonance Energy Transfer

(2011) Atsushi Miyawaki   Annual Review of Biochemistry

Exploration of Biarsenical Chemistry-Challenges in Protein Research

(2011) Adam Pomorski et al.   CHEMBIOCHEM

Genetically Encodable Fluorescent Biosensors for Tracking Signaling Dynamics in Living Cells

(2011) Robert H. Newman et al.   CHEMICAL REVIEWS

Cross-talk between Carboxypeptidase M and the Kinin B1 Receptor Mediates a New Mode of G Protein-coupled Receptor Signaling

(2011) Xianming Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Developing Chemical Genetic Approaches to Explore G Protein-Coupled Receptor Function: Validation of the Use of a Receptor Activated Solely by Synthetic Ligand (RASSL)

(2011) E. Alvarez-Curto et al.   MOLECULAR PHARMACOLOGY

Structure of a nanobody-stabilized active state of the β2 adrenoceptor

(2011) Søren G. F. Rasmussen et al.   NATURE

Crystal structure of the β2 adrenergic receptor–Gs protein complex

(2011) Søren G. F. Rasmussen et al.   NATURE

A Polymorphism-Specific "Memory" Mechanism in the  2-Adrenergic Receptor

(2011) A. Ahles et al.   Science Signaling

Site-Specific, Orthogonal Labeling of Proteins in Intact Cells with Two Small Biarsenical Fluorophores

(2010) Alexander Zürn et al.   BIOCONJUGATE CHEMISTRY

FRET-based sensors for the human M1-, M3-, and M5-acetylcholine receptors

(2010) Nicole Ziegler et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Ligand-induced Rearrangements of the GABABReceptor Revealed by Fluorescence Resonance Energy Transfer

(2010) Shinichi Matsushita et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Fluorescence Resonance Energy Transfer-based M2Muscarinic Receptor Sensor Reveals Rapid Kinetics of Allosteric Modulation

(2010) Monika Maier-Peuschel et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Differential Signaling of the Endogenous Agonists at the β2-Adrenergic Receptor

(2010) Susanne Reiner et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Fluorescent labeling of tetracysteine-tagged proteins in intact cells

(2010) Carsten Hoffmann et al.   Nature Protocols

Fluorescent-Protein-Based Biosensors: Modulation of Energy Transfer as a Design Principle

(2009) Robert E. Campbell   ANALYTICAL CHEMISTRY

Fluorescence changes reveal kinetic steps of muscarinic receptor–mediated modulation of phosphoinositides and Kv7.2/7.3 K+channels

(2009) Jill B. Jensen et al.   JOURNAL OF GENERAL PHYSIOLOGY

Analysis of full and partial agonists binding to β2-adrenergic receptor suggests a role of transmembrane helix V in agonist-specific conformational changes

(2009) Vsevolod Katritch et al.   JOURNAL OF MOLECULAR RECOGNITION

Hairpin Structure of a Biarsenical−Tetracysteine Motif Determined by NMR Spectroscopy

(2009) Fatemeh Madani et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

An Engineered Protein Tag for Multiprotein Labeling in Living Cells

(2008) Arnaud Gautier et al.   CHEMISTRY & BIOLOGY

Fluorescence Resonance Energy Transfer Analysis of  2a-Adrenergic Receptor Activation Reveals Distinct Agonist-Specific Conformational Changes

(2008) A. Zurn et al.   MOLECULAR PHARMACOLOGY

Conformational cross-talk between α2A-adrenergic and μ-opioid receptors controls cell signaling

(2008) Jean-Pierre Vilardaga et al.   Nature Chemical Biology

Conformational changes in G-protein-coupled receptors-the quest for functionally selective conformations is open

(2007) C Hoffmann et al.   BRITISH JOURNAL OF PHARMACOLOGY

Heterotrimeric G protein activation by G-protein-coupled receptors

(2007) William M. Oldham et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY