Deciphering biased-agonism complexity reveals a new active AT1 receptor entity

Probing Heterotrimeric G Protein Activation: Applications to Biased Ligands

(2012) Colette Denis et al.   CURRENT PHARMACEUTICAL DESIGN

Crystal structure of the β2 adrenergic receptor–Gs protein complex

(2011) Søren G. F. Rasmussen et al.   NATURE

The role of conformational ensembles of seven transmembrane receptors in functional selectivity

(2010) Nagarajan Vaidehi et al.   CURRENT OPINION IN PHARMACOLOGY

Combining resonance energy transfer methods reveals a complex between the α2A-adrenergic receptor, Gαi1β1γ2, and GRK2

(2010) Billy Breton et al.   FASEB JOURNAL

Differential Signaling of the Endogenous Agonists at the β2-Adrenergic Receptor

(2010) Susanne Reiner et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Functional Selectivity and Biased Receptor Signaling

(2010) T. Kenakin   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Selectively Engaging  -Arrestins at the Angiotensin II Type 1 Receptor Reduces Blood Pressure and Increases Cardiac Performance

(2010) J. D. Violin et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Quantitative Phosphoproteomics Dissection of Seven-transmembrane Receptor Signaling Using Full and Biased Agonists

(2010) Gitte L. Christensen et al.   MOLECULAR & CELLULAR PROTEOMICS

AT1 receptor Gαq protein-independent signalling transcriptionally activates only a few genes directly, but robustly potentiates gene regulation from the β2-adrenergic receptor

(2010) Gitte L. Christensen et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Therapeutic potential of β-arrestin- and G protein-biased agonists

(2010) Erin J. Whalen et al.   TRENDS IN MOLECULAR MEDICINE

Independent β-Arrestin2 and Gq/Protein Kinase Cζ Pathways for ERK Stimulated by Angiotensin Type 1A Receptors in Vascular Smooth Muscle Cells Converge on Transactivation of the Epidermal Growth Factor Receptor

(2009) Jihee Kim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Selective engagement of G protein coupled receptor kinases (GRKs) encodes distinct functions of biased ligands

(2009) D. A. Zidar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The human angiotensin AT1 receptor supports G protein-independent extracellular signal-regulated kinase 1/2 activation and cellular proliferation

(2008) Jakob Lerche Hansen et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Bioluminescence Resonance Energy Transfer Assays Reveal Ligand-specific Conformational Changes within Preformed Signaling Complexes Containing δ-Opioid Receptors and Heterotrimeric G Proteins

(2008) Nicolas Audet et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Thromboxane A2: Physiology/pathophysiology, cellular signal transduction and pharmacology

(2008) Norimichi Nakahata   PHARMACOLOGY & THERAPEUTICS

Distinct conformational changes in  -arrestin report biased agonism at seven-transmembrane receptors

(2008) A. K. Shukla et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Conformational changes in G-protein-coupled receptors-the quest for functionally selective conformations is open

(2007) C Hoffmann et al.   BRITISH JOURNAL OF PHARMACOLOGY