Structural determinants for binding, activation, and functional selectivity of the angiotensin AT1 receptor

A century old renin–angiotensin system still grows with endless possibilities: AT1 receptor signaling cascades in cardiovascular physiopathology

(2014) Pitchai Balakumar et al.   CELLULAR SIGNALLING

Angiotensin II, From Vasoconstrictor to Growth Factor

(2014) Sasa Vukelic et al.   CIRCULATION RESEARCH

Biasing GPCR Signaling from Inside

(2014) A. K. Shukla   Science Signaling

Tissue-Specific Peroxisome Proliferator Activated Receptor Gamma Expression and Metabolic Effects of Telmisartan

(2013) V. Zidek et al.   AMERICAN JOURNAL OF HYPERTENSION

Angiotensin II Type 1 and Type 2 Receptor-induced Cell Signaling

(2013) Hiroshi Akazawa et al.   CURRENT PHARMACEUTICAL DESIGN

Class- and Molecule-specific Differential Effects of Angiotensin II Type 1 Receptor Blockers

(2013) Satoshi Imaizumi et al.   CURRENT PHARMACEUTICAL DESIGN

Structure of the Human Angiotensin II Type 1 (AT1) Receptor Bound to Angiotensin II from Multiple Chemoselective Photoprobe Contacts Reveals a Unique Peptide Binding Mode

(2013) Dany Fillion et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Arrestin-selective Angiotensin AT1Receptor Agonist [Sar1,Ile4,Ile8]-AngII Negatively Regulates Bradykinin B2Receptor Signaling via AT1-B2Receptor Heterodimers

(2013) Parker C. Wilson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ability of the new AT1 receptor blocker azilsartan to block angiotensin II-induced AT1 receptor activation after wash-out

(2013) Shin-ichiro Miura et al.   JOURNAL OF THE RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM

Reassessment of the Unique Mode of Binding between Angiotensin II Type 1 Receptor and Their Blockers

(2013) Shin-Ichiro Miura et al.   PLoS One

Allosteric interactions within the AT1 angiotensin receptor homodimer: Role of the conserved DRY motif

(2012) Bence Szalai et al.   BIOCHEMICAL PHARMACOLOGY

Restructuring G-Protein- Coupled Receptor Activation

(2012) Martin Audet et al.   CELL

Comparison of the efficacy and safety of azilsartan with that of candesartan cilexetil in Japanese patients with grade I–II essential hypertension: a randomized, double-blind clinical study

(2012) Hiromi Rakugi et al.   HYPERTENSION RESEARCH

Small Molecules with Similar Structures Exhibit Agonist, Neutral Antagonist or Inverse Agonist Activity toward Angiotensin II Type 1 Receptor

(2012) Shin-ichiro Miura et al.   PLoS One

Differential  -Arrestin-Dependent Conformational Signaling and Cellular Responses Revealed by Angiotensin Analogs

(2012) B. Zimmerman et al.   Science Signaling

Two distinct conformations of helix 6 observed in antagonist-bound structures of a  1-adrenergic receptor

(2011) R. Moukhametzianov et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Unique “delta lock” structure of telmisartan is involved in its strongest binding affinity to angiotensin II type 1 receptor

(2010) Kazuki Ohno et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

A small difference in the molecular structure of angiotensin II receptor blockers induces AT1 receptor-dependent and -independent beneficial effects

(2010) Masahiro Fujino et al.   HYPERTENSION RESEARCH

Ligand-specific Conformation of Extracellular Loop-2 in the Angiotensin II Type 1 Receptor

(2010) Hamiyet Unal et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Amino-Terminus of Angiotensin II Contacts Several Ectodomains of the Angiotensin II Receptor AT1

(2010) Dany Fillion et al.   JOURNAL OF MEDICINAL CHEMISTRY

Multiple templates-based homology modeling enhances structure quality of AT1 receptor: validation by molecular dynamics and antagonist docking

(2010) Pandian Sokkar et al.   JOURNAL OF MOLECULAR MODELING

Selectively Engaging  -Arrestins at the Angiotensin II Type 1 Receptor Reduces Blood Pressure and Increases Cardiac Performance

(2010) J. D. Violin et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Importance of the extracellular loops in G protein-coupled receptors for ligand recognition and receptor activation

(2010) M.C. Peeters et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Angiotensin II AT1 receptor constitutive activation: From molecular mechanisms to pathophysiology

(2008) Christophe Petrel et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Anti-inflammatory and anti-oxidant properties of telmisartan in cultured human umbilical vein endothelial cells

(2007) Silvana Cianchetti et al.   ATHEROSCLEROSIS

Differential Bonding Interactions of Inverse Agonists of Angiotensin II Type 1 Receptor in Stabilizing the Inactive State

(2007) Shin-ichiro Miura et al.   MOLECULAR ENDOCRINOLOGY