- Home
- Publications
- Publication Search
- Publication Details
Title
The role of kinetic context in apparent biased agonism at GPCRs
Authors
Keywords
-
Journal
Nature Communications
Volume 7, Issue -, Pages 10842
Publisher
Springer Nature
Online
2016-02-24
DOI
10.1038/ncomms10842
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Investigating the molecular mechanisms through which FTY720-P causes persistent S1P1receptor internalization
- (2014) David A Sykes et al. BRITISH JOURNAL OF PHARMACOLOGY
- Functionally Selective Dopamine D2, D3 Receptor Partial Agonists
- (2014) Dorothee Möller et al. JOURNAL OF MEDICINAL CHEMISTRY
- Structure–Activity Relationships of Privileged Structures Lead to the Discovery of Novel Biased Ligands at the Dopamine D2 Receptor
- (2014) Monika Szabo et al. JOURNAL OF MEDICINAL CHEMISTRY
- Biased Agonism at G Protein-Coupled Receptors: The Promise and the Challenges-A Medicinal Chemistry Perspective
- (2014) Jeremy Shonberg et al. MEDICINAL RESEARCH REVIEWS
- Endosomal generation of cAMP in GPCR signaling
- (2014) Jean-Pierre Vilardaga et al. Nature Chemical Biology
- Prolonged Calcitonin Receptor Signaling by Salmon, but Not Human Calcitonin, Reveals Ligand Bias
- (2014) Kim Vietz Andreassen et al. PLoS One
- An evaluation of the safety and efficacy of cariprazine in patients with acute exacerbation of schizophrenia: A phase II, randomized clinical trial
- (2014) Suresh Durgam et al. SCHIZOPHRENIA RESEARCH
- Biased ligands at G-protein-coupled receptors: promise and progress
- (2014) Jonathan D. Violin et al. TRENDS IN PHARMACOLOGICAL SCIENCES
- Structure–Kinetic Relationships—An Overlooked Parameter in Hit-to-Lead Optimization: A Case of Cyclopentylamines as Chemokine Receptor 2 Antagonists
- (2013) Maris Vilums et al. JOURNAL OF MEDICINAL CHEMISTRY
- A Structure–Activity Analysis of Biased Agonism at the Dopamine D2 Receptor
- (2013) Jeremy Shonberg et al. JOURNAL OF MEDICINAL CHEMISTRY
- Structure–Activity Relationships and Discovery of a G Protein Biased μ Opioid Receptor Ligand, [(3-Methoxythiophen-2-yl)methyl]({2-[(9R)-9-(pyridin-2-yl)-6-oxaspiro-[4.5]decan-9-yl]ethyl})amine (TRV130), for the Treatment of Acute Severe Pain
- (2013) Xiao-Tao Chen et al. JOURNAL OF MEDICINAL CHEMISTRY
- Conformational biosensors reveal GPCR signalling from endosomes
- (2013) Roshanak Irannejad et al. NATURE
- Signalling bias in new drug discovery: detection, quantification and therapeutic impact
- (2013) Terry Kenakin et al. NATURE REVIEWS DRUG DISCOVERY
- Structural Features for Functional Selectivity at Serotonin Receptors
- (2013) D. Wacker et al. SCIENCE
- Functional efficacy of adenosine A2A receptor agonists is positively correlated to their receptor residence time
- (2012) Dong Guo et al. BRITISH JOURNAL OF PHARMACOLOGY
- Deciphering biased-agonism complexity reveals a new active AT1 receptor entity
- (2012) Aude Saulière et al. Nature Chemical Biology
- Impedance Responses Reveal β2-Adrenergic Receptor Signaling Pluridimensionality and Allow Classification of Ligands with Distinct Signaling Profiles
- (2012) Wayne Stallaert et al. PLoS One
- Structural insights into biased G protein-coupled receptor signaling revealed by fluorescence spectroscopy
- (2012) R. Rahmeh et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Biased Signaling Pathways in 2-Adrenergic Receptor Characterized by 19F-NMR
- (2012) J. J. Liu et al. SCIENCE
- Crystal Structures of a Stabilized β1-Adrenoceptor Bound to the Biased Agonists Bucindolol and Carvedilol
- (2012) Tony Warne et al. STRUCTURE
- A Simple Method for Quantifying Functional Selectivity and Agonist Bias
- (2011) Terry Kenakin et al. ACS Chemical Neuroscience
- Slow dissociation of partial agonists from the D2 receptor is linked to reduced prolactin release
- (2011) Lucia Carboni et al. INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY
- Quantifying Ligand Bias at Seven-Transmembrane Receptors
- (2011) S. Rajagopal et al. MOLECULAR PHARMACOLOGY
- Pardoprunox in early Parkinson's disease: Results from 2 large, randomized double-blind trials
- (2011) Cristina Sampaio et al. MOVEMENT DISORDERS
- Multiple ligand-specific conformations of the β2-adrenergic receptor
- (2011) Alem W Kahsai et al. Nature Chemical Biology
- Discovery of -Arrestin-Biased Dopamine D2 Ligands for Probing Signal Transduction Pathways Essential for Antipsychotic Efficacy
- (2011) J. A. Allen et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Elusive equilibrium: the challenge of interpreting receptor pharmacology using calcium assays
- (2010) Steven J Charlton et al. BRITISH JOURNAL OF PHARMACOLOGY
- Morphine-like Opiates Selectively Antagonize Receptor-Arrestin Interactions
- (2010) Paola Molinari et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Histidine 6.55 Is a Major Determinant of Ligand-Biased Signaling in Dopamine D2L Receptor
- (2010) N. Tschammer et al. MOLECULAR PHARMACOLOGY
- -Opioid Receptors: Correlation of Agonist Efficacy for Signalling with Ability to Activate Internalization
- (2010) J. McPherson et al. MOLECULAR PHARMACOLOGY
- Therapeutic potential of β-arrestin- and G protein-biased agonists
- (2010) Erin J. Whalen et al. TRENDS IN MOLECULAR MEDICINE
- Exploring the Mechanism of Agonist Efficacy: A Relationship between Efficacy and Agonist Dissociation Rate at the Muscarinic M3 Receptor
- (2009) D. A. Sykes et al. MOLECULAR PHARMACOLOGY
- Sustained cyclic AMP production by parathyroid hormone receptor endocytosis
- (2009) Sébastien Ferrandon et al. Nature Chemical Biology
- Endosomes: A legitimate platform for the signaling train
- (2009) J. E. Murphy et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Residence Time of Receptor−Ligand Complexes and Its Effect on Biological Function
- (2008) Peter J. Tummino et al. BIOCHEMISTRY
- Emerging drugs for schizophrenia
- (2008) Ofer Agid et al. EXPERT OPINION ON EMERGING DRUGS
- Antagonism of dopamine D2 receptor/ -arrestin 2 interaction is a common property of clinically effective antipsychotics
- (2008) B. Masri et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Discover Peeref hubs
Discuss science. Find collaborators. Network.
Join a conversationCreate your own webinar
Interested in hosting your own webinar? Check the schedule and propose your idea to the Peeref Content Team.
Create Now