Targeting Cancer Stem Cells with Small Molecules

Evodiamine selectively targets cancer stem-like cells through the p53-p21-Rb pathway

(2016) Seula Han et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

High-throughput screening identifies artesunate as selective inhibitor of cancer stemness: Involvement of mitochondrial metabolism

(2016) Amit Subedi et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Honokiol inhibits sphere formation and xenograft growth of oral cancer side population cells accompanied with JAK/STAT signaling pathway suppression and apoptosis induction

(2016) Jhy-Shrian Huang et al.   BMC CANCER

Hallmarks of cancer stem cell metabolism

(2016) Patricia Sancho et al.   BRITISH JOURNAL OF CANCER

Forkhead Box Q1 Is a Novel Target of Breast Cancer Stem Cell Inhibition by Diallyl Trisulfide

(2016) Su-Hyeong Kim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Euphorins A–H: bioactive diterpenoids from Euphorbia fischeriana

(2016) Xinzhu Kuang et al.   Journal of Natural Medicines

Efficient elimination of pancreatic cancer stem cells by hedgehog/GLI inhibitor GANT61 in combination with mTOR inhibition

(2016) Yumi Miyazaki et al.   Molecular Cancer

EC-70124, a Novel Glycosylated Indolocarbazole Multikinase Inhibitor, Reverts Tumorigenic and Stem Cell Properties in Prostate Cancer by Inhibiting STAT3 and NF- B

(2016) G. Civenni et al.   MOLECULAR CANCER THERAPEUTICS

Eucommicin A, a β-truxinate lignan from Eucommia ulmoides , is a selective inhibitor of cancer stem cells

(2016) Ayaka Fujiwara et al.   PHYTOCHEMISTRY

Calmidazolium chloride inhibits growth of murine embryonal carcinoma cells, a model of cancer stem-like cells

(2016) Jina Lee et al.   TOXICOLOGY IN VITRO

Nanoquinacrine induced apoptosis in cervical cancer stem cells through the inhibition of hedgehog-GLI1 cascade: Role of GLI-1

(2016) Anmada Nayak et al.   Scientific Reports

Suppression of prostate cancer progression by cancer cell stemness inhibitor napabucasin

(2016) Yiming Zhang et al.   Cancer Medicine

Cucurbitacin B inhibits the stemness and metastatic abilities of NSCLC via downregulation of canonical Wnt/β-catenin signaling axis

(2016) Samriddhi Shukla et al.   Scientific Reports

The Cancer Stem Cell Niche: How Essential Is the Niche in Regulating Stemness of Tumor Cells?

(2015) Vicki Plaks et al.   Cell Stem Cell

A hostel for the hostile: the bone marrow niche in hematologic neoplasms

(2015) D. S. Krause et al.   HAEMATOLOGICA

Epigallocatechin gallate hinders human hepatoma and colon cancer sphere formation

(2015) Gizachew Y Wubetu et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Discovery of NCT-501, a Potent and Selective Theophylline-Based Inhibitor of Aldehyde Dehydrogenase 1A1 (ALDH1A1)

(2015) Shyh-Ming Yang et al.   JOURNAL OF MEDICINAL CHEMISTRY

Myrtucommulone-A treatment decreases pluripotency- and multipotency-associated marker expression in bladder cancer cell line HTB-9

(2015) Banu Iskender et al.   Journal of Natural Medicines

Metformin: A Novel but Controversial Drug in Cancer Prevention and Treatment

(2015) Xinbing Sui et al.   MOLECULAR PHARMACEUTICS

Correlating chemical sensitivity and basal gene expression reveals mechanism of action

(2015) Matthew G Rees et al.   Nature Chemical Biology

Suppression of cancer relapse and metastasis by inhibiting cancer stemness

(2015) Youzhi Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification of thiostrepton as a novel therapeutic agent that targets human colon cancer stem cells

(2015) S-Y Ju et al.   Cell Death & Disease

A hostel for the hostile: the bone marrow niche in hematologic neoplasms

(2015) D. S. Krause et al.   HAEMATOLOGICA

Therapeutic targeting of CBP/β-catenin signaling reduces cancer stem-like population and synergistically suppresses growth of EBV-positive nasopharyngeal carcinoma cells with cisplatin

(2015) King Chi Chan et al.   Scientific Reports

Synthetic, Non-saccharide, Glycosaminoglycan Mimetics Selectively Target Colon Cancer Stem Cells

(2014) Nirmita J. Patel et al.   ACS Chemical Biology

Differentiation therapy: sesamin as an effective agent in targeting cancer stem-like side population cells of human gallbladder carcinoma

(2014) Xiang Kong et al.   BMC Complementary and Alternative Medicine

Evolution of the Cancer Stem Cell Model

(2014) Antonija Kreso et al.   Cell Stem Cell

A Breast Cancer Stem Cell-Selective, Mammospheres-Potent Osmium(VI) Nitrido Complex

(2014) Kogularamanan Suntharalingam et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

MLN0128, an ATP-Competitive mTOR Kinase Inhibitor with Potent In Vitro and In Vivo Antitumor Activity, as Potential Therapy for Bone and Soft-Tissue Sarcoma

(2014) E. K. Slotkin et al.   MOLECULAR CANCER THERAPEUTICS

Honokiol inhibits melanoma stem cells by targeting notch signaling

(2014) Gaurav Kaushik et al.   MOLECULAR CARCINOGENESIS

Honokiol Suppresses Renal Cancer Cells’ Metastasis via Dual-Blocking Epithelial-Mesenchymal Transition and Cancer Stem Cell Properties through Modulating miR-141/ZEB2 Signaling

(2014) Weidong Li et al.   MOLECULES AND CELLS

Tackling the cancer stem cells — what challenges do they pose?

(2014) Diwakar R. Pattabiraman et al.   NATURE REVIEWS DRUG DISCOVERY

Hypoxia promotes stem cell phenotypes and poor prognosis through epigenetic regulation of DICER

(2014) Twan van den Beucken et al.   Nature Communications

Curcumin inhibits breast cancer stem cell migration by amplifying the E-cadherin/β-catenin negative feedback loop

(2014) Shravanti Mukherjee et al.   Stem Cell Research & Therapy

Inhibition of the autophagic flux by salinomycin in breast cancer stem-like/progenitor cells interferes with their maintenance

(2013) Wen Yue et al.   Autophagy

Cinnamides as selective small-molecule inhibitors of a cellular model of breast cancer stem cells

(2013) Andrew R. Germain et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Niche-based screening identifies small-molecule inhibitors of leukemia stem cells

(2013) Kimberly A Hartwell et al.   Nature Chemical Biology

The epigenetics of epithelial-mesenchymal plasticity in cancer

(2013) Wai Leong Tam et al.   NATURE MEDICINE

NVP-LDE-225 (Erismodegib) inhibits epithelial–mesenchymal transition and human prostate cancer stem cell growth in NOD/SCID IL2Rγ null mice by regulating Bmi-1 and microRNA-128

(2013) R Nanta et al.   Oncogenesis

Trifluoperazine, an Antipsychotic Agent, Inhibits Cancer Stem Cell Growth and Overcomes Drug Resistance of Lung Cancer

(2012) Chi-Tai Yeh et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Polyether ionophores—promising bioactive molecules for cancer therapy

(2012) Adam Huczyński   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Inhibition of Tumor Promotion by Parthenolide: Epigenetic Modulation of p21

(2012) A. Ghantous et al.   Cancer Prevention Research

Charting, Navigating, and Populating Natural Product Chemical Space for Drug Discovery

(2012) Hugo Lachance et al.   JOURNAL OF MEDICINAL CHEMISTRY

Honokiol in Combination with Radiation Targets Notch Signaling to Inhibit Colon Cancer Stem Cells

(2012) S. Ponnurangam et al.   MOLECULAR CANCER THERAPEUTICS

Dclk1 distinguishes between tumor and normal stem cells in the intestine

(2012) Yuki Nakanishi et al.   NATURE GENETICS

Cyclopamine cooperates with EGFR inhibition to deplete stem-like cancer cells in glioblastoma-derived spheroid cultures

(2012) Sandrine Eimer et al.   NEURO-ONCOLOGY

Salinomycin Induces Autophagy in Colon and Breast Cancer Cells with Concomitant Generation of Reactive Oxygen Species

(2012) Berlinda Verdoodt et al.   PLoS One

Identification of inhibitors of ovarian cancer stem-like cells by high-throughput screening

(2012) Roman Mezencev et al.   Journal of Ovarian Research

Salinomycin-induced apoptosis of human prostate cancer cells due to accumulated reactive oxygen species and mitochondrial membrane depolarization

(2011) Kwang-Youn Kim et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Salinomycin can effectively kill ALDHhigh stem-like cells on gastric cancer

(2011) Qiao Ming Zhi et al.   BIOMEDICINE & PHARMACOTHERAPY

Salinomycin inhibits osteosarcoma by targeting its tumor stem cells

(2011) Qing-Lian Tang et al.   CANCER LETTERS

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Phase I Trial of MK-0752 in Children With Refractory CNS Malignancies: A Pediatric Brain Tumor Consortium Study

(2011) Maryam Fouladi et al.   JOURNAL OF CLINICAL ONCOLOGY

The transcription factor FOXM1 is a cellular target of the natural product thiostrepton

(2011) Nagaratna S. Hegde et al.   Nature Chemistry

Hedgehog Signaling Antagonist GDC-0449 (Vismodegib) Inhibits Pancreatic Cancer Stem Cell Characteristics: Molecular Mechanisms

(2011) Brahma N. Singh et al.   PLoS One

Salinomycin inhibits Wnt signaling and selectively induces apoptosis in chronic lymphocytic leukemia cells

(2011) Desheng Lu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Salinomycin induces calpain and cytochrome c-mediated neuronal cell death

(2011) W Boehmerle et al.   Cell Death & Disease

Metformin regulates breast cancer stem cello ntogeny by transcriptional regulation of the epithelial-mesenchymal transition (EMT) status

(2010) Alejandro Vazquez-Martin et al.   CELL CYCLE

What made sesquiterpene lactones reach cancer clinical trials?

(2010) Akram Ghantous et al.   DRUG DISCOVERY TODAY

CXCR1 blockade selectively targets human breast cancer stem cells in vitro and in xenografts

(2010) Christophe Ginestier et al.   JOURNAL OF CLINICAL INVESTIGATION

Identification of Selective Inhibitors of Cancer Stem Cells by High-Throughput Screening

(2009) Piyush B. Gupta et al.   CELL

Epithelial-Mesenchymal Transitions in Development and Disease

(2009) Jean Paul Thiery et al.   CELL

Small molecule–mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer

(2009) Baozhi Chen et al.   Nature Chemical Biology

Recent Progress in the Medicinal Chemistry of γ-Secretase Inhibitors

(2008) Richard Olson et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Efficient tumour formation by single human melanoma cells

(2008) Elsa Quintana et al.   NATURE

Generation of Breast Cancer Stem Cells through Epithelial-Mesenchymal Transition

(2008) Anne-Pierre Morel et al.   PLoS One

Towards the Optimal Screening Collection: A Synthesis Strategy

(2007) Thomas E. Nielsen et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION