Evolution and Virulence of Influenza A Virus Protein PB1-F2

Effects of PB1-F2 on the pathogenicity of H1N1 swine influenza virus in mice and pigs

(2017) Jinhwa Lee et al.   JOURNAL OF GENERAL VIROLOGY

Influenza virus protein PB1-F2 interacts with CALCOCO2 (NDP52) to modulate innate immune response

(2017) Olivier Leymarie et al.   JOURNAL OF GENERAL VIROLOGY

PA-X protein contributes to virulence of triple-reassortant H1N2 influenza virus by suppressing early immune responses in swine

(2017) Guanlong Xu et al.   VIROLOGY

Rapid evolution of the PB1-F2 virulence protein expressed by human seasonal H3N2 influenza viruses reduces inflammatory responses to infection

(2017) Julie McAuley et al.   Virology Journal

Amino Acid Residues 68–71 Contribute to Influenza A Virus PB1-F2 Protein Stability and Functions

(2017) Yi-Ying Cheng et al.   Frontiers in Microbiology

PB1-F2 Peptide Derived from Avian Influenza A Virus H7N9 Induces Inflammation via Activation of the NLRP3 Inflammasome

(2016) Anita Pinar et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Influenza A virus PB1-F2 protein prolongs viral shedding in chickens lengthening the transmission window

(2016) Joe James et al.   JOURNAL OF GENERAL VIROLOGY

The Influenza Virus Protein PB1-F2 Increases Viral Pathogenesis through Neutrophil Recruitment and NK Cells Inhibition

(2016) Aurore Vidy et al.   PLoS One

Differential evolution of peripheral cytokine levels in symptomatic and asymptomatic responses to experimental influenza virus challenge

(2015) M. T. McClain et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Amyloid Assemblies of Influenza A Virus PB1-F2 Protein Damage Membrane and Induce Cytotoxicity

(2015) Jasmina Vidic et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PB1-F2 Protein Does Not Impact the Virulence of Triple-Reassortant H3N2 Swine Influenza Virus in Pigs but Alters Pathogenicity and Transmission in Turkeys

(2015) Jagadeeswaran Deventhiran et al.   JOURNAL OF VIROLOGY

Emergence of Highly Pathogenic Avian Influenza A(H5N1) Virus PB1-F2 Variants and Their Virulence in BALB/c Mice

(2015) Ram P. Kamal et al.   JOURNAL OF VIROLOGY

The Ubiquitination of the Influenza A Virus PB1-F2 Protein Is Crucial for Its Biological Function

(2015) Ivan Košík et al.   PLoS One

Early apoptosis of porcine alveolar macrophages limits avian influenza virus replication and pro-inflammatory dysregulation

(2015) Pengxiang Chang et al.   Scientific Reports

A synchronized global sweep of the internal genes of modern avian influenza virus

(2014) Michael Worobey et al.   NATURE

PB1-F2 Attenuates Virulence of Highly Pathogenic Avian H5N1 Influenza Virus in Chickens

(2014) Olivier Leymarie et al.   PLoS One

Non-Avian Animal Reservoirs Present a Source of Influenza A PB1-F2 Proteins with Novel Virulence-Enhancing Markers

(2014) Irina V. Alymova et al.   PLoS One

NLRX1 prevents mitochondrial induced apoptosis and enhances macrophage antiviral immunity by interacting with influenza virus PB1-F2 protein

(2014) J. Jaworska et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular mechanisms enhancing the proteome of influenza A viruses: An overview of recently discovered proteins

(2014) A.V. Vasin et al.   VIRUS RESEARCH

Influenza A virus protein PB1-F2 translocates into mitochondria via Tom40 channels and impairs innate immunity

(2014) Takuma Yoshizumi et al.   Nature Communications

The Adaptor MAVS Promotes NLRP3 Mitochondrial Localization and Inflammasome Activation

(2013) Naeha Subramanian et al.   CELL

Influenza A Virus PB1-F2 Protein Expression Is Regulated in a Strain-Specific Manner by Sequences Located Downstream of the PB1-F2 Initiation Codon

(2013) J. Buehler et al.   JOURNAL OF VIROLOGY

A Novel Cytotoxic Sequence Contributes to Influenza A Viral Protein PB1-F2 Pathogenicity and Predisposition to Secondary Bacterial Infection

(2013) I. V. Alymova et al.   JOURNAL OF VIROLOGY

Kinetic Characterization of PB1-F2-Mediated Immunopathology during Highly Pathogenic Avian H5N1 Influenza Virus Infection

(2013) Olivier Leymarie et al.   PLoS One

Sulfatide Regulates Caspase-3-Independent Apoptosis of Influenza A Virus through Viral PB1-F2 Protein

(2013) Tadanobu Takahashi et al.   PLoS One

The Influenza Virus Protein PB1-F2 Interacts with IKKβ and Modulates NF-κB Signalling

(2013) Ana Luísa Reis et al.   PLoS One

Activation of the NLRP3 Inflammasome by IAV Virulence Protein PB1-F2 Contributes to Severe Pathophysiology and Disease

(2013) Julie L. McAuley et al.   PLoS Pathogens

Influenza A virus protein PB1-F2 from different strains shows distinct structural signatures

(2012) Sara M.Ø. Solbak et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Strain-dependent effects of PB1-F2 of triple-reassortant H3N2 influenza viruses in swine

(2012) L. Pena et al.   JOURNAL OF GENERAL VIROLOGY

Naturally Occurring Swine Influenza A Virus PB1-F2 Phenotypes That Contribute to Superinfection with Gram-Positive Respiratory Pathogens

(2012) J. N. Weeks-Gorospe et al.   JOURNAL OF VIROLOGY

Restored PB1-F2 in the 2009 Pandemic H1N1 Influenza Virus Has Minimal Effects in Swine

(2012) L. Pena et al.   JOURNAL OF VIROLOGY

PB1-F2 Modulates Early Host Responses but Does Not Affect the Pathogenesis of H1N1 Seasonal Influenza Virus

(2012) Isabelle Meunier et al.   JOURNAL OF VIROLOGY

Influenza Virus Protein PB1-F2 Inhibits the Induction of Type I Interferon by Binding to MAVS and Decreasing Mitochondrial Membrane Potential

(2012) Zsuzsanna T. Varga et al.   JOURNAL OF VIROLOGY

The influenza virus PB1-F2 protein has interferon antagonistic activity

(2011) Sabine E. Dudek et al.   BIOLOGICAL CHEMISTRY

Behaviour of influenza A viruses differentially expressing segment 2 gene products in vitro and in vivo

(2011) S. Tauber et al.   JOURNAL OF GENERAL VIROLOGY

Influenza Virus Primes Mice for Pneumonia From Staphylococcus aureus

(2011) Amy R. Iverson et al.   JOURNAL OF INFECTIOUS DISEASES

Immunopathogenic and Antibacterial Effects of H3N2 Influenza A Virus PB1-F2 Map to Amino Acid Residues 62, 75, 79, and 82

(2011) I. V. Alymova et al.   JOURNAL OF VIROLOGY

Impact of Amino Acid Mutations in PB2, PB1-F2, and NS1 on the Replication and Pathogenicity of Pandemic (H1N1) 2009 Influenza Viruses

(2011) M. Ozawa et al.   JOURNAL OF VIROLOGY

Transcriptomic Analysis of Host Immune and Cell Death Responses Associated with the Influenza A Virus PB1-F2 Protein

(2011) Ronan Le Goffic et al.   PLoS Pathogens

Differential Contribution of PB1-F2 to the Virulence of Highly Pathogenic H5N1 Influenza A Virus in Mammalian and Avian Species

(2011) Mirco Schmolke et al.   PLoS Pathogens

The Influenza Virus Protein PB1-F2 Inhibits the Induction of Type I Interferon at the Level of the MAVS Adaptor Protein

(2011) Zsuzsanna T. Varga et al.   PLoS Pathogens

Three amino acid changes in PB1-F2 of highly pathogenic H5N1 avian influenza virus affect pathogenicity in mallard ducks

(2010) Henju Marjuki et al.   ARCHIVES OF VIROLOGY

PB1-F2 Influenza A Virus Protein Adopts a β-Sheet Conformation and Forms Amyloid Fibers in Membrane Environments

(2010) Christophe Chevalier et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Influenza A Virus Protein PB1-F2 Exacerbates IFN-  Expression of Human Respiratory Epithelial Cells

(2010) R. Le Goffic et al.   JOURNAL OF IMMUNOLOGY

PB1-F2 Expression by the 2009 Pandemic H1N1 Influenza Virus Has Minimal Impact on Virulence in Animal Models

(2010) R. Hai et al.   JOURNAL OF VIROLOGY

A Single N66S Mutation in the PB1-F2 Protein of Influenza A Virus Increases Virulence by Inhibiting the Early Interferon Response In Vivo

(2010) G. M. Conenello et al.   JOURNAL OF VIROLOGY

Differential Localization and Function of PB1-F2 Derived from Different Strains of Influenza A Virus

(2010) C.-J. Chen et al.   JOURNAL OF VIROLOGY

The Proapoptotic Influenza A Virus Protein PB1-F2 Forms a Nonselective Ion Channel

(2010) Michael Henkel et al.   PLoS One

PB1-F2 Proteins from H5N1 and 20th Century Pandemic Influenza Viruses Cause Immunopathology

(2010) Julie L. McAuley et al.   PLoS Pathogens

Phosphorylation of the influenza A virus protein PB1-F2 by PKC is crucial for apoptosis promoting functions in monocytes

(2009) David Mitzner et al.   CELLULAR MICROBIOLOGY

A Complicated Message: Identification of a Novel PB1-Related Protein Translated from Influenza A Virus Segment 2 mRNA

(2009) H. M. Wise et al.   JOURNAL OF VIROLOGY

The Effects of Influenza A Virus PB1-F2 Protein on Polymerase Activity Are Strain Specific and Do Not Impact Pathogenesis

(2009) J. L. McAuley et al.   JOURNAL OF VIROLOGY

The proapoptotic influenza A virus protein PB1-F2 regulates viral polymerase activity by interaction with the PB1 protein

(2008) Igor Mazur et al.   CELLULAR MICROBIOLOGY

Innate immunity to virus infection

(2008) Osamu Takeuchi et al.   IMMUNOLOGICAL REVIEWS