Journal
VIROLOGY JOURNAL
Volume 14, Issue -, Pages -Publisher
BIOMED CENTRAL LTD
DOI: 10.1186/s12985-017-0827-0
Keywords
PB1-F2; Influenza A virus; Pandemic; Seasonal; Inflammation; Virulence; Pathogenicity; Respiratory disease
Categories
Funding
- Australian Government National Health and Medical Research Council grant [1,026,619, 567,122]
- Australian Government Department of Health
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Influenza A virus (IAV) PB1-F2 protein has been linked to viral virulence. Strains of the H3N2 subtype historically express full-length PB1-F2 proteins but during the 2010-2011 influenza seasons, nearly half of the circulating H3N2 IAVs encoded truncated PB1-F2 protein. Using a panel of reverse engineered H3N2 IAVs differing only in the origin of the PB1 gene segment, we found that only the virus encoding the avian-derived 1968 PB1 gene matching the human pandemic strain enhanced cellular infiltrate into the alveolar spaces of infected mice. We linked this phenomenon to expression of full-length PB1-F2 protein encompassing critical inflammatory residues.
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