Matrix Metalloproteinase Gene Activation Resulting from Disordred Epigenetic Mechanisms in Rheumatoid Arthritis

Thrombospondin-2 promotes prostate cancer bone metastasis by the up-regulation of matrix metalloproteinase-2 through down-regulating miR-376c expression

(2017) Po-Chun Chen et al.   Journal of Hematology & Oncology

Methylation in the matrix metalloproteinase-2 gene is associated with cerebral ischemic stroke

(2017) Hsiu-Fen Lin et al.   JOURNAL OF INVESTIGATIVE MEDICINE

Role of miR-155 in the regulation of MMP-16 expression in intervertebral disc degeneration

(2017) Wei-Lin Zhang et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

The Histone Modification Code in the Pathogenesis of Autoimmune Diseases

(2017) Yasuto Araki et al.   MEDIATORS OF INFLAMMATION

The Involvement of miR-29b-3p in Arterial Calcification by Targeting Matrix Metalloproteinase-2

(2017) Wenhong Jiang et al.   Biomed Research International

DNA Methylation of MMP9 Is Associated with High Levels of MMP-9 Messenger RNA in Periapical Inflammatory Lesions

(2016) Kelma Campos et al.   JOURNAL OF ENDODONTICS

Historical observations contributing insights on etiopathogenesis of rheumatoid arthritis and role of rheumatoid factor

(2016) Eng M. Tan et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Dynamic DNA methylation of matrix metalloproteinase-9 in the development of diabetic retinopathy

(2016) Renu A Kowluru et al.   LABORATORY INVESTIGATION

Dysregulated miR-133a Mediates Loss of Type II Collagen by Directly Targeting Matrix Metalloproteinase 9 (MMP9) in Human Intervertebral Disc Degeneration

(2016) Yun-qiang Xu et al.   SPINE

Downregulation of miR-27b is Involved in Loss of Type II Collagen by Directly Targeting Matrix Metalloproteinase 13 (MMP13) in Human Intervertebral Disc Degeneration

(2016) Hao-ran Li et al.   SPINE

Selective Inhibition of Membrane Type 1 Matrix Metalloproteinase Abrogates Progression of Experimental Inflammatory Arthritis: Synergy With Tumor Necrosis Factor Blockade

(2016) Kazuyo Kaneko et al.   Arthritis & Rheumatology

The Mechanisms Underlying Chronic Inflammation in Rheumatoid Arthritis from the Perspective of the Epigenetic Landscape

(2016) Yasuto Araki et al.   Journal of Immunology Research

Inhibition of class I histone deacetylase activity represses matrix metalloproteinase-2 and -9 expression and preserves LV function postmyocardial infarction

(2015) Santhosh K. Mani et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Genetic studies of rheumatoid arthritis

(2015) Kazuhiko YAMAMOTO et al.   PROCEEDINGS OF THE JAPAN ACADEMY SERIES B-PHYSICAL AND BIOLOGICAL SCIENCES

The ADAMTS (A Disintegrin and Metalloproteinase with Thrombospondin motifs) family

(2015) Richard Kelwick et al.   GENOME BIOLOGY

Metalloproteinases: potential therapeutic targets for rheumatoid arthritis

(2015) Yoshifumi Itoh   Endocrine Metabolic & Immune Disorders-Drug Targets

Efficacy of biological disease-modifying antirheumatic drugs: a systematic literature review informing the 2013 update of the EULAR recommendations for the management of rheumatoid arthritis

(2014) Jackie L Nam et al.   ANNALS OF THE RHEUMATIC DISEASES

Anti-citrullinated peptides as autoantigens in rheumatoid arthritis—relevance to treatment

(2014) Lazaros I. Sakkas et al.   AUTOIMMUNITY REVIEWS

Aberrant histone acetylation contributes to elevated interleukin-6 production in rheumatoid arthritis synovial fibroblasts

(2014) Takuma Tsuzuki Wada et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The Use of Biologic Therapies in the Treatment of Rheumatoid Arthritis

(2014) Dashan Wang et al.   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

Histone Acetylation Facilitates Rapid and Robust Memory CD8 T Cell Response through Differential Expression of Effector Molecules (Eomesodermin and Its Targets: Perforin and Granzyme B)

(2014) Y. Araki et al.   JOURNAL OF IMMUNOLOGY

JAK inhibitor tofacitinib for treating rheumatoid arthritis: from basic to clinical

(2014) Yoshiya Tanaka et al.   Modern Rheumatology

Identification and consequences of miRNA–target interactions — beyond repression of gene expression

(2014) Jean Hausser et al.   NATURE REVIEWS GENETICS

Current and emerging therapeutic strategies for preventing inflammation and aggrecanase-mediated cartilage destruction in arthritis

(2014) Carolyn M Dancevic et al.   ARTHRITIS RESEARCH & THERAPY

Tofacitinib in Combination With Nonbiologic Disease-Modifying Antirheumatic Drugs in Patients With Active Rheumatoid Arthritis

(2013) Joel Kremer et al.   ANNALS OF INTERNAL MEDICINE

Tofacitinib (CP-690,550) in patients with rheumatoid arthritis receiving methotrexate: Twelve-month data from a twenty-four-month phase III randomized radiographic study

(2013) Désirée van der Heijde et al.   ARTHRITIS AND RHEUMATISM

Downregulation of miR-106b induced breast cancer cell invasion and motility in association with overexpression of matrix metalloproteinase 2

(2013) Xiaojian Ni et al.   CANCER SCIENCE

Protein arginine methylation of non-histone proteins and its role in diseases

(2013) Han Wei et al.   CELL CYCLE

Upregulated MicroRNA-155 Expression in Peripheral Blood Mononuclear Cells and Fibroblast-Like Synoviocytes in Rheumatoid Arthritis

(2013) Li Long et al.   Clinical & Developmental Immunology

The fibroblast as a therapeutic target in rheumatoid arthritis

(2013) Andrew Filer   CURRENT OPINION IN PHARMACOLOGY

Histone Deacetylase (HDAC) 10 Suppresses Cervical Cancer Metastasis through Inhibition of Matrix Metalloproteinase (MMP) 2 and 9 Expression

(2013) Chenlin Song et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Tofacitinib (CP-690,550) in combination with methotrexate in patients with active rheumatoid arthritis with an inadequate response to tumour necrosis factor inhibitors: a randomised phase 3 trial

(2013) Gerd R Burmester et al.   LANCET

Genetics of rheumatoid arthritis contributes to biology and drug discovery

(2013) Yukinori Okada et al.   NATURE

The COMPASS Family of Histone H3K4 Methylases: Mechanisms of Regulation in Development and Disease Pathogenesis

(2012) Ali Shilatifard   Annual Review of Biochemistry

Cartilage as a target of autoimmunity: A thin layer

(2012) Silvia Frisenda et al.   AUTOIMMUNITY REVIEWS

Protease signalling: the cutting edge

(2012) Boris Turk et al.   EMBO JOURNAL

Histone methylation: a dynamic mark in health, disease and inheritance

(2012) Eric L. Greer et al.   NATURE REVIEWS GENETICS

Placebo-Controlled Trial of Tofacitinib Monotherapy in Rheumatoid Arthritis

(2012) Roy Fleischmann et al.   NEW ENGLAND JOURNAL OF MEDICINE

Tofacitinib or Adalimumab versus Placebo in Rheumatoid Arthritis

(2012) Ronald F. van Vollenhoven et al.   NEW ENGLAND JOURNAL OF MEDICINE

Expression and function of EZH2 in synovial fibroblasts: epigenetic repression of the Wnt inhibitor SFRP1 in rheumatoid arthritis

(2011) M. Trenkmann et al.   ANNALS OF THE RHEUMATIC DISEASES

A Concise Review on Epigenetic Regulation: Insight into Molecular Mechanisms

(2011) Shahram Golbabapour et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

TLR2 Expression Is Regulated by MicroRNA miR-19 in Rheumatoid Fibroblast-like Synoviocytes

(2011) L. Philippe et al.   JOURNAL OF IMMUNOLOGY

The Pathogenesis of Rheumatoid Arthritis

(2011) Iain B. McInnes et al.   NEW ENGLAND JOURNAL OF MEDICINE

Golimumab in patients with active rheumatoid arthritis despite methotrexate therapy: 52-week results of the GO-FORWARD study

(2010) E. Keystone et al.   ANNALS OF THE RHEUMATIC DISEASES

Matrix metalloproteinase 8 deficiency in mice exacerbates inflammatory arthritis through delayed neutrophil apoptosis and reduced caspase 11 expression

(2010) Jennifer H. Cox et al.   ARTHRITIS AND RHEUMATISM

Golimumab, a new human anti-tumor necrosis factor α antibody, administered intravenously in patients with active rheumatoid arthritis: Forty-eight-week efficacy and safety results of a phase III randomized, double-blind, placebo-controlled study

(2010) Joel Kremer et al.   ARTHRITIS AND RHEUMATISM

Tocilizumab inhibits structural joint damage in rheumatoid arthritis patients with inadequate responses to methotrexate: Results from the double-blind treatment phase of a randomized placebo-controlled trial of tocilizumab safety and prevention of structu

(2010) Joel M. Kremer et al.   ARTHRITIS AND RHEUMATISM

Altered expression of microRNA-203 in rheumatoid arthritis synovial fibroblasts and its role in fibroblast activation

(2010) Joanna Stanczyk et al.   ARTHRITIS AND RHEUMATISM

Matrix Metalloproteinases: Regulators of the Tumor Microenvironment

(2010) Kai Kessenbrock et al.   CELL

Histone arginine methylation

(2010) Alessandra Di Lorenzo et al.   FEBS LETTERS

Membrane-Type I Matrix Metalloproteinase-Dependent Regulation of Rheumatoid Arthritis Synoviocyte Function

(2010) F. Sabeh et al.   JOURNAL OF IMMUNOLOGY

Emerging principles in protease-based drug discovery

(2010) Marcin Drag et al.   NATURE REVIEWS DRUG DISCOVERY

Periodontitis in RA—the citrullinated enolase connection

(2010) Karin Lundberg et al.   Nature Reviews Rheumatology

Effect of the oral application of a highly selective MMP-13 inhibitor in three different animal models of rheumatoid arthritis

(2009) A. Jungel et al.   ANNALS OF THE RHEUMATIC DISEASES

Comparison of tocilizumab monotherapy versus methotrexate monotherapy in patients with moderate to severe rheumatoid arthritis: the AMBITION study

(2009) G. Jones et al.   ANNALS OF THE RHEUMATIC DISEASES

Clinical efficacy and safety of abatacept in methotrexate-naive patients with early rheumatoid arthritis and poor prognostic factors

(2009) R Westhovens et al.   ANNALS OF THE RHEUMATIC DISEASES

Familial associations of rheumatoid arthritis with autoimmune diseases and related conditions

(2009) Kari Hemminki et al.   ARTHRITIS AND RHEUMATISM

DNA hypomethylation in rheumatoid arthritis synovial fibroblasts

(2009) Emmanuel Karouzakis et al.   ARTHRITIS AND RHEUMATISM

Membrane type 1 matrix metalloproteinase is a crucial promoter of synovial invasion in human rheumatoid arthritis

(2009) Mary-Clare Miller et al.   ARTHRITIS AND RHEUMATISM

Golimumab, a human anti-tumor necrosis factor α monoclonal antibody, injected subcutaneously every four weeks in methotrexate-naive patients with active rheumatoid arthritis: Twenty-four-week results of a phase III, multicenter, randomized, double-blind, placebo-controlled study of golimumab before methotrexate as first-line therapy for early-onset rheumatoid arthritis

(2009) Paul Emery et al.   ARTHRITIS AND RHEUMATISM

The folding and unfolding of eukaryotic chromatin

(2009) Andrew Bassett et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

An operational definition of epigenetics

(2009) S. L. Berger et al.   GENES & DEVELOPMENT

Genome-wide Analysis of Histone Methylation Reveals Chromatin State-Based Regulation of Gene Transcription and Function of Memory CD8+ T Cells

(2009) Yasuto Araki et al.   IMMUNITY

Fibroblast-like synoviocytes: key effector cells in rheumatoid arthritis

(2009) Beatrix Bartok et al.   IMMUNOLOGICAL REVIEWS

Small silencing RNAs: an expanding universe

(2009) Megha Ghildiyal et al.   NATURE REVIEWS GENETICS

Efficacy and safety of certolizumab pegol plus methotrexate in active rheumatoid arthritis: the RAPID 2 study. A randomised controlled trial

(2008) J Smolen et al.   ANNALS OF THE RHEUMATIC DISEASES

Efficacy and safety of certolizumab pegol monotherapy every 4 weeks in patients with rheumatoid arthritis failing previous disease-modifying antirheumatic therapy: the FAST4WARD study

(2008) R Fleischmann et al.   ANNALS OF THE RHEUMATIC DISEASES

IL-6 receptor inhibition with tocilizumab improves treatment outcomes in patients with rheumatoid arthritis refractory to anti-tumour necrosis factor biologicals: results from a 24-week multicentre randomised placebo-controlled trial

(2008) P. Emery et al.   ANNALS OF THE RHEUMATIC DISEASES

Golimumab, a human antibody to tumour necrosis factor   given by monthly subcutaneous injections, in active rheumatoid arthritis despite methotrexate therapy: the GO-FORWARD Study

(2008) E C Keystone et al.   ANNALS OF THE RHEUMATIC DISEASES

Interleukin-6 receptor inhibition with tocilizumab reduces disease activity in rheumatoid arthritis with inadequate response to disease-modifying antirheumatic drugs: The tocilizumab in combination with traditional disease-modifying antirheumatic drug therapy study

(2008) Mark C. Genovese et al.   ARTHRITIS AND RHEUMATISM

Results of a two-year followup study of patients with rheumatoid arthritis who received a combination of abatacept and methotrexate

(2008) Joel M. Kremer et al.   ARTHRITIS AND RHEUMATISM

Certolizumab pegol plus methotrexate is significantly more effective than placebo plus methotrexate in active rheumatoid arthritis: Findings of a fifty-two-week, phase III, multicenter, randomized, double-blind, placebo-controlled, parallel-group study

(2008) Edward Keystone et al.   ARTHRITIS AND RHEUMATISM

Altered expression of MicroRNA in synovial fibroblasts and synovial tissue in rheumatoid arthritis

(2008) Joanna Stanczyk et al.   ARTHRITIS AND RHEUMATISM

Golimumab in patients with active rheumatoid arthritis despite treatment with methotrexate: A randomized, double-blind, placebo-controlled, dose-ranging study

(2008) Jonathan Kay et al.   ARTHRITIS AND RHEUMATISM

The development of novel therapies for rheumatoid arthritis

(2008) Ling-dong Quan et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

The role and therapeutic implications of fibroblast-like synoviocytes in inflammation and cartilage erosion in rheumatoid arthritis

(2008) Erika H. Noss et al.   IMMUNOLOGICAL REVIEWS

Proteases: Multifunctional Enzymes in Life and Disease

(2008) Carlos López-Otín et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Effect of interleukin-6 receptor inhibition with tocilizumab in patients with rheumatoid arthritis (OPTION study): a double-blind, placebo-controlled, randomised trial

(2008) Josef S Smolen et al.   LANCET

Comparison of methotrexate monotherapy with a combination of methotrexate and etanercept in active, early, moderate to severe rheumatoid arthritis (COMET): a randomised, double-blind, parallel treatment trial

(2008) Paul Emery et al.   LANCET

Combinatorial patterns of histone acetylations and methylations in the human genome

(2008) Zhibin Wang et al.   NATURE GENETICS