Protein arginine methylation of non-histone proteins and its role in diseases

Role of lysine methylation of NF- B in differential gene regulation

(2013) T. Lu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PRMT5 dimethylates R30 of the p65 subunit to activate NF- B

(2013) H. Wei et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Automethylation of protein arginine methyltransferase 6 (PRMT6) regulates its stability and its anti-HIV-1 activity

(2013) Diane N Singhroy et al.   Retrovirology

Protein arginine methyltransferase 5 is essential for growth of lung cancer cells

(2012) Zhongping Gu et al.   BIOCHEMICAL JOURNAL

Protein arginine methyltransferase 5 is a potential oncoprotein that upregulates G1 cyclins/cyclin-dependent kinases and the phosphoinositide 3-kinase/AKT signaling cascade

(2012) Tong-You W. Wei et al.   CANCER SCIENCE

Arginine methylation controls growth regulation by E2F-1

(2012) Er-Chieh Cho et al.   EMBO JOURNAL

Protein Arginine Methyltransferase 7 Regulates Cellular Response to DNA Damage by Methylating Promoter Histones H2A and H4 of the Polymerase δ Catalytic Subunit Gene,POLD1

(2012) Vrajesh Karkhanis et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

HOXA9 Methylation by PRMT5 Is Essential for Endothelial Cell Expression of Leukocyte Adhesion Molecules

(2012) S. Bandyopadhyay et al.   MOLECULAR AND CELLULAR BIOLOGY

Epigenetic protein families: a new frontier for drug discovery

(2012) Cheryl H. Arrowsmith et al.   NATURE REVIEWS DRUG DISCOVERY

Symmetric dimethylation of H3R2 is a newly identified histone mark that supports euchromatin maintenance

(2012) Valentina Migliori et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Cell Cycle Regulation by the PRMT6 Arginine Methyltransferase through Repression of Cyclin-Dependent Kinase Inhibitors

(2012) Markus A. Kleinschmidt et al.   PLoS One

Crystal structure of the human PRMT5:MEP50 complex

(2012) S. Antonysamy et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Activity-Based Protein Profiling of Protein Arginine Methyltransferase 1

(2011) Obiamaka Obianyo et al.   ACS Chemical Biology

JAK2V617F-Mediated Phosphorylation of PRMT5 Downregulates Its Methyltransferase Activity and Promotes Myeloproliferation

(2011) Fan Liu et al.   CANCER CELL

Protein Arginine Methyltransferase 5 Accelerates Tumor Growth by Arginine Methylation of the Tumor Suppressor Programmed Cell Death 4

(2011) M. A. Powers et al.   CANCER RESEARCH

Protein Arginine Methylation in Parasitic Protozoa

(2011) John C. Fisk et al.   EUKARYOTIC CELL

Protein-arginine Methyltransferase 1 (PRMT1) Methylates Ash2L, a Shared Component of Mammalian Histone H3K4 Methyltransferase Complexes

(2011) Jill S. Butler et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Methylation of H2AR29 is a novel repressive PRMT6 target

(2011) Tanja Waldmann et al.   Epigenetics & Chromatin

Nuclear Cyclin D1/CDK4 Kinase Regulates CUL4 Expression and Triggers Neoplastic Growth via Activation of the PRMT5 Methyltransferase

(2010) Priya Aggarwal et al.   CANCER CELL

Prmt5 is essential for early mouse development and acts in the cytoplasm to maintain ES cell pluripotency

(2010) W.-W. Tee et al.   GENES & DEVELOPMENT

Dysregulation of PRMT1 and PRMT6, Type I arginine methyltransferases, is involved in various types of human cancers

(2010) Masanori Yoshimatsu et al.   INTERNATIONAL JOURNAL OF CANCER

Arginine methylation of the B cell antigen receptor promotes differentiation

(2010) Simona Infantino et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Lysine methylation of the NF-κB subunit RelA by SETD6 couples activity of the histone methyltransferase GLP at chromatin to tonic repression of NF-κB signaling

(2010) Dan Levy et al.   NATURE IMMUNOLOGY

Arginine methylation in subunits of mammalian pre-mRNA cleavage factor I

(2010) G. Martin et al.   RNA

Kinetic analysis of human protein arginine N-methyltransferase 2: formation of monomethyl- and asymmetric dimethyl-arginine residues on histone H4

(2009) Ted M. Lakowski et al.   BIOCHEMICAL JOURNAL

Optimization of pyrazole inhibitors of Coactivator Associated Arginine Methyltransferase 1 (CARM1)

(2009) Tram Huynh et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Arginine methyltransferase CARM1/PRMT4 regulates endochondral ossification

(2009) Tatsuo Ito et al.   BMC DEVELOPMENTAL BIOLOGY

The protein arginine methyltransferase family: an update about function, new perspectives and the physiological role in humans

(2009) S. S. Wolf   CELLULAR AND MOLECULAR LIFE SCIENCES

Negative regulation of NF-κB action by Set9-mediated lysine methylation of the RelA subunit

(2009) Xiao-Dong Yang et al.   EMBO JOURNAL

Role of pICLn in Methylation of Sm Proteins by PRMT5

(2009) G. Scott Pesiridis et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Mouse PRMT1 Null Allele Defines an Essential Role for Arginine Methylation in Genome Maintenance and Cell Proliferation

(2009) Z. Yu et al.   MOLECULAR AND CELLULAR BIOLOGY

Protein Arginine Methylation in Mammals: Who, What, and Why

(2009) Mark T. Bedford et al.   MOLECULAR CELL

Minireview: Protein Arginine Methylation of Nonhistone Proteins in Transcriptional Regulation

(2009) Young-Ho Lee et al.   MOLECULAR ENDOCRINOLOGY

Role of the PRMT–DDAH–ADMA axis in the regulation of endothelial nitric oxide production

(2009) Arthur J. Pope et al.   PHARMACOLOGICAL RESEARCH

Validation-based insertional mutagenesis identifies lysine demethylase FBXL11 as a negative regulator of NF B

(2009) T. Lu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation of NF-κB activity through lysine monomethylation of p65

(2009) Chee-Kwee Ea et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation of NF- B by NSD1/FBXL11-dependent reversible lysine methylation of p65

(2009) T. Lu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Caenorhabditis elegans Protein Arginine Methyltransferase PRMT-5 Negatively Regulates DNA Damage-Induced Apoptosis

(2009) Mei Yang et al.   PLoS Genetics

N-Benzyl-1-heteroaryl-3-(trifluoromethyl)-1H-pyrazole-5-carboxamides as inhibitors of co-activator associated arginine methyltransferase 1 (CARM1)

(2008) Martin Allan et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

CARM1 Regulates Estrogen-Stimulated Breast Cancer Growth through Up-regulation of E2F1

(2008) S. Frietze et al.   CANCER RESEARCH

PRMT1 mediated methylation of TAF15 is required for its positive gene regulatory function

(2008) Laure Jobert et al.   EXPERIMENTAL CELL RESEARCH

Methylation of RUNX1 by PRMT1 abrogates SIN3A binding and potentiates its transcriptional activity

(2008) X. Zhao et al.   GENES & DEVELOPMENT

Association of asymmetric dimethylarginine with sickle cell disease-related pulmonary hypertension

(2008) P. P. Landburg et al.   HAEMATOLOGICA

Protein Arginine Methyltransferase 1 Coactivates NF-κB-Dependent Gene Expression Synergistically with CARM1 and PARP1

(2008) Paul O. Hassa et al.   JOURNAL OF MOLECULAR BIOLOGY

Protein Arginine Methyltransferase 5 Suppresses the Transcription of the RB Family of Tumor Suppressors in Leukemia and Lymphoma Cells

(2008) L. Wang et al.   MOLECULAR AND CELLULAR BIOLOGY

Regulation of Estrogen Rapid Signaling through Arginine Methylation by PRMT1

(2008) Muriel Le Romancer et al.   MOLECULAR CELL

Arginine methylation regulates the p53 response

(2008) Martin Jansson et al.   NATURE CELL BIOLOGY