Current and emerging therapeutic strategies for preventing inflammation and aggrecanase-mediated cartilage destruction in arthritis

Therapeutic efficacy of tocilizumab in patients with rheumatoid arthritis refractory to anti-tumor-necrosis-factor inhibitors: 1 year follow-up with low-field extremity MRI

(2014) Takeshi Suzuki et al.   Modern Rheumatology

Celecoxib exerts protective effects on extracellular matrix metabolism of mandibular condylar chondrocytes under excessive mechanical stress

(2014) S.-C. Su et al.   OSTEOARTHRITIS AND CARTILAGE

Biosynthesis and Expression of a Disintegrin-like and Metalloproteinase Domain with Thrombospondin-1 Repeats-15

(2013) Carolyn M. Dancevic et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Targeting of ADAMTS5's ancillary domain with the recombinant mAb CRB0017 ameliorates disease progression in a spontaneous murine model of osteoarthritis

(2013) R. Chiusaroli et al.   OSTEOARTHRITIS AND CARTILAGE

Mutation of Membrane Type-1 Metalloproteinase, MT1-MMP, Causes the Multicentric Osteolysis and Arthritis Disease Winchester Syndrome

(2012) Brad R. Evans et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Down-titration and discontinuation of infliximab in rheumatoid arthritis patients with stable low disease activity and stable treatment: an observational cohort study

(2012) Aatke van der Maas et al.   ANNALS OF THE RHEUMATIC DISEASES

MMP proteolysis of the human extracellular matrix protein aggrecan is mainly a process of normal turnover

(2012) André Struglics et al.   BIOCHEMICAL JOURNAL

Development of a novel immunoassay for the measurement of type II collagen neoepitope generated by collagenase cleavage

(2012) Tatsuya Takahashi et al.   CLINICA CHIMICA ACTA

Adalimumab in the treatment of rheumatoid arthritis

(2012) Paraskevi V Voulgari et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

Steroid Modulation of Cytokine Release and Desmosine Levels in Bilateral Total Knee Replacement

(2012) Kethy M Jules-Elysee et al.   JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME

Discovery of Highly Potent and Selective Small Molecule ADAMTS-5 Inhibitors That Inhibit Human Cartilage Degradation via Encoded Library Technology (ELT)

(2012) Hongfeng Deng et al.   JOURNAL OF MEDICINAL CHEMISTRY

Efficacy of concurrent administration of cilostazol and methotrexate in rheumatoid arthritis: Pharmacologic and clinical significance

(2012) Hye Young Kim et al.   LIFE SCIENCES

Optimizing outcomes in patients with rheumatoid arthritis and an inadequate response to anti-TNF treatment

(2012) P. Emery   RHEUMATOLOGY

Inhibitory effects of simvastatin on migration and invasion of rheumatoid fibroblast-like synoviocytes by preventing geranylgeranylation of RhoA

(2012) Youjun Xiao et al.   RHEUMATOLOGY INTERNATIONAL

Rosuvastatin might have an effect on C-reactive protein but not on rheumatoid disease activity: Tayside randomized controlled study

(2012) P Kumar et al.   SCOTTISH MEDICAL JOURNAL

Tocilizumab as monotherapy or in combination with nonbiologic disease-modifying antirheumatic drugs: Twenty-four-week results of an open-label, clinical practice study

(2012) Michael E. Weinblatt et al.   ARTHRITIS CARE & RESEARCH

Statins accelerate the onset of collagen type II-induced arthritis in mice

(2012) Rob J Vandebriel et al.   ARTHRITIS RESEARCH & THERAPY

Orally active achiral N-hydroxyformamide inhibitors of ADAM-TS4 (aggrecanase-1) and ADAM-TS5 (aggrecanase-2) for the treatment of osteoarthritis

(2011) Chris De Savi et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Structure–activity study on a series of α-glutamic acid scaffold based compounds as new ADAMTS inhibitors

(2011) Lijie Peng et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Oxidative stress as a mechanism underlying sulfasalazine-induced toxicity

(2011) Victoria Linares et al.   Expert Opinion On Drug Safety

Interleukin-6 upregulates expression of ADAMTS-4 in fibroblast-like synoviocytes from patients with rheumatoid arthritis

(2011) Yoshikuni MIMATA et al.   International Journal of Rheumatic Diseases

Adamts5 (aggrecanase-2) is widely expressed in the mouse musculoskeletal system and is induced in specific regions of knee joint explants by inflammatory cytokines

(2011) James D. Wylie et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Zonal differences in meniscus matrix turnover and cytokine response

(2011) E.S. Fuller et al.   OSTEOARTHRITIS AND CARTILAGE

The role of synovial macrophages and macrophage-produced mediators in driving inflammatory and destructive responses in osteoarthritis

(2010) Jan Bondeson et al.   ARTHRITIS AND RHEUMATISM

Reactive-site mutants of N-TIMP-3 that selectively inhibit ADAMTS-4 and ADAMTS-5: biological and structural implications

(2010) Ngee H. Lim et al.   BIOCHEMICAL JOURNAL

New non-hydroxamic ADAMTS-5 inhibitors based on the 1,2,4-triazole-3-thiol scaffold

(2010) Lucie Maingot et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Effect of Atorvastatin on Inflammation and Modification of Vascular Risk Factors in Rheumatoid Arthritis

(2010) A. M. EL-BARBARY et al.   JOURNAL OF RHEUMATOLOGY

Mutations in MMP9 and MMP13 Determine the Mode of Inheritance and the Clinical Spectrum of Metaphyseal Anadysplasia

(2009) Ekkehart Lausch et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Synthesis and SAR of 2-phenyl-1-sulfonylaminocyclopropane carboxylates as ADAMTS-5 (Aggrecanase-2) inhibitors

(2009) Makoto Shiozaki et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Structural and Inhibition Analysis Reveals the Mechanism of Selectivity of a Series of Aggrecanase Inhibitors

(2009) Micky D. Tortorella et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The C-terminal domains of ADAMTS-4 and ADAMTS-5 promote association with N-TIMP-3

(2009) Linda Troeberg et al.   MATRIX BIOLOGY

Efficacy and safety of steroid injections for shoulder and elbow tendonitis: a meta-analysis of randomised controlled trials

(2008) C Gaujoux-Viala et al.   ANNALS OF THE RHEUMATIC DISEASES

Golimumab, a human antibody to tumour necrosis factor   given by monthly subcutaneous injections, in active rheumatoid arthritis despite methotrexate therapy: the GO-FORWARD Study

(2008) E C Keystone et al.   ANNALS OF THE RHEUMATIC DISEASES

N-((8-Hydroxy-5-substituted-quinolin-7-yl)(phenyl)methyl)-2-phenyloxy/amino-acetamide inhibitors of ADAMTS-5 (Aggrecanase-2)

(2008) Adam M. Gilbert et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Mevastatin reduces cartilage degradation in rabbit experimental osteoarthritis through inhibition of synovial inflammation

(2008) Y. Akasaki et al.   OSTEOARTHRITIS AND CARTILAGE

Cartilage degradation is fully reversible in the presence of aggrecanase but not matrix metalloproteinase activity

(2008) Morten A Karsdal et al.   ARTHRITIS RESEARCH & THERAPY