Neuroprotective Strategy in Retinal Degeneration: Suppressing ER Stress-Induced Cell Death via Inhibition of the mTOR Signal

mTOR signaling regulates myotube hypertrophy by modulating protein synthesis, rDNA transcription, and chromatin remodeling

(2016) Ferdinand von Walden et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

The antidepressant-like effect of alarin is related to TrkB-mTOR signaling and synaptic plasticity

(2016) Fuzhi Zhuang et al.   BEHAVIOURAL BRAIN RESEARCH

miR-18a promotes cell proliferation of esophageal squamous cell carcinoma cells by increasing cylin D1 via regulating PTEN-PI3K-AKT-mTOR signaling axis

(2016) Weiguo Zhang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Bridges between mitochondrial oxidative stress, ER stress and mTOR signaling in pancreatic β cells

(2016) Jing Wang et al.   CELLULAR SIGNALLING

Performance of a phosphoflow assay to determine phosphorylation of S6 ribosomal protein as a pharmacodynamic read out for mTOR inhibition

(2016) Emaad Abdel-Kahaar et al.   CLINICAL BIOCHEMISTRY

Inhibition of mTOR reduces lipotoxic cell death in primary macrophages through an autophagy-independent mechanism

(2016) Li He et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Swiss Family with Dominant Stargardt Disease Caused by a Recurrent Mutation in the ELOVL4 Gene

(2016) H. Tran et al.   KLINISCHE MONATSBLATTER FUR AUGENHEILKUNDE

Neuroprotection Through Rapamycin-Induced Activation of Autophagy and PI3K/Akt1/mTOR/CREB Signaling Against Amyloid-β-Induced Oxidative Stress, Synaptic/Neurotransmission Dysfunction, and Neurodegeneration in Adult Rats

(2016) Abhishek Kumar Singh et al.   MOLECULAR NEUROBIOLOGY

Defects in retinal pigment epithelial cell proteolysis and the pathology associated with age-related macular degeneration

(2016) Deborah A. Ferrington et al.   PROGRESS IN RETINAL AND EYE RESEARCH

Anti-Breast Cancer Potential of Quercetin via the Akt/AMPK/Mammalian Target of Rapamycin (mTOR) Signaling Cascade

(2016) Amilcar Rivera Rivera et al.   PLoS One

Limited ATF4 Expression in Degenerating Retinas with Ongoing ER Stress Promotes Photoreceptor Survival in a Mouse Model of Autosomal Dominant Retinitis Pigmentosa

(2016) Yogesh Bhootada et al.   PLoS One

Transcriptional induction of the heat shock protein B8 mediates the clearance of misfolded proteins responsible for motor neuron diseases

(2016) Valeria Crippa et al.   Scientific Reports

Multiple Mechanisms of Unfolded Protein Response–Induced Cell Death

(2015) Nobuhiko Hiramatsu et al.   AMERICAN JOURNAL OF PATHOLOGY

Preventive Effects of Rapamycin on Inflammation and Capillary Degeneration in a Rat Model of NMDA-Induced Retinal Injury

(2015) Yuto Aoki et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Regulation of protein homeostasis in neurodegenerative diseases: the role of coding and non-coding genes

(2015) Olga Sin et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Photoreceptor cell fate specification in vertebrates

(2015) Joseph A. Brzezinski et al.   DEVELOPMENT

Genetic ablation of N-linked glycosylation reveals two key folding pathways for R345W fibulin-3, a secreted protein associated with retinal degeneration

(2015) John D. Hulleman et al.   FASEB JOURNAL

Gene Therapy of Inherited Retinal Degenerations: Prospects and Challenges

(2015) Ivana Trapani et al.   HUMAN GENE THERAPY

Advancing Therapeutic Strategies for Inherited Retinal Degeneration: Recommendations From the Monaciano Symposium

(2015) D. A. Thompson et al.   INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE

La-related Protein 1 (LARP1) Represses Terminal Oligopyrimidine (TOP) mRNA Translation Downstream of mTOR Complex 1 (mTORC1)

(2015) Bruno D. Fonseca et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Stat1 stimulates cap-independent mRNA translation to inhibit cell proliferation and promote survival in response to antitumor drugs

(2015) Shuo Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Role of mTOR1 and mTOR2 complexes in MEG-01 cell physiology

(2015) Esther López et al.   THROMBOSIS AND HAEMOSTASIS

Modulation of cellular signaling pathways in P23H rhodopsin photoreceptors

(2014) Olga S. Sizova et al.   CELLULAR SIGNALLING

p70 Ribosomal protein S6 kinase (Rps6kb1): an update

(2014) Farnaz Bahrami-B et al.   JOURNAL OF CLINICAL PATHOLOGY

Proteomic Survey Reveals Altered Energetic Patterns and Metabolic Failure Prior to Retinal Degeneration

(2014) A. Griciuc et al.   JOURNAL OF NEUROSCIENCE

Ral and Rheb GTPase Activating Proteins Integrate mTOR and GTPase Signaling in Aging, Autophagy, and Tumor Cell Invasion

(2014) Timothy D. Martin et al.   MOLECULAR CELL

Robust Endoplasmic Reticulum-Associated Degradation of Rhodopsin Precedes Retinal Degeneration

(2014) Wei-Chieh Chiang et al.   MOLECULAR NEUROBIOLOGY

Clinical Characteristics and Current Therapies for Inherited Retinal Degenerations

(2014) J.-A. Sahel et al.   Cold Spring Harbor Perspectives in Medicine

Proteostasis and neurodegeneration: The roles of proteasomal degradation and autophagy

(2013) Keiji Tanaka et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

The cell stress machinery and retinal degeneration

(2013) Dimitra Athanasiou et al.   FEBS LETTERS

A channel for ERAD

(2013) Alison Schuldt   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Deciphering mutant ELOVL4 activity in autosomal-dominant Stargardt macular dystrophy

(2013) S. Logan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Caspase-7 ablation modulates UPR, reprograms TRAF2-JNK apoptosis and protects T17M rhodopsin mice from severe retinal degeneration

(2013) S Choudhury et al.   Cell Death & Disease

Loss of Pde6 reduces cell body Ca2+ transients within photoreceptors

(2013) E Y Ma et al.   Cell Death & Disease

Endoplasmic reticulum stress in human skeletal muscle: any contribution to sarcopenia?

(2013) Louise Deldicque   Frontiers in Physiology

IRE1 directs proteasomal and lysosomal degradation of misfolded rhodopsin

(2012) Wei-Chieh Chiang et al.   MOLECULAR BIOLOGY OF THE CELL

Bidirectional crosstalk between endoplasmic reticulum stress and mTOR signaling

(2012) Christian Appenzeller-Herzog et al.   TRENDS IN CELL BIOLOGY

Ulk1-mediated phosphorylation of AMPK constitutes a negative regulatory feedback loop

(2011) Antje S. Löffler et al.   Autophagy

Atg13 and FIP200 act independently of Ulk1 and Ulk2 in autophagy induction

(2011) Sebastian Alers et al.   Autophagy

ER Stress and Apoptosis: A New Mechanism for Retinal Cell Death

(2011) Guangjun Jing et al.   Experimental Diabetes Research

Effects of rapamycin and TOR on aging and memory: implications for Alzheimer’s disease

(2011) Renato X. Santos et al.   JOURNAL OF NEUROCHEMISTRY

Clearance of RhodopsinP23H aggregates requires the ERAD effector VCP

(2010) Ana Griciuc et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Parallel information processing channels created in the retina

(2010) P. H. Schiller   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Restoration of visual function in P23H rhodopsin transgenic rats by gene delivery of BiP/Grp78

(2010) M. S. Gorbatyuk et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inactivation of VCP/ter94 Suppresses Retinal Pathology Caused by Misfolded Rhodopsin in Drosophila

(2010) Ana Griciuc et al.   PLoS Genetics

Biological and Chemical Approaches to Diseases of Proteostasis Deficiency

(2009) Evan T. Powers et al.   Annual Review of Biochemistry

ER stress protects from retinal degeneration

(2009) César S Mendes et al.   EMBO JOURNAL

Prospects for retinal gene replacement therapy

(2009) Alexander J. Smith et al.   TRENDS IN GENETICS

Pharmacological manipulation of gain-of-function and dominant-negative mechanisms in rhodopsin retinitis pigmentosa

(2008) Hugo F. Mendes et al.   HUMAN MOLECULAR GENETICS

Loss of Neuroprotective Survival Signal in Mice Lacking Insulin Receptor Gene in Rod Photoreceptor Cells

(2008) Ammaji Rajala et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cell death and endoplasmic reticulum stress: disease relevance and therapeutic opportunities

(2008) Inki Kim et al.   NATURE REVIEWS DRUG DISCOVERY