Neuroprotective Strategy in Retinal Degeneration: Suppressing ER Stress-Induced Cell Death via Inhibition of the mTOR Signal
出版年份 2017 全文链接
标题
Neuroprotective Strategy in Retinal Degeneration: Suppressing ER Stress-Induced Cell Death via Inhibition of the mTOR Signal
作者
关键词
-
出版物
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 18, Issue 1, Pages 201
出版商
MDPI AG
发表日期
2017-01-19
DOI
10.3390/ijms18010201
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- mTOR signaling regulates myotube hypertrophy by modulating protein synthesis, rDNA transcription, and chromatin remodeling
- (2016) Ferdinand von Walden et al. AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
- The antidepressant-like effect of alarin is related to TrkB-mTOR signaling and synaptic plasticity
- (2016) Fuzhi Zhuang et al. BEHAVIOURAL BRAIN RESEARCH
- miR-18a promotes cell proliferation of esophageal squamous cell carcinoma cells by increasing cylin D1 via regulating PTEN-PI3K-AKT-mTOR signaling axis
- (2016) Weiguo Zhang et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Bridges between mitochondrial oxidative stress, ER stress and mTOR signaling in pancreatic β cells
- (2016) Jing Wang et al. CELLULAR SIGNALLING
- Performance of a phosphoflow assay to determine phosphorylation of S6 ribosomal protein as a pharmacodynamic read out for mTOR inhibition
- (2016) Emaad Abdel-Kahaar et al. CLINICAL BIOCHEMISTRY
- Inhibition of mTOR reduces lipotoxic cell death in primary macrophages through an autophagy-independent mechanism
- (2016) Li He et al. JOURNAL OF LEUKOCYTE BIOLOGY
- Swiss Family with Dominant Stargardt Disease Caused by a Recurrent Mutation in the ELOVL4 Gene
- (2016) H. Tran et al. KLINISCHE MONATSBLATTER FUR AUGENHEILKUNDE
- Neuroprotection Through Rapamycin-Induced Activation of Autophagy and PI3K/Akt1/mTOR/CREB Signaling Against Amyloid-β-Induced Oxidative Stress, Synaptic/Neurotransmission Dysfunction, and Neurodegeneration in Adult Rats
- (2016) Abhishek Kumar Singh et al. MOLECULAR NEUROBIOLOGY
- Defects in retinal pigment epithelial cell proteolysis and the pathology associated with age-related macular degeneration
- (2016) Deborah A. Ferrington et al. PROGRESS IN RETINAL AND EYE RESEARCH
- Anti-Breast Cancer Potential of Quercetin via the Akt/AMPK/Mammalian Target of Rapamycin (mTOR) Signaling Cascade
- (2016) Amilcar Rivera Rivera et al. PLoS One
- Limited ATF4 Expression in Degenerating Retinas with Ongoing ER Stress Promotes Photoreceptor Survival in a Mouse Model of Autosomal Dominant Retinitis Pigmentosa
- (2016) Yogesh Bhootada et al. PLoS One
- Transcriptional induction of the heat shock protein B8 mediates the clearance of misfolded proteins responsible for motor neuron diseases
- (2016) Valeria Crippa et al. Scientific Reports
- Multiple Mechanisms of Unfolded Protein Response–Induced Cell Death
- (2015) Nobuhiko Hiramatsu et al. AMERICAN JOURNAL OF PATHOLOGY
- Preventive Effects of Rapamycin on Inflammation and Capillary Degeneration in a Rat Model of NMDA-Induced Retinal Injury
- (2015) Yuto Aoki et al. BIOLOGICAL & PHARMACEUTICAL BULLETIN
- Regulation of protein homeostasis in neurodegenerative diseases: the role of coding and non-coding genes
- (2015) Olga Sin et al. CELLULAR AND MOLECULAR LIFE SCIENCES
- Photoreceptor cell fate specification in vertebrates
- (2015) Joseph A. Brzezinski et al. DEVELOPMENT
- Genetic ablation of N-linked glycosylation reveals two key folding pathways for R345W fibulin-3, a secreted protein associated with retinal degeneration
- (2015) John D. Hulleman et al. FASEB JOURNAL
- Gene Therapy of Inherited Retinal Degenerations: Prospects and Challenges
- (2015) Ivana Trapani et al. HUMAN GENE THERAPY
- Advancing Therapeutic Strategies for Inherited Retinal Degeneration: Recommendations From the Monaciano Symposium
- (2015) D. A. Thompson et al. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
- La-related Protein 1 (LARP1) Represses Terminal Oligopyrimidine (TOP) mRNA Translation Downstream of mTOR Complex 1 (mTORC1)
- (2015) Bruno D. Fonseca et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Stat1 stimulates cap-independent mRNA translation to inhibit cell proliferation and promote survival in response to antitumor drugs
- (2015) Shuo Wang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Role of mTOR1 and mTOR2 complexes in MEG-01 cell physiology
- (2015) Esther López et al. THROMBOSIS AND HAEMOSTASIS
- Modulation of cellular signaling pathways in P23H rhodopsin photoreceptors
- (2014) Olga S. Sizova et al. CELLULAR SIGNALLING
- p70 Ribosomal protein S6 kinase (Rps6kb1): an update
- (2014) Farnaz Bahrami-B et al. JOURNAL OF CLINICAL PATHOLOGY
- Proteomic Survey Reveals Altered Energetic Patterns and Metabolic Failure Prior to Retinal Degeneration
- (2014) A. Griciuc et al. JOURNAL OF NEUROSCIENCE
- Ral and Rheb GTPase Activating Proteins Integrate mTOR and GTPase Signaling in Aging, Autophagy, and Tumor Cell Invasion
- (2014) Timothy D. Martin et al. MOLECULAR CELL
- Robust Endoplasmic Reticulum-Associated Degradation of Rhodopsin Precedes Retinal Degeneration
- (2014) Wei-Chieh Chiang et al. MOLECULAR NEUROBIOLOGY
- Clinical Characteristics and Current Therapies for Inherited Retinal Degenerations
- (2014) J.-A. Sahel et al. Cold Spring Harbor Perspectives in Medicine
- Proteostasis and neurodegeneration: The roles of proteasomal degradation and autophagy
- (2013) Keiji Tanaka et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
- The cell stress machinery and retinal degeneration
- (2013) Dimitra Athanasiou et al. FEBS LETTERS
- A channel for ERAD
- (2013) Alison Schuldt NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Deciphering mutant ELOVL4 activity in autosomal-dominant Stargardt macular dystrophy
- (2013) S. Logan et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Caspase-7 ablation modulates UPR, reprograms TRAF2-JNK apoptosis and protects T17M rhodopsin mice from severe retinal degeneration
- (2013) S Choudhury et al. Cell Death & Disease
- Loss of Pde6 reduces cell body Ca2+ transients within photoreceptors
- (2013) E Y Ma et al. Cell Death & Disease
- Endoplasmic reticulum stress in human skeletal muscle: any contribution to sarcopenia?
- (2013) Louise Deldicque Frontiers in Physiology
- IRE1 directs proteasomal and lysosomal degradation of misfolded rhodopsin
- (2012) Wei-Chieh Chiang et al. MOLECULAR BIOLOGY OF THE CELL
- Bidirectional crosstalk between endoplasmic reticulum stress and mTOR signaling
- (2012) Christian Appenzeller-Herzog et al. TRENDS IN CELL BIOLOGY
- Ulk1-mediated phosphorylation of AMPK constitutes a negative regulatory feedback loop
- (2011) Antje S. Löffler et al. Autophagy
- Atg13 and FIP200 act independently of Ulk1 and Ulk2 in autophagy induction
- (2011) Sebastian Alers et al. Autophagy
- ER Stress and Apoptosis: A New Mechanism for Retinal Cell Death
- (2011) Guangjun Jing et al. Experimental Diabetes Research
- Effects of rapamycin and TOR on aging and memory: implications for Alzheimer’s disease
- (2011) Renato X. Santos et al. JOURNAL OF NEUROCHEMISTRY
- Clearance of RhodopsinP23H aggregates requires the ERAD effector VCP
- (2010) Ana Griciuc et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
- Parallel information processing channels created in the retina
- (2010) P. H. Schiller PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Restoration of visual function in P23H rhodopsin transgenic rats by gene delivery of BiP/Grp78
- (2010) M. S. Gorbatyuk et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Inactivation of VCP/ter94 Suppresses Retinal Pathology Caused by Misfolded Rhodopsin in Drosophila
- (2010) Ana Griciuc et al. PLoS Genetics
- Biological and Chemical Approaches to Diseases of Proteostasis Deficiency
- (2009) Evan T. Powers et al. Annual Review of Biochemistry
- ER stress protects from retinal degeneration
- (2009) César S Mendes et al. EMBO JOURNAL
- Prospects for retinal gene replacement therapy
- (2009) Alexander J. Smith et al. TRENDS IN GENETICS
- Pharmacological manipulation of gain-of-function and dominant-negative mechanisms in rhodopsin retinitis pigmentosa
- (2008) Hugo F. Mendes et al. HUMAN MOLECULAR GENETICS
- Loss of Neuroprotective Survival Signal in Mice Lacking Insulin Receptor Gene in Rod Photoreceptor Cells
- (2008) Ammaji Rajala et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Cell death and endoplasmic reticulum stress: disease relevance and therapeutic opportunities
- (2008) Inki Kim et al. NATURE REVIEWS DRUG DISCOVERY
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreCreate your own webinar
Interested in hosting your own webinar? Check the schedule and propose your idea to the Peeref Content Team.
Create Now