Limited ATF4 Expression in Degenerating Retinas with Ongoing ER Stress Promotes Photoreceptor Survival in a Mouse Model of Autosomal Dominant Retinitis Pigmentosa

Parkin promotes proteasomal degradation of p62: implication of selective vulnerability of neuronal cells in the pathogenesis of Parkinson’s disease

(2016) Pingping Song et al.   Protein & Cell

Autophagy supports survival and phototransduction protein levels in rod photoreceptors

(2015) Z Zhou et al.   CELL DEATH AND DIFFERENTIATION

Coordinated Regulation of the Neutral Amino Acid Transporter SNAT2 and the Protein Phosphatase Subunit GADD34 Promotes Adaptation to Increased Extracellular Osmolarity

(2015) Dawid Krokowski et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Activation of NRF2 by p62 and proteasome reduction in sphere-forming breast carcinoma cells

(2015) In-geun Ryoo et al.   Oncotarget

GADD34 inhibits activation-induced apoptosis of macrophages through enhancement of autophagy

(2015) Sachiko Ito et al.   Scientific Reports

p62 provides dual cytoprotection against oxidative stress in the retinal pigment epithelium

(2014) Lei Wang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Autophagy in the eye: Implications for ocular cell health

(2014) Laura S. Frost et al.   EXPERIMENTAL EYE RESEARCH

Photoactivation-Induced Instability of Rhodopsin Mutants T4K and T17M in Rod Outer Segments Underlies Retinal Degeneration in X. laevis Transgenic Models of Retinitis Pigmentosa

(2014) B. M. Tam et al.   JOURNAL OF NEUROSCIENCE

ATF4 activation by the p38MAPK-eIF4E axis mediates apoptosis and autophagy induced by selenite in Jurkat cells

(2013) Qian Jiang et al.   FEBS LETTERS

Hsp90 inhibition protects against inherited retinal degeneration

(2013) Mònica Aguilà et al.   HUMAN MOLECULAR GENETICS

Lower mRNA and Protein Expression Levels of LC3 and Beclin1, Markers of Autophagy, were Correlated with Progression of Renal Clear Cell Carcinoma

(2013) Q. Deng et al.   JAPANESE JOURNAL OF CLINICAL ONCOLOGY

Autophagy Protects the Retina from Light-induced Degeneration

(2013) Yu Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ATF4 Protects Against Neuronal Death in Cellular Parkinson's Disease Models by Maintaining Levels of Parkin

(2013) X. Sun et al.   JOURNAL OF NEUROSCIENCE

Regulatory Nexus of Synthesis and Degradation Deciphers Cellular Nrf2 Expression Levels

(2013) T. Suzuki et al.   MOLECULAR AND CELLULAR BIOLOGY

CHOP induces activating transcription factor 5 (ATF5) to trigger apoptosis in response to perturbations in protein homeostasis

(2013) Brian F. Teske et al.   MOLECULAR BIOLOGY OF THE CELL

Phosphorylation of p62 Activates the Keap1-Nrf2 Pathway during Selective Autophagy

(2013) Yoshinobu Ichimura et al.   MOLECULAR CELL

The eIF2α/ATF4 pathway is essential for stress-induced autophagy gene expression

(2013) Wafa B’chir et al.   NUCLEIC ACIDS RESEARCH

Ablation of C/EBP Homologous Protein Does Not Protect T17M RHO Mice from Retinal Degeneration

(2013) Sonali Nashine et al.   PLoS One

Caspase-7 ablation modulates UPR, reprograms TRAF2-JNK apoptosis and protects T17M rhodopsin mice from severe retinal degeneration

(2013) S Choudhury et al.   Cell Death & Disease

Activation of Endoplasmic Reticulum Stress by Hyperglycemia Is Essential for Muller Cell-Derived Inflammatory Cytokine Production in Diabetes

(2012) Y. Zhong et al.   DIABETES

Effects of activating transcription factor 4 deficiency on carbohydrate and lipid metabolism in mammals

(2012) Chunxia Wang et al.   IUBMB LIFE

ER Stress in Retinal Degeneration in S334ter Rho Rats

(2012) Vishal M. Shinde et al.   PLoS One

Gadd34 induces autophagy through the suppression of the mTOR pathway during starvation

(2011) Mohammad Nizam Uddin et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Molecular definitions of cell death subroutines: recommendations of the Nomenclature Committee on Cell Death 2012

(2011) L Galluzzi et al.   CELL DEATH AND DIFFERENTIATION

GADD34 mediates cytoprotective autophagy in mutant huntingtin expressing cells via the mTOR pathway

(2011) Alise Hyrskyluoto et al.   EXPERIMENTAL CELL RESEARCH

Jun and JunD-dependent functions in cell proliferation and stress response

(2010) A Meixner et al.   CELL DEATH AND DIFFERENTIATION

Parkin is transcriptionally regulated by ATF4: evidence for an interconnection between mitochondrial stress and ER stress

(2010) L Bouman et al.   CELL DEATH AND DIFFERENTIATION

Prevention of autosomal dominant retinitis pigmentosa by systemic drug therapy targeting heat shock protein 90 (Hsp90)

(2010) Lawrence C.S. Tam et al.   HUMAN MOLECULAR GENETICS

Activation transcription factor-4 and the acute vascular response to injury

(2010) Kristine P. Malabanan et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Autophagy-Dependent Rhodopsin Degradation Prevents Retinal Degeneration in Drosophila

(2010) R. Midorikawa et al.   JOURNAL OF NEUROSCIENCE

Restoration of visual function in P23H rhodopsin transgenic rats by gene delivery of BiP/Grp78

(2010) M. S. Gorbatyuk et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Endoplasmic reticulum stress is implicated in retinal inflammation and diabetic retinopathy

(2009) Jingming Li et al.   FEBS LETTERS

Molecular Mechanisms of Rhodopsin Retinitis Pigmentosa and the Efficacy of Pharmacological Rescue

(2009) Mark P. Krebs et al.   JOURNAL OF MOLECULAR BIOLOGY

Classification of cell death: recommendations of the Nomenclature Committee on Cell Death 2009

(2008) G Kroemer et al.   CELL DEATH AND DIFFERENTIATION

Targeting gene expression to cones with human cone opsin promoters in recombinant AAV

(2008) A M Komáromy et al.   GENE THERAPY

ATF4 is an oxidative stress–inducible, prodeath transcription factor in neurons in vitro and in vivo

(2008) Philipp S. Lange et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Effect of Late-stage Therapy on Disease Progression in AAV-mediated Rescue of Photoreceptor Cells in the Retinoschisin-deficient Mouse

(2008) Andreas Janssen et al.   MOLECULAR THERAPY