Toll-like receptors in inflammatory bowel diseases: A decade later

Flagellin Treatment Protects against Chemicals, Bacteria, Viruses, and Radiation

(2014) M. Vijay-Kumar et al.   JOURNAL OF IMMUNOLOGY

TLR4 signaling in effector CD4+ T cells regulates TCR activation and experimental colitis in mice

(2010) José M. González-Navajas et al.   JOURNAL OF CLINICAL INVESTIGATION

Bacterial manipulation of innate immunity to promote infection

(2010) Lautaro Diacovich et al.   NATURE REVIEWS MICROBIOLOGY

Like Will to Like: Abundances of Closely Related Species Can Predict Susceptibility to Intestinal Colonization by Pathogenic and Commensal Bacteria

(2010) Bärbel Stecher et al.   PLoS Pathogens

Epistasis Between Toll-Like Receptor-9 Polymorphisms and Variants in NOD2 and IL23R Modulates Susceptibility to Crohn's Disease

(2009) Helga P Török et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Latent Cytomegalovirus Infection Exacerbates Experimental Colitis

(2009) Chukwuma Onyeagocha et al.   AMERICAN JOURNAL OF PATHOLOGY

Positive Role of CCAAT/Enhancer-Binding Protein Homologous Protein, a Transcription Factor Involved in the Endoplasmic Reticulum Stress Response in the Development of Colitis

(2009) Takushi Namba et al.   AMERICAN JOURNAL OF PATHOLOGY

Lipopolysaccharide activates innate immune responses in murine intestinal myofibroblasts through multiple signaling pathways

(2009) Kristen L. W. Walton et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

A novel Toll-like receptor 4 antagonist antibody ameliorates inflammation but impairs mucosal healing in murine colitis

(2009) Ryan Ungaro et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Toll-like receptors and innate immunity

(2009) Himanshu Kumar et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Induction of Intestinal Th17 Cells by Segmented Filamentous Bacteria

(2009) Ivaylo I. Ivanov et al.   CELL

A20 is an early responding negative regulator of Toll-like receptor 5 signalling in intestinal epithelial cells during inflammation

(2009) N. Oshima et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Regulation of Colonic Epithelial Repair in Mice by Toll-Like Receptors and Hyaluronic Acid

(2009) Ling Zheng et al.   GASTROENTEROLOGY

Colitis-Associated Variant of TLR2 Causes Impaired Mucosal Repair Because of TFF3 Deficiency

(2009) Daniel K. Podolsky et al.   GASTROENTEROLOGY

Increased Short- and Long-Term Risk of Inflammatory Bowel Disease After Salmonella or Campylobacter Gastroenteritis

(2009) Kim O. Gradel et al.   GASTROENTEROLOGY

Interactions among genes influencing bacterial recognition increase IBD risk in a population-based New Zealand cohort

(2009) Ivonne Petermann et al.   HUMAN IMMUNOLOGY

The Key Role of Segmented Filamentous Bacteria in the Coordinated Maturation of Gut Helper T Cell Responses

(2009) Valérie Gaboriau-Routhiau et al.   IMMUNITY

Innate immune signaling by Toll-like receptor-4 (TLR4) shapes the inflammatory microenvironment in colitis-associated tumors

(2009) Masayuki Fukata et al.   INFLAMMATORY BOWEL DISEASES

Multidrug resistance gene deficient (mdr1a-/-) mice have an altered caecal microbiota that precedes the onset of intestinal inflammation

(2009) K. Nones et al.   JOURNAL OF APPLIED MICROBIOLOGY

TLR2 Mediates Gap Junctional Intercellular Communication through Connexin-43 in Intestinal Epithelial Barrier Injury

(2009) Birgit Ey et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

STAT3 links IL-22 signaling in intestinal epithelial cells to mucosal wound healing

(2009) Geethanjali Pickert et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Hyporesponsiveness of Intestinal Dendritic Cells to TLR Stimulation Is Limited to TLR4

(2009) V. Cerovic et al.   JOURNAL OF IMMUNOLOGY

Ethyl pyruvate decreases HMGB1 release and ameliorates murine colitis

(2009) Shaival H. Davé et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Loss of Toll-like Receptor 2 and 4 Leads to Differential Induction of Endoplasmic Reticulum Stress and Proapoptotic Responses in the Intestinal Epithelium under Conditions of Chronic Inflammation

(2009) Anja Messlik et al.   JOURNAL OF PROTEOME RESEARCH

Innate immune recognition of infected apoptotic cells directs TH17 cell differentiation

(2009) Miriam Beer Torchinsky et al.   NATURE

Adaptive suppression of the ATF4–CHOP branch of the unfolded protein response by toll-like receptor signalling

(2009) Connie W. Woo et al.   NATURE CELL BIOLOGY

Enteric defensins are essential regulators of intestinal microbial ecology

(2009) Nita H Salzman et al.   NATURE IMMUNOLOGY

Interleukin 10 acts on regulatory T cells to maintain expression of the transcription factor Foxp3 and suppressive function in mice with colitis

(2009) Masako Murai et al.   NATURE IMMUNOLOGY

A human colonic commensal promotes colon tumorigenesis via activation of T helper type 17 T cell responses

(2009) Shaoguang Wu et al.   NATURE MEDICINE

Inflammatory Bowel Disease

(2009) Clara Abraham et al.   NEW ENGLAND JOURNAL OF MEDICINE

Inflammatory Bowel Disease and Mutations Affecting the Interleukin-10 Receptor

(2009) Erik-Oliver Glocker et al.   NEW ENGLAND JOURNAL OF MEDICINE

A dominant, coordinated T regulatory cell-IgA response to the intestinal microbiota

(2009) Y. Cong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Negative regulation of MyD88-dependent signaling by IL-10 in dendritic cells

(2009) J. Chang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Innate and Adaptive Immunity Cooperate Flexibly to Maintain Host-Microbiota Mutualism

(2009) E. Slack et al.   SCIENCE

Campylobacter jejuni induces transcellular translocation of commensal bacteria via lipid rafts

(2009) Lisa D Kalischuk et al.   Gut Pathogens

Unstable Composition of the Fecal Microbiota in Ulcerative Colitis During Clinical Remission

(2008) Cristina Martinez et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

The ‘Ethereal’ nature of TLR4 agonism and antagonism in the AGP class of lipid A mimetics

(2008) Hélène G. Bazin et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

XBP1 Links ER Stress to Intestinal Inflammation and Confers Genetic Risk for Human Inflammatory Bowel Disease

(2008) Arthur Kaser et al.   CELL

Specific Microbiota Direct the Differentiation of IL-17-Producing T-Helper Cells in the Mucosa of the Small Intestine

(2008) Ivaylo I. Ivanov et al.   Cell Host & Microbe

Gut flora, Toll-like receptors and nuclear receptors: a tripartite communication that tunes innate immunity in large intestine

(2008) Annelie Lundin et al.   CELLULAR MICROBIOLOGY

Microbial Influences in Inflammatory Bowel Diseases

(2008) R. Balfour Sartor   GASTROENTEROLOGY

CpG Motifs of Bacterial DNA Exert Protective Effects in Mouse Models of IBD by Antigen-Independent Tolerance Induction

(2008) Andre Bleich et al.   GASTROENTEROLOGY

The Cytosolic Sensors Nod1 and Nod2 Are Critical for Bacterial Recognition and Host Defense after Exposure to Toll-like Receptor Ligands

(2008) Yun-Gi Kim et al.   IMMUNITY

Commensal DNA Limits Regulatory T Cell Conversion and Is a Natural Adjuvant of Intestinal Immune Responses

(2008) Jason A. Hall et al.   IMMUNITY

Early molecular and functional changes in colonic epithelium that precede increased gut permeability during colitis development in mdr1a(−/−) mice

(2008) Andrew Collett et al.   INFLAMMATORY BOWEL DISEASES

Crohnʼs disease-associated Escherichia coli LF82 aggravates colitis in injured mouse colon via signaling by flagellin

(2008) Frédéric A. Carvalho et al.   INFLAMMATORY BOWEL DISEASES

Impaired Bcl3 Up-regulation Leads to Enhanced Lipopolysaccharide-induced Interleukin (IL)-23P19 Gene Expression in IL-10–/–Mice

(2008) Marcus Mühlbauer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Homeostatic MyD88-dependent signals cause lethal inflamMation in the absence of A20

(2008) Emre E. Turer et al.   JOURNAL OF EXPERIMENTAL MEDICINE

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(2008) Bart Ferwerda et al.   MOLECULAR MEDICINE

Barrier-protective function of intestinal epithelial Toll-like receptor 2

(2008) E Cario   Mucosal Immunology

A microbial symbiosis factor prevents intestinal inflammatory disease

(2008) Sarkis K. Mazmanian et al.   NATURE

Vancomycin-resistant enterococci exploit antibiotic-induced innate immune deficits

(2008) Katharina Brandl et al.   NATURE

ATP drives lamina propria TH17 cell differentiation

(2008) Koji Atarashi et al.   NATURE

Sequence variants in IL10, ARPC2 and multiple other loci contribute to ulcerative colitis susceptibility

(2008) Andre Franke et al.   NATURE GENETICS

Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease

(2008) Jeffrey C Barrett et al.   NATURE GENETICS

Paneth cells directly sense gut commensals and maintain homeostasis at the intestinal host-microbial interface

(2008) S. Vaishnava et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Faecalibacterium prausnitzii is an anti-inflammatory commensal bacterium identified by gut microbiota analysis of Crohn disease patients

(2008) H. Sokol et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Aberrant Mucin Assembly in Mice Causes Endoplasmic Reticulum Stress and Spontaneous Inflammation Resembling Ulcerative Colitis

(2008) Chad K Heazlewood et al.   PLOS MEDICINE