Inflammasomes and the microbiota—partners in the preservation of mucosal homeostasis

NLRP6 Inflammasome Orchestrates the Colonic Host-Microbial Interface by Regulating Goblet Cell Mucus Secretion

(2014) Marta Wlodarska et al.   CELL

Mechanisms and Functions of Inflammasomes

(2014) Mohamed Lamkanfi et al.   CELL

Exploring New Horizons in Microbiome Research

(2014) Christoph A. Thaiss et al.   Cell Host & Microbe

Inflammasome activation has an important role in the development of spontaneous colitis

(2014) J Zhang et al.   Mucosal Immunology

Caspase-11 activation requires lysis of pathogen-containing vacuoles by IFN-induced GTPases

(2014) Etienne Meunier et al.   NATURE

In Vivo IFN-γ Secretion by NK Cells in Response to Salmonella Typhimurium Requires NLRC4 Inflammasomes

(2014) Andreas Kupz et al.   PLoS One

Inflammasome activation causes dual recruitment of NLRC4 and NLRP3 to the same macromolecular complex

(2014) S. M. Man et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Liver May Act as a Firewall Mediating Mutualism Between the Host and Its Gut Commensal Microbiota

(2014) M. L. Balmer et al.   Science Translational Medicine

Malaria-Induced NLRP12/NLRP3-Dependent Caspase-1 Activation Mediates Inflammation and Hypersensitivity to Bacterial Superinfection

(2014) Marco A. Ataide et al.   PLoS Pathogens

Inflammasomes and Metabolic Disease

(2013) Jorge Henao-Mejia et al.   Annual Review of Physiology

The interplay between the innate immune system and the microbiota

(2013) Christoph A Thaiss et al.   CURRENT OPINION IN IMMUNOLOGY

Autophagy proteins control goblet cell function by potentiating reactive oxygen species production

(2013) Khushbu K Patel et al.   EMBO JOURNAL

K+ Efflux Is the Common Trigger of NLRP3 Inflammasome Activation by Bacterial Toxins and Particulate Matter

(2013) Raúl Muñoz-Planillo et al.   IMMUNITY

Role of the intestinal microbiome in liver disease

(2013) Jorge Henao-Mejia et al.   JOURNAL OF AUTOIMMUNITY

The Gordian Knot of dysbiosis, obesity and NAFLD

(2013) Wajahat Z. Mehal   Nature Reviews Gastroenterology & Hepatology

The gut microbiota — masters of host development and physiology

(2013) Felix Sommer et al.   NATURE REVIEWS MICROBIOLOGY

Characterization of NLRP12 during the In Vivo Host Immune Response to Klebsiella pneumoniae and Mycobacterium tuberculosis

(2013) Irving C. Allen et al.   PLoS One

Microbiota-induced activation of epithelial IL-6 signaling links inflammasome-driven inflammation with transmissible cancer

(2013) B. Hu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Salmonella exploits NLRP12-dependent innate immune signaling to suppress host defenses during infection

(2013) M. H. Zaki et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Protective and Aggravating Effects of Nlrp3 Inflammasome Activation in IBD Models: Influence of Genetic and Environmental Factors

(2012) Christian Bauer et al.   DIGESTIVE DISEASES

The NLRP12 Inflammasome Recognizes Yersinia pestis

(2012) Gregory I. Vladimer et al.   IMMUNITY

NLRP12 Suppresses Colon Inflammation and Tumorigenesis through the Negative Regulation of Noncanonical NF-κB Signaling

(2012) Irving C. Allen et al.   IMMUNITY

IL-1β mediates chronic intestinal inflammation by promoting the accumulation of IL-17A secreting innate lymphoid cells and CD4+Th17 cells

(2012) Margherita Coccia et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Integrative inflammasome activity in the regulation of intestinal mucosal immune responses

(2012) E Elinav et al.   Mucosal Immunology

Caspase-11 increases susceptibility to Salmonella infection in the absence of caspase-1

(2012) Petr Broz et al.   NATURE

NLRP6 negatively regulates innate immunity and host defence against bacterial pathogens

(2012) Paras K. Anand et al.   NATURE

NLRC4-driven production of IL-1β discriminates between pathogenic and commensal bacteria and promotes host intestinal defense

(2012) Luigi Franchi et al.   NATURE IMMUNOLOGY

The NOD-Like Receptor NLRP12 Attenuates Colon Inflammation and Tumorigenesis

(2011) Md. Hasan Zaki et al.   CANCER CELL

NLRP6 Inflammasome Regulates Colonic Microbial Ecology and Risk for Colitis

(2011) Eran Elinav et al.   CELL

The NLRP3/ASC/Caspase-1 axis regulates IL-1β processing in neutrophils

(2011) Arun K. Mankan et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

A Functional Role for Nlrp6 in Intestinal Inflammation and Tumorigenesis

(2011) G. Y. Chen et al.   JOURNAL OF IMMUNOLOGY

Differential Expression of NLRP3 among Hematopoietic Cells

(2011) G. Guarda et al.   JOURNAL OF IMMUNOLOGY

The NLRC4 inflammasome receptors for bacterial flagellin and type III secretion apparatus

(2011) Yue Zhao et al.   NATURE

Innate immune recognition of bacterial ligands by NAIPs determines inflammasome specificity

(2011) Eric M. Kofoed et al.   NATURE

Non-canonical inflammasome activation targets caspase-11

(2011) Nobuhiko Kayagaki et al.   NATURE

Nod-like receptor pyrin domain-containing protein 6 (NLRP6) controls epithelial self-renewal and colorectal carcinogenesis upon injury

(2011) S. Normand et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Colitis induced in mice with dextran sulfate sodium (DSS) is mediated by the NLRP3 inflammasome

(2010) C. Bauer et al.   GUT

Interleukin-18 in Intestinal Inflammation: Friend and Foe?

(2010) Britta Siegmund   IMMUNITY

The NLRP3 Inflammasome Protects against Loss of Epithelial Integrity and Mortality during Experimental Colitis

(2010) Md. Hasan Zaki et al.   IMMUNITY

Genetic association between NLRP3 variants and Crohnʼs disease does not replicate in a large UK panel

(2010) Gregory J. Lewis et al.   INFLAMMATORY BOWEL DISEASES

NLRP3 inflammasome plays a key role in the regulation of intestinal homeostasis

(2010) Simon A. Hirota et al.   INFLAMMATORY BOWEL DISEASES

The NLRP3 inflammasome functions as a negative regulator of tumorigenesis during colitis-associated cancer

(2010) Irving C. Allen et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Cutting Edge: NLRP12 Controls Dendritic and Myeloid Cell Migration To Affect Contact Hypersensitivity

(2010) J. C. Arthur et al.   JOURNAL OF IMMUNOLOGY

Activation of  -Catenin in Dendritic Cells Regulates Immunity Versus Tolerance in the Intestine

(2010) S. Manicassamy et al.   SCIENCE

Combined Polymorphisms in Genes Encoding the Inflammasome Components NALP3 and CARD8 Confer Susceptibility to Crohn's Disease in Swedish Men

(2009) Ida Schoultz et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

The Inflammasomes: Guardians of the Body

(2009) Fabio Martinon et al.   Annual Review of Immunology

Cutting Edge: TNF-  Mediates Sensitization to ATP and Silica via the NLRP3 Inflammasome in the Absence of Microbial Stimulation

(2009) L. Franchi et al.   JOURNAL OF IMMUNOLOGY

Common variants in the NLRP3 region contribute to Crohn's disease susceptibility

(2008) Alexandra-Chloé Villani et al.   NATURE GENETICS

Critical function for Naip5 in inflammasome activation by a conserved carboxy-terminal domain of flagellin

(2008) Karla L Lightfield et al.   NATURE IMMUNOLOGY

Pseudomonas aeruginosa activates caspase 1 through Ipaf

(2008) E. A. Miao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA