Sphingolipid pathway enzymes modulate cell fate and immune responses

Sphingosine-1-Phosphate Receptor-3 Supports Hematopoietic Stem and Progenitor Cell Residence Within the Bone Marrow Niche

(2017) Molly E. Ogle et al.   STEM CELLS

Differential S1P Receptor Profiles on M1- and M2-Polarized Macrophages Affect Macrophage Cytokine Production and Migration

(2017) Jan Müller et al.   Biomed Research International

Dihydroceramide accumulation mediates cytotoxic autophagy of cancer cells via autolysosome destabilization

(2016) Sonia Hernández-Tiedra et al.   Autophagy

Ceramide 1-phosphate regulates cell migration and invasion of human pancreatic cancer cells

(2016) Io-Guané Rivera et al.   BIOCHEMICAL PHARMACOLOGY

Interaction of acid ceramidase inhibitor LCL521 with tumor response to photodynamic therapy and photodynamic therapy-generated vaccine

(2016) Mladen Korbelik et al.   INTERNATIONAL JOURNAL OF CANCER

Sphingosine-1-phosphate/sphingosine-1-phosphate receptor 1 signaling is required for migration of naive human T cells from the thymus to the periphery

(2016) Rachel S. Resop et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Gradients of the signaling lipid S1P in lymph nodes position natural killer cells and regulate their interferon-γ response

(2016) Victoria Fang et al.   NATURE IMMUNOLOGY

Targeting glucosylceramide synthase upregulation reverts sorafenib resistance in experimental hepatocellular carcinoma

(2016) Milica Stefanovic et al.   Oncotarget

Sphingosine 1-phosphate Receptor 2 Signaling Suppresses Macrophage Phagocytosis and Impairs Host Defense against Sepsis

(2015) JinChao Hou et al.   ANESTHESIOLOGY

Autophagy in the light of sphingolipid metabolism

(2015) Eva Bang Harvald et al.   APOPTOSIS

Targeting glucosylceramide synthase induction of cell surface globotriaosylceramide (Gb3) in acquired cisplatin-resistance of lung cancer and malignant pleural mesothelioma cells

(2015) Andreas Tyler et al.   EXPERIMENTAL CELL RESEARCH

Markedly perturbed hematopoiesis in acid ceramidase deficient mice

(2015) S. Dworski et al.   HAEMATOLOGICA

Acid Ceramidase in Melanoma

(2015) Natalia Realini et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Homeostatic regulation of T cell trafficking by a B cell–derived peptide is impaired in autoimmune and chronic inflammatory disease

(2015) Myriam Chimen et al.   NATURE MEDICINE

Sphingosine 1-Phosphate Receptor 2 and 3 Mediate Bone Marrow-Derived Monocyte/Macrophage Motility in Cholestatic Liver Injury in Mice

(2015) Le Yang et al.   Scientific Reports

Markedly perturbed hematopoiesis in acid ceramidase deficient mice

(2015) S. Dworski et al.   HAEMATOLOGICA

Peripheral Blood T Cell Dynamics Predict Relapse in Multiple Sclerosis Patients on Fingolimod

(2015) Zi-Ye Song et al.   PLoS One

Controlled release of sphingosine-1-phosphate agonist with gelatin hydrogels for macrophage recruitment

(2014) Masahiro Murakami et al.   Acta Biomaterialia

Evolving concepts in cancer therapy through targeting sphingolipid metabolism

(2014) Jean-Philip Truman et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

The ceramide kinase inhibitor NVP-231 inhibits breast and lung cancer cell proliferation by inducing M phase arrest and subsequent cell death

(2014) Oleksandr Pastukhov et al.   BRITISH JOURNAL OF PHARMACOLOGY

Sphingosine Kinase 2 Promotes Acute Lymphoblastic Leukemia by Enhancing MYC Expression

(2014) C. T. Wallington-Beddoe et al.   CANCER RESEARCH

Sphingosine 1-phosphate induced anti-atherogenic and atheroprotective M2 macrophage polarization through IL-4

(2014) Soo-Jin Park et al.   CELLULAR SIGNALLING

A sphingosine kinase inhibitor combined with temozolomide induces glioblastoma cell death through accumulation of dihydrosphingosine and dihydroceramide, endoplasmic reticulum stress and autophagy

(2014) J Noack et al.   Cell Death & Disease

S1PR1 Is Crucial for Accumulation of Regulatory T Cells in Tumors via STAT3

(2014) Saul J. Priceman et al.   Cell Reports

Tumor-Associated Macrophages as Major Players in the Tumor Microenvironment

(2014) Theerawut Chanmee et al.   Cancers

Ceramide 1-phosphate induces macrophage chemoattractant protein-1 release: involvement in ceramide 1-phosphate-stimulated cell migration

(2013) Lide Arana et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Endogenous lipid activated G protein-coupled receptors: Emerging structural features from crystallography and molecular dynamics simulations

(2013) Dow P. Hurst et al.   CHEMISTRY AND PHYSICS OF LIPIDS

Systemic ceramide accumulation leads to severe and varied pathological consequences

(2013) Abdulfatah M. Alayoubi et al.   EMBO Molecular Medicine

S1PR5 is pivotal for the homeostasis of patrolling monocytes

(2013) Emilie Debien et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Sphingosine signalling regulates decidual NK cell angiogenic phenotype and trophoblast migration

(2013) Jianhong Zhang et al.   HUMAN REPRODUCTION

Circulating Monocytes Are Reduced by Sphingosine-1-Phosphate Receptor Modulators Independently of S1P3

(2013) N. D. Lewis et al.   JOURNAL OF IMMUNOLOGY

Acid Ceramidase Promotes Nuclear Export of PTEN through Sphingosine 1-Phosphate Mediated Akt Signaling

(2013) Thomas H. Beckham et al.   PLoS One

Sphingosine 1-phosphate receptor 3 regulates recruitment of anti-inflammatory monocytes to microvessels during implant arteriogenesis

(2013) Anthony O. Awojoodu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Discovery of highly potent acid ceramidase inhibitors with in vitro tumor chemosensitizing activity

(2013) Natalia Realini et al.   Scientific Reports

Tumor-derived microvesicles: shedding light on novel microenvironment modulators and prospective cancer biomarkers

(2012) C. D'Souza-Schorey et al.   GENES & DEVELOPMENT

Long chain ceramides and very long chain ceramides have opposite effects on human breast and colon cancer cell growth

(2012) Daniela Hartmann et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Nuclear PTEN Regulates the APC-CDH1 Tumor-Suppressive Complex in a Phosphatase-Independent Manner

(2011) Min Sup Song et al.   CELL

Macrophages programmed by apoptotic cells promote angiogenesis via prostaglandin E2

(2011) Kerstin Brecht et al.   FASEB JOURNAL

Identification of Dihydroceramide Desaturase as a Directin VitroTarget for Fenretinide

(2011) Mehrdad Rahmaniyan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Targeting glucosylceramide synthase sensitizes imatinib-resistant chronic myeloid leukemia cells via endogenous ceramide accumulation

(2011) Yusuf Baran et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

The Targeting of Plasmalemmal Ceramide to Mitochondria during Apoptosis

(2011) Eduard B. Babiychuk et al.   PLoS One

Sphingosine-1-Phosphate Receptor-2 Function in Myeloid Cells Regulates Vascular Inflammation and Atherosclerosis

(2010) Athanasia Skoura et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

The Expression of Sphingosine Kinase-1 in Head and Neck Carcinoma

(2010) María M. Facchinetti et al.   CELLS TISSUES ORGANS

Sphingosine-1-Phosphate Receptor 3 Promotes Recruitment of Monocyte/Macrophages in Inflammation and Atherosclerosis

(2010) Petra Keul et al.   CIRCULATION RESEARCH

Ceramide-rich platforms in transmembrane signaling

(2010) Branka Stancevic et al.   FEBS LETTERS

Sphingosine-1-phosphate receptor-2 deficiency leads to inhibition of macrophage proinflammatory activities and atherosclerosis in apoE-deficient mice

(2010) Fei Wang et al.   JOURNAL OF CLINICAL INVESTIGATION

The S1P1-mTOR axis directs the reciprocal differentiation of TH1 and Treg cells

(2010) Guangwei Liu et al.   NATURE IMMUNOLOGY

Targeting Sphingosine Kinase 1 Inhibits Akt Signaling, Induces Apoptosis, and Suppresses Growth of Human Glioblastoma Cells and Xenografts

(2009) D. Kapitonov et al.   CANCER RESEARCH

Regulation of macrophage function by sphingosine-1-phosphate

(2009) Andreas Weigert et al.   IMMUNOBIOLOGY

Sphingosine kinase 2 deficient tumor xenografts show impaired growth and fail to polarize macrophages towards an anti-inflammatory phenotype

(2009) Andreas Weigert et al.   INTERNATIONAL JOURNAL OF CANCER

T-bet–dependent S1P5expression in NK cells promotes egress from lymph nodes and bone marrow

(2009) Craig N. Jenne et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Inhibitory Role of Sphingosine 1-Phosphate Receptor 2 in Macrophage Recruitment during Inflammation

(2009) J. Michaud et al.   JOURNAL OF IMMUNOLOGY

The Sphingosine 1-Phosphate Receptor Agonist FTY720 Potently Inhibits Regulatory T Cell Proliferation In Vitro and In Vivo

(2009) A. M. Wolf et al.   JOURNAL OF IMMUNOLOGY

The role of sphingosine kinase 1 in cancer: Oncogene or non-oncogene addiction?

(2008) M VADAS   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Molecular profiling of LGL leukemia reveals role of sphingolipid signaling in survival of cytotoxic lymphocytes

(2008) M. V. Shah et al.   BLOOD

A selective sphingosine kinase 1 inhibitor integrates multiple molecular therapeutic targets in human leukemia

(2008) S. W. Paugh et al.   BLOOD

Ceramide 1-phosphate (C1P) promotes cell migration

(2008) María H. Granado et al.   CELLULAR SIGNALLING

Sphingosine-1-Phosphate Induces an Antiinflammatory Phenotype in Macrophages

(2008) Jeniter E. Hughes et al.   CIRCULATION RESEARCH

Clinical Significance of Sphingosine Kinase-1 Expression in Human Astrocytomas Progression and Overall Patient Survival

(2008) J. Li et al.   CLINICAL CANCER RESEARCH

Targeting SphK1 as a New Strategy against Cancer

(2008) Dai Shida et al.   CURRENT DRUG TARGETS

Apoptosis induces expression of sphingosine kinase 1 to release sphingosine-1-phosphate as a “come-and-get-me” signal

(2008) David R. Gude et al.   FASEB JOURNAL

Protection from High Fat Diet-induced Increase in Ceramide in Mice Lacking Plasminogen Activator Inhibitor 1

(2008) Charmi Shah et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Fluorescent Annexin A1 Reveals Dynamics of Ceramide Platforms in Living Cells

(2008) Eduard B. Babiychuk et al.   TRAFFIC