Systemic ceramide accumulation leads to severe and varied pathological consequences

Editorial [Hot Topic: Therapeutic Targeting of the Sphingolipid “Biostat” in Hematologic Malignancies (Guest Editors: Thomas P. Loughran and Hong-Gang Wang)]

(2012) Thomas P. Loughran et al.   Anti-Cancer Agents in Medicinal Chemistry

Construction of Conditional Acid Ceramidase Knockout Mice andin vivoEffects on Oocyte Development and Fertility

(2012) Efrat Eliyahu et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Ceramide kinase deficiency improves diet-induced obesity and insulin resistance

(2012) Susumu Mitsutake et al.   FEBS LETTERS

Acid ceramidase-mediated production of sphingosine 1-phosphate promotes prostate cancer invasion through upregulation of cathepsin B

(2012) Thomas H. Beckham et al.   INTERNATIONAL JOURNAL OF CANCER

Autologous Transplantation of Lentivector/Acid Ceramidase–Transduced Hematopoietic Cells in Nonhuman Primates

(2011) Jagdeep S. Walia et al.   HUMAN GENE THERAPY

Genistein Stimulates MCF-7 Breast Cancer Cell Growth by Inducing Acid Ceramidase (ASAH1) Gene Expression

(2011) Natasha C. Lucki et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The PDL1-PD1 Axis Converts Human TH1 Cells into Regulatory T Cells

(2011) S. Amarnath et al.   Science Translational Medicine

Sphingosine-1-phosphate signaling and its role in disease

(2011) Michael Maceyka et al.   TRENDS IN CELL BIOLOGY

Farber lipogranulomatosis type 1 – Late presentation and early death in a Croatian boy with a novel homozygous ASAH1 mutation

(2010) L. Cvitanovic-Sojat et al.   EUROPEAN JOURNAL OF PAEDIATRIC NEUROLOGY

Structures of an Isopenicillin N Converting Ntn-Hydrolase Reveal Different Catalytic Roles for the Active Site Residues of Precursor and Mature Enzyme

(2010) Marcel Bokhove et al.   STRUCTURE

Central role of ceramide biosynthesis in body weight regulation, energy metabolism, and the metabolic syndrome

(2009) Guang Yang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Structures of the human ceramide activator protein saposin D

(2008) Konstantin Popovic et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

I-TASSER server for protein 3D structure prediction

(2008) Yang Zhang   BMC BIOINFORMATICS

Synthesis and Biological Activity of a Novel Inhibitor of Dihydroceramide Desaturase

(2008) Jose M. Munoz-Olaya et al.   ChemMedChem

Autoproteolytic Cleavage and Activation of Human Acid Ceramidase

(2008) Nataly Shtraizent et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

In vivo delivery of human acid ceramidase via cord blood transplantation and direct injection of lentivirus as novel treatment approaches for Farber disease

(2008) Shobha Ramsubir et al.   MOLECULAR GENETICS AND METABOLISM