Autophagy in the light of sphingolipid metabolism

Autophagy mediates pharmacological lifespan extension by spermidineand resveratrol

(2016) Eugenia Morselli et al.   Aging-US

The role of TOR in autophagy regulation from yeast to plants and mammals

(2014) Sandra Díaz-Troya et al.   Autophagy

High sphingomyelin levels induce lysosomal damage and autophagy dysfunction in Niemann Pick disease type A

(2014) E Gabandé-Rodríguez et al.   CELL DEATH AND DIFFERENTIATION

Neutral Lipid Stores and Lipase PNPLA5 Contribute to Autophagosome Biogenesis

(2014) Nicolas Dupont et al.   CURRENT BIOLOGY

Preconditioning Stimuli Induce Autophagy via Sphingosine Kinase 2 in Mouse Cortical Neurons

(2014) Rui Sheng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Autophagy regulates sphingolipid levels in the liver

(2014) Aikaterini Alexaki et al.   JOURNAL OF LIPID RESEARCH

Sphingolipid metabolism regulates development and lifespan in Caenorhabditis elegans

(2014) Roy G. Cutler et al.   MECHANISMS OF AGEING AND DEVELOPMENT

The HOPS complex mediates autophagosome–lysosome fusion through interaction with syntaxin 17

(2014) Peidu Jiang et al.   MOLECULAR BIOLOGY OF THE CELL

Reducing sphingolipid synthesis orchestrates global changes to extend yeast lifespan

(2013) Jun Liu et al.   AGING CELL

ATG16L1 meets ATG9 in recycling endosomes

(2013) Claudia Puri et al.   Autophagy

Sphingolipids as modulators of membrane proteins

(2013) Andreas Max Ernst et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Autophagy paradox and ceramide

(2013) Wenhui Jiang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Transformation-Associated Changes in Sphingolipid Metabolism Sensitize Cells to Lysosomal Cell Death Induced by Inhibitors of Acid Sphingomyelinase

(2013) Nikolaj H.T. Petersen et al.   CANCER CELL

Membranes and mammalian glycolipid transferring proteins

(2013) Jessica Tuuf et al.   CHEMISTRY AND PHYSICS OF LIPIDS

TORC1-regulated protein kinase Npr1 phosphorylates Orm to stimulate complex sphingolipid synthesis

(2013) Mitsugu Shimobayashi et al.   MOLECULAR BIOLOGY OF THE CELL

Rab11 facilitates cross-talk between autophagy and endosomal pathway through regulation of Hook localization

(2013) Zsuzsanna Szatmári et al.   MOLECULAR BIOLOGY OF THE CELL

Ripples in the pond – using a systems approach to decipher the cellular functions of membrane microdomains

(2013) Kerry L. Inder et al.   Molecular BioSystems

Non-vesicular trafficking by a ceramide-1-phosphate transfer protein regulates eicosanoids

(2013) Dhirendra K. Simanshu et al.   NATURE

Autophagosomes form at ER–mitochondria contact sites

(2013) Maho Hamasaki et al.   NATURE

ULK1 induces autophagy by phosphorylating Beclin-1 and activating VPS34 lipid kinase

(2013) Ryan C. Russell et al.   NATURE CELL BIOLOGY

Caveolae as plasma membrane sensors, protectors and organizers

(2013) Robert G. Parton et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Functional Loss of Two Ceramide Synthases Elicits Autophagy-Dependent Lifespan Extension in C. elegans

(2013) Mai-Britt Mosbech et al.   PLoS One

TORC1 Inhibits GSK3-Mediated Elo2 Phosphorylation to Regulate Very Long Chain Fatty Acid Synthesis and Autophagy

(2013) Christine Zimmermann et al.   Cell Reports

Ceramide and Apoptosis: Exploring the Enigmatic Connections between Sphingolipid Metabolism and Programmed Cell Death

(2012) Thomas D. Mullen et al.   Anti-Cancer Agents in Medicinal Chemistry

The Hairpin-type Tail-Anchored SNARE Syntaxin 17 Targets to Autophagosomes for Fusion with Endosomes/Lysosomes

(2012) Eisuke Itakura et al.   CELL

Regulation of lipid stores and metabolism by lipophagy

(2012) K Liu et al.   CELL DEATH AND DIFFERENTIATION

The control of the balance between ceramide and sphingosine-1-phosphate by sphingosine kinase: Oxidative stress and the seesaw of cell survival and death

(2012) James R. Van Brocklyn et al.   COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY

Dihydroceramide delays cell cycle G1/S transition via activation of ER stress and induction of autophagy

(2012) Vincenzo Gagliostro et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Regulation of Autophagy and Its Associated Cell Death by “Sphingolipid Rheostat”

(2012) Makoto Taniguchi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TBC1D14 regulates autophagosome formation via Rab11- and ULK1-positive recycling endosomes

(2012) Andrea Longatti et al.   JOURNAL OF CELL BIOLOGY

Ceramide synthase 5 mediates lipid-induced autophagy and hypertrophy in cardiomyocytes

(2012) Sarah Brice Russo et al.   JOURNAL OF CLINICAL INVESTIGATION

Plasma membrane stress induces relocalization of Slm proteins and activation of TORC2 to promote sphingolipid synthesis

(2012) Doris Berchtold et al.   NATURE CELL BIOLOGY

Plasma membrane recruitment and activation of the AGC kinase Ypk1 is mediated by target of rapamycin complex 2 (TORC2) and its effector proteins Slm1 and Slm2

(2012) B. J. Niles et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Down-Regulating Sphingolipid Synthesis Increases Yeast Lifespan

(2012) Xinhe Huang et al.   PLoS Genetics

Sphingolipid synthesis is involved in autophagy in Saccharomyces cerevisiae

(2011) Maki Yamagata et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Sphingolipid-based drugs selectively kill cancer cells by down-regulating nutrient transporter proteins

(2011) Kimberly Romero Rosales et al.   BIOCHEMICAL JOURNAL

NBR1 and p62 as cargo receptors for selective autophagy of ubiquitinated targets

(2011) Trond Lamark et al.   CELL CYCLE

A Genome-Wide Enhancer Screen Implicates Sphingolipid Composition in Vacuolar ATPase Function in Saccharomyces cerevisiae

(2011) G. C. Finnigan et al.   GENETICS

Protein kinase Ypk1 phosphorylates regulatory proteins Orm1 and Orm2 to control sphingolipid homeostasis in Saccharomyces cerevisiae

(2011) F. M. Roelants et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Membrane Fusion: Five Lipids, Four SNAREs, Three Chaperones, Two Nucleotides, and a Rab, All Dancing in a Ring on Yeast Vacuoles

(2010) William Wickner   Annual Review of Cell and Developmental Biology

The Golgi as a potential membrane source for autophagy

(2010) Jiefei Geng et al.   Autophagy

Mitochondria Supply Membranes for Autophagosome Biogenesis during Starvation

(2010) Dale W. Hailey et al.   CELL

Sphingosine-1-phosphate phosphohydrolase-1 regulates ER stress-induced autophagy

(2010) S Lépine et al.   CELL DEATH AND DIFFERENTIATION

Phosphorylation of the Immunomodulator FTY720 Inhibits Programmed Cell Death of Fibroblasts Via the S1P3 Receptor Subtype and Bcl-2 Activation

(2010) Henrik Potteck et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Altered lipid content inhibits autophagic vesicular fusion

(2010) Hiroshi Koga et al.   FASEB JOURNAL

SYMPOSIUM REVIEW: Lipid microdomains and the regulation of ion channel function

(2010) Caroline Dart   JOURNAL OF PHYSIOLOGY-LONDON

Orm family proteins mediate sphingolipid homeostasis

(2010) David K. Breslow et al.   NATURE

Hsp70 stabilizes lysosomes and reverts Niemann–Pick disease-associated lysosomal pathology

(2010) Thomas Kirkegaard et al.   NATURE

The plasma membrane brings autophagosomes to life

(2010) Ana Maria Cuervo   NATURE CELL BIOLOGY

The origin of the autophagosomal membrane

(2010) Sharon A. Tooze et al.   NATURE CELL BIOLOGY

Regulation of Mammalian Autophagy in Physiology and Pathophysiology

(2010) Brinda Ravikumar et al.   PHYSIOLOGICAL REVIEWS

Different dietary restriction regimens extend lifespan by both independent and overlapping genetic pathways inC. elegans

(2009) Eric L. Greer et al.   AGING CELL

Mammalian autophagy: core molecular machinery and signaling regulation

(2009) Zhifen Yang et al.   CURRENT OPINION IN CELL BIOLOGY

Antiapoptotic roles of ceramide-synthase-6-generated C16-ceramide via selective regulation of the ATF6/CHOP arm of ER-stress-response pathways

(2009) Can E. Senkal et al.   FASEB JOURNAL

Glycosphingolipids in microdomain formation and their spatial organization

(2009) Garima Gupta et al.   FEBS LETTERS

Expression of ceramide glucosyltransferases, which are essential for glycosphingolipid synthesis, is only required in a small subset of C. elegans cells

(2009) E. Marza et al.   JOURNAL OF CELL SCIENCE

Hypoxia-Induced Autophagy Is Mediated through Hypoxia-Inducible Factor Induction of BNIP3 and BNIP3L via Their BH3 Domains

(2009) G. Bellot et al.   MOLECULAR AND CELLULAR BIOLOGY

Autophagy regulates lipid metabolism

(2009) Rajat Singh et al.   NATURE

Growth control via TOR kinase signaling, an intracellular sensor of amino acid and energy availability, with crosstalk potential to proline metabolism

(2008) Xin-Hua Liao et al.   AMINO ACIDS

Effects of ceramide and other simple sphingolipids on membrane lateral structure

(2008) Félix M. Goñi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Regulation of Ceramide Biosynthesis by TOR Complex 2

(2008) Sofia Aronova et al.   Cell Metabolism

Sphingosine-1-phosphate induced mTOR-activation is mediated by the E3-ubiquitin ligase PAM

(2008) Christian Maeurer et al.   CELLULAR SIGNALLING

The cell biology of autophagy in metazoans: a developing story

(2008) A. Melendez et al.   DEVELOPMENT

Niemann-Pick disease type C1 is a sphingosine storage disease that causes deregulation of lysosomal calcium

(2008) Emyr Lloyd-Evans et al.   NATURE MEDICINE

A Role for Autophagy in the Extension of Lifespan by Dietary Restriction in C. elegans

(2008) Malene Hansen et al.   PLoS Genetics

Structural basis for specific lipid recognition by CERT responsible for nonvesicular trafficking of ceramide

(2008) N. Kudo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ceramide starves cells to death by downregulating nutrient transporter proteins

(2008) G. G. Guenther et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sphingomyelinase generation of ceramide promotes clustering of nanoscale domains in supported bilayer membranes

(2007) Ira et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Regulation of macroautophagy by mTOR and Beclin 1 complexes

(2007) Sophie Pattingre et al.   BIOCHIMIE