Antibody-virus co-evolution in HIV infection: paths for HIV vaccine development

HIV-1 Neutralizing Antibodies with Limited Hypermutation from an Infant

(2016) Cassandra A. Simonich et al.   CELL

Maturation Pathway from Germline to Broad HIV-1 Neutralizer of a CD4-Mimic Antibody

(2016) Mattia Bonsignori et al.   CELL

HIV-Host Interactions: Implications for Vaccine Design

(2016) Barton F. Haynes et al.   Cell Host & Microbe

Early Antibody Lineage Diversification and Independent Limb Maturation Lead to Broad HIV-1 Neutralization Targeting the Env High-Mannose Patch

(2016) Daniel T. MacLeod et al.   IMMUNITY

HIV-1 broadly neutralizing antibody precursor B cells revealed by germline-targeting immunogen

(2016) J. G. Jardine et al.   SCIENCE

Fusion peptide of HIV-1 as a site of vulnerability to neutralizing antibody

(2016) R. Kong et al.   SCIENCE

Initiation of immune tolerance–controlled HIV gp41 neutralizing B cell lineages

(2016) Ruijun Zhang et al.   Science Translational Medicine

Optimal Combinations of Broadly Neutralizing Antibodies for Prevention and Treatment of HIV-1 Clade C Infection

(2016) Kshitij Wagh et al.   PLoS Pathogens

Sequence-Intrinsic Mechanisms that Target AID Mutational Outcomes on Antibody Genes

(2015) Leng-Siew Yeap et al.   CELL

Structural Repertoire of HIV-1-Neutralizing Antibodies Targeting the CD4 Supersite in 14 Donors

(2015) Tongqing Zhou et al.   CELL

Strain-Specific V3 and CD4 Binding Site Autologous HIV-1 Neutralizing Antibodies Select Neutralization-Resistant Viruses

(2015) M. Anthony Moody et al.   Cell Host & Microbe

Affinity Maturation of a Potent Family of HIV Antibodies Is Primarily Focused on Accommodating or Avoiding Glycans

(2015) Fernando Garces et al.   IMMUNITY

Identification of Common Features in Prototype Broadly Neutralizing Antibodies to HIV Envelope V2 Apex to Facilitate Vaccine Design

(2015) Raiees Andrabi et al.   IMMUNITY

New Member of the V1V2-Directed CAP256-VRC26 Lineage That Shows Increased Breadth and Exceptional Potency

(2015) Nicole A. Doria-Rose et al.   JOURNAL OF VIROLOGY

Antibody responses to envelope glycoproteins in HIV-1 infection

(2015) Dennis R Burton et al.   NATURE IMMUNOLOGY

Viral variants that initiate and drive maturation of V1V2-directed HIV-1 broadly neutralizing antibodies

(2015) Jinal N Bhiman et al.   NATURE MEDICINE

Structures of HIV-1 Env V1V2 with broadly neutralizing antibodies reveal commonalities that enable vaccine design

(2015) Jason Gorman et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Diversion of HIV-1 vaccine-induced immunity by gp41-microbiota cross-reactive antibodies

(2015) W. B. Williams et al.   SCIENCE

Insights into the trimeric HIV-1 envelope glycoprotein structure

(2015) Andrew B. Ward et al.   TRENDS IN BIOCHEMICAL SCIENCES

Longitudinal Antigenic Sequences and Sites from Intra-Host Evolution (LASSIE) Identifies Immune-Selected HIV Variants

(2015) Peter Hraber et al.   Viruses-Basel

Structures of HIV-1 Env V1V2 with broadly neutralizing antibodies reveal commonalities that enable vaccine design

(2015) Jason Gorman et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Cooperation of B Cell Lineages in Induction of HIV-1-Broadly Neutralizing Antibodies

(2014) Feng Gao et al.   CELL

Structural Evolution of Glycan Recognition by a Family of Potent HIV Antibodies

(2014) Fernando Garces et al.   CELL

HIV-1 Envelope gp41 Antibodies Can Originate from Terminal Ileum B Cells that Share Cross-Reactivity with Commensal Bacteria

(2014) Ashley M. Trama et al.   Cell Host & Microbe

Immunoglobulin Gene Insertions and Deletions in the Affinity Maturation of HIV-1 Broadly Reactive Neutralizing Antibodies

(2014) Thomas B. Kepler et al.   Cell Host & Microbe

An autoreactive antibody from an SLE/HIV-1 individual broadly neutralizes HIV-1

(2014) Mattia Bonsignori et al.   JOURNAL OF CLINICAL INVESTIGATION

Two Classes of Broadly Neutralizing Antibodies within a Single Lineage Directed to the High-Mannose Patch of HIV Envelope

(2014) Katie J. Doores et al.   JOURNAL OF VIROLOGY

Broad and potent HIV-1 neutralization by a human antibody that binds the gp41–gp120 interface

(2014) Jinghe Huang et al.   NATURE

Rapid development of broadly influenza neutralizing antibodies through redundant mutations

(2014) Leontios Pappas et al.   NATURE

Structure and immune recognition of trimeric pre-fusion HIV-1 Env

(2014) Marie Pancera et al.   NATURE

Developmental pathway for potent V1V2-directed HIV-neutralizing antibodies

(2014) Nicole A. Doria-Rose et al.   NATURE

Early development of broadly neutralizing antibodies in HIV-1–infected infants

(2014) Leslie Goo et al.   NATURE MEDICINE

Recombinant HIV envelope trimer selects for quaternary-dependent antibodies targeting the trimer apex

(2014) Devin Sok et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Promiscuous Glycan Site Recognition by Antibodies to the High-Mannose Patch of gp120 Broadens Neutralization of HIV

(2014) D. Sok et al.   Science Translational Medicine

IDEPI: Rapid Prediction of HIV-1 Antibody Epitopes and Other Phenotypic Features from Sequence Data Using a Flexible Machine Learning Platform

(2014) N. Lance Hepler et al.   PLoS Computational Biology

Reconstructing a B-Cell Clonal Lineage. II. Mutation, Selection, and Affinity Maturation

(2014) Thomas B. Kepler et al.   Frontiers in Immunology

Prevalence of broadly neutralizing antibody responses during chronic HIV-1 infection

(2013) Peter Hraber et al.   AIDS

Human Circulating PD-1+CXCR3−CXCR5+ Memory Tfh Cells Are Highly Functional and Correlate with Broadly Neutralizing HIV Antibody Responses

(2013) Michela Locci et al.   IMMUNITY

Vaccine Induction of Antibodies against a Structurally Heterogeneous Site of Immune Pressure within HIV-1 Envelope Protein Variable Regions 1 and 2

(2013) Hua-Xin Liao et al.   IMMUNITY

HIV-1 neutralizing antibodies: understanding nature's pathways

(2013) John R. Mascola et al.   IMMUNOLOGICAL REVIEWS

Engineering HIV envelope protein to activate germline B cell receptors of broadly neutralizing anti-CD4 binding site antibodies

(2013) Andrew T. McGuire et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Optimization and validation of the TZM-bl assay for standardized assessments of neutralizing antibodies against HIV-1

(2013) Marcella Sarzotti-Kelsoe et al.   JOURNAL OF IMMUNOLOGICAL METHODS

Induction of HIV-1 Broad Neutralizing Antibodies in 2F5 Knock-in Mice: Selection against Membrane Proximal External Region-Associated Autoreactivity Limits T-Dependent Responses

(2013) L. Verkoczy et al.   JOURNAL OF IMMUNOLOGY

Immune Tolerance Negatively Regulates B Cells in Knock-In Mice Expressing Broadly Neutralizing HIV Antibody 4E10

(2013) C. Doyle-Cooper et al.   JOURNAL OF IMMUNOLOGY

Common Tolerance Mechanisms, but Distinct Cross-Reactivities Associated with gp41 and Lipids, Limit Production of HIV-1 Broad Neutralizing Antibodies 2F5 and 4E10

(2013) Y. Chen et al.   JOURNAL OF IMMUNOLOGY

Multiple Pathways of Escape from HIV Broadly Cross-Neutralizing V2-Dependent Antibodies

(2013) P. L. Moore et al.   JOURNAL OF VIROLOGY

Residue-Level Prediction of HIV-1 Antibody Epitopes Based on Neutralization of Diverse Viral Strains

(2013) G.-Y. Chuang et al.   JOURNAL OF VIROLOGY

Co-evolution of a broadly neutralizing HIV-1 antibody and founder virus

(2013) Hua-Xin Liao et al.   NATURE

Structural basis for diverse N-glycan recognition by HIV-1–neutralizing V1–V2–directed antibody PG16

(2013) Marie Pancera et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Supersite of immune vulnerability on the glycosylated face of HIV-1 envelope glycoprotein gp120

(2013) Leopold Kong et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Computational analysis of anti-HIV-1 antibody neutralization panel data to identify potential functional epitope residues

(2013) A. P. West et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Recognition of synthetic glycopeptides by HIV-1 broadly neutralizing antibodies and their unmutated ancestors

(2013) S. M. Alam et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

HIV-1 envelope glycoprotein signatures that correlate with the development of cross-reactive neutralizing activity

(2013) Tom L G M van den Kerkhof et al.   Retrovirology

Delineating Antibody Recognition in Polyclonal Sera from Patterns of HIV-1 Isolate Neutralization

(2013) I. S. Georgiev et al.   SCIENCE

Rational HIV Immunogen Design to Target Specific Germline B Cell Receptors

(2013) J. Jardine et al.   SCIENCE

Identification of broadly neutralizing antibody epitopes in the HIV-1 envelope glycoprotein using evolutionary models

(2013) Miguel Lacerda et al.   Virology Journal

HIV Transmission

(2013) G. M. Shaw et al.   Cold Spring Harbor Perspectives in Medicine

Recombinant HIV Envelope Proteins Fail to Engage Germline Versions of Anti-CD4bs bNAbs

(2013) Sam Hoot et al.   PLoS Pathogens

The Effects of Somatic Hypermutation on Neutralization and Binding in the PGT121 Family of Broadly Neutralizing HIV Antibodies

(2013) Devin Sok et al.   PLoS Pathogens

Characterization of human IgG repertoires in an acute HIV-1 infection

(2012) Weizao Chen et al.   EXPERIMENTAL AND MOLECULAR PATHOLOGY

Human Antibodies that Neutralize HIV-1: Identification, Structures, and B Cell Ontogenies

(2012) Peter D. Kwong et al.   IMMUNITY

Two Distinct Broadly Neutralizing Antibody Specificities of Different Clonal Lineages in a Single HIV-1-Infected Donor: Implications for Vaccine Design

(2012) Mattia Bonsignori et al.   JOURNAL OF VIROLOGY

B-cell–lineage immunogen design in vaccine development with HIV-1 as a case study

(2012) Barton F Haynes et al.   NATURE BIOTECHNOLOGY

Evolution of an HIV glycan–dependent broadly neutralizing antibody epitope through immune escape

(2012) Penny L Moore et al.   NATURE MEDICINE

Complex-type N-glycan recognition by potent broadly neutralizing HIV antibodies

(2012) H. Mouquet et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Characterization of germline antibody libraries from human umbilical cord blood and selection of monoclonal antibodies to viral envelope glycoproteins: Implications for mechanisms of immune evasion and design of vaccine immunogens

(2011) Weizao Chen et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Initial antibodies binding to HIV-1 gp41 in acutely infected subjects are polyreactive and highly mutated

(2011) Hua-Xin Liao et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Rescue of HIV-1 Broad Neutralizing Antibody-Expressing B Cells in 2F5 VH x VL Knockin Mice Reveals Multiple Tolerance Controls

(2011) L. Verkoczy et al.   JOURNAL OF IMMUNOLOGY

Differential Reactivity of Germ Line Allelic Variants of a Broadly Neutralizing HIV-1 Antibody to a gp41 Fusion Intermediate Conformation

(2011) S. M. Alam et al.   JOURNAL OF VIROLOGY

Analysis of a Clonal Lineage of HIV-1 Envelope V2/V3 Conformational Epitope-Specific Broadly Neutralizing Antibodies and Their Inferred Unmutated Common Ancestors

(2011) M. Bonsignori et al.   JOURNAL OF VIROLOGY

Potent and Broad Neutralization of HIV-1 Subtype C by Plasma Antibodies Targeting a Quaternary Epitope Including Residues in the V2 Loop

(2011) P. L. Moore et al.   JOURNAL OF VIROLOGY

Polyclonal B Cell Responses to Conserved Neutralization Epitopes in a Subset of HIV-1-Infected Individuals

(2011) G. D. Tomaras et al.   JOURNAL OF VIROLOGY

Structure of HIV-1 gp120 V1/V2 domain with broadly neutralizing antibody PG9

(2011) Jason S. McLellan et al.   NATURE

Broad neutralization coverage of HIV by multiple highly potent antibodies

(2011) Laura M. Walker et al.   NATURE

Acute HIV-1 Infection

(2011) Myron S. Cohen et al.   NEW ENGLAND JOURNAL OF MEDICINE

Isolation of a Human Anti-HIV gp41 Membrane Proximal Region Neutralizing Antibody by Antigen-Specific Single B Cell Sorting

(2011) Lynn Morris et al.   PLoS One

Focused Evolution of HIV-1 Neutralizing Antibodies Revealed by Structures and Deep Sequencing

(2011) X. Wu et al.   SCIENCE

Sequence and Structural Convergence of Broad and Potent HIV Antibodies That Mimic CD4 Binding

(2011) J. F. Scheid et al.   SCIENCE

A Potent and Broad Neutralizing Antibody Recognizes and Penetrates the HIV Glycan Shield

(2011) R. Pejchal et al.   SCIENCE

Crystal Structure of PG16 and Chimeric Dissection with Somatically Related PG9: Structure-Function Analysis of Two Quaternary-Specific Antibodies That Effectively Neutralize HIV-1

(2010) M. Pancera et al.   JOURNAL OF VIROLOGY

Analysis of Memory B Cell Responses and Isolation of Novel Monoclonal Antibodies with Neutralizing Breadth from HIV-1-Infected Individuals

(2010) Davide Corti et al.   PLoS One

Structure and function of broadly reactive antibody PG16 reveal an H3 subdomain that mediates potent neutralization of HIV-1

(2010) R. Pejchal et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural Basis for Broad and Potent Neutralization of HIV-1 by Antibody VRC01

(2010) T. Zhou et al.   SCIENCE

Rational Design of Envelope Identifies Broadly Neutralizing Human Monoclonal Antibodies to HIV-1

(2010) X. Wu et al.   SCIENCE

Genetic Signatures in the Envelope Glycoproteins of HIV-1 that Associate with Broadly Neutralizing Antibodies

(2010) S. Gnanakaran et al.   PLoS Computational Biology

Germline-like predecessors of broadly neutralizing antibodies lack measurable binding to HIV-1 envelope glycoproteins: Implications for evasion of immune responses and design of vaccine immunogens

(2009) Xiaodong Xiao et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The first T cell response to transmitted/founder virus contributes to the control of acute viremia in HIV-1 infection

(2009) Nilu Goonetilleke et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Tiered Categorization of a Diverse Panel of HIV-1 Env Pseudoviruses for Assessment of Neutralizing Antibodies

(2009) M. S. Seaman et al.   JOURNAL OF VIROLOGY

Autoreactivity in an HIV-1 broadly reactive neutralizing antibody variable region heavy chain induces immunologic tolerance

(2009) L. Verkoczy et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Broad and Potent Neutralizing Antibodies from an African Donor Reveal a New HIV-1 Vaccine Target

(2009) L. M. Walker et al.   SCIENCE

Profiling the Specificity of Neutralizing Antibodies in a Large Panel of Plasmas from Patients Chronically Infected with Human Immunodeficiency Virus Type 1 Subtypes B and C

(2008) J. M. Binley et al.   JOURNAL OF VIROLOGY

Initial B-Cell Responses to Transmitted Human Immunodeficiency Virus Type 1: Virion-Binding Immunoglobulin M (IgM) and IgG Antibodies Followed by Plasma Anti-gp41 Antibodies with Ineffective Control of Initial Viremia

(2008) G. D. Tomaras et al.   JOURNAL OF VIROLOGY

Rapid cloning of high-affinity human monoclonal antibodies against influenza virus

(2008) Jens Wrammert et al.   NATURE