The complement system in systemic lupus erythematosus: an update

C1q Binds Phosphatidylserine and Likely Acts as a Multiligand-Bridging Molecule in Apoptotic Cell Recognition

(2014) H. Paidassi et al.   JOURNAL OF IMMUNOLOGY

Deletion Variants ofRABGAP1L, 10q21.3, andC4Are Associated With the Risk of Systemic Lupus Erythematosus in Korean Women

(2013) Ji-Hong Kim et al.   ARTHRITIS AND RHEUMATISM

Multiple Lupus-AssociatedITGAMVariants Alter Mac-1 Functions on Neutrophils

(2013) Yebin Zhou et al.   ARTHRITIS AND RHEUMATISM

C-reactive protein, immunoglobulin G and complement co-localize in renal immune deposits of proliferative lupus nephritis

(2013) Christopher Sjöwall et al.   AUTOIMMUNITY

Targeting the complement system in systemic lupus erythematosus and other diseases

(2013) Maria-Louise Barilla-LaBarca et al.   CLINICAL IMMUNOLOGY

Complement C4 maintains peripheral B-cell tolerance in a myeloid cell dependent manner

(2013) Priyadarshini Chatterjee et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

The variant of CD11b, rs1143679 within ITGAM, is associated with systemic lupus erythematosus and clinical manifestations in Brazilian patients

(2013) Juliana Escher Toller-Kawahisa et al.   HUMAN IMMUNOLOGY

Successful cure of C1q deficiency in human subjects treated with hematopoietic stem cell transplantation

(2013) Peter D. Arkwright et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Anti-DNA antibodies cross-react with C1q

(2013) Giovanni Franchin et al.   JOURNAL OF AUTOIMMUNITY

Complement Receptor 3 Influences Toll-like Receptor 7/8-Dependent Inflammation

(2013) Joanne H. Reed et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Macrophage Clearance of Neutrophil Extracellular Traps Is a Silent Process

(2013) C. Farrera et al.   JOURNAL OF IMMUNOLOGY

The scavenger receptor SCARF1 mediates the clearance of apoptotic cells and prevents autoimmunity

(2013) Zaida G Ramirez-Ortiz et al.   NATURE IMMUNOLOGY

The identification of a novel splicing mutation in C1qB in a Japanese family with C1q deficiency: a case report

(2013) Yousuke Higuchi et al.   Pediatric Rheumatology

Phagocytosis Is the Main CR3-Mediated Function Affected by the Lupus-Associated Variant of CD11b in Human Myeloid Cells

(2013) Liliane Fossati-Jimack et al.   PLoS One

Atypical Hemolytic Uremic Syndrome

(2013) David Kavanagh et al.   SEMINARS IN NEPHROLOGY

Degradation of neutrophil extracellular traps co-varies with disease activity in patients with systemic lupus erythematosus

(2013) Jonatan Leffler et al.   ARTHRITIS RESEARCH & THERAPY

Anti-C1q Autoantibodies, Novel Tests, and Clinical Consequences

(2013) Michael Mahler et al.   Frontiers in Immunology

Genetically Determined Partial Complement C4 Deficiency States Are Not Independent Risk Factors for SLE in UK and Spanish Populations

(2012) Lora Boteva et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Thers1143679(R77H) lupus associated variant ofITGAM(CD11b) impairs complement receptor 3 mediated functions in human monocytes

(2012) Benjamin Rhodes et al.   ANNALS OF THE RHEUMATIC DISEASES

Defective Complement Inhibitory Function Predisposes to Renal Disease

(2012) Anuja Java et al.   Annual Review of Medicine

Identification of a major linear C1q epitope allows detection of systemic lupus erythematosus anti-C1q antibodies by a specific peptide-based enzyme-linked immunosorbent assay

(2012) Dominique Vanhecke et al.   ARTHRITIS AND RHEUMATISM

Measurement of cell-bound complement activation products enhances diagnostic performance in systemic lupus erythematosus

(2012) Kenneth C. Kalunian et al.   ARTHRITIS AND RHEUMATISM

Increased IgG on cell-derived plasma microparticles in systemic lupus erythematosus is associated with autoantibodies and complement activation

(2012) Christoffer T. Nielsen et al.   ARTHRITIS AND RHEUMATISM

Complement system and small HDL particles are associated with subclinical atherosclerosis in SLE patients

(2012) Sandra Parra et al.   ATHEROSCLEROSIS

Diminished Expression of Complement Regulatory Proteins on Peripheral Blood Cells from Systemic Lupus Erythematosus Patients

(2012) Ana Paula Alegretti et al.   Clinical & Developmental Immunology

Anti-C1q antibody is a valuable biological marker for prediction of renal pathological characteristics in lupus nephritis

(2012) Zhu Chen et al.   CLINICAL RHEUMATOLOGY

Lupus neutrophils

(2012) Jason S. Knight et al.   CURRENT OPINION IN RHEUMATOLOGY

Annexin A2 and A5 Serve as New Ligands for C1q on Apoptotic Cells

(2012) Myriam Martin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Neutrophil Extracellular Traps That Are Not Degraded in Systemic Lupus Erythematosus Activate Complement Exacerbating the Disease

(2012) J. Leffler et al.   JOURNAL OF IMMUNOLOGY

Absence of CD59 Exacerbates Systemic Autoimmunity in MRL/lpr Mice

(2012) T. Miwa et al.   JOURNAL OF IMMUNOLOGY

Complement Protein C1q Directs Macrophage Polarization and Limits Inflammasome Activity during the Uptake of Apoptotic Cells

(2012) M. E. Benoit et al.   JOURNAL OF IMMUNOLOGY

Combination of Autoantibodies Against Different Histone Proteins Influences Complement-dependent Phagocytosis of Necrotic Cell Material by Polymorphonuclear Leukocytes in Systemic Lupus Erythematosus

(2012) BIRGITTA GULLSTRAND et al.   JOURNAL OF RHEUMATOLOGY

Expression and significance of leukocyte membrane cofactor protein transcript in systemic lupus erythematosus

(2012) B Biswas et al.   LUPUS

Identification of novel coding mutation in C1qA gene in an African–American pedigree with lupus and C1q deficiency

(2012) B Namjou et al.   LUPUS

Complement fragment C3d is colocalized within the lipid rafts of T cells and promotes cytokine production

(2012) O Borschukova et al.   LUPUS

Increased C1q, C4 and C3 deposition on platelets in patients with systemic lupus erythematosus – a possible link to venous thrombosis?

(2012) C Lood et al.   LUPUS

Association study of C1qA polymorphisms with systemic lupus erythematosus in a Han population

(2012) C-W Cao et al.   LUPUS

Diagnostic value of serum anti-C1q antibodies in patients with lupus nephritis: a meta-analysis

(2012) Y Yin et al.   LUPUS

Transcriptional effects of a lupus-associated polymorphism in the 5′ untranslated region (UTR) of human complement receptor 2 (CR2/CD21)

(2012) Mark N. Cruickshank et al.   MOLECULAR IMMUNOLOGY

Human complement receptor 2 (CR2/CD21) as a receptor for DNA: Implications for its roles in the immune response and the pathogenesis of systemic lupus erythematosus (SLE)

(2012) Rengasamy Asokan et al.   MOLECULAR IMMUNOLOGY

Eculizumab for the Treatment of Dense-Deposit Disease

(2012) Marina Vivarelli et al.   NEW ENGLAND JOURNAL OF MEDICINE

C1q limits dendritic cell differentiation and activation by engaging LAIR-1

(2012) M. Son et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Role of Complement in the Antiphospholipid Syndrome: A Novel Mechanism for Pregnancy Morbidity

(2012) Michael Samarkos et al.   SEMINARS IN ARTHRITIS AND RHEUMATISM

Factor H autoantibodies and deletion of Complement Factor H-Related protein-1 in rheumatic diseases in comparison to atypical hemolytic uremic syndrome

(2012) Anna Foltyn Zadura et al.   ARTHRITIS RESEARCH & THERAPY

Macrophages and neutrophils in SLE—An online molecular catalog

(2011) Jacob Orme et al.   AUTOIMMUNITY REVIEWS

Immune complexes and late complement proteins trigger activation of Syk tyrosine kinase in human CD4+ T cells

(2011) A. K. Chauhan et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Molecular basis of hereditary C1q deficiency—revisited: identification of several novel disease-causing mutations

(2011) L Schejbel et al.   GENES AND IMMUNITY

Human complement Factor H modulates C1q-mediated phagocytosis of apoptotic cells

(2011) Yu-Hoi Kang et al.   IMMUNOBIOLOGY

Anti-C1q autoantibodies specific against the globular domain of the C1qB-chain from patient with lupus nephritis inhibit C1q binding to IgG and CRP

(2011) Maria Radanova et al.   IMMUNOBIOLOGY

Complement and non-complement activating functions of C1q: A prototypical innate immune molecule

(2011) Annapurna Nayak et al.   Innate Immunity

A Systemic Lupus Erythematosus-associated R77H Substitution in the CD11b Chain of the Mac-1 Integrin Compromises Leukocyte Adhesion and Phagocytosis

(2011) Matthew MacPherson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

IgG Autoantibodies against Deposited C3 Inhibit Macrophage-Mediated Apoptotic Cell Engulfment in Systemic Autoimmunity

(2011) K. D. Kenyon et al.   JOURNAL OF IMMUNOLOGY

Functional Complement C1q Abnormality Leads to Impaired Immune Complexes and Apoptotic Cell Clearance

(2011) Lubka T. Roumenina et al.   JOURNAL OF IMMUNOLOGY

Plasmacytoid Dendritic Cells and C1q Differentially Regulate Inflammatory Gene Induction by Lupus Immune Complexes

(2011) D. M. Santer et al.   JOURNAL OF IMMUNOLOGY

Detection of glomerular complement C3 fragments by magnetic resonance imaging in murine lupus nephritis

(2011) Siranush A. Sargsyan et al.   KIDNEY INTERNATIONAL

Risk of pulmonary embolism in patients with autoimmune disorders: a nationwide follow-up study from Sweden

(2011) Bengt Zöller et al.   LANCET

Prospective assessment of C4d deposits on circulating cells and renal tissues in lupus nephritis: a pilot study

(2011) I Batal et al.   LUPUS

Nonrenal and renal activity of systemic lupus erythematosus: a comparison of two anti-C1q and five anti-dsDNA assays and complement C3 and C4

(2011) Heikki Julkunen et al.   RHEUMATOLOGY INTERNATIONAL

Complement components 2 and 7 (C2 and C7) gene polymorphisms are not major risk factors for SLE susceptibility in the Malaysian population

(2011) Lay-Hoong Lian et al.   RHEUMATOLOGY INTERNATIONAL

Neutrophils Activate Plasmacytoid Dendritic Cells by Releasing Self-DNA-Peptide Complexes in Systemic Lupus Erythematosus

(2011) R. Lande et al.   Science Translational Medicine

Netting Neutrophils Are Major Inducers of Type I IFN Production in Pediatric Systemic Lupus Erythematosus

(2011) G. S. Garcia-Romo et al.   Science Translational Medicine

Evolution of disease burden over five years in a multicenter inception systemic lupus erythematosus cohort

(2011) M. B. Urowitz et al.   ARTHRITIS CARE & RESEARCH

Mutations in genes encoding complement inhibitors CD46 and CFH affect the age at nephritis onset in patients with systemic lupus erythematosus

(2011) Andreas Jönsen et al.   ARTHRITIS RESEARCH & THERAPY

Autoantibodies predate the onset of systemic lupus erythematosus in northern Sweden

(2011) Catharina Eriksson et al.   ARTHRITIS RESEARCH & THERAPY

Association of Genetic Variants in Complement Factor H and Factor H-Related Genes with Systemic Lupus Erythematosus Susceptibility

(2011) Jian Zhao et al.   PLoS Genetics

Network analysis of associations between serum interferon-α activity, autoantibodies, and clinical features in systemic lupus erythematosus

(2010) Corinna E. Weckerle et al.   ARTHRITIS AND RHEUMATISM

Complement: a key system for immune surveillance and homeostasis

(2010) Daniel Ricklin et al.   NATURE IMMUNOLOGY

Impairment of neutrophil extracellular trap degradation is associated with lupus nephritis

(2010) A. Hakkim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

C1q inhibits immune complex-induced interferon-α production in plasmacytoid dendritic cells: A novel link between C1q deficiency and systemic lupus erythematosus pathogenesis

(2009) Christian Lood et al.   ARTHRITIS AND RHEUMATISM

Complement classical pathway components are all important in clearance of apoptotic and secondary necrotic cells

(2009) B. Gullstrand et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Evaluation of C1q genomic region in minority racial groups of lupus

(2009) B Namjou et al.   GENES AND IMMUNITY

Fcγ receptor biology and systemic lupus erythematosus

(2009) Vojislav JOVANOVIC et al.   International Journal of Rheumatic Diseases

Expression and role of CR1 and CR2 on B and T lymphocytes under physiological and autoimmune conditions

(2009) Anna Erdei et al.   MOLECULAR IMMUNOLOGY

SLE with C1q deficiency treated with fresh frozen plasma: a 10-year experience

(2009) P. Mehta et al.   RHEUMATOLOGY

Thrombosis in Systemic Lupus Erythematosus

(2009) Anita Palatinus et al.   SEMINARS IN THROMBOSIS AND HEMOSTASIS

Complement activation and inhibition: a delicate balance

(2009) A.P. Sjöberg et al.   TRENDS IN IMMUNOLOGY

A nonsynonymous functional variant in integrin-αM (encoded by ITGAM) is associated with systemic lupus erythematosus

(2008) Swapan K Nath et al.   NATURE GENETICS

Defining the Role of the MHC in Autoimmunity: A Review and Pooled Analysis

(2008) Michelle M. A. Fernando et al.   PLoS Genetics